Glutamate receptor 3

BE0000831ProteinHumansGRIA3

Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (By similarity). It is acted on by 15 drugs in DrugBank.

Gene name
GRIA3
UniProtKB entry
P42263Swiss-Prot
Cellular location
Cell membrane
Residues / weight
894 residues · 101,156 Da
Also known as
AMPA-selective glutamate receptor 3 · GluA3 · GluR-3 · GluR-C · GluR-K3

Resolves to

Protein
UniProtP42263UniProt nameGRIA3_HUMAN
Gene
HGNCHGNC:4573NCBI Gene2892GenBank507829GeneCardsGRIA3
Pharmacology
IUPHAR/GtoPdb446KEGGhsa:2892
Drugs

What you can answer from here — as of September 07, 2019

15DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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34+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutamate receptor 3, how selective are they, and which programs against it are still in active trials?

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