Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
- Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
- Accession Number
Source: Volpi-abadie J, Kaye AM, Kaye AD. Serotonin syndrome. Ochsner J. 2013;13(4):533-40.
Drug Drug Description Phentermine A sympathomimetic anorectic agent used as a short-term adjunct therapy that is included in a regimen of weight reduction in cases of exogenous obesity. Nefazodone An antidepressant used in the treatment of depression. Trazodone A serotonin uptake inhibitor used to treat major depressive disorder. Granisetron A 5HT3 antagonist used to treat nausea and vomiting in cancer therapy and postoperatively. Ondansetron A serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively. Chlorpheniramine A histamine-H1 receptor antagonist indicated for the management of symptoms associated with upper respiratory allergies. Levorphanol An opioid analgesic used to treat moderate to severe pain. Meperidine An opioid agonist with analgesic and sedative properties used to manage severe pain. Methadone An opioid analgesic indicated for management of severe pain that is not responsive to alternative treatments. Also used to aid in detoxification and maintenance treatment of opioid addiction. Pentazocine An analgesic used to treat moderate to severe pain. Tapentadol An opioid used to manage severe pain that has not responded to non-opioid medications, and for which opioid analgesic therapy is appropriate. Tramadol A centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults. Cocaine An ester local anesthetic used during diagnostic procedures and surgeries in or through the nasal cavities. Midomafetamine Clinical trials are now testing the therapeutic potential of MDMA for post-traumatic stress disorder (PTSD) and anxiety associated with terminal cancer. MDMA is one of the four most widely used... St. John's Wort An herbal ingredient used in non-prescription therapeutic products for the short-term treatment of minor skin irritations, insomnia, depression, and anxiety. Dextromethorphan An NMDA receptor antagonist used to treat cases of dry cough. Desvenlafaxine An antidepressant agent and SNRI used for the treatment of major depressive disorders in adults. Venlafaxine A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depression, generalized or social anxiety disorder, and panic disorder. Duloxetine A serotonin norepinephrine reuptake inhibitor used to treat generalized anxiety disorder, neuropathic pain, osteoarthritis, and stress incontinence. Citalopram A selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression. Escitalopram A selective serotonin re-uptake inhibitor used in the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), and other select psychiatric disorders such as obsessive-compulsive disorder (OCD). Fluoxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I. Fluvoxamine A selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder. Paroxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. Sertraline A selective serotonin reuptake inhibitor (SSRI) indicated to treat major depressive disorder, social anxiety disorder and many other psychiatric conditions. Amitriptyline A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety. Amoxapine A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression. Clomipramine A tricyclic antidepressant used in the treatment of obsessive-compulsive disorder and disorders with an obsessive-compulsive component, such as depression, schizophrenia, and Tourette’s disorder. Desipramine A tricyclic antidepressant used in the treatment of depression. Doxepin A psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia. Imipramine A tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis. Maprotiline A tetracyclic antidepressant used to treat depressive illness, major depressive disorder, bipolar disorder, and anxiety associated with depression. Nortriptyline A tricyclic antidepressant used in the treatment of depression. Protriptyline A tricyclic antidepressant that is indicated in the treatment of depression only under close clinical supervision. Trimipramine A tricyclic antidepressant used to treat depression. Buspirone An anxiolytic agent used for short-term treatment of generalized anxiety and second-line treatment of depression. Furazolidone A drug for the treatment of infectious diarrhea. Isocarboxazid A monoamine oxidase inhibitor used to treat enduring and debilitating symptoms of depression following inadequate clinical response to other antidepressant drugs. Linezolid An oxazolidinone antibiotic used to treat infections by susceptible strains of aerobic Gram-positive bacteria. Methylene blue An oxidation-reduction agent used for the treatment of pediatric and adult patients with acquired methemoglobinemia. Phenelzine A monoamine oxidase inhibitor used to treat atypical, nonendogenous, or neurotic depression. Selegiline A monoamine oxidase inhibitor used to treat major depressive disorder and Parkinson's. Tranylcypromine A monoamine oxidase inhibitor used to treat major depressive disorder. Almotriptan A 5-HT1B/1D receptor agonist used to treat migraines. Eletriptan A triptan used for the treatment of migraines. Frovatriptan A 5-HT1B/1D receptor agonist used to treat migraines. Naratriptan A 5-HT1B/1D receptor agonist used to treat migraines. Rizatriptan A triptan used