- Sequestering Agents
- Accession Number
Compounds that bind to and reduce the biological availability of a chemical or pharmaceutical agent.
Drug Drug Description Colestipol A bile acid sequestrant used as an adjunct to diet and exercise to reduce LDL-C cholesterol levels in patients with primary hypercholesterolemia. Tolevamer A potassium-binding resin used in the treatment of hyperkalemia. Alanosine Investigated for use/treatment in brain cancer and cancer/tumors (unspecified). Casein An extract from Casein used in allergy testing. Betadex Not Available Calcium acetate A phosphate binder used in patients with end-stage renal disease (ESRD) to prevent elevated phosphate levels and resulting ectopic calcification and secondary hyperparathyroidism. Succimer A mercaptodicarboxylic acid heavy metal chelator used in the treatment of heavy metal poisoning. Sevelamer A phosphate binder used to treat hyperphosphatemia. Deferoxamine A chelating agent used to treat iron or aluminum toxicity and some blood transfusion dependent anemias. Penicillamine A chelator used to treat Wilson's disease, cystinuria, and rheumatoid arthritis. Edetic acid A chelating agent used to treat mercury and lead toxicity and some blood transfusion dependent anemias. Deferasirox An iron chelator used to treat chronic iron overload caused by blood transfusions. Also used in patients with non-transfusion-dependent thalassemia syndromes, and in patients with elevated liver iron concentration and serum ferritin. 1,10-Phenanthroline Not Available Ditiocarb A chelating agent that has been used to mobilize toxic metals from the tissues of man and experimental animals. It is the main metabolite of DISULFIRAM. Nitrilotriacetic acid Nitrilotriacetic acid is a derivative of acetic acid, N(CH2COOH)3. It is a complexing (sequestering) agent that forms stable complexes with Zn2+. (From Miall's Dictionary of Chemistry, 5th ed.) Dipicolinic acid Not Available Citric acid An anti-chelation additive used in blood collection tubes and as a flavoring and preservative agent in various cosmetic and pharmaceutical products. Thenoyltrifluoroacetone Thenoyltrifluoroacetone is a chelating agent and inhibitor of cellular respiration. Tagatose Intended for use as a therapeutic adjunct in the treatment of type II diabetes. Tetrathiomolybdate Investigated for use/treatment in liver disease and pulmonary fibrosis. Dimercaprol A chelating agent used as an antidote to arsenic, gold, and mercury poisoning, as well as acute lead poisoning in combination with edetate calcium disodium. Triethylenetetramine A copper chelating agent used for the management of Wilson's disease in cases where penicillamine therapy is clinically inappropriate. Deferiprone An iron chelator used to treat patients with transfusional iron overload caused by thalassemia syndromes. Gadoteric acid A diagnostic contrast agent used with magnetic resonance imaging to provide contrast enhancement for intracranial and spinal lesions with abnormal blood brain barrier or abnormal vascularity, and for whole body imaging. Thiosulfuric acid A sulfur donor used sequentially with sodium nitrite for the reversal of life-threatening acute cyanide poisoning. Also used to reduce the risk of ototoxicity associated with cisplatin. Zinc picolinate Zinc picolinate is a zinc salt of picolinic acid. It is available as OTC dietary supplements as a source of zinc to treat and prevent zinc deficiency. The absorption of... Poliglusam Poliglusam, or chitosan, is a linear polysaccharide consisting of D-glucosamine and N-acetyl-D-glucosamine. Naturally-occuring poliglusam is found in the cell walls of fungi, soil and sediments where it is produced from... Chromium picolinate Chromium picolinate has a chemical formula CrPic3 and reddish-pink color. It is a coordination complex consisting of chromium(III) and picolinic acid. Chromium picolinate is used as a nutritional supplement for... Benfotiamine A derivative of thiamine thought to be useful in the management of diabetic neuropathy, although evidence is lacking. Emeramide Emeramide has been used in trials studying the treatment of Mercury Poisoning. Acteoside Acteoside is under investigation in clinical trial NCT02662283 (Validity and Security of Reh-acteoside Therapy for Patients of IgA Nephropathy). Sodium feredetate Not Annotated Pentetic acid DTPA is widely used in industry and medicine. As a medical agent, it is approved for its use in medical imaging and for the decorporation of internally deposited radionuclides. It... Dimercaptosuccinic acid Not Annotated Ditiocarb zinc Ditiocarb Zinc is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6... Edetate calcium disodium anhydrous A chelating agent used to treat lead poisoning. 2,3-Dimercapto-1-propanesulfonic acid Not Annotated Picolinic acid Investigated for use/treatment in acne, herpes labialis infections (cold sores), and venereal disease. Ammonium tetrathiomolybdate Not Annotated
- Drugs & Drug Targets