Gamma-secretase subunit APH-1B

BE0017533ProteinHumansAPH1B

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It is acted on by 12 drugs in DrugBank.

Gene name
APH1B
UniProtKB entry
Q8WW43Swiss-Prot
Cellular location
Membrane
Residues / weight
257 residues · 28,460 Da
Also known as
APH-1b · Aph-1beta · Presenilin-stabilization factor-like · PSFL

Resolves to

Protein
UniProtQ8WW43UniProt nameAPH1B_HUMAN
Gene
HGNCHGNC:24080NCBI Gene83464GeneCardsAPH1B
Pharmacology
KEGGhsa:83464
Structure
PDB8OQYPDB8OQZ
Drugs

What you can answer from here — as of September 03, 2024

12DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Gamma-secretase subunit APH-1B, how selective are they, and which programs against it are still in active trials?

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