to treat migraines with or without aura. Sumatriptan A serotonin receptor agonist used to treat migraines and cluster headaches. Zolmitriptan A member of the triptan class of 5-HT(1B/1D/1F) receptor agonist drugs used for the acute treatment of migraine with or without aura in adults. Tryptophan An amino acid commonly found as a component of total parenteral nutrition. Mirtazapine A tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite. Oxycodone An opioid used in the management of moderate to severe pain. Levodopa A dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. Dihydroergotamine An ergot alkaloid used in the acute treatment of migraine headache and cluster headache. Fentanyl An opioid analgesic used in anesthesia, for breakthrough cancer pain, or round the clock pain management. Lysergic acid diethylamide Debate continues over the nature and causes of chronic flashbacks. Explanations in terms of LSD physically remaining in the body for months or years after consumption have been discounted by... Lithium cation A drug used for the management of bipolar disorder and other psychiatric conditions. Metoclopramide An antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying. Risperidone A second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. Levomilnacipran A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder (MDD) in adults. Moclobemide A monoamine oxidase inhibitor used in the treatment of major depressive disorder and bipolar disorder. Rasagiline An irreversible inhibitor of monoamine oxidase used for the symptomatic management of idiopathic Parkinson's disease as initial monotherapy and as adjunct therapy to levodopa. Safinamide A MAO-B inhibitor used as an add-on treatment to levodopa/carbidopa for Parkinson's disease during "off" episodes. Toloxatone For the treatment of major depressive disorder. Pirlindole For the treatment of major depression. It is being studied in the treatment of fibromyalgia pain syndrome. One study determined that the effect of pirlindole on sensorimotor performance while driving... Bifemelane Not Annotated Hydracarbazine Was used for the treatment of hypertension . Nialamide Withdrawn from the Canadian, US, and UK markets in 1963 due to interactions with food products containing tyrosine. Milnacipran A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of fibromyalgia and a short-term treatment of major depressive disorder. Vortioxetine A serotonin modulating antidepressant indicated for the treatment of major depressive disorder (MDD). Vilazodone An antidepressant agent used for the treatment of major depressive disorder that targets the 5-HT transporter and 5-HT1A receptors. Dapoxetine A selective serotonin reuptake inhibitor used in the treatment of premature ejaculation. Aripiprazole An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome. Pargyline For the treatment of moderate to severe hypertension. Minaprine For the treatment of depression Iproniazid For the treatment of depression (originally intended to treat tuberculosis). Benmoxin For the treatment of depression. Mebanazine For the treatment of depression. Octamoxin For the treatment of depression. Pheniprazine For the treatment of depression, schizophrenia, and angina pectoris. Phenoxypropazine For the treatment of depression. Pivhydrazine For the treatment of depression. Safrazine For the treatment of depression. Caroxazone For the treatment of depression. Harmaline Not Annotated Morphine An opioid agonist used for the relief of moderate to severe acute and chronic pain. Hydromorphone An opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated. Butorphanol An opioid agonist-antagonist used to treat moderate to severe pain. Dextropropoxyphene An opioid analgesic used to treat mild to moderate pain. Nalbuphine An opioid agonist-antagonist used to treat pain, for pre and postoperative analgesia, and for analgesia in labor and delivery. Buprenorphine A partial opioid agonist used for management of severe pain that is not responsive to alternative treatments. Also used for maintenance treatment of opioid addiction. Dezocine Indicated in the treatment of moderate to severe pain. Dextromoramide An opioid analgesic structurally related to methadone and used in the treatment of severe pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1070) Dihydrocodeine An opioid analgesic agent used for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Ketobemidone For the treatment of all types of severe pain, such as postoperative, cancer, kidney stones and fractures. Piritramide A synthetic opioid used in the treatment of severe pain. Meptazinol Not Annotated Phenazocine Not Annotated Tilidine A synthetic opioid indicated in the treatment of severe pain. Codeine An opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated. Sufentanil An opioid used to induce and maintain anesthesia, to act as an analgesic in labor and delivery, and to treat severe, acute pain. Alfentanil An opioid agonist used to induce and maintain anesthesia, as well as an analgesic. Remifentanil An opioid analgesic used in anesthesia. Hydrocodone An opioid agonist used as an analgesic and antitussive agent. Diphenoxylate An antidiarrheal medication used with atropine to manage diarrhea. Oxymorphone An opioid analgesic used in the management of moderate-to-severe pain and for analgesic