Displaying drugs 151 - 175 of 5058 in total
Insulin aspart
Insulin aspart is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the...
Approved
Matched Synonyms: … Insulin aspart recombinant ... Insulin aspart protamine recombinant …
Matched Description: … Insulin aspart is a recombinant, biosynthetic, fast-acting insulin analogue. ... Insulin also inhibits hepatic glucose production, enhances protein synthesis, and inhibits lipolysis …
Matched Products: … NovoRapid FlexPen 100U/ml solution for injection in pre-filled pen ... RYZODEG® FLEXTOUCH® SOLUTION FOR INJECTION IN PRE-FILLED PEN 100 U/ml ... NovoRapid® FlexPen® 100 U/ml Solution for Injection in Pre-filled Pen …
Matched Description: … Insulin aspart is a recombinant, biosynthetic, fast-acting insulin analogue. ... Insulin also inhibits hepatic glucose production, enhances protein synthesis, and inhibits lipolysis …
Matched Products: … NovoRapid FlexPen 100U/ml solution for injection in pre-filled pen ... RYZODEG® FLEXTOUCH® SOLUTION FOR INJECTION IN PRE-FILLED PEN 100 U/ml ... NovoRapid® FlexPen® 100 U/ml Solution for Injection in Pre-filled Pen …
Nonacog beta pegol
Nonacog beta pegol is a recombinant coagulation factor IX derivative. It is produced without animal-derived materials and with an attached 40kDa polyethylene glycol (PEG) molecule for peptide activation by a site-directed glycoPEGylation. Once activated, the activation molecule with PEG is cleaved to leave the activated factor IX (Factor IXa). Nonacog...
Approved
Investigational
Matched Synonyms: … Coagulation Factor IX (Recombinant), GlycoPEGylated …
Matched Description: … Nonacog beta pegol is a recombinant coagulation factor IX derivative. …
Matched Categories: … Protein Precursors …
Matched Description: … Nonacog beta pegol is a recombinant coagulation factor IX derivative. …
Matched Categories: … Protein Precursors …
Ocriplasmin
Ocriplasmin is a recombinant truncated form of human plasmin with a molecular weight of 27.2 kDa produced by recombinant DNA technology in a Pichia pastoris expression system. Ocriplasmin is a protein made up of 249 amino acids and has two peptide chains. Agent for pharmacologic vitreolysis; thrombolytic agent. FDA approved...
Approved
Matched Synonyms: … Recombinant human microplasmin …
Matched Description: … Ocriplasmin is a protein made up of 249 amino acids and has two peptide chains. ... by recombinant DNA technology in a Pichia pastoris expression system. ... Ocriplasmin is a recombinant truncated form of human plasmin with a molecular weight of 27.2 kDa produced …
Matched Description: … Ocriplasmin is a protein made up of 249 amino acids and has two peptide chains. ... by recombinant DNA technology in a Pichia pastoris expression system. ... Ocriplasmin is a recombinant truncated form of human plasmin with a molecular weight of 27.2 kDa produced …
Choriogonadotropin alfa
Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each with N-and O-linked carbohydrate moieties linked to ASN-52 and ASN-78 (on alpha subunit) and ASN-13, ASN-30, SER-121, SER-127, SER-132 and SER-138 (on beta subunit). The primary structure of the alpha-chain of r-hCG is identical...
Approved
Matched Synonyms: … Chorionic gonadotropin (recombinant) …
Matched Description: … Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each …
Matched Description: … Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each …
Valoctocogene roxaparvovec
Valoctocogene roxaparvovec is an adeno-associated virus serotype 5 (AAV5) based gene therapy vector that expresses the B-domain deleted SQ form of human coagulation factor VIII (hFVIII-SQ). The expression of hFVIII-SQ is driven by a liver-specific promoter, which enables hepatocytes to produce factor VIII protein and increase the levels of active...
Approved
Investigational
Matched Synonyms: … DNA (synthetic adeno-associated virus 5 vector BMN 270 human blood-coagulation factor VIII SQ variant-specifying …
Matched Description: … Valoctocogene roxaparvovec is an adeno-associated virus serotype 5 (AAV5) based gene therapy vector that ... hFVIII-SQ is driven by a liver-specific promoter, which enables hepatocytes to produce factor VIII protein …
Matched Categories: … Protein Precursors ... Recombinant Proteins …
Matched Description: … Valoctocogene roxaparvovec is an adeno-associated virus serotype 5 (AAV5) based gene therapy vector that ... hFVIII-SQ is driven by a liver-specific promoter, which enables hepatocytes to produce factor VIII protein …
Matched Categories: … Protein Precursors ... Recombinant Proteins …
Parathyroid hormone
Parathyroid hormone (PTH) is a single-chain polypeptide composed of 84 amino acids. Available as Preotact, it is an identical form of human recombinant hormome which produced as a fusion protein undergoeing post-translational processing involving the cleavage of the OmpA leader sequence, leaving the mature protein as a single-chain 84 amino-acids...
