Benzylidene Compounds

Name
Benzylidene Compounds
Accession Number
DBCAT000619
Description

Compounds containing the PhCH= radical.

Drugs
DrugDrug Description
RaloxifeneA selective estrogen receptor modulator that is used to prevent and treat osteoporosis and reduce the risk of invasive breast cancer in high-risk postmenopausal women.
ToremifeneA first generation nonsteroidal selective estrogen receptor modulator used to treat certain breast cancers.
TamoxifenA selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer following surgery, or reduce the risk of breast cancer in high risk women.
DiethylstilbestrolUsed in the treatment of prostate cancer. Previously used in the prevention of miscarriage or premature delivery in pregnant women prone to miscarriage or premature delivery.
ChlorotrianiseneUsed to treat symptoms of menopause, deficiencies in ovary function (including underdevelopment of female sexual characteristics and some types of infertility), and in rare cases, prostate cancer. Chlorotrianisene may also...
ClomifeneA medication used to induce ovulation.
DienestrolA non steroidal estrogen used to treat atrophic vaginitis and kraurosis vulvae.
TolevamerA potassium-binding resin used in the treatment of hyperkalemia.
ResveratrolBeing investigated for the treatment of Herpes labialis infections (cold sores).
AfimoxifeneFor the potential treatment of menstrual-cycle related mastalgia, fibrocystic breast disease, breast disease, gynecomastia and Keloid scarring.
OspemifeneA non-hormonal estrogen receptor modulator (SERM) used to treat moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause.
OXI-4503Investigated for use/treatment in cancer/tumors (unspecified).
TapinarofA therapeutic aryl hydrocarbon receptor-modulating agent (TAMA) indicated for the treatment of adult psoriasis.
FispemifeneInvestigated for use/treatment in male hormonal deficiencies/abnormalities.
EnclomipheneNot Annotated
HexestrolA synthetic estrogen that has been used as a hormonal antineoplastic agent.
PiceatannolNot Available
Florbetaben F-18A radiopharmaceutical diagnostic agent used during Positron Emission Tomography (PET) imaging of the brain to estimate β-amyloid neuritic plaque density in adult patients to diagnose the causes of cognitive impairment.
PolydatinPolydatin, or Piceid, is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensis or Polygonum cuspidatum, polydatin...
FosbretabulinFosbretabulin has been investigated for the treatment of Anaplastic Thyroid Cancer.
2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenolTIMBD is an azaresveratrol analog.
Dienestrol diacetateNot Annotated
Combretastatin A4Not Annotated
HydroxystilbamidineUsed in the treatment of nonprogressive blastomycosis of the skin and other mycoses.
DroloxifeneDroloxifene, a derivative of the triphenylethylene drug tamoxifen, is a novel selective estrogen receptor modulator (SERM). Droloxifene also exhibits more rapid pharmacokinetics, reaching peak concentrations and being eliminated much more...
PalovaroteneA selective agonist of retinoic acid receptor gamma (RARγ) used to reduce heterotopic ossification in patients with Fibrodysplasia Ossificans Progressiva (FOP).
Tyrphostin B44Not Annotated
Tyrphostin AG 555Not Annotated
Tyrphostin B48Not Annotated
Tyrphostin B56Not Annotated
Tyrphostin AG 879Not Annotated
WP-1066WP1066 has been used in trials studying the treatment of Melanoma, Brain Cancer, Solid Tumors, and Central Nervous System Neoplasms.