therapies. Levacetylmethadol For the treatment and management of opiate dependence. It is sometimes used to treat severe pain in terminal patients. Methadyl acetate Used mainly in the treatment of narcotic dependence. Dihydroetorphine Not Available Ethylmorphine An opioid analgesic and antitussive agent used to reduce coughs caused by colds and lung infections in combination with codeine. Etorphine Etorphine is only available for its use in veterinary. This main usage is related to the immobilization of large mammals. Carfentanil Carfentanil is similar (but more potent) to the opioid analgesic fentanyl. It is used as a tranquilizer for large animals. Alphacetylmethadol A narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. [PubChem] Dihydromorphine Dihydromorphine is an opioid analgesic used for moderate to severe pain relief. DPDPE A heterodetic cyclic peptide that is a cyclic enkephalin analogue, having D-penicillaminyl residues located at positions 2 and 5, which form the heterocycle via a disulfide bond. Lofentanil Lofentanil is an analog of fentanyl and is one of the most potent opioids available today. It displays most similarity to carfentanil (4-carbomethoxyfentanyl) and is considered to be slightly more... Opium A medication used to treat moderate to severe pain. Normethadone An opioid antitussive used to treat a cough associated with inflamed mucosa. Alphaprodine Not Annotated Phenoperidine Not Annotated Bezitramide A narcotic analgesic once used for the treatment of severe chronic pain. Nicomorphine Not Annotated Naltrexone A narcotic antagonist used in opioid overdose. Eluxadoline A mixed mu-opioid receptor agonist used to treat irritable bowel syndrome with diarrhea. Indalpine Indalpine was one of the first selective serotonin reuptake inhibitors to reach the American market. It was initially marketed by Pharmuka. However, after the emergence of widespread concern regarding adverse... Zimelidine For the treatment of depression. Alaproclate Alaproclate was developed as one of the first selective serotonin reuptake inhibitor (SSRI) antidepressants by Astra AB (now AstraZeneca) in the 1970s. Development was discontinued due to concerns over hepatotoxicity... Ritanserin Ritanserin has been used in trials studying the treatment of Cocaine-Related Disorders. Butriptyline Butriptyline is a tricyclic antidepressant which has been used in Europe since 1974. It is the isobutyl side chain homologue of amitriptyline. Amitriptylinoxide A tricyclic antidepressant indicated in the treatment of depressive disorders. Melitracen A thioxanthene neuroleptic indicated in the treatment of anxiety, depression, and asthenia. Dimetacrine Dimetacrine is also known as dimethacrine or acripamine. It is marketed under the names Istonil, Istonyl, Linostil, and Miroistonil. Dimetacrine is a tricyclic antidepressant (TCA) with imipramine-like effects used in... Amineptine For the treatment of depression. Dosulepin A tricyclic antidepressant commonly used only in patients for whom alternative therapies are ineffective due to its toxicity potential. Tianeptine An atypical tricyclic antidepressant with antidepressant and anxiolytic effects primarily used to treat major depressive disorder. Opipramol A medication to treat general anxiety and somatoform disorders. Dibenzepin Dibenzepin is approved for use in Europe. Lofepramine Not Annotated Iprindole Not Annotated Cyclobenzaprine A skeletal muscle relaxant that works on the brainstem to treat muscle spasms of local origin. Oxaprotiline Investigated for the treatment of depression. Quinupramine Quinupramine has been approved in France under the brand name Kinupril, as an antidepressant . Imipramine oxide Not Annotated Tenamfetamine An amphetamine derivative that inhibits uptake of catecholamine neurotransmitters. It is a hallucinogen. It is less toxic than its methylated derivative but in sufficient doses may still destroy serotonergic neurons... 2,5-Dimethoxy-4-ethylthioamphetamine 2,5-Dimethoxy-4-ethylthioamphetamine (ALEPH-2) is a phenylisopropylamine derivative with alleged anxiolytic and hallucinogenic properties. 4-Bromo-2,5-dimethoxyamphetamine Not Available 5-methoxy-N,N-dimethyltryptamine 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a tryptamine with psychedelic properties. It is found in a wide variety of plant species, and a single psychoactive toad species, the Colorado River toad. This drug,... Apomorphine A morphine derivative D2 dopamine agonist used to treat hypomobile "off" episodes of advanced Parkinson's disease. Aripiprazole lauroxil An antipsychotic used to treat schizophrenia in adults. Asenapine An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia. Blonanserin Used for the treatment of schizophrenia . Brexpiprazole A serotonin–dopamine activity modulator used in the treatment of major depressive disorder as an adjunct, schizophrenia, and agitation associated with dementia due to Alzheimer’s disease. Cabergoline A dopamine receptor agonist used for the treatment of hyperprolactinemic conditions due to various causes. Cannabidiol An active cannabinoid used as an adjunctive treatment for the management of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome and symptomatic relief of moderate to severe neuropathic pain or other painful conditions, like cancer. Cariprazine An atypical antipsychotic