OATP1B3 substrates

Name

OATP1B3 substrates

Accession Number

DBCAT004563

Description

Not Available

Drugs

Drug	Drug Description
Revefenacin	An anticholinergic agent used to treat COPD.
Rifampin	An antibiotic used alone or in combination with other antimicrobial drugs to treat tuberculosis and asymptomatic carriers of Neisseria meningitidis.
Taurocholic acid	The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats...
Conjugated estrogens	A mixture of estrogens used in estrogen replacement therapy for menopause and hypoestrogenism, used in the treatment of various malignancies, and used in the treatment of postmenopausal osteoporosis.
Cholic Acid	A bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function.
Liothyronine	A thyroid hormone replacement therapy used to treat hypothyroidism, to suppress TSH, and to help in the diagnosis of hyperthyroidism.
Ouabain	For the treatment of atrial fibrillation and flutter and heart failure
Methotrexate	An antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis.
Caspofungin	An echinocandin used to treat a variety of fungal infections.
Olmesartan	An angiotensin receptor blocker (ARB) used in the treatment of hypertension.
Valsartan	An angiotensin-receptor blocker used to manage hypertension alone or in combination with other antihypertensive agents and to manage heart failure in patients who are intolerant to ACE inhibitors.
Liotrix	May be used to treat primary, secondary or tertiary hypothyroidism. May also be used to suppress thyroid stimulating hormone (TSH) secretion in patients with simple (nontoxic) goiter, subacute or chronic...
Cholecystokinin	For use as a diagnostic aid for evaluation of gallbladder disorders. It is also used in conjunction with secretin in pancreatic insufficiency .
Pitavastatin	An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
Gadoxetic acid	A gadolinium-based contrast agent (GBCA) used with contrasted magnetic resonance imaging (MRI) to detect and visualize the liver.
Atorvastatin	An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
Mycophenolate mofetil	An inosine monophosphate dehydrogenase inhibitor used to prevent the rejection of kidney, heart, or liver transplants.
Pravastatin	An HMG-CoA reductase inhibitor used to lower lipid levels and to reduce the risk of cardiovascular events, including myocardial infarction and stroke.
Paclitaxel	A taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer.
Docetaxel	A taxoid antineoplastic agent used in the treatment of various cancers, such as locally advanced or metastatic breast cancer, metastatic prostate cancer, gastric adenocarcinoma, and head and neck cancer.
Selexipag	A non prostanoid IP prostacyclin receptor agonist used to treat pulmonary arterial hypertension.
Ambrisentan	A selective type A endothelin receptor antagonist used to treat primary pulmonary arterial hypertension and pulmonary arterial hypertension based on diagnostic classifications.
Grazoprevir	An antiviral and NS3/4A protease inhibitor used to treat hepatitis C infections.
Technetium Tc-99m mebrofenin	A diagnostic radiopharmaceutical agent used during hepatobiliary imaging tests.
Parachlorophenol	An antibacterial agent used to prevent infections in root canals.
Levosalbutamol	A beta-2 adrenergic receptor agonist used to treat COPD and asthma.
Levomenol	Levomenol has been known to elicit a number of potentially beneficial pharmacological effects, including anti-irritant, anti-inflammatory, and anti-microbial actions. Bisabolol is also demonstrated to enhance the percutaneous absorption of certain...
Simeprevir	A direct-acting antiviral agent that inhibits HCV NS3/4A protease to treat chronic hepatitis C virus (HCV) infection in adults with HCV genotype 1 or 4.
Voxilaprevir	A nonstructural protein 3 and 4a protease inhibitor used to treat Hepatitis C infections.
Glecaprevir	A Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C.
Letermovir	An antiviral medication used for prophylaxis in adult transplant recipients at risk of cytomegalovirus (CMV) infection and disease.
Paritaprevir	A direct acting antiviral agent used in combination with other antiviral agents for the treatment of Hepatitis C Virus (HCV) infections.
Sincalide	A diagnostic agent used to stimulate gallbladder contraction or pancreatic secretion during diagnostic tests, and accelerate fluoroscopy and x-ray examination of the intestinal tract.
Fluvastatin	An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
Erythromycin	A macrolide antibiotic used to treat and prevent a variety of bacterial infections.
Tenofovir alafenamide	A nucleoside analog reverse transcriptase inhibitor used for the treatment of chronic hepatitis B virus infection in adults with compensated liver disease.
Raloxifene	A selective estrogen receptor modulator that is used to prevent and treat osteoporosis and reduce the risk of invasive breast cancer in high-risk postmenopausal women.
Testosterone	A hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause.
Fexofenadine	A selective H1-antagonist for the symptomatic treatment of seasonal allergic rhinitis and chronic idiopathic urticaria.
Trastuzumab deruxtecan	An antibody used to treat certain types of unresectable or metastatic HER2 positive breast cancer.
Ubrogepant	An oral CGRP antagonist used in the acute treatment of migraine with or without aura.
Bempedoic acid	A drug used in conjunction with lifestyle modification and/or other agents for the treatment of refractory hypercholesterolemia.
Prasterone	A steroid formulated as a vaginal insert indicated for the treatment of moderate to severe dyspareunia associated with menopausal vulvar and vaginal atrophy.
Empagliflozin	An SGLT2 inhibitor used to manage type 2 diabetes mellitus.
Belantamab mafodotin	An anti B-cell maturation antigen antibody conjugated to a microtubule inhibitor to treat relapsed or refractory multiple myeloma.
Opicapone	A catechol-O-methyltransferase inhibitor used as an adjunct treatment for Parkinson's Disease in adults currently receiving levodopa and a dopa decarboxylase inhibitor.
