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Displaying drugs 2301 - 2325 of 15090 in total

Enfortumab vedotin

Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protease-cleavable link. It is similar to brentuximab vedotin, another...
Approved
Investigational
Matched Description: … clinical development of enfortumab vedotin was the result of a collaboration between Astellas Pharma and ... Seattle Genetics [A188868] and it was first approved for use in the United States in December 2019 under ... [L10836] It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Eftrenonacog alfa

Eftrenonacog alfa is a long-acting recombinant fusion protein used in the treatment of hemophilia B. It is comprised of a single molecule of human factor IX (FIX) covalently linked to the constant region (Fc) domain of human IgG1 via recombinant DNA technology in a human embryonic kidney cell line (HEK293H)...
Approved
Investigational
Matched Description: … It was first approved by the FDA in March 2014 and later approved by the EMA in May 2016. ... Eftrenonacog alfa was developed and marketed as Alprolix for intravenous injection by Biogen. ... blood disorder with an incidence of approximately once every 30,000 male births in all populations and …
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins …

Hepatitis B immune globulin

Long-term hepatitis B immune globulin (HBIG) has been shown to reduce hepatitis B virus (HBV) reinfection in patients transplanted for hepatitis B. Infection with hepatitis B may lead to hepatocellular carcinoma, a type of liver cancer. Therefore, the hepatitis-B vaccines are cancer-preventing vaccines. According to the Centers for Disease Control...
Approved
Investigational
Matched Description: … The preparation is tested for absence of HIV, HCV, herpes virus, and reovirus. ... During the process, viruses are deactivated, and in the final steps, solvents used in the preparation ... According to the Centers for Disease Control and Prevention (CDC), the hepatitis B vaccine was the first …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Immune Sera and Immunoglobulins …

Imlifidase

Chronic kidney disease (CKD) is a progressive and irreversible disease that represents a significant burden for both the individual and healthcare system at large. Currently available treatments for end-stage renal disease are limited to dialysis and renal transplantation, with the former associated with significant costs and lower quality of life.[A225836,A225916]...
Approved
Investigational
Matched Description: … burden for both the individual and healthcare system at large. ... Chronic kidney disease (CKD) is a progressive and irreversible disease that represents a significant ... transplantation, with the former associated with significant costs and lower quality of life. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Darvadstrocel

Darvadstrocel is a suspension of expanded human allogeneic adipose-derived mesenchymal stem cells extracted from the subdermal adipose tissue of healthy donors via liposuction. Darvadstrocel was first approved by the European Commission on March 23, 2018, under the brand name Alofisel. It is indicated for the treatment of complex perianal fistulas...
Approved
Experimental
Matched Description: … and enhance tissue repair in perianal fistulas. ... may be associated with complex presentations and symptoms. ... Perianal fistula is a common manifestation of Crohn’s disease and is often difficult to manage, as it …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Natalizumab

Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA reintroduced the drug to the...
Approved
Investigational
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Idebenone

Idebenone is a synthetic analogue of ubiquinone (also known as Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC). It has been proposed that by interacting with the ETC, idebenone increases ATP production required for mitochondrial function, reduces free radicals, inhibits lipid peroxidation, and...
Approved
Investigational
Matched Description: … for its potential use in Alzheimer's Disease and other cognitivie disorders [A19769]. ... consequently protects the lipid membrane and mitochondria from oxidative damage [A19768]. ... Idebenone is a synthetic analogue of ubiquinone (also known as Coenzyme Q10), a vital cell antioxidant and …
Matched Categories: … Enzymes and Coenzymes ... Psychostimulants, Agents Used for ADHD and Nootropics …

Wheat bran

Wheat bran allergenic extract is used in allergenic testing.
Approved
Matched Categories: … Diet, Food, and Nutrition …

Fluclorolone acetonide

Fluclorolone acetonide (INN) or flucloronide (USAN) is a topical corticosteroid. It is marketed under the brand names Cutanit and Topicon.
Approved
Withdrawn
Matched Description: … It is marketed under the brand names Cutanit and Topicon. …

Pinaverium

Pinaverium is a spasmolytic agent used for functional gastrointestinal disorders. It is a quaternary ammonium compound that acts as an atypical calcium antagonist to restore normal bowel function. It is shown to relieve GI spasm and pain, transit disturbances and other symptoms related to motility disorders and may be considered...
Approved
Matched Description: … It is shown to relieve GI spasm and pain, transit disturbances and other symptoms related to motility ... disorders [A19697] and may be considered as effective first-lline therapy for patients with irritable …
Matched Categories: … Alimentary Tract and Metabolism ... Calcium-Regulating Hormones and Agents …

