Dual specificity mitogen-activated protein kinase kinase 2

BE0004744ProteinHumansMAP2K2

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. It is acted on by 22 drugs in DrugBank.

Gene name
MAP2K2
UniProtKB entry
P36507Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
400 residues · 44,424 Da
Also known as
2.7.12.2 · ERK activator kinase 2 · MAP kinase kinase 2 · MAPK/ERK kinase 2 · MAPKK 2

Resolves to

Protein
UniProtP36507UniProt nameMP2K2_HUMAN
Gene
HGNCHGNC:6842NCBI Gene5605GeneCardsMAP2K2
Pharmacology
IUPHAR/GtoPdb2063KEGGhsa:5605
Structure
PDB1S9IPDB4H3Q
Drugs

What you can answer from here — as of September 07, 2019

22DrugsApproved to experimental, with action, bond type and pharmacological action
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9Clinical trialsTrials of drugs acting on it, by phase and status
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29GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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93+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dual specificity mitogen-activated protein kinase kinase 2, how selective are they, and which programs against it are still in active trials?

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