Prostaglandin E2 receptor EP3 subtype

BE0002375ProteinHumansPTGER3

Receptor for prostaglandin E2 (PGE2) (PubMed:7883006, PubMed:7981210, PubMed:8117308, PubMed:8135729, PubMed:8307176). It is acted on by 17 drugs in DrugBank.

Gene name
PTGER3
UniProtKB entry
P43115Swiss-Prot
Cellular location
Cell membrane
Residues / weight
390 residues · 43,309 Da
Also known as
PGE receptor EP3 subtype · PGE2 receptor EP3 subtype · PGE2-R · Prostanoid EP3 receptor

Resolves to

Protein
UniProtP43115UniProt namePE2R3_HUMAN
Gene
HGNCHGNC:9595NCBI Gene5733GeneCardsPTGER3
Pharmacology
IUPHAR/GtoPdb342KEGGhsa:5733
Structure
PDB6AK3PDB6M9TPDB7WU9
Drugs

What you can answer from here — as of September 07, 2019

17DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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53+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Prostaglandin E2 receptor EP3 subtype, how selective are they, and which programs against it are still in active trials?

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