PterostilbeneNot Annotated
Drugs & Drug Targets
DrugTargetType
RaloxifeneEstrogen receptor alphatarget
RaloxifeneEstrogen receptor betatarget
RaloxifeneAldehyde oxidaseenzyme
RaloxifeneCytochrome P450 2C8enzyme
RaloxifeneCytochrome P450 2B6enzyme
RaloxifeneCytochrome P450 19A1enzyme
RaloxifeneCytochrome P450 3A4enzyme
RaloxifeneSerpin B9target
RaloxifeneTrefoil factor 1target
RaloxifeneUDP-glucuronosyltransferase 1-1enzyme
RaloxifeneSerum albumincarrier
RaloxifeneAlpha-1-acid glycoprotein 1carrier
RaloxifeneSolute carrier organic anion transporter family member 1B1transporter
RaloxifeneSolute carrier organic anion transporter family member 1B3transporter
RaloxifeneP-glycoprotein 1transporter
RaloxifeneATP-binding cassette sub-family G member 2transporter
RaloxifeneCanalicular multispecific organic anion transporter 1transporter
RaloxifeneCanalicular multispecific organic anion transporter 2transporter
RaloxifeneMultidrug resistance-associated protein 4transporter
RaloxifeneUDP-glucuronosyltransferase 1-10enzyme
RaloxifeneUDP-glucuronosyltransferase 1-8enzyme
ToremifeneEstrogen receptor alphatarget
ToremifeneCytochrome P450 3A4enzyme
ToremifeneP-glycoprotein 1transporter
ToremifeneCytochrome P450 1A1enzyme
ToremifeneSex hormone-binding globulintarget
TamoxifenEstrogen receptor alphatarget
TamoxifenEstrogen receptor betatarget
TamoxifenCytochrome P450 2C9enzyme
TamoxifenCytochrome P450 3A4enzyme
TamoxifenCytochrome P450 2D6enzyme
TamoxifenCytochrome P450 2C8enzyme
TamoxifenCytochrome P450 2B6enzyme
TamoxifenLiver carboxylesterase 1enzyme
TamoxifenCytochrome P450 3A5enzyme
TamoxifenCytochrome P450 1A1enzyme
TamoxifenCytochrome P450 1B1enzyme
TamoxifenCytochrome P450 2C19enzyme
TamoxifenDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
TamoxifenDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
TamoxifenCytochrome P450 3A7enzyme
TamoxifenP-glycoprotein 1transporter
TamoxifenATP-binding cassette sub-family G member 2transporter
TamoxifenCytochrome P450 19A1enzyme
TamoxifenCytochrome P450 2A6enzyme
TamoxifenCytochrome P450 2E1enzyme
TamoxifenUDP-glucuronosyltransferase 1-10enzyme
TamoxifenSulfotransferase 1A1enzyme
TamoxifenCanalicular multispecific organic anion transporter 1transporter
Tamoxifen3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerasetarget
TamoxifenProtein kinase Ctarget
TamoxifenAndrogen receptortarget
TamoxifenPotassium voltage-gated channel subfamily H member 2target
TamoxifenNuclear receptor subfamily 1 group I member 2target
TamoxifenEstrogen-related receptor gammatarget
TamoxifenSex hormone-binding globulintarget
TamoxifenBile salt export pumptransporter
TamoxifenThyroxine-binding globulincarrier
TamoxifenBile salt sulfotransferaseenzyme
TamoxifenCytochrome P450 1A2enzyme
TamoxifenUDP-glucuronosyltransferase 2B7enzyme
TamoxifenUDP-glucuronosyltransferase 2B17enzyme
TamoxifenEstrogen sulfotransferaseenzyme
TamoxifenATP-binding cassette sub-family A member 1transporter
TamoxifenMitogen-activated protein kinase 8target
TamoxifenSerum albumincarrier
DiethylstilbestrolEstrogen receptor alphatarget
DiethylstilbestrolEstrogen-related receptor gammatarget
DiethylstilbestrolTransthyretincarrier
DiethylstilbestrolCatechol O-methyltransferaseenzyme
DiethylstilbestrolCytochrome P450 19A1enzyme
DiethylstilbestrolATP-binding cassette sub-family G member 2transporter
DiethylstilbestrolP-glycoprotein 1transporter
DiethylstilbestrolEstrogen receptor betatarget
DiethylstilbestrolCytochrome P450 3A4enzyme
DiethylstilbestrolCytochrome P450 2C8enzyme
DiethylstilbestrolCytochrome P450 2C9enzyme
DiethylstilbestrolCytochrome P450 2E1enzyme
DiethylstilbestrolSteroid hormone receptor ERR1target
DiethylstilbestrolSteroid hormone receptor ERR2target
DiethylstilbestrolNuclear receptor coactivator 2target
DiethylstilbestrolNuclear receptor subfamily 1 group I member 2target
DiethylstilbestrolAndrogen receptortarget
DiethylstilbestrolSex hormone-binding globulintarget
DiethylstilbestrolSolute carrier organic anion transporter family member 1B1transporter
DiethylstilbestrolSolute carrier organic anion transporter family member 2B1transporter
DiethylstilbestrolBile salt export pumptransporter
