Displaying drugs 201 - 225 of 241 in total
Vilanterol
Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug administration). Vilanterol was...
Approved
Matched Iupac: … 4-[(1R)-2-[(6-{2-[(2,6-dichlorophenyl)methoxy]ethoxy}hexyl)amino]-1-hydroxyethyl]-2-(hydroxymethyl)phenol …
Matched Description: … 5 years and older respectively. ... [A259961] Vilanterol is 1000 and 400 fold more selective for β2 than β1 and β3 adrenoceptors, respectively ... BREO ELLIPTA are approved for maintenance treatments of asthma in patients aged 18 years and older and …
Matched Mixtures name: … Fluticasone Furoate and Vilanterol ... Fluticasone Furoate and Vilanterol …
Matched Categories: … Adrenergic beta-2 Receptor Agonists ... vilanterol and fluticasone furoate ... vilanterol and umeclidinium bromide ... vilanterol, umeclidinium bromide and fluticasone furoate …
Matched Description: … 5 years and older respectively. ... [A259961] Vilanterol is 1000 and 400 fold more selective for β2 than β1 and β3 adrenoceptors, respectively ... BREO ELLIPTA are approved for maintenance treatments of asthma in patients aged 18 years and older and …
Matched Mixtures name: … Fluticasone Furoate and Vilanterol ... Fluticasone Furoate and Vilanterol …
Matched Categories: … Adrenergic beta-2 Receptor Agonists ... vilanterol and fluticasone furoate ... vilanterol and umeclidinium bromide ... vilanterol, umeclidinium bromide and fluticasone furoate …
Levothyroxine
Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quantities of the...
Approved
Matched Iupac: … (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid …
Matched Description: … 14:1 ratio of secretion by the human thyroid gland. ... T3 have a relative potency of ~1:4 (T4:T3). ... Desiccated thyroid products contain a ratio of T4 to T3 of 4.2:1, which is significantly lower than the …
Matched Mixtures name: … Levothyroxine and Liothyronine Thyroid ... Levothyroxine and Liothyronine Thyroid ... Levothyroxine and Liothyronine Thyroid …
Matched Categories: … Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... levothyroxine sodium and iodine compounds ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Description: … 14:1 ratio of secretion by the human thyroid gland. ... T3 have a relative potency of ~1:4 (T4:T3). ... Desiccated thyroid products contain a ratio of T4 to T3 of 4.2:1, which is significantly lower than the …
Matched Mixtures name: … Levothyroxine and Liothyronine Thyroid ... Levothyroxine and Liothyronine Thyroid ... Levothyroxine and Liothyronine Thyroid …
Matched Categories: … Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... levothyroxine sodium and iodine compounds ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Elivaldogene autotemcel
Elivaldogene autotemcel is a gene therapy consisting of genetically modified autologous cells. It is used to provide functional copies of human adrenoleukodystrophy protein (ALDP) in patients with adrenoleukodystrophy, an X-linked genetic disorder characterized by missing or non-functional ABCD1 gene that codes for ALDP. ALDP is a key protein that normally...
Approved
Matched Description: … It is used to provide functional copies of human adrenoleukodystrophy protein (ALDP) in patients with ... destruction of myelin, which is an insulating layer and essential component of nerves. ... Without sufficient levels of functional ALDP, VLCFAs accumulate in the body leading to inflammation and …
Matched Categories: … Cellular and Gene Therapy ... Alimentary Tract and Metabolism ... Various Alimentary Tract and Metabolism Products …
Matched Categories: … Cellular and Gene Therapy ... Alimentary Tract and Metabolism ... Various Alimentary Tract and Metabolism Products …
INVAC-1
INVAC-1 is under investigation in clinical trial NCT03265717 (DNA Plasmid Encoding a Modified Human Telomerase Reverse Transcriptase (Htert), Invac-1 in Chronic Lymphocytic Leukemia).
