Genome of the bacterium Streptococcus pneumoniae strain R6.

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Hoskins J, Alborn WE Jr, Arnold J, Blaszczak LC, Burgett S, DeHoff BS, Estrem ST, Fritz L, Fu DJ, Fuller W, Geringer C, Gilmour R, Glass JS, Khoja H, Kraft AR, Lagace RE, LeBlanc DJ, Lee LN, Lefkowitz EJ, Lu J, Matsushima P, McAhren SM, McHenney M, McLeaster K, Mundy CW, Nicas TI, Norris FH, O'Gara M, Peery RB, Robertson GT, Rockey P, Sun PM, Winkler ME, Yang Y, Young-Bellido M, Zhao G, Zook CA, Baltz RH, Jaskunas SR, Rosteck PR Jr, Skatrud PL, Glass JI

Genome of the bacterium Streptococcus pneumoniae strain R6.

J Bacteriol. 2001 Oct;183(19):5709-17.

PubMed ID
11544234 [ View in PubMed
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Abstract

Streptococcus pneumoniae is among the most significant causes of bacterial disease in humans. Here we report the 2,038,615-bp genomic sequence of the gram-positive bacterium S. pneumoniae R6. Because the R6 strain is avirulent and, more importantly, because it is readily transformed with DNA from homologous species and many heterologous species, it is the principal platform for investigation of the biology of this important pathogen. It is also used as a primary vehicle for genomics-based development of antibiotics for gram-positive bacteria. In our analysis of the genome, we identified a large number of new uncharacterized genes predicted to encode proteins that either reside on the surface of the cell or are secreted. Among those proteins there may be new targets for vaccine and antibiotic development.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Penicillin-binding protein 2XP59676Details
Chorismate synthaseP0A2Y7Details
Peptide deformylaseQ8DP79Details
Holo-[acyl-carrier-protein] synthaseP0A2W7Details
Penicillin-binding protein 2BP0A3M6Details
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligaseQ8DNV6Details
Penicillin-binding protein 1AQ8DR59Details
Penicillin-binding protein 1bQ7CRA4Details
Penicillin-binding protein 2aQ8DNB6Details