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Displaying drugs 2001 - 2025 of 2444 in total
ONT-093
ONT-093 is an orally bioavailable inhibitor of P-glycoprotein (P-gp). In pre-clinical studies, ONT-093 could inhibit P-gp and reverse multidrug resistance at nM concentrations with no effect on paclitaxel pharmacokinetics.
Investigational
Matched Categories: … P-glycoprotein inhibitors …
Licogliflozin
Licogliflozin is under investigation in clinical trial NCT03320941 (A Dose-finding Study to Evaluate the Change in Weight After Treatment With LIK066 in Japanese Patients With Obesity).
Investigational
Matched Categories: … Sodium-Glucose Transporter 2 Inhibitors …
Aclimostat
Aclimostat is under investigation in clinical trial NCT03254368 (Study to Assess the Effects and Safety of ZGN-1061 in Overweight and Obese Participants With Type 2 Diabetes).
Investigational
Matched Categories: … Enzyme Inhibitors …
Sorbinil
Experimental
Investigational
Matched Categories: … Aldehyde Reductase, antagonists & inhibitors …
CYC116
CYC116 is a novel anticancer compound with a unique target profile involving both cell cycle and angiogenesis inhibition mechanisms. In preclinical studies, CYC116 has demonstrated antitumor activity in both solid tumors and hematological cancers.
Cyclacel's small molecule investigational drug, CYC116, is the third orally-available Cyclacel drug to enter development, which...
Investigational
Matched Categories: … Protein Kinase Inhibitors …
AT-7519
AT7519 is a selective inhibitor of certain Cyclin Dependent Kinases (CDKs) leading to tumour regression. It is developed by Astex for the treatment of solid tumours and haematological malignancies.
Investigational
Matched Categories: … Cyclin-Dependent Kinases, antagonists & inhibitors …
MK-4965
MK-4965 is an HIV-1 reverse transcriptase inhibitor.
Experimental
Matched Categories: … HIV Reverse Transcriptase, antagonists & inhibitors …
SB-705498
SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis.
Investigational
Matched Categories: … TRPV Cation Channels, antagonists & inhibitors …
Reversin 121
Reversin 121 is a hydrophobic peptide chemosensitizer that can reverse P-glycoprotein-mediated multidrug resistance.
Experimental
Matched Categories: … P-glycoprotein inhibitors …
Epalrestat
Epalrestat is under investigation in clinical trial NCT03244358 (Evaluation of Epalrestat in Metastatic Triple-negative Breast Cancer).
Investigational
Matched Categories: … Enzyme Inhibitors …
SNX-2112
SNX-2112 is a heat shock protein 90 (Hsp90) inhibitor.
Investigational
Matched Categories: … HSP90 Heat-Shock Proteins, antagonists & inhibitors …
TAK-075 Free base
Investigational
Matched Categories: … Receptors, Calcium-Sensing, antagonists & inhibitors …
RWJ-800088
RWJ-800088 is a synthetic PEGylated thrombopoietin (TPO) mimetic (TPOm) peptide with no sequence homology to endogenous TPO.
Investigational
Matched Categories: … Thrombopoietin, antagonists & inhibitors …
Talampanel
Talampanel is a substance that is being studied in the treatment of brain tumors and other brain disorders, such as epilepsy and Parkinson disease. It is a type of AMPA receptor antagonist.
Investigational
Matched Categories: … Receptors, AMPA, antagonists & inhibitors …
Aprinocarsen
Aprinocarsen is a specific antisense oligonucleotide inhibitor of protein kinase C-alpha.
Investigational
Matched Categories: … Protein Kinase C, antagonists & inhibitors …
SKF-91488
Experimental
Matched Categories: … Histamine N-Methyltransferase, antagonists & inhibitors …
Tosedostat
Tosedostat has been used in trials studying the treatment and supportive care of AML, Leukemia, Pancreas Cancer, Multiple Myeloma, and Pancreatic Cancer, among others.
Tosedostat is an inhibitor of the M1 family of aminopeptidases, in particular PuSA, and LTA4 hydrolase. It has demonstrated anti-tumour activity in a number of models...
Investigational
Matched Categories: … Enzyme Inhibitors …
AZD-9164
AZD9164 has been used in trials studying the basic science and treatment of Chronic Obstructive Pulmonary Disease.
Investigational
Matched Categories: … Receptor, Muscarinic M3, antagonists & inhibitors …
Apitolisib
Apitolisib has been used in trials studying the treatment of Solid Cancers, Breast Cancer, Prostate Cancer, Renal Cell Carcinoma, and Endometrial Carcinoma, among others.
Investigational
Matched Categories: … Phosphatidylinositol 3-Kinases, antagonists & inhibitors …
LY-2584702
LY2584702 has been used in trials studying the treatment of Cancer, Advanced Cancer, Renal Cell Carcinoma, Metastases, Neoplasm, and Neuroendocrine Tumors, among others.
Investigational
Matched Categories: … Ribosomal Protein S6 Kinases, 70-kDa, antagonists & inhibitors …
VS-4718
VS-4718 is under investigation in clinical trial NCT02215629 (Dose Escalation Study in Acute Myeloid or B-Cell Acute Lymphoblastic Leukemia).
Investigational
Matched Categories: … Focal Adhesion Protein-Tyrosine Kinases, antagonists & inhibitors …
NSC-663284
NSC-663284 is a potent quinolinedione Cdc25 phosphatase inhibitor.
Investigational
Matched Categories: … cdc25 Phosphatases, antagonists & inhibitors …
1,10-Phenanthroline
Experimental
Matched Categories: … Enzyme Inhibitors ... Cholinesterase Inhibitors …
Deracoxib
Deracoxib is a non-steroidal anti-inflammatory drug of the coxib class, used in veterinary medicine to treat osteoarthritis in dogs. It is sold in tablets, which have added beefy flavour to increase palatability. Deramaxx received FDA approval in August 2002 for "the control of post operative pain and inflammation associated with...
Vet approved
Matched Categories: … Enzyme Inhibitors ... Cyclooxygenase Inhibitors …
Displaying drugs 2001 - 2025 of 2444 in total