Gamma-secretase subunit APH-1B

Details

Name
Gamma-secretase subunit APH-1B
Kind
protein
Synonyms
  • APH-1b
  • Aph-1beta
  • Presenilin-stabilization factor-like
  • PSFL
Gene Name
APH1B
UniProtKB Entry
Q8WW43Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0060503|Gamma-secretase subunit APH-1B
MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
DNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVS
GLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDG
CEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKL
CLLCQDKNFLLYNQRSR
Number of residues
257
Molecular Weight
28459.6
Theoretical pI
Not Available
GO Classification
Functions
endopeptidase activator activity / protein-macromolecule adaptor activity
Processes
amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein intracellular domain proteolysis / Notch receptor processing / Notch signaling pathway / positive regulation of endopeptidase activity / protein processing
Components
endoplasmic reticulum / endoplasmic reticulum membrane / endosome membrane / gamma-secretase complex / Golgi membrane / membrane / plasma membrane / transport vesicle
General Function
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A
Specific Function
endopeptidase activator activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
5-25 32-52 71-91 115-135 158-178 186-206 213-233
Cellular Location
Membrane
Gene sequence
Not Available
Chromosome Location
15
Locus
15q22.2
External Identifiers
ResourceLink
UniProtKB IDQ8WW43
UniProtKB Entry NameAPH1B_HUMAN
GeneCard IDAPH1B
HGNC IDHGNC:24080
PDB ID(s)8OQY, 8OQZ
KEGG IDhsa:83464
NCBI Gene ID83464
General References
Not Available

Associated Data

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