Nicastrin

Details

Name
Nicastrin
Kind
protein
Synonyms
  • KIAA0253
Gene Name
NCSTN
UniProtKB Entry
Q92542Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0060736|Nicastrin
MATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI
GCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG
LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI
FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF
SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA
SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD
SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ
PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV
TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ
DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY
EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI
FLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY
Number of residues
709
Molecular Weight
78410.16
Theoretical pI
Not Available
GO Classification
Functions
aspartic endopeptidase activity, intramembrane cleaving / ATPase binding / growth factor receptor binding / protein-macromolecule adaptor activity
Processes
adult behavior / amyloid precursor protein biosynthetic process / amyloid precursor protein catabolic process / amyloid precursor protein metabolic process / amyloid-beta formation / cellular response to calcium ion / central nervous system myelination / cerebellum development / epithelial cell proliferation / G protein-coupled dopamine receptor signaling pathway / glutamate receptor signaling pathway / learning or memory / membrane protein ectodomain proteolysis / membrane protein intracellular domain proteolysis / myeloid cell homeostasis / neuron apoptotic process / Notch receptor processing / Notch signaling pathway / positive regulation of amyloid precursor protein biosynthetic process / positive regulation of endopeptidase activity / protein processing / proteolysis / regulation of long-term synaptic potentiation / short-term synaptic potentiation / T cell proliferation
Components
azurophil granule membrane / early endosome / endoplasmic reticulum / endoplasmic reticulum membrane / endosome membrane / extracellular exosome / focal adhesion / gamma-secretase complex / Golgi apparatus / Golgi membrane / lysosomal membrane / melanosome / membrane / plasma membrane / presynaptic membrane / sarcolemma / synaptic vesicle
General Function
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels
Specific Function
aspartic endopeptidase activity, intramembrane cleaving
Pfam Domain Function
Signal Regions
1-33
Transmembrane Regions
670-690
Cellular Location
Membrane
Gene sequence
Not Available
Chromosome Location
1
Locus
1q23.2
External Identifiers
ResourceLink
UniProtKB IDQ92542
UniProtKB Entry NameNICA_HUMAN
GeneCard IDNCSTN
HGNC IDHGNC:17091
PDB ID(s)2N7Q, 2N7R, 4UIS, 5A63, 5FN2, 5FN3, 5FN4, 5FN5, 6IDF, 6IYC, 6LQG, 6LR4, 7C9I, 7D8X, 7Y5T, 7Y5X, 7Y5Z, 8IM7, 8K8E, 8OQY, 8OQZ, 8X52, 8X53, 8X54
KEGG IDhsa:23385
NCBI Gene ID23385
General References
Not Available

Associated Data

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