Clinically significant psychotropic drug-drug interactions in the primary care setting.

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English BA, Dortch M, Ereshefsky L, Jhee S

Clinically significant psychotropic drug-drug interactions in the primary care setting.

Curr Psychiatry Rep. 2012 Aug;14(4):376-90. doi: 10.1007/s11920-012-0284-9.

PubMed ID

22707017 [ View in PubMed

]

Abstract

In recent years, the growing numbers of patients seeking care for a wide range of psychiatric illnesses in the primary care setting has resulted in an increase in the number of psychotropic medications prescribed. Along with the increased utilization of psychotropic medications, considerable variability is noted in the prescribing patterns of primary care providers and psychiatrists. Because psychiatric patients also suffer from a number of additional medical comorbidities, the increased utilization of psychotropic medications presents an elevated risk of clinically significant drug interactions in these patients. While life-threatening drug interactions are rare, clinically significant drug interactions impacting drug response or appearance of serious adverse drug reactions have been documented and can impact long-term outcomes. Additionally, the impact of genetic variability on the psychotropic drug's pharmacodynamics and/or pharmacokinetics may further complicate drug therapy. Increased awareness of clinically relevant psychotropic drug interactions can aid clinicians to achieve optimal therapeutic outcomes in patients in the primary care setting.

DrugBank Data that Cites this Article

Drugs

Temazepam

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Fluoxetine	Cytochrome P450 1A2	Protein	Humans	Unknown	Substrate Inhibitor	Details
Norfloxacin	Cytochrome P450 1A2	Protein	Humans	Unknown	Inhibitor	Details
Prulifloxacin	Cytochrome P450 1A2	Protein	Humans	No	Inhibitor	Details
Rosoxacin	Cytochrome P450 1A2	Protein	Humans	No	Inhibitor	Details

Drug Interactions

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drugs	Interaction
Integrate drug-drug interactions in your software
Buspirone Nefazodone	The serum concentration of Buspirone can be increased when it is combined with Nefazodone.
Haloperidol Celecoxib	The serum concentration of Haloperidol can be increased when it is combined with Celecoxib.
Haloperidol Rofecoxib	The serum concentration of Haloperidol can be increased when it is combined with Rofecoxib.
Haloperidol Valdecoxib	The serum concentration of Haloperidol can be increased when it is combined with Valdecoxib.
Haloperidol Diclofenac	The serum concentration of Haloperidol can be increased when it is combined with Diclofenac.
Haloperidol Meloxicam	The serum concentration of Haloperidol can be increased when it is combined with Meloxicam.
Haloperidol Ibuprofen	The serum concentration of Haloperidol can be increased when it is combined with Ibuprofen.
Haloperidol Aminophenazone	The serum concentration of Haloperidol can be increased when it is combined with Aminophenazone.
Haloperidol Antipyrine	The serum concentration of Haloperidol can be increased when it is combined with Antipyrine.
Haloperidol Nimesulide	The serum concentration of Haloperidol can be increased when it is combined with Nimesulide.

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