Approved
Investigational
Matched Synonyms: … Parathormone (human recombinant) ... Parathyroid hormone (1-84) human recombinant …
Matched Description: … Available as Preotact, it is an identical form of human recombinant hormome which produced as a fusion ... , leaving the mature protein as a single-chain 84 amino-acids polypeptide (9.4 kDa). ... protein undergoeing post-translational processing involving the cleavage of the OmpA leader sequence …
Matched Description: … Available as Preotact, it is an identical form of human recombinant hormome which produced as a fusion ... , leaving the mature protein as a single-chain 84 amino-acids polypeptide (9.4 kDa). ... protein undergoeing post-translational processing involving the cleavage of the OmpA leader sequence …
Oprelvekin
Oprelvekin, the active ingredient in Neumega®, is recombinant Interleukin-11 (IL-11), which is produced in Escherichia coli (E. coli) by recombinant DNA technology. With a molecular mass of approximately 19,000 daltons, the non-glycosylated protein is 177 amino acids in length in comparison to the natural IL-11, which is 178 amino acid...
Approved
Investigational
Matched Synonyms: … Recombinant interleukin-11 …
Matched Description: … in Escherichia coli (E. coli) by recombinant DNA technology. ... Oprelvekin, the active ingredient in Neumega®, is recombinant Interleukin-11 (IL-11), which is produced ... With a molecular mass of approximately 19,000 daltons, the non-glycosylated protein is 177 amino acids …
Matched Description: … in Escherichia coli (E. coli) by recombinant DNA technology. ... Oprelvekin, the active ingredient in Neumega®, is recombinant Interleukin-11 (IL-11), which is produced ... With a molecular mass of approximately 19,000 daltons, the non-glycosylated protein is 177 amino acids …
Sargramostim
Sargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.
Approved
Investigational
Matched Synonyms: … Recombinant human granulocyte-macrophage colony stimulating factor …
Matched Description: … Substitution of Leu23 leads to a difference from native protein. ... Sargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed …
Matched Description: … Substitution of Leu23 leads to a difference from native protein. ... Sargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed …
Florbetapir (18F)
Florbetapir (18F) is a radiopharmaceutical compound containing the radionuclide fluorine-18 bound to the compound florbetapir, a molecule that binds with high affinity to beta amyloid plaque, a peptide that plays a key role in Alzheimer's Disease pathogenesis. Marketed as the product Amyvid, florbetapir 18F is indicated for positron emission tomography...
Approved
Investigational
Matched Synonyms: … Florbetapir F-18 …
Matched Iupac: … 4-[(E)-2-[6-(2-{2-[2-(¹⁸F)fluoroethoxy]ethoxy}ethoxy)pyridin-3-yl]ethenyl]-N-methylaniline …
Matched Iupac: … 4-[(E)-2-[6-(2-{2-[2-(¹⁸F)fluoroethoxy]ethoxy}ethoxy)pyridin-3-yl]ethenyl]-N-methylaniline …
Becaplermin
Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet derived growth factor (PDGF) into the yeast, Saccharomyces cerevisiae. Becaplermin has a molecular weight of approximately 25 KD and is a homodimer composed of two identical polypeptide chains that are bound together...
Approved
Investigational
Matched Synonyms: … Platelet-derived growth factor BB, recombinant ... Recombinant platelet-derived growth factor BB …
Matched Description: … Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet …
Matched Description: … Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet …
Human interferon beta
Human interferon beta is a polypeptide used in the management of relapsing forms of Multiple Sclerosis (MS), and was initially approved by the FDA in 1992. Multiple Sclerosis is a devastating neurodegenerative disease that is usually progressive and significantly debilitating with a profound impact on the quality of life. Interferon...
Approved
Investigational
Matched Synonyms: … Interferon beta (recombinant) …
Matched Description: … causing Middle Eastern Respiratory Syndrome (MERS). ... the past in clinical studies with other coronaviruses due to its demonstrated activity against the virus ... studied as a possible treatment for COVID-19, which results from infection with the novel 2019 SARS-CoV-2 virus …
Matched Description: … causing Middle Eastern Respiratory Syndrome (MERS). ... the past in clinical studies with other coronaviruses due to its demonstrated activity against the virus ... studied as a possible treatment for COVID-19, which results from infection with the novel 2019 SARS-CoV-2 virus …
Avalglucosidase alfa
Avalglucosidase alfa, or NeoGAA, is a drug for enzyme replacement therapy specifically designed for Pompe disease, a rare inherited neuromuscular disorder caused by the deficiency of the alpha-glucosidase (GAA) enzyme. GAA is an essential enzyme that hydrolyzes glycogen into free glucose for use in cellular functions. In Pompe disease, the...