Investigational
Matched Synonyms: … Human telomerase reverse transcriptase (htert) dna vaccine invac-1 ... Invac-1, a double stranded dna plasmid vaccine construct encoding ubiquitin-human telomerase reverse …
Matched Name: … INVAC-1 …
Matched Description: … INVAC-1 is under investigation in clinical trial NCT03265717 (DNA Plasmid Encoding a Modified Human Telomerase ... Reverse Transcriptase (Htert), Invac-1 in Chronic Lymphocytic Leukemia). …
Matched Name: … INVAC-1 …
Matched Description: … INVAC-1 is under investigation in clinical trial NCT03265717 (DNA Plasmid Encoding a Modified Human Telomerase ... Reverse Transcriptase (Htert), Invac-1 in Chronic Lymphocytic Leukemia). …
Delolimogene mupadenorepvec
Investigational
Matched Synonyms: … Dna (synthetic human adenovirus 5/35 vector load703 human cd137 ligand and trimerized membrane-bound ... isoleucine zipper-containing human cd40 ligand-specifying) …
Dabocemagene autoficel
Dabocemagene autoficel is an ex vivo, autologous cell-based gene therapy. It comprises autologous dermal fibroblasts genetically modified to express functional type VII collagen. Developed by Castle Creek Biosciences Inc., dabocemagene autoficel is being investigated for the treatment of dystrophic epidermolysis bullosa.
Investigational
Matched Synonyms: … HUMAN CYTOMEGALOVIRUS PROMOTER/UTR-AND 3'-LTR/PO ... , SELF-INACTIVATING LENTIVIRUS VECTOR THAT ENCODES HUMAN COLLAGEN TYPE VII ALPHA 1 (COL7A1) UNDER THE ... DNA (RECOMBINANT LENTIVIRUS VECTOR INXN-2004-TRANSDUCED HUMAN AUTOLOGOUS DYSTROPHIC EPIDERMOLYSIS BULLOSA …
Tavokinogene telseplasmid
Tavokinogene telseplasmid consists of a DNA Plasmid Vector Encoding IL-12.
Investigational
Matched Synonyms: … Dna plasmid containing genes coding for the human interleukin 12 (il-12) p35 and p40 subunits that are ... Dna plasmid encoding interleukin-12 ino-9012 ... DNA Plasmid Vector encoding IL-12 (pUMVC3-hIL-12-NGVL331) …
Matched Description: … Tavokinogene telseplasmid consists of a DNA Plasmid Vector Encoding IL-12. …
Matched Description: … Tavokinogene telseplasmid consists of a DNA Plasmid Vector Encoding IL-12. …
Leuvectin
Leuvectin (formerly known as VCL-1102) is a component of gene therapy along with cationic lipid 1,2-dimyristyloxypropyl-3-dimethyl-hydroxyethyl ammonium bromide/dioleyl-phosphatidyl-ethanolamine (DMRIE/DOPE).
Investigational
Matched Synonyms: … DNA-lipid complex (DMRIE/DOPE)/plasmid vector (VCL-1102, Vical) expressing human interleukin-2 …
Suratadenoturev
Suratadenoturev is a gene-modified oncolytic adenovirus expressing the telomerase reverse transcriptase gene.
Investigational
Matched Synonyms: … DNA (recombinant human telomerase-specific replication-competent oncolytic adenovirus 5 vector OBP-301 ... A replication-competent adenovirus type 5 in which the E1A and E1B genes are under the control of a human ... telomerase reverse transcriptase (hTERT) and IRES, respectively. …
Resamirigene bilparvovec
AT132 is under investigation in clinical trial NCT03199469 (Gene Transfer Clinical Study in X-linked Myotubular Myopathy).
Investigational
Matched Synonyms: … DNA (synthetic adeno-associated virus 8 vector AT132 human myotubularin cDNA-specifying) ... Non-replicating adeno-associated viral vector, serotype 8, expressing human myotubularin gene …
Zinpentraxin alfa
Zinpentraxin alfa is a recombinant form of PTX-2, a naturally circulating human protein. It is under investigation in clinical trial NCT01981850 (A Phase 2 Study Of PRM-151 In Subjects With Myelofibrosis).
