Cytochrome P-450 CYP2C8 Substrates
- Cytochrome P-450 CYP2C8 Substrates
- Accession Number
Drug Drug Description Torasemide A diuretic used to treat hypertension and edema associated with heart failure, renal failure, or liver disease. Cerivastatin A statin (or HMG CoA reductase inhibitor) used with dietary changes to decrease lipid levels and reduce the risk of cardiovascular events. Repaglinide A antihyperglycemic used to improve glycemic control in diabetes. Paclitaxel A taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer. Amodiaquine An antimalarial drug. Phenytoin An anticonvulsant drug used in the prophylaxis and control of various types of seizures. Fosphenytoin An antiepileptic agent used for the management of generalized convulsive status epilepticus and prevention and treatment of seizures occurring during neurosurgery. Elagolix A gonadotropin releasing hormone receptor antagonist used to treat moderate to severe pain in endometriosis. Vortioxetine A serotonin modulating antidepressant indicated for the treatment of major depressive disorder (MDD). Pazopanib An antineoplastic agent used in the treatment of advanced renal cell cancer and advanced soft tissue sarcoma in patients with prior chemotherapy. Apixaban An anticoagulant used for the prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation, and deep vein thrombosis(DVT) leading to pulmonary embolism(PE), including in patients after a hip or knee replacement surgery. Balaglitazone Balaglitazone has been used in trials studying the treatment of Diabetes Mellitus, Type 2. Ciglitazone Developed by Takeda Pharmaceuticals in the early 1980s, it is considered the prototypical compound for the thiazolidinedione class. Ciglitazone was never used as a medication, but it sparked interest in... Lobeglitazone Lobeglitazone was approved by the Ministry of Food and Drug Safety (South Korea) in 2013, and is being monitored by postmarketing surveillance until 2019. Lobeglitazone is not approved for use... Netoglitazone Netoglitazone (MCC-555) is a hypoglycemic agent. Pioglitazone A thiazolidinedione used adjunctively with diet and exercise to normalize glycemic levels in adults with type 2 diabetes mellitus. Rivoglitazone Rivoglitazone (INN) is a thiazolidinedione undergoing research for use in the treatment of type 2 diabetes. It is being developed by Daiichi Sankyo Co. Rosiglitazone A thiazolidinedione indicated as an adjunct to diet and exercise to maintain glycemic control in type 2 diabetes. Troglitazone For the treatment of Type II diabetes mellitus. It is used alone or in combination with a sulfonylurea, metformin, or insulin as an adjunct to diet and exercise. Lapatinib An antineoplastic agent and tyrosine kinase inhibitor used for the treatment of advanced or metastatic HER-negative breast cancer in patients who received prior chemotherapeutic treatments. (R)-warfarin Warfarin consists of a racemic mixture of two active enantiomers—R- and S- forms—each of which is cleared by different pathways. S-warfarin is 2-5 times more potent than the R-isomer in... Phenprocoumon An anticoagulant drug used for the prevention of thrombosis. (S)-Warfarin Warfarin consists of a racemic mixture of two active enantiomers—R- and S- forms—each of which is cleared by different pathways. S-warfarin is 2-5 times more potent than the R-isomer in... Lansoprazole A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome. Ombitasvir A direct acting antiviral agent used in combination with other antiviral agents for the treatment of Hepatitis C Virus (HCV) infections. Dasabuvir A direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents. Buprenorphine A partial opioid agonist used for management of severe pain that is not responsive to alternative treatments. Also used for maintenance treatment of opioid addiction. Atorvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Amiodarone A class III antiarrhythmic indicated for the treatment of recurrent hemodynamically unstable ventricular tachycardia and recurrent ventricular fibrillation. Loperamide A long acting antidiarrheal used to control nonspecific diarrhea and chronic diarrhea caused by inflammatory bowel disease, or gastroenteritis. Trimethadione An anticonvulsant agent indicated for the control of treatment-refractory petit mal seizures. Diethylstilbestrol Used in the treatment of prostate cancer. Previously used in the prevention of miscarriage or premature delivery in pregnant women prone to miscarriage or premature delivery. Estradiol An estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate. Estradiol cypionate An estradiol prodrug used to treat vasomotor symptoms and hypoestrogenisms from hypogonadism. Estradiol valerate An estradiol prodrug used to treat some effects of menopause, hypoestrogenism, androgen dependant carcinoma of the prostate, and in combination products for endometriosis and contraception. Ethinylestradiol An estradiol used as a contraceptive. Mestranol A synthetic estradiol found in oral contraceptive pills for contraception and the treatment of other conditions in the female reproductive system, such as dysmenorrhea and dysfunctional uterine bleeding. Fluvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Propacetamol