Antineoplastic Agents, Phytogenic

Name
Antineoplastic Agents, Phytogenic
Accession Number
DBCAT000717
Description

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.

Drugs
DrugDrug Description
VindesineA vinca alkaloid derived from vinblastine used for various types of malignancies, but mainly acute lymphocytic leukemia (ALL).
VincristineA vinca alkaloid used to treat acute leukemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis.
VinblastineA vinca alkaloid used to treat breast cancer, testicular cancer, neuroblastoma, Hodgkin's and non-Hodgkins lymphoma, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.
Omacetaxine mepesuccinateA cephalotaxine used in the treatment of Chronic Myeloid Leukemia (CML) that is intolerant to or resistant to two or more tyrosine kinase inhibitors.
NamitecanNamitecan has been used in trials studying the treatment of Solid Tumors.
10-hydroxycamptothecin10-hydroxycamptothecin is under investigation in clinical trial NCT00956787 (Study of AR-67 (DB-67) in Myelodysplastic Syndrome (MDS)).
FosbretabulinFosbretabulin has been investigated for the treatment of Anaplastic Thyroid Cancer.
CombretastatinCombretastatin has been investigated for the treatment of Anaplastic Thyroid Cancer.
Combretastatin A4Not Annotated
Lorvotuzumab mertansineLorvotuzumab mertansine has been used in trials studying the treatment of SCLC, Leukemia, Ovarian Cancer, Multiple Myeloma, and Merkel Cell Carcinoma, among others.
Ursolic acidNot Annotated
Vitis vinifera seedNot Annotated
VinorelbineA vinca alkaloid used in the treatment of metastatic non-small cell lung carcinoma (NSLC) and in conjunction with other drugs in locally advanced NSCLC.
EtoposideA podophyllotoxin derivative used to treat testicular and small cell lung tumors.
PodofiloxA topical agent used for the treatment of external genital warts and perianal warts.
PaclitaxelA taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer.
CamptothecinInvestigated for the treatment of cancer.
PodophyllinA cytotoxic agent used for the removal of soft genital (venereal) warts (condylomata acuminata).
SilibininA flavonolignan with hepatoprotective effects used to treat toxic liver damage and as an adjunct in the management of chronic conditions such as cirrhosis and hepatitis.
Betulinic AcidBetulinic Acid has been used in trials studying the treatment of Dysplastic Nevus Syndrome.
ActeosideActeoside is under investigation in clinical trial NCT02662283 (Validity and Security of Reh-acteoside Therapy for Patients of IgA Nephropathy).
SizofiranA beta-D-glucan obtained from the Aphyllophoral fungus Schizophyllum commune. It is used as an immunoadjuvant in the treatment of neoplasms, especially tumors found in the stomach. Sizofiran has been used...
DemecolcineNot Annotated
TetrandrineNot Annotated
CinnamaldehydeCinnamaldehyde is approved by the FDA for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in...
Drugs & Drug Targets
DrugTargetType
VindesineTubulin beta-1 chaintarget
VindesineCytochrome P450 3A4enzyme
VincristineTubulin beta chaintarget
VincristineCytochrome P450 3A4enzyme
VincristineCytochrome P450 3A5enzyme
VincristineCytochrome P450 3A7enzyme
VincristineP-glycoprotein 1transporter
VincristineCanalicular multispecific organic anion transporter 2transporter
VincristineSolute carrier family 22 member 3transporter
VincristineMultidrug resistance-associated protein 1transporter
VincristineMultidrug resistance-associated protein 7transporter
VincristineCanalicular multispecific organic anion transporter 1transporter
VincristineBile salt export pumptransporter
VincristineATP-binding cassette sub-family G member 2transporter