Investigational
Matched Synonyms: … Recombinant human pentraxin-2 ... rhPTX-2 ... RECOMBINANT HUMAN SERUM AMYLOID P …
Matched Description: … Zinpentraxin alfa is a recombinant form of PTX-2, a naturally circulating human protein. ... It is under investigation in clinical trial NCT01981850 (A Phase 2 Study Of PRM-151 In Subjects With …
Matched Categories: … DNA-Binding Proteins ... Amino Acids, Peptides, and Proteins …
Matched Description: … Zinpentraxin alfa is a recombinant form of PTX-2, a naturally circulating human protein. ... It is under investigation in clinical trial NCT01981850 (A Phase 2 Study Of PRM-151 In Subjects With …
Matched Categories: … DNA-Binding Proteins ... Amino Acids, Peptides, and Proteins …
Olenasufligene relduparvovec
Olenasufligene relduparvovec is under investigation in clinical trial NCT03612869 (Study of aavrh10-h.sgsh Gene Therapy in Patients With Mucopolysaccharidosis Type IIIA (MPS IIIA)). It is an adeno-associated virus (AAV) vector that delivers a functional copy of the human SGSH gene.
Investigational
Matched Synonyms: … Dna (recombinant adeno-associated virus 2 vector lys-saf302 human n-sulfoglucosamine sulfohydrolase cdna-specifying …
Matched Description: … It is an adeno-associated virus (AAV) vector that delivers a functional copy of the human SGSH gene. …
Matched Description: … It is an adeno-associated virus (AAV) vector that delivers a functional copy of the human SGSH gene. …
DCLL-9718S
DCLL9718S is an antibody-drug conjugate targeting C-type lectin-like molecule-1 (CLL-1). DCLL9718S is under investigation in clinical trial NCT03298516 (A Study of DCLL9718S in Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML) or DCLL9718S in Combination With Azacitidine in Participants With Previously Untreated AML Unsuitable for Intensive Induction Chemotherapy).
Investigational
Matched Synonyms: … antibody and DNA alkylating cross-linking agent pyrrolo [2,1-c][1,4] benzodiazepine dimer ... THIOMAB antibody drug conjugate comprised of humanized IgG1 anti-C-type lectin-like molecule-1 monoclonal …
Matched Description: … DCLL9718S is an antibody-drug conjugate targeting C-type lectin-like molecule-1 (CLL-1). …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … DCLL9718S is an antibody-drug conjugate targeting C-type lectin-like molecule-1 (CLL-1). …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Botaretigene sparoparvovec
Investigational
Matched Synonyms: … DNA (RECOMBINANT PSEUDOTYPED ADENO-ASSOCIATED VIRUS 5 VECTOR AAV-RPGR HUMAN RHODOPSIN KINASE PROMOTER ... ADENO-ASSOCIATED VIRUS 2 INVERTED TERMINAL REPEAT FL ... FRAGMENT-REGULATED HUMAN RETINITIS PIGMENTOSA GTPASE REGULATOR RPGR-ORF15 ISOFORM GENE VARIANT PLUS …
Basic Fibroblast Growth Factor
Basic Fibroblast Growth Factor (bFGF) is a single-chain polypeptide growth factor that plays a significant role in the process of wound healing and is a potent inducer of physiologic angiogenesis. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative...
Investigational
Matched Synonyms: … Basic fibroblast growth factor, recombinant human, KCB-1 ... Recombinant human basic fibroblast growth factor, KCB-1 ... FGF 2 …
Matched Description: … start sites within the fgf-2 gene. ... It has a 55 percent amino acid residue identity to Fibroblast Growth Factor 1 and has potent heparin-binding ... The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm …
Matched Categories: … Fibroblast Growth Factor 2, antagonists & inhibitors ... Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …
Matched Description: … start sites within the fgf-2 gene. ... It has a 55 percent amino acid residue identity to Fibroblast Growth Factor 1 and has potent heparin-binding ... The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm …
Matched Categories: … Fibroblast Growth Factor 2, antagonists & inhibitors ... Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …
Fibrinolysin
Fibrinolysin consists of two polypeptide chains, one light and one heavy, linked by a disulfide bond. The light chain has a molecular weight of approximately 27,000 Da and contains the active center of Fibrinolysin; the heavy chain has a molecular weight of approximately 57,000 Da. Fibrinolysin is used as a...
