Clinically significant psychotropic drug-drug interactions in the primary care setting.
Article Details
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English BA, Dortch M, Ereshefsky L, Jhee S
Clinically significant psychotropic drug-drug interactions in the primary care setting.
Curr Psychiatry Rep. 2012 Aug;14(4):376-90. doi: 10.1007/s11920-012-0284-9.
- PubMed ID
- 22707017 [ View in PubMed]
- Abstract
In recent years, the growing numbers of patients seeking care for a wide range of psychiatric illnesses in the primary care setting has resulted in an increase in the number of psychotropic medications prescribed. Along with the increased utilization of psychotropic medications, considerable variability is noted in the prescribing patterns of primary care providers and psychiatrists. Because psychiatric patients also suffer from a number of additional medical comorbidities, the increased utilization of psychotropic medications presents an elevated risk of clinically significant drug interactions in these patients. While life-threatening drug interactions are rare, clinically significant drug interactions impacting drug response or appearance of serious adverse drug reactions have been documented and can impact long-term outcomes. Additionally, the impact of genetic variability on the psychotropic drug's pharmacodynamics and/or pharmacokinetics may further complicate drug therapy. Increased awareness of clinically relevant psychotropic drug interactions can aid clinicians to achieve optimal therapeutic outcomes in patients in the primary care setting.
DrugBank Data that Cites this Article
- Drugs
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Fluoxetine Cytochrome P450 1A2 Protein Humans UnknownSubstrateInhibitorDetails Norfloxacin Cytochrome P450 1A2 Protein Humans UnknownInhibitorDetails Prulifloxacin Cytochrome P450 1A2 Protein Humans NoInhibitorDetails Rosoxacin Cytochrome P450 1A2 Protein Humans NoInhibitorDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareBuspironeNefazodone The serum concentration of Buspirone can be increased when it is combined with Nefazodone. HaloperidolCelecoxib The serum concentration of Haloperidol can be increased when it is combined with Celecoxib. HaloperidolRofecoxib The serum concentration of Haloperidol can be increased when it is combined with Rofecoxib. HaloperidolValdecoxib The serum concentration of Haloperidol can be increased when it is combined with Valdecoxib. HaloperidolDiclofenac The serum concentration of Haloperidol can be increased when it is combined with Diclofenac.