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Displaying drugs 1976 - 2000 of 3674 in total
Investigational
Matched Synonyms: … 2-benzofurancarboxylic acid, 4-chloro-5-(4-((2,6-dichlorophenyl)sulfonyl)-1-piperazinyl)- …
Acne vulgaris is a multifactorial disorder of the pilosebaceous unit involving increased sebum production, inflammation, and hyperproliferation/hyperkeratinization of the follicular infundibulum. It is also associated with Cutibacterium acnes (also known as Propionibacterium acnes). Adapalene is a third-generation topical retinoid used for the treatment of acne vulgaris. Adapalene has similar efficacy...
Approved
Matched Synonyms: … 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid
Matched Iupac: … 6-[3-(adamantan-1-yl)-4-methoxyphenyl]naphthalene-2-carboxylic acid
Matched Description: … multifactorial disorder of the pilosebaceous unit involving increased sebum production, inflammation, and ... [A193521] [Tazarotene] is more efficacious than adapalene but is designated as pregnancy category X and ... can also be combined with benzoyl peroxide (BPO), which possesses bactericidal properties[A193524], and
Matched Mixtures name: … Adapalene 0.3% / Niacinamide 4% ... Adapalene 0.3% / Benzoyl Peroxide 2.5% / Niacinamide 4% ... Adapalene 0.1% / Benzoyl Peroxide 2.5% / Niacinamide 4% …
Matched Categories: … Skin and Mucous Membrane Agents …
Ambrisentan is an orally active selective type A endothelin receptor antagonist indicated for the treatment of pulmonary arterial hypertension. It is approved in Europe, Canada and the United States for use as a single agent to improve exercise ability and delay clinical worsening. In addition, it is approved in the...
Approved
Investigational
Matched Synonyms: … (2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy- 3,3-diphenylpropanoic acid
Matched Iupac: … (2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid
Matched Description: … ability and delay clinical worsening. ... It is approved in Europe, Canada and the United States for use as a single agent to improve exercise ... States for use in combination with tadalafil to reduce the risks of disease progression, hospitalization and
Matched Categories: … ambrisentan and tadalafil ... Acids, Carbocyclic ... Carboxylic Acids
Matched Products: … AMBRISENTAN BETA 5 MG FTA ... AMBRISENTAN BETA 10 MG FTA …
Gluconolactone is a naturally-occurring food additive used as a sequestrant, an acidifier, or a curing, pickling, or leavening agent. It is a cyclic ester of D-gluconic acid. Pure gluconolactone is a white odorless crystalline powder.
Approved
Experimental
Matched Synonyms: … Gluconic acid lactone ... D-gluconic acid delta-lactone …
Matched Description: … It is a cyclic ester of D-gluconic acid. Pure gluconolactone is a white odorless crystalline powder. …
Matched Categories: … Acids, Acyclic ... Sugar Acids ... Hydroxy Acids ... Carboxylic Acids
Zomepirac, formerly marketed as Zomax tablets, was associated with fatal and near-fatal anaphylactoid reactions. The manufacturer voluntarily removed Zomax tablets from the Canadian, US, and UK markets in March 1983.
Withdrawn
Matched Synonyms: … 5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetic acid
Matched Iupac: … 2-[5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl]acetic acid
Matched Description: … Zomepirac, formerly marketed as Zomax tablets, was associated with fatal and near-fatal anaphylactoid ... The manufacturer voluntarily removed Zomax tablets from the Canadian, US, and UK markets in March 1983 …
Matched Categories: … Acetic Acid Derivatives and Related Substances ... Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Glucarpidase is a recombinant carboxypeptidase G2 produced by genetically modified Escherichia coli bacteria. It is a 390-amino acid homodimer protein. High-dose methotrexate, an antifolate agent, has been widely and safely used for many decades in treating various cancers; however, even with aggressive hydration, urine alkalinization, and leucovorin rescue, some patients...
Approved
Investigational
Matched Synonyms: … Pteroylmonoglutamic acid hydrolase G2 …
Matched Description: … It is a 390-amino acid homodimer protein. ... [L39855] High-dose [methotrexate], an antifolate agent, has been widely and safely used for many decades ... in treating various cancers; however, even with aggressive hydration, urine alkalinization, and leucovorin …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Enzymes and Coenzymes …
Indium In-111 pentetate disodium is a radioactive diagnostic indicated for use in radionuclide cisternography. Decay of In-111 by electron capture allows for detection with a gamma camera for visualization of the brain and spinal column.
Approved
Matched Synonyms: … Indium (111In) pentetic acid
Matched Iupac: … (111In)indium(3+) ion 2-[bis({2-[bis(carboxymethyl)amino]ethyl})amino]acetate
Matched Description: … In-111 by electron capture allows for detection with a gamma camera for visualization of the brain and
Matched Categories: … indium (111In) pentetic acid
Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929 , investigations regarding its possible use as a laxative for...