used to treat schizophrenia and acute manic or mixed episodes due to bipolar I disorder. Chlorpromazine A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. Cinitapride A benzamide with gastroprokinetic and antiemetic properties typically used for the treatment of gastrointestinal motility disorders such as gastroesophageal reflux disease (GERD), non-ulcer dyspepsia, and delayed gastric emptying. Cisapride A medication used to treat heartburn associated with GERD. Dexmethylphenidate A norepinephrine-dopamine reuptake inhibitor used in the treatment of ADHD in conjunction with other therapies. Dimethyltryptamine Some people use this compound as a psychedelic inducing agent. Dolasetron An antinauseant and antiemetic used in chemotherapy and postoperatively. Eltoprazine Eltoprazine has been used in trials studying the treatment of Schizophrenia and Cognitive Impairment. Ergoloid mesylate A nootropic with an unknown mechanism of action indicated in individuals over sixty who manifest signs and symptoms of an idiopathic decline in mental capacity. Ergometrine An ergot alkaloid used for the treatment of postpartum haemorrhage and post abortion hemorrhage in patients with uterine atony. Ergotamine An alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches. Etoperidone Etoperidone has been studied for the treatment of depression , tremors in Parkinson, extrapyramidal symptoms and male impotence . It is not certain if it was ever approved and marketed... Fenfluramine Fenfluramine is a phenethylamine that is structurally similar to serotonin. Due to its ability to increase extracellular serotonin levels, modulate serotonergic and other neurologic receptors, and control neurotransmission, it is effective in treating pharmacoresistant seizures. Flibanserin A 5-HT receptor modulator used for the treatment of selected premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD). Flupentixol A thioxanthene neuroleptic used to treat schizophrenia and depression. Fluspirilene An antipsychotic agent used in the treatment of schizophrenia. Gepirone Gepirone has been used in trials studying the treatment of Cocaine-Related Disorders. Iloperidone An atypical antipsychotic agent used for the acute treatment of schizophrenia in adults. Ketanserin Ketanserin has been investigated for the treatment of Septic Shock, Severe Sepsis, and Diabetic Foot Ulcer. Lasmiditan An oral 5HT1F agonist used for the acute treatment of migraine headache with or without aura. Lisuride For the management of Parkinson's Disease Lofexidine A centrally acting alpha2-adrenergic agonist used for the symptomatic treatment of acute opioid withdrawal syndrome to facilitate abrupt opioid discontinuation in adults. Lorcaserin A serotonin 2C receptor agonist used in conjunction with physical activity and calorie restriction for weight loss in obese patients with a body mass index (BMI) of 30 and above, and in overweight patients with weight-related comorbidities. Loxapine A antipsychotic used for the treatment of schizophrenia. Lurasidone An atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder. m-Chlorophenylpiperazine m-Chlorophenylpiperazine has been used in trials studying the treatment of Alcoholism. Mazindol A sympathomimetic used to treat obesity in combination with lifestyle modifications. Methotrimeprazine A phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder. Dextroamphetamine A sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. Metamfetamine A sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and exogenous obesity. Dexfenfluramine For the management of obesity including weight loss and maintenance of weight loss in patients on a reduced calorie diet Mianserin A tetracyclic antidepressant with therapeutic activity similar to amitriptyline used to treat depression and anxiety. MK-212 MK-212 has been used in trials studying the treatment of Alcoholism. MMDA MMDA is a recreational drug. It has no current medical uses and is a Schedule I controlled substance in the USA at present. Mosapride A prokinetic 5-HT4 receptor agonist used to stimulate gastric motility. N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine 25CN-NBOH (N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine) is a newly developed selective 5-HT2A agonist. It has been tested with regard to the head-twitch-response (HTR) model of 5-HT2A activity and effects on locomotion . It was... Olanzapine An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders. Paliperidone An atypical antipsychotic used in the treatment of schizophrenia and other schizoaffective or delusional disorders. Palonosetron A serotonin antagonist used in the prophylaxis or management of vomiting that results from emetogenic chemotherapy, and for the management of postoperative nausea and vomiting. Pergolide A long-acting dopamine agonist that is uncommonly used for the management of Parkinson's disease, due to the risk for cardiac valvulopathy. Pindolol A beta adrenoceptor antagonist used to treat hypertension, edema, ventricular tachycardias, and atrial fibrillation. Pipamperone Treatment of chronic psychoses and states of aggressiveness of various origins . Pizotifen A serotonin and tryptamine antagonist indicated for migraine prophylaxis. Procarbazine An antineoplastic agent indicated for the treatment of stage III and stage IV