Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

BE0002406ProteinHumansPIK3CD

Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:9235916). It is acted on by 29 drugs in DrugBank.

Gene name
PIK3CD
UniProtKB entry
O00329Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,044 residues · 119,478 Da
Also known as
2.7.1.137 · 2.7.1.153 · p110delta · Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta · PI3-kinase subunit delta

Resolves to

Protein
UniProtO00329UniProt namePK3CD_HUMAN
Gene
HGNCHGNC:8977NCBI Gene5293GeneCardsPIK3CD
Pharmacology
IUPHAR/GtoPdb2155KEGGhsa:5293
Structure
PDB5DXUPDB5M6UPDB5T8F
Drugs

What you can answer from here — as of September 07, 2019

29DrugsApproved to experimental, with action, bond type and pharmacological action
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9Clinical trialsTrials of drugs acting on it, by phase and status
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12GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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103+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, how selective are they, and which programs against it are still in active trials?

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