Approved
Matched Synonyms: … 4-O-beta-D-Galactopyranosyl-D-fructose ... 4-O-beta-D-Galactopyranosyl-D-fructofuranose …
Matched Description: … possible use as a laxative for the treatment of chronic constipation did not occur until the 1960s and ... [L6202] Nevertheless, although lactulose received formal FDA approval in 1977 and has since become ... List of Essential Medicines as one of the most effective and safe medicines employed in a health system …
Matched Categories: … Alimentary Tract and Metabolism …
Experimental
Matched Synonyms: … (5-oxo-5,6-dihydro-indolo[1,2-a]quinazolin-7-yl)-acetic acid
Matched Name: … (5-hydroxyindolo[1,2-a]quinazolin-7-yl)acetic acid
Matched Iupac: … 2-{5-oxo-5H,6H-indolo[1,2-a]quinazolin-7-yl}acetic acid
Experimental
Matched Synonyms: … m-Cresylic acid
S-Ethylisothiourea is a nitric oxide synthase inhibitor.
Experimental
Matched Synonyms: … CARBAMIMIDOTHIOIC ACID, ETHYL ESTER …
Matched Description: … S-Ethylisothiourea is a nitric oxide synthase inhibitor. …
Matched Categories: … Hypnotics and Sedatives ... Nitric Oxide Synthase, antagonists & inhibitors …
Cilomilast (Ariflo, SB-207,499) is a drug which was developed for the treatment of respiratory disorders such as asthma and Chronic Obstructive Pulmonary Disease (COPD). It is orally active and acts as a selective Phosphodiesterase-4 inhibitor. Following four clinical trials, the drug proved to be effective in treating COPD, however it...
Investigational
Matched Synonyms: … cis-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphenyl)cyclohexanecarboxylic acid
Matched Iupac: … (1s,4s)-4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexane-1-carboxylic acid
Matched Description: … SB-207,499) is a drug which was developed for the treatment of respiratory disorders such as asthma and ... It is orally active and acts as a selective Phosphodiesterase-4 inhibitor. …
Matched Categories: … Carboxylic Acids ... Acids, Carbocyclic …
Approved
Matched Synonyms: … Citric acid, trilithium salt …
Matched Categories: … Acids, Acyclic ... Carboxylic Acids ... Tricarboxylic Acids
Diltiazem is a benzothiazepine derivative with antihypertensive and vasodilating properties. Approved in 1982 by the FDA, it is a member of the non-dihydropyridine calcium channel blockers drug class. It works through various mechanisms of action, but it primarily works by inhibiting the calcium influx into cardiac and vascular smooth muscle...
Approved
Investigational
Matched Synonyms: … Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][ ... cis-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ... -5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate
Matched Iupac: … 3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
Matched Description: … Diltiazem is a benzothiazepine derivative with antihypertensive and vasodilating properties. ... into cardiac and vascular smooth muscle during depolarization. ... Compared to dihydropyridine drugs, such as [nifedipine], that preferentially act on vascular smooth muscle and
Matched Salts name: … Diltiazem hydrochloride
Matched Categories: … Calcium-Regulating Hormones and Agents ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use ... Calcium Channel Blockers ... Calcium Channel Blockers (Nondihydropyridine) ... Miscellaneous Calcium-channel Blocking Agents …
Matched Products: … Diltiazem Hydrochloride ... Diltiazem hydrochloride ... DILTIAZEM HYDROCHLORIDE
Terlipressin is a synthetic analogue of vasopressin, which is an endogenous neurohormone that acts as a vasoconstrictor. It is a prodrug of lypressin, or lysine vasopressin. Compared to endogenous vasopressin, terlipressin has a longer half life and increased selectivity for the V1 receptor. As a potent vasopressor, terlipressin has been...
Approved
Investigational
Matched Description: … Compared to endogenous vasopressin, terlipressin has a longer half life and increased selectivity for ... [L43217] As a potent vasopressor, terlipressin has been investigated in various shock states and conditions ... [A2601, A2602, A2603, A2604, A2605] It was also studied in hepatorenal syndrome (HRS) and variceal bleeding …
Matched Salts name: … Terlipressin acetate
Matched Categories: … Amino Acids, Peptides, and Proteins ... Pituitary and Hypothalamic Hormones and Analogues ... Hormones, Hormone Substitutes, and Hormone Antagonists ... Sex Hormones and Insulins ... Vasopressin and Analogues …
Matched Products: … TERLIPRESSINA ACETATO EVER PHARMA …
Green tea leaf is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Investigational
Matched Synonyms: … Camelliae Folium ... Camelliae Sinensis Folium ... Camelliae Sinensis Non Fermentatum Folium
Matched Categories: … Diet, Food, and Nutrition …
Investigational
Matched Synonyms: … PXL770 free acid anhydrous ... PXL 770 free acid anhydrous …
Matched Name: … PXL-770 free acid anhydrous …
Pramocaine (also known as pramoxine or pramoxine HCI) is a topical anesthetic and antipruritic. It is used for many dermatological and anorectal/anogenital conditions including minor cuts/burns, insect bites, hives/rashes due to poison ivy exposure, hemorrhoids and other anorectal/anogenital disorders. Pramocaine is available by itself and in combination with other medications...
