Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.
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Hall N, Pain A, Berriman M, Churcher C, Harris B, Harris D, Mungall K, Bowman S, Atkin R, Baker S, Barron A, Brooks K, Buckee CO, Burrows C, Cherevach I, Chillingworth C, Chillingworth T, Christodoulou Z, Clark L, Clark R, Corton C, Cronin A, Davies R, Davis P, Dear P, Dearden F, Doggett J, Feltwell T, Goble A, Goodhead I, Gwilliam R, Hamlin N, Hance Z, Harper D, Hauser H, Hornsby T, Holroyd S, Horrocks P, Humphray S, Jagels K, James KD, Johnson D, Kerhornou A, Knights A, Konfortov B, Kyes S, Larke N, Lawson D, Lennard N, Line A, Maddison M, McLean J, Mooney P, Moule S, Murphy L, Oliver K, Ormond D, Price C, Quail MA, Rabbinowitsch E, Rajandream MA, Rutter S, Rutherford KM, Sanders M, Simmonds M, Seeger K, Sharp S, Smith R, Squares R, Squares S, Stevens K, Taylor K, Tivey A, Unwin L, Whitehead S, Woodward J, Sulston JE, Craig A, Newbold C, Barrell BG
Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.
Nature. 2002 Oct 3;419(6906):527-31.
- PubMed ID
- 12368867 [ View in PubMed]
- Abstract
Since the sequencing of the first two chromosomes of the malaria parasite, Plasmodium falciparum, there has been a concerted effort to sequence and assemble the entire genome of this organism. Here we report the sequence of chromosomes 1, 3-9 and 13 of P. falciparum clone 3D7--these chromosomes account for approximately 55% of the total genome. We describe the methods used to map, sequence and annotate these chromosomes. By comparing our assemblies with the optical map, we indicate the completeness of the resulting sequence. During annotation, we assign Gene Ontology terms to the predicted gene products, and observe clustering of some malaria-specific terms to specific chromosomes. We identify a highly conserved sequence element found in the intergenic region of internal var genes that is not associated with their telomeric counterparts.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 Details Peptide deformylase Q8I372 Details 1-cys peroxiredoxin Q5MYR6 Details Translationally-controlled tumor protein homolog Q8I3Z5 Details Ornithine aminotransferase Q6LFH8 Details Heat shock protein 70 Q8IB24 Details Cell division cycle protein 48 homologue,putative C6KT34 Details Heat shock protein 90 Q8IC05 Details Pyruvate kinase C6KTA4 Details Protein disulfide-isomerase C0H4Y6 Details Thioredoxin-related protein, putative Q8IDH5 Details Probable ATP-dependent 6-phosphofructokinase Q8I2Z8 Details S-adenosylmethionine synthase Q7K6A4 Details 60S ribosomal protein L4 Q8I431 Details Phosphoethanolamine N-methyltransferase Q8IDQ9 Details 40S ribosomal protein S3a O97313 Details High molecular weight rhoptry protein 2 C0H571 Details 40S ribosomal protein S19 C0H5C2 Details V-type proton ATPase catalytic subunit A Q76NM6 Details 60S ribosomal protein L2 Q8I3T9 Details 14-3-3 protein C0H4V6 Details Mature parasite-infected erythrocyte surface antigen Q8I492 Details Importin-7, putative C0H4L1 Details Peptidyl-prolyl cis-trans isomerase Q76NN7 Details DnaJ protein, putative Q8IB72 Details Glutamate--tRNA ligase Q8IDD3 Details T-complex protein 1 subunit eta O77323 Details Chaperone, putative C0H546 Details 40S ribosomal protein S5, putative Q8IBN5 Details Skeleton-binding protein 1 Q8I487 Details Adenosylhomocysteinase P50250 Details Carbamoyl phosphate synthetase Q8IEN3 Details Aspartate carbamoyltransferase Q8IDP8 Details Parasite-infected erythrocyte surface protein O77361 Details Coatomer alpha subunit, putative C6KSR5 Details Proteasome subunit alpha type Q8IBI3 Details Ubiquitin-conjugating enzyme E2 Q8IDP1 Details 60S ribosomal protein L24, putative Q8IEM3 Details 60S ribosomal protein L23 Q8IE82 Details 60S ribosomal protein L17, putative Q8IDI5 Details Heat shock protein 110, putative C0H5H0 Details Ubiquitin-60S ribosomal protein L40 Q8ID50 Details Calcium-dependent protein kinase 4 Q8IBS5 Details Nucleoside transporter 2 Q8IB78 Details Anamorsin homolog C0H4X5 Details Glutamine synthetase, putative C0H551 Details Elongation factor 1-gamma, putative Q8IDV0 Details Pyridoxal 5'-phosphate synthase subunit Pdx1 C6KT50 Details Ferredoxin--NADP reductase, apicoplast C6KT68 Details Importin subunit alpha Q8IAW0 Details Phosphoribosylpyrophosphate synthetase Q8IE67 Details