Investigational
Matched Synonyms: … Fibrinolysin, human ... Fibrinolysin (human) …
Matched Description: … The combination is available as ointment containing 1 BU (Biological Unit) Fibrinolysin and 666 BUs desoxyribonuclease ... Fibrinolysin and deoxyribonuclease both act as lytic enzymes. ... Fibrinolysin consists of two polypeptide chains, one light and one heavy, linked by a disulfide bond. …
Matched Categories: … Enzymes and Coenzymes ... Blood and Blood Forming Organs ... fibrinolysin and desoxyribonuclease …
Matched Description: … The combination is available as ointment containing 1 BU (Biological Unit) Fibrinolysin and 666 BUs desoxyribonuclease ... Fibrinolysin and deoxyribonuclease both act as lytic enzymes. ... Fibrinolysin consists of two polypeptide chains, one light and one heavy, linked by a disulfide bond. …
Matched Categories: … Enzymes and Coenzymes ... Blood and Blood Forming Organs ... fibrinolysin and desoxyribonuclease …
INO-4800
INO-4800 is a DNA vaccine containing the full sequence for the SARS-CoV-2 Spike (S) protein in development for immunization against COVID-19. Early in vitro studies using HEK-293T cells demonstrated that the transfection of INO-4800 results in the expression of S protein by human cells.[A214475, A214478] Follow up studies in both...
Investigational
Matched Synonyms: … INO-4800 DNA Coronavirus Vaccine …
Matched Description: … INO-4800 is a DNA vaccine containing the full sequence for the SARS-CoV-2 Spike (S) protein in development ... [L14372] A Phase 1/2 clinical trial through South Korea's Seoul National University Hospital was announced ... of INO-4800 to induce both humoral and T cell-mediated immunity against SARS-CoV-2, including in the …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … INO-4800 is a DNA vaccine containing the full sequence for the SARS-CoV-2 Spike (S) protein in development ... [L14372] A Phase 1/2 clinical trial through South Korea's Seoul National University Hospital was announced ... of INO-4800 to induce both humoral and T cell-mediated immunity against SARS-CoV-2, including in the …
Matched Categories: … Amino Acids, Peptides, and Proteins …
PX-12
PX-12 (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits tumor growth in animal models. Since high levels of Trx-1 have been associated with colorectal, gastric and lung cancers, PX-12 is indicated as a potential cancer treatment...
Investigational
Matched Synonyms: … 1-Methylpropyl-2-imidazolyl disulfide …
Matched Iupac: … 2-(butan-2-yldisulfanyl)-1H-imidazole …
Matched Description: … PX-12 (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), ... Since high levels of Trx-1 have been associated with colorectal, gastric and lung cancers, PX-12 is indicated ... stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Iupac: … 2-(butan-2-yldisulfanyl)-1H-imidazole …
Matched Description: … PX-12 (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), ... Since high levels of Trx-1 have been associated with colorectal, gastric and lung cancers, PX-12 is indicated ... stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Inodiftagene vixteplasmid
Inodiftagene vixteplasmid is a plasmid DNA vector encoding the diphtheria toxin A (dT-a) gene under transcriptional regulation of the promoter region of the human H19 gene (an imprinted maternally expressed non-protein coding gene).
Investigational
Matched Synonyms: … Dna Plasmid Expressing Diphtheria Toxin Triggered By The Presence Of Oncofetal Gene H19 …
Matched Description: … regulation of the promoter region of the human H19 gene (an imprinted maternally expressed non-protein ... Inodiftagene vixteplasmid is a plasmid DNA vector encoding the diphtheria toxin A (dT-a) gene under transcriptional …
Matched Description: … regulation of the promoter region of the human H19 gene (an imprinted maternally expressed non-protein ... Inodiftagene vixteplasmid is a plasmid DNA vector encoding the diphtheria toxin A (dT-a) gene under transcriptional …
Riferminogene pecaplasmid
Riferminogene pecaplasmid (non-viral fibroblast growth factor 1; NV1FGF) is a recombinant DNA plasmid in a pCOR backbone allowing expression of human FGF1.