Brincidofovir	An oral lipid prodrug of cidofovir used in the treatment of human smallpox disease.
Belzutifan	An inhibitor of hypoxia-inducible factor 2α used as an antineoplastic in the treatment of certain cancers associated with von Hippel-Lindau (VHL) disease.
Atogepant	An oral CGRP antagonist used for the preventative therapy of episodic migraine headaches.
Pafolacianine	An optical imaging agent indicated in adult patients with ovarian cancer as an adjunct for intraoperative identification of malignant lesions.
Testosterone undecanoate	An androgen indicated for testosterone replacement therapy in adult males with primary hypogonadism and hypogonadotropic hypogonadism.
Pralatrexate	An antineoplastic agent used for the treatment of relapsed or refractory peripheral T-cell lymphoma.
Dabrafenib	A kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer.
Imatinib	A tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors.
Linzagolix	A selective gonadotropin-releasing hormone (GnRH) receptor antagonist used for the symptomatic treatment of uterine fibroids.
Mesalazine	An aminosalicylate drug used to treat mild to moderate active ulcerative colitis and also to maintain remission once achieved.
Zavegepant	A calcitonin gene-related peptide receptor antagonist indicated for the acute treatment of migraine with or without aura.
Momelotinib	A Janus Kinase inhibitor used to treat intermediate or high-risk myelofibrosis.
Resmetirom	A thyroid hormone receptor-beta agonist used to treat noncirrhotic nonalcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis in adults.

Drugs & Drug Targets

Drug	Target	Type
Revefenacin	Cytochrome P450 2D6	enzyme
Revefenacin	Muscarinic acetylcholine receptor	target
Revefenacin	Albumin	carrier
Revefenacin	Solute carrier organic anion transporter family member 1B1	transporter
Revefenacin	Solute carrier organic anion transporter family member 1B3	transporter
Revefenacin	ATP-dependent translocase ABCB1	transporter
Revefenacin	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Rifampin	Nuclear receptor subfamily 1 group I member 2	target
Rifampin	Cytochrome P450 3A4	enzyme
Rifampin	Cytochrome P450 1A2	enzyme
Rifampin	Cytochrome P450 2C8	enzyme
Rifampin	UDP-glucuronosyltransferase 1A1	enzyme
Rifampin	Cytochrome P450 2C9	enzyme
Rifampin	Cytochrome P450 2B6	enzyme
Rifampin	Cytochrome P450 2C19	enzyme
Rifampin	ATP-binding cassette sub-family C member 3	transporter
Rifampin	ATP-binding cassette sub-family C member 5	transporter
Rifampin	ATP-dependent translocase ABCB1	transporter
Rifampin	ATP-binding cassette sub-family C member 2	transporter
Rifampin	Solute carrier organic anion transporter family member 2B1	transporter
Rifampin	Bile salt export pump	transporter
Rifampin	Multidrug resistance-associated protein 1	transporter
Rifampin	Solute carrier organic anion transporter family member 1A2	transporter
Rifampin	Solute carrier organic anion transporter family member 1B3	transporter
Rifampin	Solute carrier family 22 member 7	transporter
Rifampin	Solute carrier organic anion transporter family member 1B1	transporter
Rifampin	Cytochrome P450 2A6	enzyme
Rifampin	Cytochrome P450 2E1	enzyme
Rifampin	Cytochrome P450 3A43	enzyme
Rifampin	Cytochrome P450 3A7	enzyme
Rifampin	Solute carrier family 22 member 6	transporter
Rifampin	Organic anion transporter 3	transporter
Rifampin	UDP-glucuronosyltransferase 1A9	enzyme
Rifampin	Cytochrome P450 3A5	enzyme
Rifampin	Albumin	carrier
Rifampin	alpha1-acid glycoprotein	carrier
Rifampin	DNA-directed RNA polymerase subunit beta	target
Taurocholic acid	Bile salt-activated lipase	target
Taurocholic acid	Gastrotropin	target
Taurocholic acid	Bile salt export pump	transporter
Taurocholic acid	Multidrug resistance-associated protein 1	transporter
Taurocholic acid	Solute carrier organic anion transporter family member 1A2	transporter
Taurocholic acid	Ileal sodium/bile acid cotransporter	transporter
Taurocholic acid	ATP-binding cassette sub-family C member 2	transporter
Taurocholic acid	Solute carrier organic anion transporter family member 1B1	transporter
Taurocholic acid	ATP-binding cassette sub-family C member 3	transporter
Taurocholic acid	ATP-binding cassette sub-family C member 4	transporter
Taurocholic acid	ATP-dependent translocase ABCB1	transporter
Taurocholic acid	Solute carrier family 22 member 6	transporter
Taurocholic acid	ATP-binding cassette sub-family C member 10	transporter
Taurocholic acid	Organic anion transporter 3	transporter
Taurocholic acid	Solute carrier organic anion transporter family member 4A1	transporter
Taurocholic acid	ATP-binding cassette sub-family C member 11	transporter
Taurocholic acid	Solute carrier organic anion transporter family member 1C1	transporter
Taurocholic acid	Solute carrier organic anion transporter family member 3A1	transporter
Taurocholic acid	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Taurocholic acid	Solute carrier organic anion transporter family member 2B1	transporter
Taurocholic acid	Monocarboxylate transporter 1	transporter