Approved
Investigational
Matched Synonyms: … Neo-recombinant human acid alpha-glucosidase …
Matched Description: … [A232955] Avalglucosidase alfa is a recombinant form of GAA that restores deficient enzyme levels. ... Pompe disease is characterized by progressive muscle weakness and loss of motor function, including respiratory ... associated with a range of debilitating physical symptoms, such as progressive muscle weakness, including respiratory …
Matched Description: … [A232955] Avalglucosidase alfa is a recombinant form of GAA that restores deficient enzyme levels. ... Pompe disease is characterized by progressive muscle weakness and loss of motor function, including respiratory ... associated with a range of debilitating physical symptoms, such as progressive muscle weakness, including respiratory …
Lenograstim
Lenograstim is a recombinant granulocyte colony-stimulating factor used as an immunostimulating agent.
Approved
Investigational
Matched Synonyms: … Glycosylated recombinant G-CSF ... Glycosylated recombinant granulocyte colony stimulating factor …
Matched Description: … Lenograstim is a recombinant granulocyte colony-stimulating factor used as an immunostimulating agent …
Matched Description: … Lenograstim is a recombinant granulocyte colony-stimulating factor used as an immunostimulating agent …
Turoctocog alfa pegol
Turoctocog alfa pegol is a pegylated version of turoctocog alfa. Novo Nordisk's brand name Esperoct (turoctocog alfa pegol, N8-GP) was approved by the US FDA on February 19, 2019.
Fundamentally, the N8-GP moiety is identical to turoctocog alfa, a recombinant human clotting factor VIII (rFVIII) with a truncated B-domain made...
Approved
Matched Synonyms: … Antihemophilic factor (recombinant), glycopegylated-exei …
Matched Description: … Fundamentally, the N8-GP moiety is identical to [turoctocog alfa], a recombinant human clotting factor …
Matched Categories: … Recombinant Proteins …
Matched Description: … Fundamentally, the N8-GP moiety is identical to [turoctocog alfa], a recombinant human clotting factor …
Matched Categories: … Recombinant Proteins …
Cipaglucosidase alfa
Cipaglucosidase alfa (ATB200) is a novel recombinant human acid alpha-glucosidase (GAA) investigated for the treatment of patients with Pompe disease, a rare inherited metabolic disorder characterized by a deficiency in GAA. Other types of enzyme replacement therapy for the treatment of Pompe disease include alglucosidase alfa and avalglucosidase alfa. Cipaglucosidase...
Approved
Investigational
Matched Synonyms: … Recombinant human acid alpha-glucosidase optimized for high expression of mannose 6-phosphate …
Matched Description: … Cipaglucosidase alfa (ATB200) is a novel recombinant human acid alpha-glucosidase (GAA) investigated …
Matched Description: … Cipaglucosidase alfa (ATB200) is a novel recombinant human acid alpha-glucosidase (GAA) investigated …
Asparaginase Erwinia chrysanthemi
Asparaginase Erwinia chrysanthemi is an asparaginase-specific enzyme derived from Erwinia chrysanthemi used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-asparaginase was first identified in...
Approved
Investigational
Matched Synonyms: … Asparaginase Erwinia chrysanthemi (recombinant) ... asparaginase erwinia chrysanthemi (recombinant)-rywn …
Matched Description: … [L149] In June 2021, the recombinant form of asparaginase _Erwinia chrysanthemi_ was approved by the …
Matched Description: … [L149] In June 2021, the recombinant form of asparaginase _Erwinia chrysanthemi_ was approved by the …
Casein
Casein allergenic extract is used in allergenic testing.
Approved
Matched Synonyms: … Milk protein …
Sulesomab
Market product is Tc99m-labeled murine antibody fragment for nuclear imaging of activated granulocytes.
Approved
Matched Synonyms: … Immunoglobulin G1 (mouse monoclonal IMMU-MN3 Fab' fragment gamma-chain anti-human NCA-90 granulocyte cell antigen …
Factor XIII (human)
Factor XIII (human) is a heat-treated, lyophilized concentrate of coagulation factor XIII, an endogenous enzyme responsible for the crosslinking of fibrin and an essential component of the coagulation cascade [FDA Label]. For people with congenital deficiency or mutation of Factor XIII, a rare bleeding disorder, exogenous replacement of this key...
