Clinically significant psychotropic drug-drug interactions in the primary care setting.

Article Details

Citation

English BA, Dortch M, Ereshefsky L, Jhee S

Clinically significant psychotropic drug-drug interactions in the primary care setting.

Curr Psychiatry Rep. 2012 Aug;14(4):376-90. doi: 10.1007/s11920-012-0284-9.

PubMed ID
22707017 [ View in PubMed
]
Abstract

In recent years, the growing numbers of patients seeking care for a wide range of psychiatric illnesses in the primary care setting has resulted in an increase in the number of psychotropic medications prescribed. Along with the increased utilization of psychotropic medications, considerable variability is noted in the prescribing patterns of primary care providers and psychiatrists. Because psychiatric patients also suffer from a number of additional medical comorbidities, the increased utilization of psychotropic medications presents an elevated risk of clinically significant drug interactions in these patients. While life-threatening drug interactions are rare, clinically significant drug interactions impacting drug response or appearance of serious adverse drug reactions have been documented and can impact long-term outcomes. Additionally, the impact of genetic variability on the psychotropic drug's pharmacodynamics and/or pharmacokinetics may further complicate drug therapy. Increased awareness of clinically relevant psychotropic drug interactions can aid clinicians to achieve optimal therapeutic outcomes in patients in the primary care setting.

DrugBank Data that Cites this Article

Drugs
Drug Enzymes
DrugEnzymeKindOrganismPharmacological ActionActions
FluoxetineCytochrome P450 1A2ProteinHumans
Unknown
Substrate
Inhibitor
Details
NorfloxacinCytochrome P450 1A2ProteinHumans
Unknown
Inhibitor
Details
PrulifloxacinCytochrome P450 1A2ProteinHumans
No
Inhibitor
Details
RosoxacinCytochrome P450 1A2ProteinHumans
No
Inhibitor
Details
Drug Interactions
DrugsInteraction
Buspirone
Nefazodone
The serum concentration of Buspirone can be increased when it is combined with Nefazodone.
Haloperidol
Celecoxib
The serum concentration of Haloperidol can be increased when it is combined with Celecoxib.
Haloperidol
Rofecoxib
The serum concentration of Haloperidol can be increased when it is combined with Rofecoxib.
Haloperidol
Valdecoxib
The serum concentration of Haloperidol can be increased when it is combined with Valdecoxib.
Haloperidol
Diclofenac
The serum concentration of Haloperidol can be increased when it is combined with Diclofenac.