Taurocholic acid	Hepatic sodium/bile acid cotransporter	transporter
Taurocholic acid	Organic solute transporter subunit alpha	transporter
Taurocholic acid	Organic solute transporter subunit beta	transporter
Taurocholic acid	Solute carrier organic anion transporter family member 1B3	transporter
Taurocholic acid	Cystine/glutamate transporter	transporter
Taurocholic acid	Bile acid receptor	target
Taurocholic acid	G-protein coupled bile acid receptor 1	target
Taurocholic acid	Ileal sodium/bile acid cotransporter	target
Conjugated estrogens	Estrogen receptor	target
Conjugated estrogens	Cytochrome P450 3A4	enzyme
Conjugated estrogens	Cytochrome P450 1A2	enzyme
Conjugated estrogens	Catechol O-methyltransferase	enzyme
Conjugated estrogens	ATP-binding cassette sub-family C member 3	transporter
Conjugated estrogens	ATP-binding cassette sub-family C member 4	transporter
Conjugated estrogens	Multidrug resistance-associated protein 1	transporter
Conjugated estrogens	Solute carrier organic anion transporter family member 1A2	transporter
Conjugated estrogens	Hepatic sodium/bile acid cotransporter	transporter
Conjugated estrogens	Solute carrier family 22 member 10	transporter
Conjugated estrogens	Organic anion transporter 3	transporter
Conjugated estrogens	Solute carrier organic anion transporter family member 1C1	transporter
Conjugated estrogens	Solute carrier organic anion transporter family member 1B1	transporter
Conjugated estrogens	Solute carrier organic anion transporter family member 2B1	transporter
Conjugated estrogens	ATP-dependent translocase ABCB1	transporter
Conjugated estrogens	Solute carrier family 22 member 6	transporter
Conjugated estrogens	Organic solute transporter subunit alpha	transporter
Conjugated estrogens	Organic solute transporter subunit beta	transporter
Conjugated estrogens	ATP-binding cassette sub-family C member 2	transporter
Conjugated estrogens	Solute carrier organic anion transporter family member 4A1	transporter
Conjugated estrogens	ATP-binding cassette sub-family C member 11	transporter
Conjugated estrogens	Solute carrier organic anion transporter family member 1B3	transporter
Conjugated estrogens	Solute carrier family 22 member 11	transporter
Conjugated estrogens	Solute carrier organic anion transporter family member 3A1	transporter
Conjugated estrogens	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Conjugated estrogens	Thyroxine-binding globulin	carrier
Conjugated estrogens	Sex hormone-binding globulin	carrier
Conjugated estrogens	Albumin	carrier
Conjugated estrogens	Estrogen receptor beta	target
Cholic Acid	Ferrochelatase, mitochondrial	target
Cholic Acid	Bile salt export pump	transporter
Cholic Acid	ATP-dependent translocase ABCB1	transporter
Cholic Acid	Multidrug resistance-associated protein 1	transporter
Cholic Acid	Solute carrier organic anion transporter family member 1A2	transporter
Cholic Acid	Ileal sodium/bile acid cotransporter	transporter
Cholic Acid	ATP-binding cassette sub-family C member 2	transporter
Cholic Acid	Solute carrier organic anion transporter family member 1B1	transporter
Cholic Acid	ATP-binding cassette sub-family C member 3	transporter
Cholic Acid	ATP-binding cassette sub-family C member 4	transporter
Cholic Acid	Hepatic sodium/bile acid cotransporter	transporter
Cholic Acid	Organic anion transporter 3	transporter
Cholic Acid	Solute carrier family 22 member 7	transporter
Cholic Acid	Solute carrier organic anion transporter family member 1B3	transporter
Cholic Acid	Alcohol dehydrogenase 1C	target
Cholic Acid	Estrogen-related receptor gamma	target
Cholic Acid	Gastrotropin	target
Cholic Acid	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	target
Cholic Acid	Cytochrome c oxidase subunit 1	target
Cholic Acid	Cytochrome c oxidase subunit 2	target
Cholic Acid	Cytochrome c oxidase subunit 3	target
Cholic Acid	Cytochrome c oxidase subunit 5A, mitochondrial	target
Cholic Acid	Cytochrome c oxidase subunit 5B, mitochondrial	target
Cholic Acid	Cytochrome c oxidase subunit 6C	target
Cholic Acid	Cytochrome c oxidase subunit 7B, mitochondrial	target
Cholic Acid	Cytochrome c oxidase subunit 7C, mitochondrial	target
Cholic Acid	Cytochrome c oxidase subunit 8A, mitochondrial	target
Cholic Acid	Cytochrome c oxidase subunit 6A2, mitochondrial	target
Cholic Acid	Cytochrome c oxidase subunit 6B1	target
Cholic Acid	Cytochrome c oxidase subunit 7A1, mitochondrial	target
Cholic Acid	Phospholipase A2	target
Cholic Acid	Liver carboxylesterase 1	target
Cholic Acid	Fatty acid-binding protein, liver	carrier
Cholic Acid	Choloylglycine hydrolase	target
Cholic Acid	Bile acid receptor	target
Cholic Acid	G-protein coupled bile acid receptor 1	target
Liothyronine	Thyroid hormone receptor beta	target
Liothyronine	Thyroid hormone receptor alpha	target
Liothyronine	Thyroxine-binding globulin	carrier
Liothyronine	Transthyretin	carrier
Liothyronine	Albumin	carrier
Liothyronine	ATP-dependent translocase ABCB1	transporter
Liothyronine	Organic anion transporter 3	transporter
