Sodium channel protein type 1 subunit alpha

BE0000141ProteinHumansSCN1A

Pore-forming subunit of Nav1.1, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. It is acted on by 8 drugs in DrugBank.

Gene name
SCN1A
UniProtKB entry
P35498Swiss-Prot
Cellular location
Cell membrane
Residues / weight
2,009 residues · 228,969 Da
Also known as
NAC1 · SCN1 · Sodium channel protein brain I subunit alpha · Sodium channel protein type I subunit alpha · Voltage-gated sodium channel subunit alpha Nav1.1

Resolves to

Protein
UniProtP35498UniProt nameSCN1A_HUMAN
Gene
HGNCHGNC:10585NCBI Gene6323GenBank12642270GeneCardsSCN1A
Pharmacology
IUPHAR/GtoPdb578KEGGhsa:6323
Structure
PDB7DTD
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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95+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium channel protein type 1 subunit alpha, how selective are they, and which programs against it are still in active trials?

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