UDP-glucuronosyltransferase 1A6

BE0004694ProteinHumansUGT1A6

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to facilitate their inactivation and excretion from the body (PubMed:15231852, PubMed:21422672). It is acted on by 22 drugs in DrugBank.

Gene name
UGT1A6
UniProtKB entry
P19224Swiss-Prot
Cellular location
Microsome
Residues / weight
532 residues · 60,750 Da
Also known as
2.4.1.17 · GNT1 · Phenol-metabolizing UDP-glucuronosyltransferase · UDP-glucuronosyltransferase 1-6 · UDP-glucuronosyltransferase 1-F

Resolves to

Protein
UniProtP19224UniProt nameUD16_HUMAN
Gene
HGNCHGNC:12538NCBI Gene54578GeneCardsUGT1A6
Pharmacology
KEGGhsa:54578
Drugs

What you can answer from here — as of February 11, 2025

22DrugsApproved to experimental, with action, bond type and pharmacological action
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6Metabolic reactionsDrug transformations it catalyses, substrate to product
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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43+ReferencesStructured and connected to the statements they support
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Which approved drugs act on UDP-glucuronosyltransferase 1A6, how selective are they, and which programs against it are still in active trials?

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