Drugs that are Mainly Renally Excreted with Narrow Therapeutic Index

Name
Drugs that are Mainly Renally Excreted with Narrow Therapeutic Index
Accession Number
DBCAT003988
Description
Not Available
Drugs
DrugDrug Description
CapreomycinAn aminoglycoside antibiotic used as an adjunct drug in tuberculosis.
CarbamazepineAn anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia.
DigoxinA cardiac glycoside used in the treatment of mild to moderate heart failure and for ventricular response rate control in chronic atrial fibrillation.
IsotretinoinA retinoid used to treat severe recalcitrant acne.
PlazomicinAn aminoglycoside antibiotic used to treat complicated urinary tract infections.
ProcainamideA medication used to treat life threatening ventricular arrhythmias.
QuinidineA medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias.
VancomycinA glycopeptide antibiotic used to treat severe but susceptible bacterial infections such as MRSA (methicillin-resistant Staphylococcus aureus) infections.
WarfarinA vitamin K antagonist used to treat venous thromboembolism, pulmonary embolism, thromboembolism with atrial fibrillation, thromboembolism with cardiac valve replacement, and thromboembolic events post myocardial infarction.
Lithium carbonateA medication used to treat manic episodes of bipolar disorder.
PemetrexedA folate analog used to treat mesothelioma and non-small cell lung cancer.
CisplatinA platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors.
AmikacinAn aminoglycoside used to treat infections caused by more resistant strains of Gram negative bacteria and some Gram positive bacteria.
TobramycinAn aminoglycoside antibiotic used to treat cystic fibrosis, lung infections, eye infections, and a variety of other infections.
GentamicinAn aminoglycoside used to treat a wide variety of infections in the body.
NeomycinAn aminoglycoside antibiotic agent used orally and topically to treat a wide variety of infections in the body.
StreptomycinAn aminoglycoside antibiotic indicated to treat mycobacterium tuberculosis and various non-tuberculosis infections.
FramycetinAn aminoglycoside antibiotic used in various formulations and combinations with other agents to treat hemorrhoids, eye and ear infections, and to reduce nasal carriage of staphylococcus.
NetilmicinAn aminoglycoside used to treat a wide variety of infections in the body.
KanamycinAn aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria.
ParomomycinAn aminoglycoside antibiotic used in the treatment of acute and chronic intestinal amebiasis, and as an adjunct for the management of hepatic coma.
RibostamycinA broad spectrum aminoglycoside antibiotic on the list of WHO critical antimicrobials for human medicine.
GeneticinGeneticin (also known as G418) is an aminoglycoside antibiotic similar in structure to gentamicin B1, produced by Micromonospora rhodorangea. Geneticin blocks polypeptide synthesis by inhibiting the elongation step in both...
ApramycinFor the treatment of bacterial infections in animals.
Gentamicin C1aNot Available
NeamineNot Available
ArbekacinArbekacin is used for the short term treatment of multi-resistant bacterial infections, such as methicillin-resistant Staphylococcus aureus (MRSA).
PuromycinPuromycin is an antibiotic that prevents bacterial protein translation. It is utilized as a selective agent in laboratory cell cultures. Puromycin is toxic to both prokaryotic and eukaryotic cells, resulting...
DihydrostreptomycinDihydrostreptomycin is an antibiotic.
Hygromycin BHygromycin B is an aminoglycoside antibiotic produced by the bacterium Streptomyces hygroscopicus which kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis.
SisomicinSisomicin has been used in trials studying the treatment of Pyoderma.
DibekacinDibekacin is an aminoglycoside antibiotic marketed in Japan .
MicronomicinMicronomicin is an aminoglycoside antibiotic which is marketed in Japan, and sold under the brand names Sagamicin and Luxomicina.
IsepamicinNot Annotated
BekanamycinNot Annotated
ColistinA polymyxin antibiotic used to treat bacterial infections caused by susceptible Gram negative bacteria.
FloxuridineAn antimetabolite used as palliative management for liver metastases of gastrointestinal malignancy.
PentostatinAn adenosine deaminase inhibitor used to treat hairy cell leukemia.
NedaplatinUsed in the treatment of non-small cell lung cancer, small cell lung cancer, oesophygeal cancer, and head and neck cancers .
