Free Radicals

Name
Free Radicals
Accession Number
DBCAT000863
Description

Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated.

Drugs
DrugDrug Description
Nitric OxideA vasodilating agent used in the treatment of hypoxic respiratory failure in premature neonates.
ArtesunateArtesunate is an artemesinin derivative indicated for the initial treatment of severe malaria.
Hydrogen peroxideA compound used as a disinfectant and sterilizer.
Carbamide peroxideA medication used to loosen ear wax, whiten teeth, and clean oral wounds.
TempolTempol has been used in trials studying the treatment of Anal Cancer.
Drugs & Drug Targets
DrugTargetType
Nitric OxideGuanylate cyclase soluble subunit alpha-2target
Nitric OxideAldehyde dehydrogenase, mitochondrialenzyme
Nitric OxideCytochrome P450 1A2enzyme
Nitric OxideCytochrome P450 2B6enzyme
Nitric OxideCytochrome P450 3A4enzyme
Nitric OxideMetallothionein-1Atarget
Nitric OxideIndoleamine 2,3-dioxygenase 1target
ArtesunateMalaria protein EXP-1target
ArtesunateCytochrome P450 2A6enzyme
ArtesunateUDP-glucuronosyltransferase 2B7enzyme
ArtesunateUDP-glucuronosyltransferase 1-9enzyme
ArtesunateATP-binding cassette sub-family G member 2transporter
ArtesunateP-glycoprotein 1transporter
ArtesunateSolute carrier organic anion transporter family member 1B1transporter
ArtesunateSolute carrier family 22 member 8transporter
ArtesunateSerum albumincarrier
Hydrogen peroxideGlutathione peroxidase 1enzyme
Hydrogen peroxideCatalaseenzyme
Hydrogen peroxideAlkaline phosphatase, placental-likeenzyme