Tyrosine-protein kinase ABL1

BE0000014ProteinHumansABL1

Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage... It is acted on by 36 drugs in DrugBank.

Gene name
ABL1
UniProtKB entry
P00519Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton
Residues / weight
1,130 residues · 122,871 Da
Also known as
2.7.10.2 · Abelson murine leukemia viral oncogene homolog 1 · Abelson tyrosine-protein kinase 1 · ABL · JTK7

Resolves to

Protein
UniProtP00519UniProt nameABL1_HUMAN
Gene
HGNCHGNC:76NCBI Gene25GenBank28237GeneCardsABL1
Pharmacology
IUPHAR/GtoPdb1923KEGGhsa:25
Structure
PDB1AB2PDB1AWOPDB1BBZ
Drugs

What you can answer from here — as of September 07, 2019

36DrugsApproved to experimental, with action, bond type and pharmacological action
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77Clinical trialsTrials of drugs acting on it, by phase and status
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47GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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188+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine-protein kinase ABL1, how selective are they, and which programs against it are still in active trials?

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