Approved
Investigational
Matched Synonyms: … Coagulation factor XIII, recombinant …
Matched Description: … DNA technology where the target protein is grown in yeast and then isolated [FDA Label]. ... drug products with similar structure and function to Factor XIII (human) include [DB09310], which is a recombinant ... Compared to Factor XIII (human), which is purified from pooled human plasma, [DB09310] is produced through recombinant …
Matched Categories: … Protein Precursors …
Matched Description: … DNA technology where the target protein is grown in yeast and then isolated [FDA Label]. ... drug products with similar structure and function to Factor XIII (human) include [DB09310], which is a recombinant ... Compared to Factor XIII (human), which is purified from pooled human plasma, [DB09310] is produced through recombinant …
Matched Categories: … Protein Precursors …
Elranatamab
Elranatamab is a bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager. It is a humanized immunoglobulin 2-alanine kappa antibody derived from two monoclonal antibodies (mAbs), an anti-BCMA mAb and an anti-CD3 mAb, each of which contributes one heavy chain and one light chain to drug structure. The resulting 4-chain bispecific...
Approved
Investigational
Matched Synonyms: … B-CELL MATURATION ANTIGEN (BCMA) CLUSTER OF DIFFERENTIATION 3 (CD3) BISPECIFIC MONOCLONAL ANTIBODY (MAB ... IMMUNOGLOBULIN G2 (224-ARGININE,265-ALANINE,330-SERINE,331-SERINE), ANTI-(HUMAN CD3 ANTIGEN .EPSILON. ... IMMUNOGLOBULIN G2-KAPPA, ANTI-(HOMO SAPIENS T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN CD3E (T-CELL SURFACE ANTIGEN …
Matched Description: … Elranatamab is a bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager. …
Matched Categories: … Bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager …
Matched Description: … Elranatamab is a bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager. …
Matched Categories: … Bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager …
Elotuzumab
Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family member 7, a cell surface glycoprotein. Elotuzumab...
Approved
Matched Synonyms: … Immunoglobulin G1, anti-(human protein CS1) (human-mouse HuLuc63 heavy chain), disulfide with human-mouse …
Matched Description: … Elotuzumab is produced in NS0 cells by recombinant DNA technology. …
Matched Description: … Elotuzumab is produced in NS0 cells by recombinant DNA technology. …
Palivizumab
Humanized monoclonal antibody (IgG1k) produced by recombinant DNA technology, directed to an epitope in the A antigenic site of the F protein of respiratory syncytial virus (RSV). Synagis is a composite of human (95%) and murine (5%) antibody sequences. The human heavy chain sequence was derived from the constant domains...
Approved
Investigational
Matched Description: … in the A antigenic site of the F protein of respiratory syncytial virus (RSV). ... Humanized monoclonal antibody (IgG1k) produced by recombinant DNA technology, directed to an epitope …
Matched Categories: … Respiratory Syncytial Virus Anti-F Protein Monoclonal Antibody ... Fusion Protein Inhibitors …
Matched Categories: … Respiratory Syncytial Virus Anti-F Protein Monoclonal Antibody ... Fusion Protein Inhibitors …
Hydrocortisone
Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone was granted FDA approval on 5 August 1952.
Approved
Vet approved
Matched Synonyms: … Kendall's compound F …
Matched Description: … L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, …
Matched Categories: … Respiratory System …
Matched Description: … L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, …
Matched Categories: … Respiratory System …
Viper antivenom
Viper antivenom consists of antibodies derived from horses immunized and subsequently developed antibodies against snake venoms. ANAVIP, an equine-derived antivenom made with venom from Bothrops asper and Crotalus durissus, was first approved by the FDA on October 1, 2015, for the management of North American rattlesnake envenomation.
Approved
Matched Synonyms: … Crotalidae immune F(ab')2 (equine) ... Antivenin crotaline (pit-viper) equine immune F(ab)2) …
Dostarlimab
Dostarlimab is an IgG4 humanized monoclonal antibody targeted against the human programmed death receptor-1 (PD-1). PD-1 receptors are found on T-cells and, when activated, serve to inhibit immune responses - some cancers leverage this system by overexpressing PD-1 ligands, thereby effectively inhibiting the anti-tumor immune response that would typically attempt...
Approved
Investigational
Matched Synonyms: … Immunoglobulin G4, anti-programmed cell death protein 1 (PDCD1) (humanized clone ABT1 gamma4-chain), …
Matched Categories: … PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitors ... PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitors …
Matched Categories: … PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitors ... PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitors …
Displaying drugs 151 - 175 of 5058 in total