Lycopene

Lycopene is a naturally occurring red carotenoid pigment that is responsible for red to pink colors seen in tomatoes, pink grapefruit, and other foods . Having a chemical formula of C40H56, lycopene is a tetraterpene assembled from eight isoprene units that are solely composed of carbon and hydrogen. Lycopene may...
Approved
Investigational
Matched Description: … red carotenoid pigment that is responsible for red to pink colors seen in tomatoes, pink grapefruit, and ... , lycopene is a tetraterpene assembled from eight isoprene units that are solely composed of carbon and ... classified as a non-provitamin A carotenoid pigment since it lacks a terminal beta-ionone ring [A27242] and …

Squalene

Squalene is originally obtained from shark liver oil. It is a natural 30-carbon isoprenoid compound and intermediate metabolite in the synthesis of cholesterol. It is not susceptible to lipid peroxidation and provides skin protection. It is ubiquitously distributed in human tissues where it is transported in serum generally in association...
Approved
Vet approved
Matched Description: … It is not susceptible to lipid peroxidation and provides skin protection. ... It is a natural 30-carbon isoprenoid compound and intermediate metabolite in the synthesis of cholesterol …

Steviolbioside

Steviolbioside has been used in trials studying the treatment of HIV-1 Infection.
Approved
Investigational
Matched Iupac: … oxan-2-yl]oxy}-5,9-dimethyl-14-methylidenetetracyclo[11.2.1.0^{1,10}.0^{4,9}]hexadecane-5-carboxylic acid …
Matched Categories: … Diet, Food, and Nutrition …

Vamorolone

Vamorolone is a novel and fully synthetic glucocorticoid developed by Santhera Pharmaceuticals. It is used to manage inflammation and immune dysregulation in patients with Duchenne muscular dystrophy (DMD), a neuromuscular disorder characterized by the insidious regression of neuromuscular function and the most common form of muscular dystrophy in the United...
Approved
Investigational
Matched Description: … Vamorolone is a novel and fully synthetic glucocorticoid developed by Santhera Pharmaceuticals. ... It is used to manage inflammation and immune dysregulation in patients with Duchenne muscular dystrophy ... (DMD), a neuromuscular disorder characterized by the insidious regression of neuromuscular function and …
Matched Categories: … Sex Hormones and Insulins …

Lutein

Lutein is an xanthophyll and one of 600 known naturally occurring carotenoids. Lutein is synthesized only by plants and like other xanthophylls is found in high quantities in green leafy vegetables such as spinach, kale and yellow carrots. In green plants, xanthophylls act to modulate light energy and serve as...
Approved
Investigational
Nutraceutical
Matched Description: … leafy vegetables such as spinach, kale and yellow carrots. ... Lutein is an xanthophyll and one of 600 known naturally occurring carotenoids. ... Lutein is synthesized only by plants and like other xanthophylls is found in high quantities in green …

Docosanol

Docosanol is a drug used for topical treatment for recurrent herpes simplex labialis episodes (episodes of cold sores or fever blisters). A saturated 22-carbon aliphatic alcohol, docosanol exhibits antiviral activity against many lipid enveloped viruses including herpes simplex virus (HSV). Docosanol inhibits fusion between the plasma membrane and the herpes...
Approved
Investigational
Matched Description: … preventing viral entry into cells and subsequent viral replication. ... Docosanol inhibits fusion between the plasma membrane and the herpes simplex virus (HSV) envelope, thereby …

Ulipristal

Ulipristal is a selective progesterone receptor modulator used for the purposes of emergency contraception (Ella) and for the treatment of uterine fibroids (Fibristal). It is a derivative of 19-norprogesterone and has both antagonistic and partial agonist activity at the progesterone receptor. It also binds to glucocorticoid receptor, however compared to...
Approved
Matched Description: … It is a derivative of 19-norprogesterone and has both antagonistic and partial agonist activity at the ... has lower glucocorticoid activity and better binding affinity. ... a selective progesterone receptor modulator used for the purposes of emergency contraception (Ella) and …
Matched Categories: … Genito Urinary System and Sex Hormones ... Sex Hormones and Modulators of the Genital System …

