Nicastrin

BE0017775ProteinHumansNCSTN

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). It is acted on by 12 drugs in DrugBank.

Gene name
NCSTN
UniProtKB entry
Q92542Swiss-Prot
Cellular location
Membrane
Residues / weight
709 residues · 78,410 Da
Also known as
KIAA0253

Resolves to

Protein
UniProtQ92542UniProt nameNICA_HUMAN
Gene
HGNCHGNC:17091NCBI Gene23385GeneCardsNCSTN
Pharmacology
KEGGhsa:23385
Structure
PDB2N7QPDB2N7RPDB4UIS
Drugs

What you can answer from here — as of September 03, 2024

12DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1GO termFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
12+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Nicastrin, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In