Steroid 17-alpha-hydroxylase/17,20 lyase

BE0000344ProteinHumansCYP17A1

A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis (PubMed:22266943, PubMed:25301938, PubMed:27339894, PubMed:9452426). It is acted on by 22 drugs in DrugBank.

Gene name
CYP17A1
UniProtKB entry
P05093Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
508 residues · 57,370 Da
Also known as
1.14.14.19 · 17-alpha-hydroxyprogesterone aldolase · CYP17 · CYPXVII · Cytochrome P450 17A1

Resolves to

Protein
UniProtP05093UniProt nameCP17A_HUMAN
Gene
HGNCHGNC:2593NCBI Gene1586GenBank181342GeneCardsCYP17A1
Pharmacology
IUPHAR/GtoPdb1361KEGGhsa:1586
Structure
PDB3RUKPDB3SWZPDB4NKV
Drugs

What you can answer from here — as of September 07, 2019

22DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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94+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Steroid 17-alpha-hydroxylase/17,20 lyase, how selective are they, and which programs against it are still in active trials?

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