Liothyronine	Monocarboxylate transporter 10	transporter
Liothyronine	Solute carrier organic anion transporter family member 4A1	transporter
Liothyronine	Solute carrier organic anion transporter family member 1C1	transporter
Liothyronine	Solute carrier organic anion transporter family member 1A2	transporter
Liothyronine	Hepatic sodium/bile acid cotransporter	transporter
Liothyronine	Solute carrier organic anion transporter family member 4C1	transporter
Liothyronine	Solute carrier organic anion transporter family member 1B3	transporter
Liothyronine	Solute carrier organic anion transporter family member 1B1	transporter
Liothyronine	Large neutral amino acids transporter small subunit 1	transporter
Liothyronine	Proliferating cell nuclear antigen	target
Liothyronine	UDP-glucuronosyltransferase 1A1	enzyme
Ouabain	Sodium/potassium-transporting ATPase subunit alpha-1	target
Ouabain	Solute carrier organic anion transporter family member 1A2	transporter
Ouabain	Organic anion transporter 3	transporter
Ouabain	Solute carrier organic anion transporter family member 4C1	transporter
Ouabain	Solute carrier organic anion transporter family member 1B3	transporter
Ouabain	Solute carrier organic anion transporter family member 1C1	transporter
Ouabain	Solute carrier organic anion transporter family member 1B1	transporter
Ouabain	Sodium/potassium-transporting ATPase subunit alpha-2	target
Ouabain	Sodium/potassium-transporting ATPase subunit alpha-3	target
Methotrexate	Dihydrofolate reductase	target
Methotrexate	Aldehyde oxidase	enzyme
Methotrexate	Methylenetetrahydrofolate reductase (NADPH)	enzyme
Methotrexate	Albumin	carrier
Methotrexate	ATP-binding cassette sub-family C member 3	transporter
Methotrexate	ATP-binding cassette sub-family C member 4	transporter
Methotrexate	Multidrug resistance-associated protein 1	transporter
Methotrexate	Solute carrier family 22 member 6	transporter
Methotrexate	ATP-binding cassette sub-family C member 10	transporter
Methotrexate	Organic anion transporter 3	transporter
Methotrexate	ATP-binding cassette sub-family C member 2	transporter
Methotrexate	ATP-dependent translocase ABCB1	transporter
Methotrexate	Solute carrier organic anion transporter family member 1A2	transporter
Methotrexate	Monocarboxylate transporter 1	transporter
Methotrexate	ATP-binding cassette sub-family C member 11	transporter
Methotrexate	Solute carrier organic anion transporter family member 1B3	transporter
Methotrexate	Solute carrier family 22 member 11	transporter
Methotrexate	Solute carrier organic anion transporter family member 1C1	transporter
Methotrexate	Solute carrier organic anion transporter family member 3A1	transporter
Methotrexate	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Methotrexate	Solute carrier family 22 member 7	transporter
Methotrexate	Solute carrier organic anion transporter family member 1B1	transporter
Methotrexate	6-phosphogluconate dehydrogenase, decarboxylating	enzyme
Methotrexate	Proton-coupled folate transporter	transporter
Methotrexate	Folylpolyglutamate synthase, mitochondrial	enzyme
Methotrexate	Gamma-glutamyl hydrolase	enzyme
Methotrexate	Dihydrofolate reductase	enzyme
Methotrexate	Thymidylate synthase	enzyme
Methotrexate	Bifunctional purine biosynthesis protein ATIC	enzyme
Methotrexate	Solute carrier organic anion transporter family member 4C1	transporter
Methotrexate	Reduced folate transporter	transporter
Methotrexate	Folate receptor alpha	transporter
Methotrexate	Cytochrome P450 3A4	enzyme
Methotrexate	Thymidylate synthase	target
Methotrexate	Bifunctional purine biosynthesis protein ATIC	target
Methotrexate	Folate receptor beta	transporter
Methotrexate	Solute carrier family 15 member 1	transporter
Methotrexate	Proton-coupled amino acid transporter 1	transporter
Methotrexate	Carboxypeptidase G2	enzyme
Methotrexate	Proton-coupled folate transporter	target
Methotrexate	Reduced folate transporter	target
Caspofungin	Solute carrier family 22 member 1	transporter
Caspofungin	ATP-dependent translocase ABCB1	transporter
Caspofungin	Solute carrier family 22 member 6	transporter
Caspofungin	Solute carrier organic anion transporter family member 1B1	transporter
Caspofungin	Solute carrier organic anion transporter family member 1B3	transporter
Caspofungin	Cytochrome P450 3A4	enzyme
Caspofungin	1,3-beta-glucan synthase component FKS1	target
Caspofungin	1,3-beta-glucan synthase component GSC2	target
Olmesartan	Type-1 angiotensin II receptor	target
Olmesartan	ATP-binding cassette sub-family C member 2	transporter
Olmesartan	Solute carrier organic anion transporter family member 1B3	transporter
Olmesartan	Solute carrier organic anion transporter family member 1B1	transporter
Olmesartan	Bile salt export pump	transporter
Valsartan	Type-1 angiotensin II receptor	target
Valsartan	Cytochrome P450 2C9	enzyme
Valsartan	Solute carrier organic anion transporter family member 1B3	transporter
Valsartan	Solute carrier organic anion transporter family member 1B1	transporter
Valsartan	ATP-binding cassette sub-family C member 2	transporter
