Tumor necrosis factor

BE0000704ProteinHumansTNF

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is acted on by 69 drugs in DrugBank.

Gene name
TNF
UniProtKB entry
P01375Swiss-Prot
Cellular location
Cell membrane
Residues / weight
233 residues · 25,644 Da
Also known as
Cachectin · TNF-a · TNF-alpha · TNFA · TNFSF2

Resolves to

Protein
UniProtP01375UniProt nameTNFA_HUMAN
Gene
HGNCHGNC:11892NCBI Gene7124GenBank339741GeneCardsTNF
Pharmacology
KEGGhsa:7124
Structure
PDB1A8MPDB1TNFPDB21TV
Drugs

What you can answer from here — as of September 07, 2019

69DrugsApproved to experimental, with action, bond type and pharmacological action
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147Clinical trialsTrials of drugs acting on it, by phase and status
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104GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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152+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tumor necrosis factor, how selective are they, and which programs against it are still in active trials?

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