Approved
Matched Description: … Pramocaine (also known as pramoxine or pramoxine HCI) is a topical anesthetic and antipruritic. ... It is used for many dermatological and anorectal/anogenital conditions including minor cuts/burns, insect ... bites, hives/rashes due to poison ivy exposure, hemorrhoids and other anorectal/anogenital disorders …
Matched Mixtures name: … Mineral Oil, Pramoxine Hydrochloride and Zinc Oxide ... Hydrocortisone Acetate and Pramoxine Hydrochloride ... Hydrocortisone Acetate and Pramoxine Hydrochloride
Matched Salts name: … Pramoxine hydrochloride
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use ... Antipruritics and Local Anesthetics …
Matched Products: … Pramoxine Hydrochloride ... Pramoxine hydrochloride ... Anti Itch Soothing 1 Pramoxine Hydrochloride
Mirvetuximab soravtansine-gynx (IMGN853) is an antibody-drug conjugate (ADC) formed by a monoclonal antibody (M9346A) that targets folate receptor alpha (FRĪ±), covalently joined by a cleavable disulfide linker to the genotoxic compound DM4 (also known as soravtansine or ravtansine).[A254392,L43967] DM4 is conjugated to the antibody with a drug-to-antibody ratio of 3.5:1....
Approved
Investigational
Matched Synonyms: … Anti-FOLR1-monoclonal-antibody-maytansinoid-conjugate-IMGN-853 …
Matched Description: … DM4 leads to cell-cycle arrest and apoptosis and is also able to diffuse into neighboring cells and induce ... the surface of epithelial tumor cells, characteristic of ovarian, endometrial, triple-negative breast and ... [A254382] After an ADC/receptor complex is formed, mirvetuximab soravtansine-gynx is internalized, and
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
CH-1504 L-isomer is under investigation in clinical trial NCT01116141 (A Study of CH-4051 in Patients With Rheumatoid Arthritis (RA)).
Investigational
Matched Synonyms: … 4-methylene-n-(4-(2-(2,4-diaminoquinazolin-6-yl)ethyl)benzoyl)-l-glutamic acid ... L-glutamic acid, n-(4-(2-(2,4-diamino-6-quinazolinyl)ethyl)benzoyl)-4-methylene- ... (2s)-2-((4-(2-(2,4-diaminoquinazolin-6-yl)ethyl)benzoyl)amino)-4-methylene-pentanedioic acid
Experimental
Matched Name: … 2-(Oxalyl-Amino)-4,5,6,7-Tetrahydro-Thieno[2,3-C]Pyridine-3-Carboxylic Acid
Matched Iupac: … 2-(carboxyformamido)-4H,5H,6H,7H-thieno[2,3-c]pyridine-3-carboxylic acid
Benzoin is a white crystalline compound prepared by condensation of benzaldehyde in potassium cyanide, and is used in organic syntheses. This should not be confused with benzoin gum from STYRAX (see DB11222). Benzoin is an FDA-approved colour additive used for marking fruits and vegetables.
Approved
Experimental
Matched Synonyms: … alpha-Hydroxy-alpha-phenylacetophenone ... alpha-Hydroxybenzyl phenyl ketone ... Phenyl-alpha-hydroxybenzyl ketone …
Matched Description: … Benzoin is a white crystalline compound prepared by condensation of benzaldehyde in potassium cyanide, and ... Benzoin is an FDA-approved colour additive used for marking fruits and vegetables. …
Investigational
Matched Synonyms: … -4-yl]-4-methyl-1-oxopentan-2-yl]-4-[5-fluoro-2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide hydrochloride
Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections.
Approved
Investigational
Withdrawn
Matched Synonyms: … 1-ethyl-6,7-methylenedioxy-4(1H)-oxocinnoline-3-carboxylic acid ... 5-Ethyl-8-oxo-5,8-dihydro-1,3-dioxa-5,6-diaza-cyclopenta[b]naphthalene-7-carboxylic acid
Matched Iupac: … 1-ethyl-4-oxo-1H,4H,7H-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid
Matched Description: … Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections …
Matched Categories: … Acids, Heterocyclic …
A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does not...
Approved
Vet approved
Matched Synonyms: … Thiopentobarbituric acid ... 2-Thio-5-ethyl-5-sec-pentylbarbituric acid
Matched Description: … It is also used for hypnosis and for the control of convulsive states. ... Small doses have been shown to be anti-analgesic and lower the pain threshold. ... It does not produce any excitation but has poor analgesic and muscle relaxant properties. …
Matched Categories: … Hypnotics and Sedatives …
Displaying drugs 1976 - 2000 of 3674 in total