This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Saccharin is a non-nutritive artificial sweetener for sweetening foods and drinks.
- Generic Name
- Saccharin
- DrugBank Accession Number
- DB12418
- Background
Saccharin has been investigated for the treatment of Hypertension and Hyperglycemia.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Saccharin (DB12418)
- Weight
- Average: 183.185
Monoisotopic: 182.999013721 - Chemical Formula
- C7H5NO3S
- Synonyms
- Saccharin
- External IDs
- E-954(I)
- INS NO.954(I)
- INS-954(I)
Pharmacology
- Indication
Not Available
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- Contraindications & Blackbox Warnings
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Not Available
- Mechanism of action
Target Actions Organism UCarbonic anhydrase 3 inhibitorHumans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key Saccharin calcium 5101OP7P2I 6381-91-5 NNOYLBKZPCUCQT-UHFFFAOYSA-L Saccharin potassium K2BEG3J28N 10332-51-1 HEKURBKACCBNEJ-UHFFFAOYSA-M Saccharin sodium SB8ZUX40TY 6155-57-3 AYGJDUHQRFKLBG-UHFFFAOYSA-M - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image ENO FRUIT SALT (LEMON FLAVOURED)(AUSTRALIA) Saccharin sodium (0.003 g) + Citric acid (1.85 g) + Sodium bicarbonate (1.96 g) + Sodium carbonate (0.43 g) Powder, for solution Oral STERLING DRUG (MALAYA) SDN. BHD. 2020-09-08 2022-05-03 Malaysia 
FORTRANS Saccharin sodium (0.1 g/73.69g) + Polyethylene glycol (64 g/73.69g) + Potassium chloride (0.75 g/73.69g) + Sodium bicarbonate (1.68 g/73.69g) + Sodium chloride (1.46 g/73.69g) + Sodium sulfate (5.7 g/73.69g) Powder, for solution Oral EP PLUS GROUP SDN. BHD. 2020-09-08 Not applicable Malaysia
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as benzothiazoles. These are organic compounds containing a benzene fused to a thiazole ring (a five-membered ring with four carbon atoms, one nitrogen atom and one sulfur atom).
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Benzothiazoles
- Sub Class
- Not Available
- Direct Parent
- Benzothiazoles
- Alternative Parents
- Benzenoids / Organosulfonic acids and derivatives / Carboxylic acids and derivatives / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds / Organonitrogen compounds / Organic oxides / Hydrocarbon derivatives
- Substituents
- 1,2-benzothiazole / Aromatic heteropolycyclic compound / Azacycle / Benzenoid / Carboxylic acid derivative / Hydrocarbon derivative / Organic nitrogen compound / Organic oxide / Organic oxygen compound / Organic sulfonic acid or derivatives
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- sulfone, lactam, 1,2-benzisothiazole (CHEBI:32111)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- FST467XS7D
- CAS number
- 81-07-2
- InChI Key
- CVHZOJJKTDOEJC-UHFFFAOYSA-N
- InChI
- InChI=1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)
- IUPAC Name
- 2,3-dihydro-1lambda6,2-benzothiazole-1,1,3-trione
- SMILES
- O=C1NS(=O)(=O)C2=C1C=CC=C2
References
- General References
- Dulcaryl (saccharin) effervescent tablets (User Guide) [Link]
- External Links
- Human Metabolome Database
- HMDB0029723
- KEGG Compound
- C12283
- PubChem Compound
- 5143
- PubChem Substance
- 347828662
- ChemSpider
- 4959
- BindingDB
- 29278
- 9509
- ChEBI
- 32111
- ChEMBL
- CHEMBL310671
- ZINC
- ZINC000002560357
- PDBe Ligand
- LSA
- Wikipedia
- Saccharin
- PDB Entries
- 2q1b / 2q38 / 3srk / 4n1o / 4riv / 5rsp / 6fjj / 7wjv
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Completed Treatment Postoperative; Dysfunction Following Cardiac Surgery 2 Not Available Not Yet Recruiting Not Available Eustachian Tube Dysfunction (ETD) 1 Not Available Withdrawn Treatment Hyperglycemia / Hypertension 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet 3.125 mg Tablet 12.5 mg Powder, for solution Oral Powder, for solution Oral 10 G - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 6.51 mg/mL ALOGPS logP 0.09 ALOGPS logP 0.45 Chemaxon logS -1.4 ALOGPS pKa (Strongest Acidic) 1.94 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 63.24 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 42.39 m3·mol-1 Chemaxon Polarizability 16.02 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Targets
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Zinc ion binding
- Specific Function
- Reversible hydration of carbon dioxide.
- Gene Name
- CA3
- Uniprot ID
- P07451
- Uniprot Name
- Carbonic anhydrase 3
- Molecular Weight
- 29557.215 Da
References
- Nishimori I, Minakuchi T, Onishi S, Vullo D, Cecchi A, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides. Bioorg Med Chem. 2007 Dec 1;15(23):7229-36. Epub 2007 Aug 25. [Article]
Drug created at October 20, 2016 22:18 / Updated at May 27, 2021 02:57