Hodgkin's disease in combination with other chemotherapeutic agents. Promazine A phenothiazine used to manage schizophrenia. Promethazine A first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness. Quetiapine A psychotropic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder. Rotigotine A non-selective dopamine agonist used for the treatment of Parkinson's Disease and Restless Leg Syndrome. Serotonin For temporary relief of nervousness, anxiety, mood swings, joint pains, weakness, drowsiness, itching and lethargy. Not evaluated by the FDA, homeopathic product. Sertindole An atypical antipsychotic indicated in the treatment of schizophrenia. Sibutramine A norepinephrine, serotonin and dopamine reuptake inhibitor indicated to assist with weight loss in obesity. Tandospirone Tandospirone has been used in trials studying the treatment of Schizophrenia. Felcisetrag Felcisetrag (TD-8954) has been used in trials studying the treatment of Enteral Feeding Intolerance and Gastrointestinal Motility Disorder. Tedizolid phosphate An oxazolidinone class antibiotic that inhibits bacterial protein synthesis and is proven to be effective in the treatment of certain Gram-positive bacterial infections. Tegaserod A serotonin-4 (5-HT4) receptor agonist indicated for the treatment of constipation predominant irritable bowel syndrome (IBS-C) specifically in women under the age of 65. There is currently no safety or efficacy data for use of tegaserol in men. Thioridazine A phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder. Vabicaserin Vabicaserin has been used in trials studying the health services research and treatment of Schizophrenia. YKP-1358 Investigated for use/treatment in schizophrenia and schizoaffective disorders. Yohimbine An alpha-2-adrenergic blocker and sympatholytic found in supplements used to. Ziprasidone An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia. Zotepine Zotepine, like other atypical antipsychotics, is considered as the first-line treatment in newly diagnosed schizophrenia. It is usually thought to be an option of choice for managing acute schizophrenic episodes... Zuclopenthixol An antipsychotic indicated for the management of schizophrenia. The acuphase formulation is indicated for initial treatment of acute psychosis or exacerbation of psychosis, while the depot formulation is best for maintenance. Amantadine A medication used to treat dyskinesia in Parkinson's patients receiving levodopa, as well as extrapyramidal side effects of medications. Isoniazid An antibiotic used to treat mycobacterial infections; most commonly use in combination with other antimycobacterial agents for the treatment of active or latent tuberculosis. Carbamazepine An anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia. Valproate bismuth A medication used to treat laryngitis. Diphenhydramine A H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes. Methylthioninium The phenothiazine cation in methylene blue commonly used to treat methemoglobinemia. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline Potent reversible inhibitor of phenylethanolamine N-methyltransferase. Amphetamine A CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Brofaromine Not Annotated Procaine A local anesthetic used for anesthesia, peripheral nerve block, and spinal nerve block. 2,5-Dimethoxy-4-ethylamphetamine Not Available Benzphetamine A sympathomimetic used to manage exogenous obesity short term. Chlorphentermine Used as an appetite suppressant. Diethylpropion An appetite suppressant used for the short term treatment of exogenous obesity in addition to calorie restriction. Gepefrine Not Annotated Hydroxyamphetamine An indirectly acting sympathomimetic agent producing mydriasis for diagnostic purposes. Iofetamine I-123 Not Annotated Lisdexamfetamine A central nervous system (CNS) stimulant used to treat attention deficit hyperactivity disorder (ADHD) and moderate to severe eating disorders. Mephedrone Mephedrone has been investigated in Alcohol-Related Disorders and Amphetamine-Related Disorders. Mephentermine A sympathomimetic agent used in the treatment of hypotension. Methoxyphenamine Not Annotated Pseudoephedrine An alpha and beta adrenergic agonist used to treat nasal and sinus congestion, as well as allergic rhinitis. Ritobegron Ritobegron is under investigation in clinical trial NCT02256735 (Study to Investigate the Effect of KUC 7483 CL on the QT/QTc Interval of the ECG in Comparison to Placebo and Moxifloxacin... Nutmeg An extract from Nutmeg used in allergy testing. Valproic acid An anticonvulsant used to control complex partial seizures and both simple and complex absence seizures. Metaxalone A muscle relaxant used to treat muscle pain or spasm. Clorgiline An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE. Lithium citrate Lithium is used as a mood stabilizer, and is used for treatment of depression and mania. It is often used in bipolar disorder treatment. Lithium carbonate A medication used to treat manic episodes of bipolar disorder. Oliceridine A biased opioid agonist indicated for the management of severe acute pain in adult patients. Through preferential activation of G-protein-coupled signalling pathways, oliceridine provides analgesic effect with a comparable or improved safety profile over conventional opioid agonists.
- Drugs & Drug Targets