Drugs & Drug Targets
DrugTargetType
Capreomycin16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyAtarget
CarbamazepineVoltage-gated sodium channel alpha subunittarget
CarbamazepineCytochrome P450 2C8enzyme
CarbamazepineCytochrome P450 2B6enzyme
CarbamazepineCytochrome P450 3A4enzyme
CarbamazepineCytochrome P450 1A2enzyme
CarbamazepineCytochrome P450 2C19enzyme
CarbamazepineCytochrome P450 2C9enzyme
CarbamazepineP-glycoprotein 1transporter
CarbamazepineCytochrome P450 3A5enzyme
CarbamazepineUDP-glucuronosyltransferase 2B7enzyme
CarbamazepineRalA-binding protein 1transporter
CarbamazepineCanalicular multispecific organic anion transporter 1transporter
CarbamazepineNeuronal acetylcholine receptor subunit alpha-4target
CarbamazepineNuclear receptor subfamily 1 group I member 2target
CarbamazepineUDP-glucuronosyltransferase 1-1enzyme
CarbamazepineUDP-glucuronosyltransferase 1-6enzyme
CarbamazepineUDP-glucuronosyltransferase 1-7enzyme
DigoxinSodium/potassium-transporting ATPase subunit alpha-1target
DigoxinCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DigoxinP-glycoprotein 1transporter
DigoxinSolute carrier organic anion transporter family member 4C1transporter
DigoxinBile salt export pumptransporter
DigoxinSolute carrier organic anion transporter family member 1A2transporter
DigoxinOrganic solute transporter subunit alphatransporter
DigoxinOrganic solute transporter subunit betatransporter
DigoxinSolute carrier organic anion transporter family member 1B1transporter
IsotretinoinRetinoic acid receptor alphatarget
IsotretinoinSerum albumincarrier
IsotretinoinRetinoic acid receptor gammatarget
IsotretinoinCytochrome P450 3A4enzyme
PlazomicinMultidrug and toxin extrusion protein 1transporter
PlazomicinMultidrug and toxin extrusion protein 2transporter
Plazomicin30S ribosomal protein S14target
Plazomicin30S ribosomal protein S11target
ProcainamideSodium channel protein type 5 subunit alphatarget
ProcainamideDNA (cytosine-5)-methyltransferase 1target
ProcainamideCytochrome P450 2D6enzyme
ProcainamideCholinesteraseenzyme
ProcainamideSolute carrier family 22 member 2transporter
ProcainamideSolute carrier family 22 member 1transporter
ProcainamideSolute carrier family 22 member 3transporter
ProcainamideSolute carrier family 22 member 5transporter
ProcainamideSolute carrier family 22 member 4transporter
ProcainamidePotassium voltage-gated channel subfamily H member 2target
ProcainamideMultidrug and toxin extrusion protein 1transporter
ProcainamideMultidrug and toxin extrusion protein 2transporter
QuinidineSodium channel protein type 5 subunit alphatarget
QuinidineAlpha-1-acid glycoprotein 1carrier
QuinidinePotassium voltage-gated channel subfamily H member 2target
QuinidinePotassium channel subfamily K member 1target
QuinidinePotassium channel subfamily K member 6target
QuinidineCytochrome P450 1A2enzyme
QuinidineCytochrome P450 2E1enzyme
QuinidineCytochrome P450 1A1enzyme
QuinidineCytochrome P450 2D6enzyme
QuinidineCytochrome P450 3A4enzyme
QuinidineCytochrome P450 3A7enzyme
QuinidineSolute carrier family 22 member 2transporter
QuinidineSolute carrier family 22 member 1transporter
QuinidineSolute carrier family 22 member 5transporter
QuinidineP-glycoprotein 1transporter
QuinidineSolute carrier organic anion transporter family member 1A2transporter
QuinidineSolute carrier family 22 member 8transporter
QuinidineCanalicular multispecific organic anion transporter 1transporter
QuinidineSolute carrier family 22 member 4transporter
QuinidineSolute carrier organic anion transporter family member 1B1transporter
QuinidineCytochrome P450 2B6enzyme
QuinidineCytochrome P450 2C9enzyme
QuinidineAlpha-1A adrenergic receptortarget
QuinidineAlpha-1B adrenergic receptortarget
QuinidineAlpha-1D adrenergic receptortarget
QuinidineBile salt export pumptransporter
QuinidineCytochrome P450 2C8enzyme
VancomycinD-Ala-D-Ala moiety of NAM/NAG peptide subunits of peptidoglycantarget
VancomycinSerum albumincarrier
Vancomycinalpha1-acid glycoproteincarrier
VancomycinHistamine H1 receptorcarrier
WarfarinVitamin K epoxide reductase complex subunit 1target
WarfarinCytochrome P450 2C8enzyme
WarfarinCytochrome P450 1A2enzyme
WarfarinCytochrome P450 2C9enzyme
WarfarinAlpha-1-acid glycoprotein 1carrier
WarfarinSerum albumincarrier
WarfarinCytochrome P450 2C19enzyme
WarfarinCytochrome P450 3A4enzyme
WarfarinCytochrome P450 2C18enzyme
WarfarinNuclear receptor subfamily 1 group I member 2target
Lithium carbonateInositol monophosphatase 2target
Lithium carbonateInositol monophosphatase 1target
Lithium carbonateGlycogen synthase kinase-3 betatarget
Lithium carbonateGlutamate receptor 3target
