Nitroarginine

DB04223InvestigationalSmall molecule

An inhibitor of nitric oxide synthetase which has been shown to prevent glutamate toxicity. Nitroarginine has been experimentally tested for its ability to prevent ammonia toxicity and ammonia-induced alterations in... (Neurochem Res 1995:200(4):451-6).

Mechanism: Pharmacologically active on Nitric oxide synthase 1 and Nitric oxide synthase 3
Curator reviewed
Formula / weight: C₆H₁₃N₅O₄ · 219.1985 g/mol (avg)
Also known as: L-NNA · omega-Nitroarginine
Code names: NSC-53662

Resolves to

Compound

UNII7O8V7H6P2JCAS2149-70-4ChEMBLCHEMBL227744ChEBI27960PubChem440005KEGGC03417

Structure

InChIKeyMRAUNPAHJZDYCK-BYPYZUCNSA-NSMILESN[C@@H](CCCNC(=N)N[N+]([O-])=O)C(O)=O

Targets

P29475NOS1P29474NOS3

What you can answer from here — as of September 19, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with Nitroarginine, and which of those have an active Phase 3 trial?

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