Propacetamol is a paracetamol prodrug of intravenous administration used to control fever and pain of perioperative period in multimodal analgesia therapy. Carbamazepine An anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia. Warfarin A vitamin K antagonist used to treat venous thromboembolism, pulmonary embolism, thromboembolism with atrial fibrillation, thromboembolism with cardiac valve replacement, and thromboembolic events post myocardial infarction. Tretinoin A vitamin A derivative used to treat acne vulgaris, certain types of promyelocytic leukemia, and fine wrinkles. Zopiclone A nonbenzodiazepine hypnotic used for the short-term management of insomnia. Sitagliptin An oral dipeptidyl peptidase-4 (DPP-4) inhibitor used for the management of type 2 diabetes mellitus. Diclofenac An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. Simvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular events including myocardial infarction and stroke. Tolbutamide A sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus. Aminophenazone An analgesic drug used to treat acute migraine attacks in combination with ergotamine and caffeine. Loratadine A second generation antihistamine used to manage the symptoms of allergic rhinitis. Ifosfamide An alkylating and immunosuppressive agent used in chemotherapy for the treatment of cancers, including testicular cancer, ovarian cancer, cervical cancer, osteocarcinoma, bladder cancer, small cell lung cancer, and non-Hodgkin's lymphoma. Antipyrine An antipyretic agent used for the symptomatic treatment of acute otitis media, most commonly in combination with benzocaine. Dapsone A sulfone drug used to treat acne vulgaris, Hansen's disease, and dermatitis herpetiformis. Terbinafine An allylamine antifungal used to treat dermatophyte infections of toenails and fingernails as well as other fungal skin infections. Azelastine A histamine H1-receptor antagonist used intranasally to treat allergic and vasomotor rhinitis and in an ophthalmic solution to treat allergic conjunctivitis. Verapamil A non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension. Ibuprofen An NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation. Naproxen An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain. Methadone An opioid analgesic indicated for management of severe pain that is not responsive to alternative treatments. Also used to aid in detoxification and maintenance treatment of opioid addiction. Caffeine A stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. Licofelone For the management of osteoarthritis. Seratrodast Seratrodast (INN) is a thromboxane receptor antagonist used primarily in the treatment of asthma. Eszopiclone A sedative-hypnotic used in the treatment of insomnia, improving both the latency phase and the maintenance phase of sleep. Cabazitaxel An antineoplastic agent used for the treatment of hormone-refractory metastatic prostate cancer previously treated with a docetaxel-containing treatment regimen. Amitriptyline A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety. Chloroquine An antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis. Cisapride A medication used to treat heartburn associated with GERD. Clozapine An antipsychotic drug used in treatment resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Cyclophosphamide A nitrogen mustard used to treat lymphomas, myelomas, leukemia, mycosis fungoides, neuroblastoma, ovarian adenocarcinoma, retinoblastoma, and breast carcinoma. Diazepam A long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. Diltiazem A calcium channel blocker used to treat hypertension and to manage chronic stable angina. Halofantrine An antimalarial used for the treatment of severe malaria. Ketamine A rapid-acting general anesthetic and NMDA receptor antagonist used for induction of anesthesia diagnostic and surgical procedures typically in combination with a muscle relaxant. Ketobemidone For the treatment of all types of severe pain, such as postoperative, cancer, kidney stones and fractures. Lidocaine A local anesthetic used in a wide variety of superficial and invasive procedures. Mephenytoin A phenylhydantoin used to treat refractory partial epilepsy. Morphine An opioid agonist used for the relief of moderate to severe acute and chronic pain. Nicotine A stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation. Omeprazole A proton pump inhibitor used to treat GERD associated conditions such as heartburn and gastric acid hypersecretion, and to promote healing of tissue damage and ulcers caused by gastric acid and H. pylori infection. Perphenazine A phenothiazine used to treat schizophrenia as well as nausea and vomiting. Propofol A medication used in general anesthesia and for sedation. Selegiline A monoamine oxidase inhibitor used to treat major depressive disorder and Parkinson's. Sulfadiazine A sulfonamide antibiotic used in a variety of infections, such as urinary tract infections, trachoma, and chancroid. Tazarotene An acetylenic retinoid used to treat fine wrinkles, mottled pigmentation of the skin, acne vulgaris, and plaque psoriasis. Temazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and