Liotrix	Thyroid hormone receptor alpha	target
Liotrix	Thyroid hormone receptor beta	target
Liotrix	Cytochrome P450 2C8	enzyme
Liotrix	Solute carrier organic anion transporter family member 1A2	transporter
Liotrix	Solute carrier organic anion transporter family member 1B1	transporter
Liotrix	Solute carrier organic anion transporter family member 1B3	transporter
Liotrix	Solute carrier organic anion transporter family member 4C1	transporter
Liotrix	Hepatic sodium/bile acid cotransporter	transporter
Liotrix	Solute carrier organic anion transporter family member 1C1	transporter
Liotrix	Solute carrier organic anion transporter family member 4A1	transporter
Liotrix	Organic anion transporter 3	transporter
Liotrix	Monocarboxylate transporter 8	transporter
Liotrix	Monocarboxylate transporter 10	transporter
Liotrix	ATP-dependent translocase ABCB1	transporter
Liotrix	Transthyretin	carrier
Liotrix	Thyroxine-binding globulin	carrier
Liotrix	Albumin	carrier
Liotrix	Cytochrome P450 3A4	enzyme
Cholecystokinin	Solute carrier organic anion transporter family member 1B3	transporter
Cholecystokinin	Cholecystokinin receptor type A	target
Cholecystokinin	RAF proto-oncogene serine/threonine-protein kinase	target
Cholecystokinin	Mitogen-activated protein kinase 3	target
Cholecystokinin	Pro-epidermal growth factor	target
Cholecystokinin	Protein kinase C beta type	target
Cholecystokinin	Gastrin/cholecystokinin type B receptor	target
Cholecystokinin	Solute carrier organic anion transporter family member 1B1	transporter
Cholecystokinin	Solute carrier organic anion transporter family member 2B1	transporter
Pitavastatin	Solute carrier organic anion transporter family member 1B1	transporter
Pitavastatin	Solute carrier organic anion transporter family member 1B3	transporter
Pitavastatin	UDP-glucuronosyltransferase 2B7	enzyme
Pitavastatin	UDP-glucuronosyltransferase 1A3	enzyme
Pitavastatin	Cytochrome P450 2C9	enzyme
Pitavastatin	Cytochrome P450 2C8	enzyme
Pitavastatin	3-hydroxy-3-methylglutaryl-coenzyme A reductase	target
Pitavastatin	Solute carrier organic anion transporter family member 2B1	transporter
Pitavastatin	Hepatic sodium/bile acid cotransporter	transporter
Pitavastatin	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Pitavastatin	ATP-dependent translocase ABCB1	transporter
Pitavastatin	ATP-binding cassette sub-family C member 2	transporter
Pitavastatin	Albumin	carrier
Pitavastatin	Alpha-1-acid glycoprotein 1	carrier
Pitavastatin	Bile salt export pump	transporter
Pitavastatin	Integrin alpha-L	target
Gadoxetic acid	Solute carrier organic anion transporter family member 1B1	transporter
Gadoxetic acid	Solute carrier organic anion transporter family member 1B3	transporter
Gadoxetic acid	ATP-binding cassette sub-family C member 3	transporter
Gadoxetic acid	ATP-binding cassette sub-family C member 4	transporter
Gadoxetic acid	ATP-binding cassette sub-family C member 2	transporter
Atorvastatin	3-hydroxy-3-methylglutaryl-coenzyme A reductase	target
Atorvastatin	Cytochrome P450 3A4	enzyme
Atorvastatin	Dipeptidyl peptidase 4	target
Atorvastatin	Cytochrome P450 2D6	enzyme
Atorvastatin	Cytochrome P450 2C9	enzyme
Atorvastatin	Cytochrome P450 2C19	enzyme
Atorvastatin	Cytochrome P450 3A5	enzyme
Atorvastatin	Cytochrome P450 3A7	enzyme
Atorvastatin	ATP-dependent translocase ABCB1	transporter
Atorvastatin	Solute carrier organic anion transporter family member 1A2	transporter
Atorvastatin	Solute carrier organic anion transporter family member 1B1	transporter
Atorvastatin	ATP-binding cassette sub-family C member 4	transporter
Atorvastatin	ATP-binding cassette sub-family C member 5	transporter
Atorvastatin	Multidrug resistance-associated protein 1	transporter
Atorvastatin	Cytochrome P450 2B6	enzyme
Atorvastatin	Cytochrome P450 2C8	enzyme
Atorvastatin	Aryl hydrocarbon receptor	target
Atorvastatin	Solute carrier organic anion transporter family member 2B1	transporter
Atorvastatin	Solute carrier organic anion transporter family member 1B3	transporter
Atorvastatin	UDP-glucuronosyltransferase 1A1	enzyme
Atorvastatin	UDP-glucuronosyltransferase 1A3	enzyme
Atorvastatin	ATP-binding cassette sub-family C member 2	transporter
Atorvastatin	Bile salt export pump	transporter
Atorvastatin	Albumin	carrier
Atorvastatin	Histone deacetylase 2	target
Atorvastatin	Nuclear receptor subfamily 1 group I member 3	target
Mycophenolate mofetil	Inosine-5'-monophosphate dehydrogenase 2	target
Mycophenolate mofetil	Inosine-5'-monophosphate dehydrogenase 1	target
Mycophenolate mofetil	UDP-glucuronosyltransferase 1A1	enzyme
Mycophenolate mofetil	UDP-glucuronosyltransferase 1A7	enzyme
Mycophenolate mofetil	UDP-glucuronosyltransferase 1-6	enzyme
Mycophenolate mofetil	UDP-glucuronosyltransferase 1A9	enzyme
Mycophenolate mofetil	UDP-glucuronosyltransferase 2B7	enzyme
Mycophenolate mofetil	UDP-glucuronosyltransferase 1A8	enzyme
Mycophenolate mofetil	UDP-glucuronosyltransferase 1A10	enzyme
Mycophenolate mofetil	Liver carboxylesterase 1	enzyme
Mycophenolate mofetil	Cytochrome P450 3A4	enzyme