Investigational
Matched Synonyms: … Non-viral fibroblast growth factor 1 …
Matched Description: … Riferminogene pecaplasmid (non-viral fibroblast growth factor 1; NV1FGF) is a recombinant DNA plasmid ... in a pCOR backbone allowing expression of human FGF1. …
Matched Description: … Riferminogene pecaplasmid (non-viral fibroblast growth factor 1; NV1FGF) is a recombinant DNA plasmid ... in a pCOR backbone allowing expression of human FGF1. …
Onercept
Investigational
Matched Synonyms: … R-HTBP-1 …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Genistein
An isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 phase arrest in human and murine cell lines.
Additionally, genistein has antihelmintic activity. It has been...
Investigational
Matched Synonyms: … 4H-1-BENZOPYRAN-4-ONE, 5,7-DIHYDROXY-3-(4-HYDROXYPHENYL)- ... 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one …
Matched Description: … It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is ... Experimentally, it has been shown to induce G2 phase arrest in human and murine cell lines. ... used as an antineoplastic and antitumor agent. …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Heterocyclic Compounds, 2-Ring ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Description: … It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is ... Experimentally, it has been shown to induce G2 phase arrest in human and murine cell lines. ... used as an antineoplastic and antitumor agent. …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Heterocyclic Compounds, 2-Ring ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Elsamitrucin
The cytostatic agent Elsamitrucin is a new fermentation product active in a variety of in vivo tumor models of murine and human origin. (PMID: 8150873)
Investigational
Matched Iupac: … }]icosa-1(19),2(7),3,5,8,12(20),13,15-octaene-10,17-dione ... 3-{[(2S,3R,4S,5S,6R)-3-{[(2R,3R,4R,5S,6R)-3-amino-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-4,5-dihydroxy ... -4,6-dimethyloxan-2-yl]oxy}-8-hydroxy-15-methyl-11,18-dioxapentacyclo[10.6.2.0^{2,7}.0^{9,19}.0^{16,20 …
Matched Description: … human origin. ... agent Elsamitrucin is a new fermentation product active in a variety of in vivo tumor models of murine and …
Matched Description: … human origin. ... agent Elsamitrucin is a new fermentation product active in a variety of in vivo tumor models of murine and …
Tenofovir
Tenofovir is an acyclic nucleotide diester analog of adenosine monophosphate. In the most strict sense and due to the fact that it presents a phosphate group bound to the nitrogenous base, it is determined as an actual nucleotide analog. The antiviral activities of tenofovir were first reported in 1993 and...
Experimental
Investigational
Matched Iupac: … ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid …
Matched Description: … [A37693] In the most strict sense and due to the fact that it presents a phosphate group bound to the ... [A37693] The antiviral activities of tenofovir were first reported in 1993 and this agent was commercially ... available since 2008 in the form of [tenofovir disoproxil] and [tenofovir alafenamide] in order to obtain …
Matched Categories: … Tenofovir and prodrugs ... Heterocyclic Compounds, 2-Ring ... Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor …
Matched Description: … [A37693] In the most strict sense and due to the fact that it presents a phosphate group bound to the ... [A37693] The antiviral activities of tenofovir were first reported in 1993 and this agent was commercially ... available since 2008 in the form of [tenofovir disoproxil] and [tenofovir alafenamide] in order to obtain …
Matched Categories: … Tenofovir and prodrugs ... Heterocyclic Compounds, 2-Ring ... Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor …
Canfosfamide
Canfosfamide is an active agent in chemotherapy-resistant ovarian cancer.
Investigational
Matched Iupac: … (2S)-2-amino-4-{[(1R)-2-[2-({bis[bis(2-chloroethyl)amino]phosphoryl}oxy)ethanesulfonyl]-1-{[(R)-carboxy …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Displaying drugs 201 - 225 of 241 in total