ChlorotrianiseneEstrogen receptor alphatarget
ChlorotrianiseneCytochrome P450 19A1enzyme
ClomifeneEstrogen receptor alphatarget
ClomifeneP-glycoprotein 1transporter
ClomifeneSex hormone-binding globulintarget
ClomifeneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DienestrolEstrogen receptor alphatarget
DienestrolSex hormone-binding globulintarget
TolevamerPotassiumtarget
ResveratrolTransthyretincarrier
ResveratrolRibosyldihydronicotinamide dehydrogenase [quinone]target
ResveratrolProstaglandin G/H synthase 1target
ResveratrolCasein kinase II subunit alphatarget
ResveratrolProstaglandin G/H synthase 2target
ResveratrolNAD-dependent protein deacetylase sirtuin-1target
ResveratrolCytochrome P450 1A1enzyme
ResveratrolCytochrome P450 3A4enzyme
ResveratrolCytochrome P450 1A2enzyme
ResveratrolCytochrome P450 1B1enzyme
ResveratrolArachidonate 15-lipoxygenasetarget
ResveratrolArachidonate 5-lipoxygenasetarget
ResveratrolAryl hydrocarbon receptortarget
ResveratrolPhosphatidylinositol 4-kinase type 2-betatarget
ResveratrolIntegrin alpha-5target
ResveratrolIntegrin beta-3target
ResveratrolSerum albumincarrier
ResveratrolAmyloid beta A4 proteintarget
ResveratrolAlpha-synucleintarget
ResveratrolEstrogen receptor alphatarget
ResveratrolMelatonin receptor type 1Atarget
ResveratrolMelatonin receptor type 1Btarget
ResveratrolC-type lectin domain family 14 member Atarget
ResveratrolNuclear receptor subfamily 1 group I member 2target
ResveratrolNuclear receptor subfamily 1 group I member 3target
ResveratrolSolute carrier family 2, facilitated glucose transporter member 1target
ResveratrolCarbonyl reductase [NADPH] 1target
ResveratrolPeroxisome proliferator-activated receptor alphatarget
ResveratrolPeroxisome proliferator-activated receptor gammatarget
ResveratrolRAC-alpha serine/threonine-protein kinasetarget
ResveratrolFar upstream element-binding protein 2target
ResveratrolTyrosine--tRNA ligase, cytoplasmictarget
ResveratrolCytochrome P450 2D6enzyme
ResveratrolCytochrome P450 2B6enzyme
ResveratrolCytochrome P450 2C19enzyme
ResveratrolCytochrome P450 2C9enzyme
AfimoxifeneEstrogen receptor alphatarget
AfimoxifeneEstrogen receptor betatarget
AfimoxifeneEstrogen-related receptor gammatarget
AfimoxifeneTrefoil factor 1target
AfimoxifeneSteroid hormone receptor ERR1target
AfimoxifeneNuclear receptor subfamily 1 group I member 2target
AfimoxifeneSex hormone-binding globulintarget
OspemifeneEstrogen receptor alphatarget
OspemifeneCytochrome P450 3A4enzyme
OspemifeneCytochrome P450 2C9enzyme
OspemifeneCytochrome P450 2C19enzyme
OspemifeneCytochrome P450 2B6enzyme
OspemifeneCytochrome P450 2D6enzyme
TapinarofAryl hydrocarbon receptortarget
TapinarofCytochrome P450 1A2enzyme
TapinarofCytochrome P450 3A4enzyme
TapinarofCytochrome P450 2C9enzyme
TapinarofCytochrome P450 2C19enzyme
TapinarofCytochrome P450 2D6enzyme
EnclomipheneCytochrome P450 2D6enzyme
HexestrolAldo-keto reductase family 1 member C1target
HexestrolEstrogen receptor alphatarget
HexestrolNuclear receptor subfamily 1 group I member 2target
HexestrolNuclear receptor subfamily 1 group I member 3target
PiceatannolATP synthase subunit alpha, mitochondrialtarget
PiceatannolATP synthase subunit beta, mitochondrialtarget
PiceatannolATP synthase subunit gamma, mitochondrialtarget
Florbetaben F-18Cytochrome P450 2J2enzyme
Florbetaben F-18Leukotriene-B(4) omega-hydroxylase 1enzyme
Florbetaben F-18Amyloid beta A4 proteintarget
PolydatinPyruvate kinase PKMtarget
2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenolEstrogen receptor betatarget
2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenolEstrogen receptor alphatarget
HydroxystilbamidineDNAtarget
PalovaroteneRetinoic acid receptor gammatarget
PalovaroteneCytochrome P450 3A4enzyme
PalovaroteneCytochrome P450 2C8enzyme
PalovaroteneCytochrome P450 2C19enzyme
PalovaroteneATP-binding cassette sub-family G member 2transporter
PalovaroteneSolute carrier organic anion transporter family member 1B1transporter
PalovaroteneSolute carrier organic anion transporter family member 1B3transporter
PalovaroteneSolute carrier family 22 member 1transporter
PalovaroteneBile salt export pumptransporter
PalovaroteneCytochrome P450 2B6enzyme