Sequestering Agents

Sequestering Agents
Accession Number

Compounds that bind to and reduce the biological availability of a chemical or pharmaceutical agent.

DrugDrug Description
ColestipolA bile acid sequestrant used as an adjunct to diet and exercise to reduce LDL-C cholesterol levels in patients with primary hypercholesterolemia.
TolevamerA potassium-binding resin used in the treatment of hyperkalemia.
AlanosineInvestigated for use/treatment in brain cancer and cancer/tumors (unspecified).
CaseinAn extract from Casein used in allergy testing.
BetadexNot Available
Calcium acetateA phosphate binder used in patients with end-stage renal disease (ESRD) to prevent elevated phosphate levels and resulting ectopic calcification and secondary hyperparathyroidism.
SuccimerA mercaptodicarboxylic acid heavy metal chelator used in the treatment of heavy metal poisoning.
SevelamerA phosphate binder used to treat hyperphosphatemia.
DeferoxamineA chelating agent used to treat iron or aluminum toxicity and some blood transfusion dependent anemias.
PenicillamineA chelator used to treat Wilson's disease, cystinuria, and rheumatoid arthritis.
Edetic acidA chelating agent used to treat mercury and lead toxicity and some blood transfusion dependent anemias.
DeferasiroxAn iron chelator used to treat chronic iron overload caused by blood transfusions. Also used in patients with non-transfusion-dependent thalassemia syndromes, and in patients with elevated liver iron concentration and serum ferritin.
1,10-PhenanthrolineNot Available
DitiocarbA chelating agent that has been used to mobilize toxic metals from the tissues of man and experimental animals. It is the main metabolite of DISULFIRAM.
Nitrilotriacetic acidNitrilotriacetic acid is a derivative of acetic acid, N(CH2COOH)3. It is a complexing (sequestering) agent that forms stable complexes with Zn2+. (From Miall's Dictionary of Chemistry, 5th ed.)
Dipicolinic acidNot Available
Citric acidAn anti-chelation additive used in blood collection tubes and as a flavoring and preservative agent in various cosmetic and pharmaceutical products.
ThenoyltrifluoroacetoneThenoyltrifluoroacetone is a chelating agent and inhibitor of cellular respiration.
TagatoseIntended for use as a therapeutic adjunct in the treatment of type II diabetes.
TetrathiomolybdateInvestigated for use/treatment in liver disease and pulmonary fibrosis.
DimercaprolA chelating agent used as an antidote to arsenic, gold, and mercury poisoning, as well as acute lead poisoning in combination with edetate calcium disodium.
TriethylenetetramineA copper chelating agent used for the management of Wilson's disease in cases where penicillamine therapy is clinically inappropriate.
DeferiproneAn iron chelator used to treat patients with transfusional iron overload caused by thalassemia syndromes.
Gadoteric acidA gadolinium-based contrast agent (GBCA) used with contrasted magnetic resonance imaging (MRI) to detect and visualize lesions and abnormal vascularity.
Thiosulfuric acidA sulfur donor used sequentially with sodium nitrite for the reversal of life-threatening acute cyanide poisoning. Also used to reduce the risk of ototoxicity associated with cisplatin.
Zinc picolinateZinc picolinate is a zinc salt of picolinic acid. It is available as OTC dietary supplements as a source of zinc to treat and prevent zinc deficiency. The absorption of...
PoliglusamPoliglusam, or chitosan, is a linear polysaccharide consisting of D-glucosamine and N-acetyl-D-glucosamine. Naturally-occuring poliglusam is found in the cell walls of fungi, soil and sediments where it is produced from...
Chromium picolinateChromium picolinate has a chemical formula CrPic3 and reddish-pink color. It is a coordination complex consisting of chromium(III) and picolinic acid. Chromium picolinate is used as a nutritional supplement for...
BenfotiamineA derivative of thiamine thought to be useful in the management of diabetic neuropathy, although evidence is lacking.