VincristineTubulin alpha-4A chaintarget
VincristineRalA-binding protein 1transporter
VincristineSolute carrier organic anion transporter family member 1B1transporter
VincristineSolute carrier organic anion transporter family member 1B3transporter
VinblastineTubulin beta chaintarget
VinblastineTranscription factor AP-1target
VinblastineCytochrome P450 3A4enzyme
VinblastineP-glycoprotein 1transporter
VinblastineMultidrug resistance-associated protein 1transporter
VinblastineCanalicular multispecific organic anion transporter 1transporter
VinblastineMultidrug resistance-associated protein 6transporter
VinblastineBile salt export pumptransporter
VinblastineTubulin alpha-1A chaintarget
VinblastineTubulin delta chaintarget
VinblastineTubulin epsilon chaintarget
VinblastineTubulin gamma-1 chaintarget
VinblastineCytochrome P450 2D6enzyme
VinblastineSolute carrier organic anion transporter family member 1B1transporter
Omacetaxine mepesuccinate50S ribosomal protein L2target
Omacetaxine mepesuccinate60S ribosomal protein L3target
Lorvotuzumab mertansineCytochrome P450 3A4enzyme
VinorelbineTubulin beta chaintarget
VinorelbineCytochrome P450 3A4enzyme
VinorelbineCytochrome P450 2D6enzyme
EtoposideDNA topoisomerase 2-alphatarget
EtoposideCytochrome P450 3A4enzyme
EtoposideCanalicular multispecific organic anion transporter 2transporter
EtoposideMultidrug resistance-associated protein 6transporter
EtoposideP-glycoprotein 1transporter
EtoposideMultidrug resistance-associated protein 1transporter
EtoposideMultidrug resistance-associated protein 7transporter
EtoposideCanalicular multispecific organic anion transporter 1transporter
EtoposideATP-binding cassette sub-family G member 2transporter
EtoposideCytochrome P450 1A2enzyme
EtoposideCytochrome P450 2E1enzyme
EtoposideCytochrome P450 3A5enzyme
EtoposideUDP-glucuronosyltransferase 1-1enzyme
EtoposideDNA topoisomerase 2-betatarget
EtoposideGlutathione S-transferase theta-1enzyme
EtoposideGlutathione S-transferase Penzyme
EtoposideProstaglandin G/H synthase 2enzyme
EtoposideProstaglandin G/H synthase 1enzyme
PodofiloxDNA topoisomerase 2-alphatarget
PodofiloxTubulin alpha-4A chaintarget
PodofiloxTubulin beta chaintarget
PaclitaxelApoptosis regulator Bcl-2target
PaclitaxelTubulin beta-1 chaintarget
PaclitaxelCytochrome P450 2C8enzyme
PaclitaxelCytochrome P450 3A4enzyme
PaclitaxelCytochrome P450 3A5enzyme
PaclitaxelCytochrome P450 3A7enzyme
PaclitaxelBile salt export pumptransporter
PaclitaxelP-glycoprotein 1transporter
PaclitaxelMultidrug resistance-associated protein 1transporter
PaclitaxelMultidrug resistance-associated protein 7transporter
PaclitaxelCytochrome P450 19A1enzyme
PaclitaxelCytochrome P450 1B1enzyme
PaclitaxelSolute carrier organic anion transporter family member 1B3transporter
PaclitaxelNuclear receptor subfamily 1 group I member 2target
PaclitaxelMicrotubule-associated protein 4target
PaclitaxelMicrotubule-associated protein 2target
PaclitaxelMicrotubule-associated protein tautarget
PaclitaxelCanalicular multispecific organic anion transporter 1transporter
CamptothecinDNA topoisomerase 1target
CamptothecinP-glycoprotein 1transporter
CamptothecinATP-binding cassette sub-family G member 2transporter
CamptothecinSerum albumincarrier
SilibininSolute carrier family 22 member 6transporter
SilibininUDP-glucuronosyltransferase 1-1enzyme
SilibininSolute carrier organic anion transporter family member 1B1transporter
SilibininSolute carrier organic anion transporter family member 1B3transporter
SilibininSolute carrier organic anion transporter family member 2B1transporter
TetrandrineP-glycoprotein 1target
TetrandrineCytochrome P450 3A4enzyme
TetrandrineP-glycoprotein 1transporter