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Displaying drugs 1926 - 1950 of 15212 in total

Dosulepin

Dosulepin (INN, BAN) formerly known as dothiepin (USAN), is a tricyclic antidepressant with anxiolytic properties that is used in several European and South Asian countries, as well as Australia, South Africa, and New Zealand. It is not FDA-approved due to low therpeutic index and significant toxicity in overdose. Dosulepin inhibits...
Approved
Matched Description: … South Asian countries, as well as Australia, South Africa, and New Zealand. ... anticholinergic, antihistamine and central sedative properties [L882]. ... It is not FDA-approved due to low therpeutic index and significant toxicity in overdose. …

Efavirenz

Efavirenz (brand names Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1. For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with...
Approved
Investigational
Matched Description: … Efavirenz (brand names Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI ... For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with ... ) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency …
Matched Mixtures name: … Efavirenz, Lamivudine and Tenofovir Disoproxil Fumarate ... Efavirenz, Lamivudine and Tenofovir Disoproxil Fumarate ... Efavirenz, Lamivudine and Tenofovir Disoproxil Fumarate …
Matched Categories: … Nucleic Acid Synthesis Inhibitors ... Metabolic Side Effects of Drugs and Substances ... lamivudine, tenofovir disoproxil and efavirenz ... emtricitabine, tenofovir disoproxil and efavirenz …

Framycetin

A component of neomycin that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)
Approved
Matched Description: … On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed) …

Calcium levulinate

The relatively new calcium levulinate is produced from a direct reaction between L- or levulinic acid levulose and calcium hydroxide . The resultant calcium levulinate formulation, when used as a calcium supplement, possesses a high calcium content that is observed to be 14.8% higher than the content typically found in...
Approved
Experimental
Matched Description: … The relatively new calcium levulinate is produced from a direct reaction between L- or levulinic acid ... levulose and calcium hydroxide [L2765]. ... milk products, soy milk and soy products with calcium nutrition [L2765]. …
Matched Categories: … Alimentary Tract and Metabolism …

Potassium alum

Potassium alum is considered by the FDA as a generally recognized as safe (GRAS) substance. It is an inorganic salt, also called potassium aluminum sulfate with a formula of AlK(SO4)2 that is predominantly produced in the dodecahydrate form (AlK(SO4)2 * 12H2O). Potassium alum is formed by large, transparent crystals that...
Approved
Matched Mixtures name: … Gingibraid W Epineph and Alum 1e ... Gingibraid W Epineph and Alum 2e ... Gingibraid W Epineph and Alum 3e …

Ifosfamide

Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent.
Approved
Matched Description: … It is active as an alkylating agent and an immunosuppressive agent. ... Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog …
Matched Mixtures name: … IFEX and MESNEX ... IFEX and MESNEX ... IFEX and MESNEX …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Bupivacaine

Bupivacaine is a widely used local anesthetic agent.
Approved
Investigational
Matched Mixtures name: … Bupivacaine Hci and Epinephrine ... Bupivacaine Hydrochloride and Epinephrine ... Bupivacaine Hydrochloride and Epinephrine …
Matched Categories: … bupivacaine and meloxicam …

Etidocaine

Etidocaine is marketed under the name Duranest. It is an injectable local anesthetic during surgery, labor, and delivery. Etidocaine has a long duration of activity, but has the main disadvantage of increased bleeding during oral surgery.
Approved
Matched Description: … It is an injectable local anesthetic during surgery, labor, and delivery. …

Valbenazine

Valbenazine is a modified metabolite of tetrabenazine, and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine receptor therapy, and until 2008 with the advent of tetrabenazine,...
Approved
Investigational
Matched Description: … safety and tolerability concerns. ... Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment ... of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Nirogacestat

Nirogacestat is a small-molecule gamma-secretase inhibitor that was investigated as a potential treatment for desmoid tumors. Desmoid tumors are typically characterized by aberrant activation in Notch signaling. Interaction between the notch receptors and their ligands activates proteolytic cleavage by gamma-secretase; therefore, the inhibition of gamma-secretase can potentially inhibit Notch signaling...
Approved
Investigational
Matched Description: … [A262556] Interaction between the notch receptors and their ligands activates proteolytic cleavage by ... of desmoid tumors, and the final approval was based on positive results obtained in the Phase 3 DeFi ... gamma-secretase; therefore, the inhibition of gamma-secretase can potentially inhibit Notch signaling and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Gamma Secretase Inhibitors and Modulators …

Capivasertib

Hormone receptor (HR) positive, especially estrogen receptor-positive, HER2-negative breast cancer is the most common subtype of metastatic breast cancer, resulting in more than 400,000 deaths annually. Although endocrine-based therapy is the first line of treatment, resistance eventually emerges, leaving chemotherapy the only but often ineffective treatment left. Therefore, significant research...
Approved
Investigational
Matched Description: … based on favorable results obtained from the CAPItello-291 trial, where the combination of capivasertib and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Indinavir

A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]
Approved
Matched Description: … A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. …

Gadodiamide

Gadodiamide is a linear, non-ionic gadolinium-based contrast agent (GBCA) that is used in magnetic resonance imaging (MRI) procedures to assist in the visualization of blood vessels.[A263086,A263091] GBCAs constitute the largest group of MR agents, and they are thought to be safer than nonionic iodinated contrast agents. Approved by the FDA...
Approved
Investigational
Matched Description: … [A263086,A263091] GBCAs constitute the largest group of MR agents, and they are thought to be safer than ... macrocyclic or ionic GBCA, gadodiamide can potentially lead to more gadolinium retention in the brain and …