EmeramideEmeramide has been used in trials studying the treatment of Mercury Poisoning.
ActeosideActeoside is under investigation in clinical trial NCT02662283 (Validity and Security of Reh-acteoside Therapy for Patients of IgA Nephropathy).
Sodium feredetateNot Annotated
Pentetic acidDTPA is widely used in industry and medicine. As a medical agent, it is approved for its use in medical imaging and for the decorporation of internally deposited radionuclides. It...
Dimercaptosuccinic acidNot Annotated
Ditiocarb zincDitiocarb Zinc is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6...
Edetate calcium disodium anhydrousA chelating agent used to treat lead poisoning.
2,3-Dimercapto-1-propanesulfonic acidNot Annotated
Picolinic acidInvestigated for use/treatment in acne, herpes labialis infections (cold sores), and venereal disease.
Ammonium tetrathiomolybdateNot Annotated
CefiderocolA cephalosporin antibiotic used in complicated urinary tract infections.
Drugs & Drug Targets
ColestipolBile acidstarget
AlanosineAspartate carbamoyltransferase catalytic chaintarget
AlanosineAdenylosuccinate synthetase isozyme 2target
AlanosineAdenylosuccinate synthetase isozyme 1target
AlanosineCystine/glutamate transportertransporter
BetadexNeopullulanase 2target
BetadexMaltose-binding periplasmic proteintarget
BetadexMaltogenic amylasetarget
Calcium acetatePhosphatetarget
DeferoxamineXanthine dehydrogenase/oxidaseenzyme
DeferoxamineAmyloid beta A4 proteintarget
PenicillamineSolute carrier organic anion transporter family member 1B1transporter
Edetic acidLeadtarget
Edetic acidIrontarget
Edetic acidManganese cationtarget
Edetic acidAdenosine deaminaseenzyme
Edetic acidSerum paraoxonase/lactonase 3enzyme
Edetic acidCytochrome P450 19A1enzyme
DeferasiroxCytochrome P450 3A4enzyme
DeferasiroxUDP-glucuronosyltransferase 1-1enzyme
DeferasiroxUDP-glucuronosyltransferase 1-3enzyme
DeferasiroxUDP-glucuronosyltransferase 1-9enzyme
DeferasiroxCytochrome P450 2C8enzyme
DeferasiroxCytochrome P450 1A2enzyme
1,10-PhenanthrolineMethyl-accepting chemotaxis protein IItarget
1,10-PhenanthrolineMetallo-beta-lactamase L1target
DitiocarbCytochrome P450 2E1enzyme
DitiocarbCytochrome P450 3A4enzyme
DitiocarbCytochrome P450 3A5enzyme
Nitrilotriacetic acidLactotransferrintarget
Dipicolinic acid4-hydroxy-tetrahydrodipicolinate reductasetarget
Dipicolinic acid4-hydroxy-tetrahydrodipicolinate reductasetarget
Citric acidBeta-lactamase 2target
Citric acidAldose reductasetarget
Citric acidCitrate synthase, mitochondrialtarget
Citric acidProto-oncogene tyrosine-protein kinase Srctarget
Citric acidRibonuclease pancreatictarget
Citric acidIsocitrate dehydrogenase [NADP]target
Citric acidEosinophil cationic proteintarget
Citric acidBeta-lactamasetarget
Citric acidFumarate hydratase class IItarget
Citric acid6-phosphogluconolactonasetarget
Citric acidL-amino-acid oxidasetarget
Citric acidCarboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1target
Citric acidCytochrome c peroxidasetarget
Citric acidHepatocyte growth factor-regulated tyrosine kinase substratetarget
Citric acidInvasintarget
Citric acidIntron-associated endonuclease 1target
Citric acidShort tail fiber proteintarget
Citric acidMalate dehydrogenase, mitochondrialtarget
Citric acidN5-carboxyaminoimidazole ribonucleotide mutasetarget
Citric acid50S ribosomal protein L4target