Lithium carbonateAmiloride-sensitive sodium channel subunit alphatransporter
Lithium carbonateAmiloride-sensitive sodium channel subunit betatransporter
Lithium carbonateAmiloride-sensitive sodium channel subunit gammatransporter
PemetrexedThymidylate synthasetarget
PemetrexedDihydrofolate reductasetarget
PemetrexedTrifunctional purine biosynthetic protein adenosine-3target
PemetrexedDeoxycytidine kinaseenzyme
PemetrexedBifunctional purine biosynthesis protein PURHtarget
PemetrexedEquilibrative nucleoside transporter 1enzyme
PemetrexedSolute carrier family 22 member 8transporter
CisplatinDNAtarget
CisplatinCanalicular multispecific organic anion transporter 2transporter
CisplatinMultidrug resistance-associated protein 5transporter
CisplatinCanalicular multispecific organic anion transporter 1transporter
CisplatinSolute carrier family 22 member 2transporter
CisplatinHigh affinity copper uptake protein 1transporter
CisplatinProbable low affinity copper uptake protein 2transporter
CisplatinMultidrug resistance-associated protein 6transporter
CisplatinP-glycoprotein 1transporter
CisplatinCopper-transporting ATPase 2transporter
CisplatinCopper-transporting ATPase 1transporter
CisplatinProstaglandin G/H synthase 2enzyme
CisplatinMyeloperoxidaseenzyme
CisplatinXanthine dehydrogenase/oxidaseenzyme
CisplatinArylamine N-acetyltransferaseenzyme
CisplatinCytochrome P450 2C9enzyme
CisplatinCytochrome P450 2B6enzyme
CisplatinCholinesteraseenzyme
CisplatinCytochrome P450 4A11enzyme
CisplatinATP-binding cassette sub-family G member 2transporter
CisplatinGlutathione S-transferase theta-1enzyme
CisplatinMetallothionein-1Aenzyme
CisplatinMetallothionein-2enzyme
CisplatinSuperoxide dismutase [Cu-Zn]enzyme
CisplatinGlutathione S-transferase Penzyme
CisplatinNAD(P)H dehydrogenase [quinone] 1enzyme
CisplatinGlutathione S-transferase Mu 1enzyme
CisplatinDNA-3-methyladenine glycosylasetarget
CisplatinAlpha-2-macroglobulintarget
CisplatinSerum albumincarrier
CisplatinSerotransferrintarget
CisplatinCopper transport protein ATOX1target
Amikacin30S ribosomal protein S12target
Tobramycin30S ribosomal protein S12target
Tobramycin16S ribosomal RNAtarget
TobramycinAminoglycoside 2'-N-acetyltransferaseenzyme
Gentamicin30S ribosomal protein S12target
Gentamicin16S ribosomal RNAtarget
GentamicinLow-density lipoprotein receptor-related protein 2target
GentamicinSolute carrier family 22 member 6transporter
GentamicinNH(3)-dependent NAD(+) synthetasetarget
GentamicinDihydrofolate reductasetarget
Neomycin30S ribosomal protein S12target
Neomycin16S ribosomal RNAtarget
NeomycinExtracellular calcium-sensing receptortarget
Streptomycin30S ribosomal protein S12target
Streptomycin16S ribosomal RNAtarget
StreptomycinSolute carrier family 22 member 6transporter
StreptomycinProtein-arginine deiminase type-4target
Framycetin30S ribosomal protein S12target
Framycetin16S ribosomal RNAtarget
FramycetinC-X-C chemokine receptor type 4target
Netilmicin30S ribosomal protein S12target
Netilmicin16S ribosomal RNAtarget
Kanamycin30S ribosomal protein S12target
Kanamycin16S ribosomal RNAtarget
KanamycinAminoglycoside 2'-N-acetyltransferaseenzyme
KanamycinKanamycin nucleotidyltransferaseenzyme
KanamycinAminoglycoside 3'-phosphotransferaseenzyme
Paromomycin16S ribosomal RNAtarget
Paromomycin30S ribosomal protein S10target
RibostamycinProtein disulfide-isomerasetarget
Ribostamycin30S ribosomal protein S12target
RibostamycinAminoglycoside N(6')-acetyltransferase type 1target
RibostamycinAminoglycoside 2'-N-acetyltransferasetarget
RibostamycinAminoglycoside 2'-N-acetyltransferaseenzyme
GeneticinOrnithine decarboxylasetarget
Apramycin16S ribosomal RNAtarget
Gentamicin C1a30S ribosomal protein S12target
Gentamicin C1a16S ribosomal RNAtarget
Arbekacin30S ribosomal protein S12target
Puromycin60S ribosomal protein L10-liketarget
Puromycin60S ribosomal protein L13atarget
Puromycin60S ribosomal protein L23target
Puromycin60S ribosomal protein L15target
Puromycin60S ribosomal protein L19target
Puromycin60S ribosomal protein L23atarget
PuromycinProbable ribosome biogenesis protein RLP24target
Puromycin60S ribosomal protein L26-like 1target
Puromycin60S ribosomal protein L8target
Puromycin60S ribosomal protein L37target
Puromycin60S ribosomal protein L3target
Puromycin60S ribosomal protein L11target
PuromycinLeucyl/phenylalanyl-tRNA--protein transferasetarget
ColistinBacterial outer membranetarget
FloxuridineThymidylate synthasetarget
FloxuridineThymidine phosphorylaseenzyme
FloxuridineCytochrome P450 2C9enzyme
FloxuridineThyroxine-binding globulincarrier
PentostatinAdenosine deaminasetarget
NedaplatinGlutathionetarget
NedaplatinDNAtarget