Mycophenolate mofetil	Cytochrome P450 3A5	enzyme
Mycophenolate mofetil	Cytochrome P450 2C8	enzyme
Mycophenolate mofetil	Solute carrier organic anion transporter family member 1B1	transporter
Mycophenolate mofetil	Solute carrier organic anion transporter family member 1B3	transporter
Mycophenolate mofetil	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Mycophenolate mofetil	ATP-dependent translocase ABCB1	transporter
Mycophenolate mofetil	6-pyruvoyl tetrahydrobiopterin synthase	target
Mycophenolate mofetil	Carboxylic ester hydrolase	enzyme
Mycophenolate mofetil	ATP-binding cassette sub-family C member 2	transporter
Mycophenolate mofetil	Prostaglandin E2 receptor EP2 subtype	target
Pravastatin	3-hydroxy-3-methylglutaryl-coenzyme A reductase	target
Pravastatin	Solute carrier organic anion transporter family member 2B1	transporter
Pravastatin	ATP-dependent translocase ABCB1	transporter
Pravastatin	Solute carrier organic anion transporter family member 1A2	transporter
Pravastatin	Solute carrier family 22 member 6	transporter
Pravastatin	Organic anion transporter 3	transporter
Pravastatin	ATP-binding cassette sub-family C member 2	transporter
Pravastatin	Solute carrier family 22 member 11	transporter
Pravastatin	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Pravastatin	Solute carrier family 22 member 7	transporter
Pravastatin	Solute carrier organic anion transporter family member 1B1	transporter
Pravastatin	Monocarboxylate transporter 1	transporter
Pravastatin	Bile salt export pump	transporter
Pravastatin	Solute carrier organic anion transporter family member 1B3	transporter
Pravastatin	Histone deacetylase 2	target
Paclitaxel	Apoptosis regulator Bcl-2	target
Paclitaxel	Tubulin beta-1 chain	target
Paclitaxel	Cytochrome P450 2C8	enzyme
Paclitaxel	Cytochrome P450 3A4	enzyme
Paclitaxel	Cytochrome P450 3A5	enzyme
Paclitaxel	Cytochrome P450 3A7	enzyme
Paclitaxel	Bile salt export pump	transporter
Paclitaxel	ATP-dependent translocase ABCB1	transporter
Paclitaxel	Multidrug resistance-associated protein 1	transporter
Paclitaxel	ATP-binding cassette sub-family C member 10	transporter
Paclitaxel	Aromatase	enzyme
Paclitaxel	Cytochrome P450 1B1	enzyme
Paclitaxel	Solute carrier organic anion transporter family member 1B3	transporter
Paclitaxel	Nuclear receptor subfamily 1 group I member 2	target
Paclitaxel	Microtubule-associated protein 4	target
Paclitaxel	Microtubule-associated protein 2	target
Paclitaxel	Microtubule-associated protein tau	target
Paclitaxel	ATP-binding cassette sub-family C member 2	transporter
Docetaxel	Apoptosis regulator Bcl-2	target
Docetaxel	Tubulin beta-1 chain	target
Docetaxel	Cytochrome P450 3A4	enzyme
Docetaxel	Cytochrome P450 3A5	enzyme
Docetaxel	Cytochrome P450 3A7	enzyme
Docetaxel	ATP-dependent translocase ABCB1	transporter
Docetaxel	ATP-binding cassette sub-family C member 10	transporter
Docetaxel	Cytochrome P450 1B1	enzyme
Docetaxel	Microtubule-associated protein 2	target
Docetaxel	Microtubule-associated protein 4	target
Docetaxel	Microtubule-associated protein tau	target
Docetaxel	Solute carrier organic anion transporter family member 1B3	transporter
Docetaxel	Solute carrier family 22 member 7	transporter
Docetaxel	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Docetaxel	ATP-binding cassette sub-family C member 2	transporter
Docetaxel	Multidrug resistance-associated protein 1	transporter
Docetaxel	Nuclear receptor subfamily 1 group I member 2	target
Selexipag	Prostacyclin receptor	target
Selexipag	Liver carboxylesterase 1	enzyme
Selexipag	Cytochrome P450 2C8	enzyme
Selexipag	Cytochrome P450 3A4	enzyme
Selexipag	Solute carrier organic anion transporter family member 1B1	transporter
Selexipag	Solute carrier organic anion transporter family member 1B3	transporter
Selexipag	ATP-dependent translocase ABCB1	transporter
Ambrisentan	Endothelin receptor type B	target
Ambrisentan	Endothelin-1 receptor	target
Ambrisentan	Cytochrome P450 2C19	enzyme
Ambrisentan	Cytochrome P450 3A4	enzyme
Ambrisentan	UDP-glucuronosyltransferase 1A9	enzyme
Ambrisentan	UDP-glucuronosyltransferase 1A3	enzyme
Ambrisentan	UDP-glucuronosyltransferase 2B7	enzyme
Ambrisentan	ATP-dependent translocase ABCB1	transporter
Ambrisentan	Solute carrier organic anion transporter family member 1B1	transporter
Ambrisentan	Solute carrier organic anion transporter family member 1B3	transporter
Ambrisentan	Cytochrome P450 3A5	enzyme
Grazoprevir	ATP-dependent translocase ABCB1	transporter
Grazoprevir	Solute carrier organic anion transporter family member 1B1	transporter
Grazoprevir	Solute carrier organic anion transporter family member 1B3	transporter
Grazoprevir	Cytochrome P450 3A4	enzyme
Grazoprevir	Genome polyprotein	target
Grazoprevir	Albumin	carrier
Grazoprevir	Alpha-1-acid glycoprotein 1	carrier
Technetium Tc-99m mebrofenin	Solute carrier organic anion transporter family member 1B1	transporter
Technetium Tc-99m mebrofenin	Solute carrier organic anion transporter family member 1B3	transporter
Parachlorophenol	Solute carrier organic anion transporter family member 1B3	transporter