Citric acidCarboxypeptidase Btarget
Citric acidHexon proteintarget
Citric acidRiboflavin biosynthesis protein RibFtarget
Citric acidBeta-fructosidasetarget
Citric acidPutative stringent starvation protein Atarget
Citric acidCitrate synthasetarget
Citric acidRNA 3'-terminal phosphate cyclasetarget
Citric acidU6 snRNA-associated Sm-like protein LSm6target
Citric acidPleckstrin homology domain-containing family A member 1target
Citric acidFe(3+)-binding periplasmic proteintarget
Citric acidSignal recognition particle receptor FtsYtarget
Citric acidNicotinate-nucleotide adenylyltransferasetarget
Citric acidN utilization substance protein B homologtarget
Citric acidComplement component C8 gamma chaintarget
Citric acidRibonucleoside-diphosphate reductase subunit betatarget
Citric acidGlutamine synthetase 1target
Citric acidCitrate synthasetarget
Citric acidProstaglandin F synthasetarget
Citric acidAdenine phosphoribosyltransferasetarget
Citric acidGlucose-1-phosphate thymidylyltransferasetarget
Citric acidGlyoxalase family proteintarget
Citric acidLaccase domain protein YfiHtarget
Citric acidRibose-5-phosphate isomerase Atarget
Citric acidGMP synthase [glutamine-hydrolyzing]target
Citric acidInosine triphosphate pyrophosphatasetarget
Citric acidLysozymetarget
Citric acidGlycerol uptake operon antiterminator regulatory proteintarget
Citric acid3-carboxy-cis,cis-muconate cycloisomerasetarget
Citric acidPyruvate decarboxylasetarget
Citric acidSolute carrier organic anion transporter family member 2B1transporter
Citric acidMetallo-beta-lactamase type 2target
ThenoyltrifluoroacetoneLiver carboxylesterase 1target
ThenoyltrifluoroacetoneSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialtarget
TetrathiomolybdateAmyloid beta A4 proteintarget
DimercaprolAmyloid beta A4 proteintarget
TriethylenetetramineDiamine acetyltransferase 1enzyme
DeferiproneUDP-glucuronosyltransferase 1-6enzyme
Thiosulfuric acidSolute carrier family 13 member 4transporter
Thiosulfuric acidThiosulfate sulfurtransferaseenzyme
Thiosulfuric acidThiosulfate:glutathione sulfurtransferaseenzyme
Thiosulfuric acidCytochrome P450 2B6enzyme
Pentetic acidTransuranium elementstarget
Pentetic acidAlpha-1-antitrypsincarrier
Dimercaptosuccinic acidMercurytarget
Dimercaptosuccinic acidArsenictarget
Edetate calcium disodium anhydrousManganese cationtarget
Edetate calcium disodium anhydrousIrontarget
Edetate calcium disodium anhydrousLeadtarget
Edetate calcium disodium anhydrousAdenosine deaminaseenzyme
Edetate calcium disodium anhydrousSerum paraoxonase/lactonase 3enzyme
Edetate calcium disodium anhydrousCytochrome P450 19A1enzyme
Edetate calcium disodium anhydrousCytochrome P450 3A4enzyme
Edetate calcium disodium anhydrousSerum paraoxonase/arylesterase 1enzyme
Picolinic acidE3 ubiquitin-protein ligase UBR4target
Picolinic acidZinc finger Y-chromosomal proteintarget
CefiderocolPenicillin-binding protein 3target
CefiderocolPenicillin-binding protein 1Atarget
CefiderocolPenicillin-binding protein 1Btarget
CefiderocolPenicillin-binding protein 2target
CefiderocolD-alanyl-D-alanine carboxypeptidase DacBtarget
CefiderocolMexAB-OprM efflux systemtransporter
CefiderocolSerum albumincarrier
CefiderocolCatecholate siderophore receptor Fiutransporter
CefiderocolColicin I receptortransporter
CefiderocolPutative outer membrane ferric siderophore receptortransporter