Purine nucleoside phosphorylase

BE0000250ProteinHumansPNP

Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (PubMed:23438750, PubMed:3029074, PubMed:9305964). It is acted on by 30 drugs in DrugBank.

Gene name
PNP
UniProtKB entry
P00491Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
289 residues · 32,118 Da
Also known as
2.4.2.1 · Inosine phosphorylase · Inosine-guanosine phosphorylase · NP · PNP

Resolves to

Protein
UniProtP00491UniProt namePNPH_HUMAN
Gene
HGNCHGNC:7892NCBI Gene4860GenBank35565GeneCardsPNP
Pharmacology
IUPHAR/GtoPdb2841KEGGhsa:4860
Structure
PDB1M73PDB1PF7PDB1PWY
Drugs

What you can answer from here — as of September 07, 2019

30DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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16GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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79+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Purine nucleoside phosphorylase, how selective are they, and which programs against it are still in active trials?

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