insomnia. Testosterone A hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause. Zidovudine A dideoxynucleoside used in the treatment of HIV infection. Erlotinib An EGFR tyrosine kinase inhibitor used to treat certain small cell lung cancers or advanced metastatic pancreatic cancers. Paramethadione Used for the control of absence (petit mal) seizures that are refractory to treatment with other medications. Beraprost For the treatment of pulmonary hypertension. Muraglitazar Investigated for use/treatment in diabetes mellitus type 2. Pitavastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Enzalutamide A second-generation androgen receptor inhibitor used to treat castration-resistant prostate cancer and metastatic castration-sensitive prostate cancer. Ponatinib A kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML). Dabrafenib A kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer. Mycophenolate mofetil An inosine monophosphate dehydrogenase inhibitor used to prevent the rejection of kidney, heart, or liver transplants. Levomilnacipran A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder (MDD). Olodaterol A long-acting beta2-adrenergic agonist used in the management of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema. Ixazomib A monoclonal antibody used with other medications to treat multiple myeloma in patients who have received one other therapy already. Selexipag A non prostanoid IP prostacyclin receptor agonist used to treat pulmonary arterial hypertension. Riociguat A stimulator of soluble guanylate cyclase indicated for the management of persistent or recurrent chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension. Velpatasvir A NS5A inhibitor used to treat chronic hepatitis C infections in patients without cirrhosis or with compensated cirrhosis. Odanacatib Investigated for use/treatment in osteoporosis . Perospirone For the treatment of schizophrenia and acute cases of bipolar mania. Voxilaprevir A nonstructural protein 3 and 4a protease inhibitor used to treat Hepatitis C infections. Enasidenib An isocitrate dehydrogenase-2 inhibitor used to treat relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-2 mutation. Brigatinib An anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer. Testosterone cypionate An androgen used to treat low or absent testosterone. Testosterone enanthate An androgen used to treat low or absent testosterone. Testosterone undecanoate An androgen indicated for testosterone replacement therapy in adult males with primary hypogonadism and hypogonadotropic hypogonadism. Estradiol acetate An estrogen used to treat vasomotor symptoms and moderate to severe vulvar and vaginal atrophy from menopause. Estradiol benzoate An estrogen indicated in combination with progesterone for the treatment of irregular menstruation. Estradiol dienanthate An estrogen used in some combined hormonal oral contraceptives. Apalutamide An androgen receptor inhibitor used to treat non metastatic, castration resistant prostate cancer. Bioallethrin Bioallethrin was used for lice and scabies infestation. Other pyrethroids are now used in place of bioallethrin. Tegafur An antineoplastic agent used in combination with other anticancer medications to treat advanced gastric and colorectal cancers. Domperidone A dopamine receptor antagonist used as a peristaltic stimulant and anti-emetic agent for dyspepsia, indigestion, epigastric pain, nausea, and vomiting. Trimethoprim An antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. Zafirlukast A leukotriene receptor antagonist used for prophylaxis and chronic treatment of asthma. Nicardipine A calcium channel blocker used for the short-term treatment of hypertension and chronic stable angina. Irbesartan An angiotensin receptor blocker used to treat hypertension, delay progression of diabetic nephropathy, and treat congestive heart failure. Quinine An alkaloid used to treat uncomplicated Plasmodium falciparum malaria. Sorafenib A kinase inhibitor used in the treatment of unresectable liver carcinoma and advanced renal carcinoma. Eltrombopag A thrombopoietin receptor agonist used to treat thrombocytopenia or aplastic anemia associated with various etiologies. Fluorouracil A pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. Piroxicam An NSAID used to treat the symptoms of osteoarthritis and rheumatoid arthritis. Theophylline A xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction. Almotriptan A 5-HT1B/1D receptor agonist used to treat migraines. Benzyl alcohol An antiparasitic agent used for the topical treatment of head lice infestation in patients 6 months of age and older. Lorlatinib An anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer. Imatinib A tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. Glasdegib A sonic hedgehog receptor inhibitor used to treat newly diagnosed acute myeloid leukemia in patients over 75 years who cannot receive intense chemotherapy. Celecoxib An NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis. Lovastatin An HMG-CoA reductase inhibitor used to lower LDL cholesterol and reduce the risk of cardiovascular disease and associated conditions, including myocardial infarction and