Cytochrome P-450 CYP3A4 Inhibitors (moderate)
- Name
- Cytochrome P-450 CYP3A4 Inhibitors (moderate)
- Accession Number
- DBCAT002648
- Description
Not Available
- Drugs
Drug Drug Description Aprepitant A substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery. Barnidipine A calcium channel blocker used to treat various forms of hypertension. Benidipine A synthetic dihydropyridine calcium channel blocker used to treat hypertension and angina pectoris. Berotralstat An inhibitor of plasma kallikrein used for prophylaxis of angioedema attacks in patients with hereditary angioedema. Ciprofloxacin A second generation fluoroquinolone used to treat various susceptible bacterial infections. Clindamycin A lincosamide antibiotic used to treat serious infections caused by susceptible anaerobic, streptococcal, staphylococcal, and pneumococcal bacteria. Clozapine An atypical or second-generation antipsychotic drug used in treatment-resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Cyclosporine A steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis. Danazol A synthetic steroid and pituitary gonadotropin inhibitor used in the treatment of endometriosis and symptomatic treatment of severe pain and tenderness associated with benign fibrocystic breasts. Desvenlafaxine An antidepressant agent and SNRI used for the treatment of major depressive disorders in adults. Diltiazem A calcium channel blocker used to treat hypertension and to manage chronic stable angina. Dronedarone An antiarrhythmic agent used in the reduce the risk of hospitalization in patients with paroxysmal or persistent atrial fibrillation. Erythromycin A macrolide antibiotic used to treat and prevent a variety of bacterial infections. Fluconazole A triazole antifungal used to treat various fungal infections including candidiasis. Fluvoxamine A selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder. Fosamprenavir An antiretroviral agent used for the treatment and postexposure prophylaxis of human immunodeficiency virus (HIV-1) infection. Fosnetupitant A medication used in combination with others to prevent chemotherapy associated nausea and vomiting. Fusidic acid A topical antibacterial agent used to prevent and treat mild to moderate skin infections caused by susceptible bacteria. Haloperidol An antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium. Indalpine Indalpine was one of the first selective serotonin reuptake inhibitors to reach the American market. It was initially marketed by Pharmuka. However, after the emergence of widespread concern regarding adverse... Isavuconazole Indicated for patients 18 years of age and older for the treatment of invasive aspergillosis [FDA Label]. Indicated for patients 18 years of age and older for the treatment of... Isavuconazonium A triazole antifungal used for the treatment of invasive aspergillosis and mucormycosis. Isoniazid An antibiotic used to treat mycobacterial infections; most commonly use in combination with other antimycobacterial agents for the treatment of active or latent tuberculosis. Isradipine A dihydropyridine calcium channel blocker used for the treatment of hypertension. Lenacapavir A first-in-class capsid inhibitor being investigated for use in HIV-1 treatment. Linagliptin A dipeptidyl peptidase-4 (DPP-4) inhibitor used to manage hyperglycemia in patients with type 2 diabetes mellitus. Luliconazole A topical antifungal agent used to treat fungal infections. Miconazole An azole antifungal with broad-spectrum activity used to treat fungal infections affecting the vagina, mouth and skin, including candidiasis. Milnacipran A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of fibromyalgia and a short-term treatment of major depressive disorder. Netupitant An antiemetic agent used in combination with palonosetron to prevent acute and delayed vomiting and nausea caused by chemotherapy. Nicardipine A calcium channel blocker used for the short-term treatment of hypertension and chronic stable angina. Nilvadipine A calcium channel blocker used to manage arterial hypertension. Primaquine An antimalarial indicated to prevent relapse of vivax malaria. Rilzabrutinib A kinase inhibitor used to treat persistent or chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment. Seproxetine Seproxetine is also known as (S)-norfluoxetine. It is a selective serotonin reuptake inhibitor (SSRI). It is an active metabolite of fluoxetine. Seproxetine was being investigated by Eli Lilly as an... Sevabertinib A HER2 kinase inhibitor used to treat non-squamous non-small cell lung cancer with HER2 (ERBB2) tyrosine kinase domain (TKD) activating mutations. Simeprevir A direct-acting antiviral agent that inhibits HCV NS3/4A protease to treat chronic hepatitis C virus (HCV) infection in adults with HCV genotype 1 or 4. Tepotinib An oral tyrosine kinase inhibitor targeted against MET for the treatment of metastatic non-small cell lung cancer in patients exhibiting MET exon 14 skipping mutations. Tioconazole An imidazole antifungal used to treat vulvovaginal candidiasis. Venetoclax A BCL-2 inhibitor used to treat chronic lymphocytic leukemia, small lymphocytic lymphoma, or acute myeloid leukemia. Verapamil A non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension. Voriconazole A triazole compound used to treat fungal infections. Zimelidine For the treatment of depression. Ziprasidone An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia. - Drugs & Drug Targets