Sequestering Agents

Name
Sequestering Agents
Accession Number
DBCAT000623
Description

Compounds that bind to and reduce the biological availability of a chemical or pharmaceutical agent.

Drugs
DrugDrug Description
Calcium acetateA phosphate binder used in patients with end-stage renal disease (ESRD) to prevent elevated phosphate levels and resulting ectopic calcification and secondary hyperparathyroidism.
ColestipolA bile acid sequestrant used as an adjunct to diet and exercise to reduce LDL-C cholesterol levels in patients with primary hypercholesterolemia.
SuccimerA mercaptodicarboxylic acid heavy metal chelator used in the treatment of heavy metal poisoning.
SevelamerA phosphate binder used to treat hyperphosphatemia.
PenicillamineA chelator used to treat Wilson's disease, cystinuria, and rheumatoid arthritis.
TolevamerA potassium-binding resin used in the treatment of hyperkalemia.
Nitrilotriacetic acidNitrilotriacetic acid is a derivative of acetic acid, N(CH2COOH)3. It is a complexing (sequestering) agent that forms stable complexes with Zn2+. (From Miall's Dictionary of Chemistry, 5th ed.)
ThenoyltrifluoroacetoneThenoyltrifluoroacetone is a chelating agent and inhibitor of cellular respiration.
AlanosineInvestigated for use/treatment in brain cancer and cancer/tumors (unspecified).
DimercaprolA chelating agent used as an antidote to arsenic, gold, and mercury poisoning, as well as acute lead poisoning in combination with edetate calcium disodium.
TriethylenetetramineA copper chelating agent used for the management of Wilson's disease in cases where penicillamine therapy is clinically inappropriate.
CaseinAn extract from Casein used in allergy testing.
BetadexNot Available
EmeramideEmeramide has been used in trials studying the treatment of Mercury Poisoning.
Dimercaptosuccinic acidNot Annotated
Drugs & Drug Targets
DrugTargetType
Calcium acetatePhosphatetarget
ColestipolBile acidstarget
SuccimerLeadtarget
SuccimerMercurytarget
SuccimerCadmiumtarget
SuccimerArsenictarget
SevelamerPhosphatetarget
PenicillamineSolute carrier organic anion transporter family member 1B1transporter
PenicillamineCoppertarget
TolevamerPotassiumtarget
Nitrilotriacetic acidLactotransferrintarget
ThenoyltrifluoroacetoneLiver carboxylesterase 1target
ThenoyltrifluoroacetoneSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialtarget
AlanosineAspartate carbamoyltransferase catalytic chaintarget
AlanosineAdenylosuccinate synthetase isozyme 2target
AlanosineAdenylosuccinate synthetase isozyme 1target
AlanosineCystine/glutamate transportertransporter
DimercaprolArsenictarget
DimercaprolCadmiumtarget
DimercaprolMercurytarget
DimercaprolAmyloid beta A4 proteintarget
TriethylenetetramineGlypican-1transporter
BetadexNeopullulanase 2target
BetadexMaltose-binding periplasmic proteintarget
BetadexMaltogenic amylasetarget
Dimercaptosuccinic acidMercurytarget
Dimercaptosuccinic acidArsenictarget