stroke. Montelukast A leukotriene receptor antagonist used as part of an asthma therapy regimen, to prevent exercise induced bronchoconstriction, and to treat seasonal allergic rhinitis. Istradefylline A selective adenoside A2A receptor antagonist indicated in adjunct to levodopa and carbidopa for the treatment of Parkinson's Disease. Dexibuprofen A pharmacologically active enantiomer of racemic ibuprofen (NSAID) used to treat pain and inflammation. Ketorolac An NSAID used to treat moderate to severe pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders, and headaches. Capravirine Investigated for use/treatment in acquired immune deficiency syndrome (AIDS) and aids-related infections and HIV infection. Anastrozole A competitive, selective, non-steroidal aromatase inhibitor used as adjuvant therapy for the treatment of hormone receptor-positive breast cancer in postmenopausal women. Trifarotene A topical retinoid indicated for the treatment of acne vulgaris. Lumateperone A novel 2nd generation antipsychotic used to manage both positive and negative symptoms in patients with schizophrenia. Meloxicam An NSAID used to treat osteoarthritis in adults, rheumatoid arthritis in adults, and juvenile rheumatoid arthritis in pediatrics. Ozanimod A sphingosine 1-phosphate receptor modulator being studied to treat Multiple Sclerosis (MS) and inflammatory bowel disease (IBD). Selumetinib A MEK 1/2 inhibitor used in pediatric patients to treat neurofibromatosis type 1 (NF1) accompanied by symptomatic, inoperable plexiform neurofibromas (PN). Tucatinib A kinase inhibitor used to treat certain types of unresectable/metastatic HER-2 positive breast cancer. Remdesivir A nucleoside analog used to treat RNA virus infections including COVID-19. Hydroxychloroquine An antimalarial medication used to treat uncomplicated cases of malaria and for chemoprophylaxis in specific regions. Also a disease modifying anti-rheumatic drug (DMARD) indicated for treatment of rheumatoid arthritis and lupus erythematosus. Apomorphine A morphine derivative D2 dopamine agonist used to treat hypomobile "off" episodes of advanced Parkinson's disease. Lonafarnib A potent farnesyl transferase inhibitor used to reduce mortality associated with Hutchinson-Gilford progeria syndrome (HGPS) and other progeroid laminopathies. Tirbanibulin A tyrosine kinase and tubulin inhibitor used to treat actinic keratosis on the face or scalp. Relugolix An oral GnRH receptor antagonist for androgen deprivation therapy in the treatment of advanced prostate cancer. Tepotinib An oral tyrosine kinase inhibitor targeted against MET for the treatment of metastatic non-small cell lung cancer in patients exhibiting MET exon 14 skipping mutations. Febuxostat A xanthine oxidase inhibitor used for the management of chronic hyperuricemia in adults with gout who have an inadequate response or intolerance to allopurinol. Azilsartan medoxomil An angiotensin II receptor blocker used to treat hypertension alone or in combination with other antihypertensive agents, such as chlorthalidone. Samidorphan A novel opioid-system modulator, similar to naltrexone, that functions primarily as a μ-opioid receptor antagonist in vivo and is used primarily in combination with antipsychotics to reduce their metabolic dysfunction-associated adverse effects. Finerenone A nonsteroidal mineralocorticoid receptor antagonist indicated to lower the risk of eGFR decline, end stage kidney disease, cardiovascular death, heart attack, and hospitalization for heart failure in chronic kidney disease associated with type 2 diabetes. Belumosudil An oral inhibitor of rho-associated coiled-coil-containing protein kinases (ROCK) used in the treatment of chronic graft-versus-host disease (GVHD). Macitentan An endothelin receptor antagonist used to manage pulmonary arterial hypertension to delay disease progression. Palovarotene A selective agonist of retinoic acid receptor gamma (RARγ) used to reduce heterotopic ossification in patients with Fibrodysplasia Ossificans Progressiva (FOP). Roxadustat A hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor used to treat symptomatic anemia associated with chronic kidney disease. Mitapivat A pyruvate kinase activator used to treat hemolytic anemia in adults with pyruvate kinase (PK) deficiency. Nabilone A synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy. Cannabidiol An active cannabinoid used as an adjunctive treatment for the management of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome and symptomatic relief of moderate to severe neuropathic pain or other painful conditions, like cancer. Medical Cannabis The use of the plant species Cannabis sativa and Cannabis indica, popularly known as marijuana, has gained popularity in recent years for the management of a wide variety of medical... Mavacamten A myosin inhibitor used to treat obstructive hypertrophic cardiomyopathy. Treprostinil A prostacyclin vasodilator for the treatment of pulmonary arterial hypertension to relieve exercise associated symptoms and to prevent clinical deterioration after stopping epoprostenol. Mycophenolic acid An immunosuppressant used to prevent organ transplant rejections.
- Drugs & Drug Targets