Identification of multispecific organic anion transporter 2 expressed predominantly in the liver.
Article Details
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Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H
Identification of multispecific organic anion transporter 2 expressed predominantly in the liver.
FEBS Lett. 1998 Jun 12;429(2):179-82.
- PubMed ID
- 9650585 [ View in PubMed]
- Abstract
In the present study, we demonstrate that NLT (novel liver-specific transport protein) is a multispecific organic anion transporter of the liver. The amino acid sequence of NLT shows 42% identity to that of the renal multispecific organic anion transporter, OAT1. When expressed in Xenopus laevis oocytes, NLT mediated uptake of organic anions, such as salicylate, acetylsalicylate, PGE2, dicarboxylates and p-aminohippurate. [14C]Salicylate uptake via NLT was saturable (Km = 88.8 +/- 23.4 microM) and sodium-independent. Expression of the mRNA of NLT was detected in the liver and kidney (liver >> kidney). We propose that NLT be renamed OAT2.
DrugBank Data that Cites this Article
- Drug Transporters
Drug Transporter Kind Organism Pharmacological Action Actions Aminohippuric acid Solute carrier family 22 member 7 Protein Humans UnknownSubstrateDetails Bumetanide Solute carrier family 22 member 7 Protein Humans UnknownInhibitorDetails Cefoperazone Solute carrier family 22 member 7 Protein Humans UnknownInhibitorDetails Cholic Acid Solute carrier family 22 member 7 Protein Humans UnknownInhibitorDetails Dinoprostone Solute carrier family 22 member 7 Protein Humans UnknownSubstrateInhibitorDetails Enalapril Solute carrier family 22 member 7 Protein Humans UnknownInhibitorDetails Ketoprofen Solute carrier family 22 member 7 Protein Humans UnknownInhibitorDetails Methotrexate Solute carrier family 22 member 7 Protein Humans UnknownSubstrateDetails Rifampicin Solute carrier family 22 member 7 Protein Humans UnknownInhibitorDetails Salicylic acid Solute carrier family 22 member 7 Protein Humans UnknownSubstrateDetails