Therapeutic role of zonisamide in neuropsychiatric disorders.
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Farooq MU, Moore PW, Bhatt A, Aburashed R, Kassab MY
Therapeutic role of zonisamide in neuropsychiatric disorders.
Mini Rev Med Chem. 2008 Sep;8(10):968-75.
- PubMed ID
- 18782051 [ View in PubMed]
- Abstract
Zonisamide (ZNS), a sulfonamide antiepileptic drug, is indicated as an adjunct therapy for partial seizure disorders with and without secondary generalization. ZNS has a favorable pharmacokinetic profile because of its rapid absorption and high bioavailability. Its activity is related to the blockade of voltage gated sodium and calcium channels, modulation of central dopaminergic, GABAergic, and serotonergic functions, as well as inhibition of carbonic anhydrase and monoamine oxidase B. ZNS has potential efficacy for an array of neuropsychiatric disorders including migraine and other headache syndromes, neuropathic pain, Parkinson's disease, essential tremor, stroke, obesity, anxiety, bipolar and binge-eating disorders.
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