Vedolizumab

Vedolizumab is a recombinant humanized IgG1 monoclonal antibody directed against the human lymphocyte α4β7 integrin, a key mediator of gastrointestinal inflammation implicated in diseases like ulcerative colitis or Crohn's disease. α4β7 integrin facilitates the interaction between lymphocytes and gut endothelial cells through the α4β7 integrin-MAdCAM1 interaction, leading to the mobilization...
Approved
Matched Description: … April and September 2023, respectively. ... six weeks and then every 8 weeks thereafter. ... [L48216] α4β7 integrin facilitates the interaction between lymphocytes and gut endothelial cells through …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Brodalumab

Brodalumab has been used in trials studying the treatment of Asthma, Psoriasis, Crohn's Disease, Psoriatic Arthritis, and Rheumatoid Arthritis. Brodalumab was FDA approved in February, 2017 as Siliq for the treatment of moderate-to-severe plaque psoriasis.
Approved
Investigational
Matched Description: … been used in trials studying the treatment of Asthma, Psoriasis, Crohn's Disease, Psoriatic Arthritis, and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Canakinumab

Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. Both heavy...
Approved
Investigational
Matched Description: … Canakinumab is marketed under the brand name Ilaris and indicated for patients 4 years of age and older ... and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. ... It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Human cytomegalovirus immune globulin

Cytomegalovirus immunoglobulin is obtained from pooled adult human plasma selected for high titers of antibody for cytomegalovirus (CMV). It contains purified immunoglobulin G (IgG) antibodies targeting cytomegalovirus (CMV)[FDA label]. Cytomegalovirus, a member of the herpes virus family, is ubiquitous the human population, leading to infections which are followed by life-long...
Approved
Matched Description: … CMV infection can lead to a high fever and severe organ-specific damage with significant morbidity and ... vaginal excretions, semen, breast milk and blood [L2228]. ... During the span of an individual's life, the virus may reactivate, resulting in repeated shedding and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Immune Sera and Immunoglobulins …

Gemtuzumab ozogamicin

Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheamicin per mole of antibody [FDA Label]. The antibody is specifically...
Approved
Investigational
Matched Description: … By binding to the CD33 antigen on tumors, the cytotoxic agent blocks the growth of cancerous cells and ... It is also indicated for the treatment of patients aged 2 years and older with CD33-positive AML who ... was voluntarily withdrawn from the market in 2010 due to safety concerns, increased patient deaths and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Silver

Silver (Ag) is a chemical element that belongs in the family of transition metals in the periodic table. It has a high electrical conductivity, thermal conductivity, and reflectivity. Silver exists as a pure elemental form, alloy with other metals, and mineral. Having critical roles in various applications inducing chemical and...
Approved
Investigational
Matched Description: … It has a high electrical conductivity, thermal conductivity, and reflectivity. ... 1800s, and they may be found in dental pastes as an active ingredients. ... Silver exists as a pure elemental form, alloy with other metals, and mineral. …
Matched Categories: … Antiseptics and Disinfectants …

Perfluorohexyloctane

Perfluorohexyloctane is a semifluorinated alkane that contains six perfluorinated carbon atoms and eight hydrogenated carbon atoms. It is an inert, slightly amphiphilic compound. Because it is a completely non-aqueous liquid, microbial growth is not possible; therefore, its drug products do not need to be combined with any preservative.[A259746, A259751] Perfluorohexyloctane...
Approved
Matched Description: … Perfluorohexyloctane is a semifluorinated alkane that contains six perfluorinated carbon atoms and eight …
Matched Categories: … Ophthalmological and Otological Preparations …

Roflumilast

Roflumilast is a highly selective phosphodiesterase-4 (PDE4) inhibitor. PDE4 is a major cyclic-3',5′-adenosinemonophosphate (cyclic AMP, cAMP)-metabolizing enzyme expressed on nearly all immune and pro-inflammatory cells, in addition to structural cells like those of the smooth muscle or epithelium. The resultant increase in intracellular cAMP induced by roflumilast's inhibition of PDE4...
Approved
Matched Description: … [L46546] It was first approved by the EMA in July 2010, and by the FDA in January 2018. ... adenosinemonophosphate (cyclic AMP, cAMP)-metabolizing enzyme [L37564] expressed on nearly all immune and ... The cream formulation was first approved by the FDA in July 2022 [L42580] and by Health Canada in April …
Displaying drugs 2301 - 2325 of 15090 in total