Isosorbide dinitrate

A vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action.
Approved
Investigational
Matched Mixtures name: … Isosorbide dinitrate and hydralazine hydrochloride ... Isosorbide Dinitrate and Hydralazine Hydrochloride ... Isosorbide Dinitrate and Hydralazine Hydrochloride …
Matched Categories: … Nitrates and Nitrites ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Orphenadrine

A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
Approved
Matched Description: … A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm …
Matched Mixtures name: … Orphenadrine Citrate, Aspirin and Caffeine ... Orphenadrine Citrate, Aspirin and Caffeine ... Orphenadrine Citrate, Aspirin and Caffeine …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …

Cannabidiol

Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact...
Approved
Investigational
Matched Description: … CBD are obtained through conversion from their precursors, tetrahydrocannabinolic acid-A (THCA-A) and ... acid (GABA), and cellular uptake of anandamide, acts on mitochondria Ca2+ stores, blocks low-voltage-activated ... cannabidiolic acid (CBDA), through decarboxylation reactions. …
Matched Categories: … Cannabinoids and similars …

Brimonidine

Brimonidine is an alpha-adrenergic agonist and 2-imidazoline derivative that was first introduced in 1996. It is considered to be a third generation alpha-2 aadrenergic receptor agonist, since it displays preferential binding at alpha-2 adrenoceptors over alpha-1 receptors. Brimonidine displays a higher selectivity toward the alpha-2 adrenergic receptors than clonidine or...
Approved
Matched Description: … Brimonidine is an alpha-adrenergic agonist and 2-imidazoline derivative that was first introduced in ... Early treatment and management of glaucoma, which predominantly involves the lowering of intraocular ... [A178945] Thus brimonidine is an effective and safe alternative to beta-blockers, in patients with, or …
Matched Mixtures name: … Brimonidine Tartrate and Timolol Maleate ... BRIMONIDINE TARTRATE and TIMOLOL MALEATE ... Brimonidine Tartrate and Timolol Maleate …
Matched Categories: … Decongestants and Antiallergics ... Skin and Mucous Membrane Agents ... Antiglaucoma Preparations and Miotics …

Tasimelteon

Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-time insomnia and day-time sleepiness. In blind individuals, a lack of light stimulation causes an extension of...
Approved
Investigational
Matched Description: … By activating melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, tasimelteon ... In blind individuals, a lack of light stimulation causes an extension of the 24-hour circadian cycle and ... Tasimelteon is currently the only drug available for the treatment of N24HSWD and was granted orphan …
Matched Categories: … Hypnotics and Sedatives …

Aliskiren

Aliskiren is the first drug in the renin inhibitor drug class and is used for the treatment of hypertension. It was developed by Speedel and Novartis and initially approved by the FDA in early 2007. Aliskiren has been proven to efficacious in reducing blood pressure when used alone or in...
Approved
Investigational
Matched Description: … [A203624] It was developed by Speedel and Novartis and initially approved by the FDA in early 2007. ... Aliskiren is the first drug in the renin inhibitor drug class and is used for the treatment of hypertension …
Matched Categories: … valsartan and aliskiren ... aliskiren and amlodipine ... aliskiren and hydrochlorothiazide ... aliskiren, amlodipine and hydrochlorothiazide …

Everolimus

Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and...
Approved
Matched Description: … Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian ... In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Prochlorperazine

Prochlorperazine, also known as compazine, is a piperazine phenothiazine and first-generation antipsychotic drug that is used for the treatment of severe nausea and vomiting, as well as short-term management of psychotic disorders such as generalized non-psychotic anxiety and schizophrenia.[label] It mainly works by depressing the chemoreceptor trigger zone and blocking...
Approved
Vet approved
Matched Description: … of psychotic disorders such as generalized non-psychotic anxiety and schizophrenia. ... It was shown to also block histaminergic, cholinergic and noradrenergic receptors. ... Prochlorperazine, also known as compazine, is a piperazine phenothiazine and first-generation antipsychotic …

Peppermint oil

Extracted from the stem, leaves, and flowers of Mentha piperita L. plant, peppermint oil (Mentha piperita) is a popular essential oil used in aromatherapy for both external and internal use. Mentha piperita is a hybrid of spearmint (Mentha spicata) and water mint (Mentha aquatica) . Medicinal use of herbal ingredients...
Approved
Investigational
Matched Description: … and as an anti-itch and cooling agent in topical pharmaceutical products. ... upper respiratory symptoms and cough [A33055]. ... , antibacterial, secretolytic, and choleretic actions [A33056]. …
Matched Categories: … Alimentary Tract and Metabolism ... Herbs and Natural Products …

Flumethasone

Flumethasone is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a privalate salt, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.
Approved
Vet approved
Matched Description: … Flumethasone is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and ... This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching …
Matched Categories: … flumetasone and antiseptics ... flumetasone and antibiotics ... flumetasone and antiinfectives ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Bendroflumethiazide

A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)
Approved
Matched Description: … A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. ... It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders …
Matched Mixtures name: … Nadolol and Bendroflumethiazide ... Nadolol and Bendroflumethiazide ... Nadolol and Bendroflumethiazide …
Matched Categories: … bendroflumethiazide and potassium ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... bendroflumethiazide and potassium-sparing agents ... Low-Ceiling Diuretics and Potassium-Sparing Agents …

Bos taurus hair

Bos taurus hair is used in allergenic testing.
Approved
Matched Mixtures name: … Cattle Hair and Epithelia ... Animal Allergens, AP Cattle Hair and Dander ... Animal Allergens, AP Cattle Hair and Dander …
Displaying drugs 1926 - 1950 of 15212 in total