Parachlorophenol	Sodium channel protein type 4 subunit alpha	target
Levosalbutamol	Beta-2 adrenergic receptor	target
Levosalbutamol	Solute carrier organic anion transporter family member 1B1	transporter
Levosalbutamol	Solute carrier organic anion transporter family member 1B3	transporter
Levomenol	Solute carrier organic anion transporter family member 1B1	transporter
Levomenol	Solute carrier organic anion transporter family member 1B3	transporter
Simeprevir	NS3 protease	target
Simeprevir	Albumin	carrier
Simeprevir	Cytochrome P450 1A2	enzyme
Simeprevir	ATP-dependent translocase ABCB1	transporter
Simeprevir	Solute carrier organic anion transporter family member 1B1	transporter
Simeprevir	Solute carrier organic anion transporter family member 1B3	transporter
Simeprevir	Cytochrome P450 3A4	enzyme
Simeprevir	ATP-binding cassette sub-family C member 2	transporter
Simeprevir	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Simeprevir	Solute carrier organic anion transporter family member 2B1	transporter
Simeprevir	Hepatic sodium/bile acid cotransporter	transporter
Simeprevir	Bile salt export pump	transporter
Simeprevir	Genome polyprotein	target
Simeprevir	Genome polyprotein	target
Voxilaprevir	Cytochrome P450 3A4	enzyme
Voxilaprevir	Cytochrome P450 1A2	enzyme
Voxilaprevir	Cytochrome P450 2C8	enzyme
Voxilaprevir	Genome polyprotein	target
Voxilaprevir	ATP-dependent translocase ABCB1	transporter
Voxilaprevir	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Voxilaprevir	Solute carrier organic anion transporter family member 1B1	transporter
Voxilaprevir	Solute carrier organic anion transporter family member 1B3	transporter
Voxilaprevir	Genome polyprotein	target
Glecaprevir	Cytochrome P450 3A Subfamily	enzyme
Glecaprevir	UDP-glucuronosyltransferase 1A1	enzyme
Glecaprevir	ATP-dependent translocase ABCB1	transporter
Glecaprevir	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Glecaprevir	Solute carrier organic anion transporter family member 1B1	transporter
Glecaprevir	Solute carrier organic anion transporter family member 1B3	transporter
Glecaprevir	NS3 protease	target
Glecaprevir	Cytochrome P450 3A4	enzyme
Glecaprevir	Genome polyprotein	target
Letermovir	UDP-glucuronosyltransferase 1A1	enzyme
Letermovir	UDP-glucuronosyltransferase 1A3	enzyme
Letermovir	Solute carrier organic anion transporter family member 1B1	transporter
Letermovir	Solute carrier organic anion transporter family member 1B3	transporter
Letermovir	Cytochrome P450 2D6	enzyme
Letermovir	Cytochrome P450 2C8	enzyme
Letermovir	Cytochrome P450 2C19	enzyme
Letermovir	Cytochrome P450 2C9	enzyme
Letermovir	Cytochrome P450 2B6	enzyme
Letermovir	ATP-dependent translocase ABCB1	transporter
Letermovir	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Letermovir	Bile salt export pump	transporter
Letermovir	Organic anion transporter 3	transporter
Letermovir	ATP-binding cassette sub-family C member 2	transporter
Letermovir	CMV DNA Terminase Complex	target
Letermovir	Cytochrome P450 3A Subfamily	enzyme
Paritaprevir	Genome polyprotein	target
Paritaprevir	Cytochrome P450 3A4	enzyme
Paritaprevir	Cytochrome P450 3A5	enzyme
Paritaprevir	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Paritaprevir	ATP-dependent translocase ABCB1	transporter
Paritaprevir	Solute carrier organic anion transporter family member 1B1	transporter
Paritaprevir	Solute carrier organic anion transporter family member 1B3	transporter
Paritaprevir	UDP-glucuronosyltransferase 1A1	enzyme
Paritaprevir	Gag-Pol polyprotein	target
Sincalide	Solute carrier organic anion transporter family member 1B3	transporter
Sincalide	Cholecystokinin receptor type A	target
Sincalide	Gastrin/cholecystokinin type B receptor	target
Fluvastatin	3-hydroxy-3-methylglutaryl-coenzyme A reductase	target
Fluvastatin	Cytochrome P450 2C9	enzyme
Fluvastatin	Cytochrome P450 3A4	enzyme
Fluvastatin	Cytochrome P450 2C8	enzyme
Fluvastatin	Cytochrome P450 2D6	enzyme
Fluvastatin	Cytochrome P450 2C19	enzyme
Fluvastatin	Cytochrome P450 1A1	enzyme
Fluvastatin	Solute carrier organic anion transporter family member 1B1	transporter
Fluvastatin	Solute carrier organic anion transporter family member 1B3	transporter
Fluvastatin	Solute carrier organic anion transporter family member 2B1	transporter
Fluvastatin	Solute carrier family 15 member 1	transporter
Fluvastatin	Cytochrome P450 3A5	enzyme
Fluvastatin	UDP-glucuronosyltransferase 1A1	enzyme
Fluvastatin	UDP-glucuronosyltransferase 1A3	enzyme
Fluvastatin	UDP-glucuronosyltransferase 2B7	enzyme
Fluvastatin	ATP-binding cassette sub-family C member 2	transporter
Fluvastatin	Cytochrome P450 2B6	enzyme
Fluvastatin	Histone deacetylase 2	target
Erythromycin	23S ribosomal RNA	target
Erythromycin	Cytochrome P450 3A4	enzyme
Erythromycin	Cytochrome P450 3A7	enzyme
Erythromycin	ATP-dependent translocase ABCB1	transporter
Erythromycin	Solute carrier organic anion transporter family member 1B1	transporter
Erythromycin	Motilin receptor	target
Erythromycin	Potassium voltage-gated channel subfamily H member 2	target
Erythromycin	Cytochrome P450 3A5	enzyme
Erythromycin	Solute carrier organic anion transporter family member 1B3	transporter
Erythromycin	Bile salt export pump	transporter
Erythromycin	ATP-binding cassette sub-family C member 2	transporter
Erythromycin	Solute carrier organic anion transporter family member 1A2	transporter
Tenofovir alafenamide	Reverse transcriptase/RNaseH	target
Tenofovir alafenamide	ATP-dependent translocase ABCB1	transporter
Tenofovir alafenamide	ATP-binding cassette sub-family C member 4	transporter
Tenofovir alafenamide	Solute carrier family 22 member 6	transporter
Tenofovir alafenamide	Organic anion transporter 3	transporter
Tenofovir alafenamide	Lysosomal protective protein	enzyme
Tenofovir alafenamide	Liver carboxylesterase 1	enzyme
Tenofovir alafenamide	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Tenofovir alafenamide	Solute carrier organic anion transporter family member 1B1	transporter
Tenofovir alafenamide	Solute carrier organic anion transporter family member 1B3	transporter
Tenofovir alafenamide	Reverse transcriptase	target
Tenofovir alafenamide	DNA polymerase	target
Tenofovir alafenamide	Albumin	carrier
Tenofovir alafenamide	Cytochrome P450 3A4	enzyme
Tenofovir alafenamide	Adenylate kinase isoenzyme 1	enzyme
Tenofovir alafenamide	Adenylate kinase 2, mitochondrial	enzyme
Tenofovir alafenamide	Nucleoside diphosphate kinase A	enzyme
Tenofovir alafenamide	Nucleoside diphosphate kinase B	enzyme
Tenofovir alafenamide	Gag-Pol polyprotein	target
Raloxifene	Estrogen receptor	target
Raloxifene	Estrogen receptor beta	target
Raloxifene	Aldehyde oxidase	enzyme
Raloxifene	Cytochrome P450 2C8	enzyme
Raloxifene	Cytochrome P450 2B6	enzyme
Raloxifene	Aromatase	enzyme
Raloxifene	Cytochrome P450 3A4	enzyme
Raloxifene	Serpin B9	target
Raloxifene	Trefoil factor 1	target
Raloxifene	UDP-glucuronosyltransferase 1A1	enzyme
Raloxifene	Albumin	carrier
Raloxifene	Alpha-1-acid glycoprotein 1	carrier
Raloxifene	Solute carrier organic anion transporter family member 1B1	transporter
Raloxifene	Solute carrier organic anion transporter family member 1B3	transporter
Raloxifene	ATP-dependent translocase ABCB1	transporter
Raloxifene	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Raloxifene	ATP-binding cassette sub-family C member 2	transporter
Raloxifene	ATP-binding cassette sub-family C member 3	transporter
Raloxifene	ATP-binding cassette sub-family C member 4	transporter
Raloxifene	UDP-glucuronosyltransferase 1A10	enzyme
Raloxifene	UDP-glucuronosyltransferase 1A8	enzyme
Testosterone	Androgen receptor	target
Testosterone	Cytochrome P450 3A4	enzyme
Testosterone	Aromatase	enzyme
Testosterone	Amine oxidase [flavin-containing] A	enzyme
Testosterone	Cholesterol side-chain cleavage enzyme, mitochondrial	enzyme
Testosterone	Albumin	carrier
Testosterone	Sex hormone-binding globulin	carrier
Testosterone	Cytochrome P450 3A5	enzyme
Testosterone	Cytochrome P450 3A7	enzyme
Testosterone	Organic anion transporter 3	transporter
Testosterone	Solute carrier family 22 member 7	transporter
Testosterone	Hepatic sodium/bile acid cotransporter	transporter
Testosterone	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Testosterone	Cytochrome P450 1A1	enzyme
Testosterone	Cytochrome P450 1B1	enzyme
Testosterone	Cytochrome P450 2A13	enzyme
Testosterone	Cytochrome P450 2B6	enzyme
Testosterone	Cytochrome P450 2C19	enzyme
Testosterone	Cytochrome P450 2C8	enzyme
Testosterone	Cytochrome P450 2C9	enzyme
Testosterone	Cytochrome P450 3A43	enzyme
Testosterone	Estrogen receptor	target
Testosterone	Mineralocorticoid receptor	target
Testosterone	Solute carrier organic anion transporter family member 1B3	transporter
Fexofenadine	Histamine H1 receptor	target
Fexofenadine	ATP-dependent translocase ABCB1	transporter
Fexofenadine	Solute carrier organic anion transporter family member 2B1	transporter
Fexofenadine	Solute carrier organic anion transporter family member 1A2	transporter
Fexofenadine	Solute carrier organic anion transporter family member 1B1	transporter
Fexofenadine	Solute carrier organic anion transporter family member 1B3	transporter
Fexofenadine	Organic anion transporter 3	transporter
Fexofenadine	ATP-binding cassette sub-family C member 2	transporter
Fexofenadine	ATP-binding cassette sub-family C member 3	transporter
Fexofenadine	Albumin	carrier
Fexofenadine	alpha1-acid glycoprotein	carrier
Trastuzumab deruxtecan	ATP-dependent translocase ABCB1	transporter
Trastuzumab deruxtecan	High affinity immunoglobulin gamma Fc receptor I	target
Trastuzumab deruxtecan	DNA topoisomerase 1	target
Trastuzumab deruxtecan	Lysosomal alpha-glucosidase	enzyme
Trastuzumab deruxtecan	DNA topoisomerase 1	enzyme
Trastuzumab deruxtecan	Cathepsin B	enzyme
Trastuzumab deruxtecan	Procathepsin L	enzyme
Trastuzumab deruxtecan	Cytochrome P450 3A4	enzyme
Trastuzumab deruxtecan	Solute carrier organic anion transporter family member 1B1	transporter
Trastuzumab deruxtecan	Solute carrier organic anion transporter family member 1B3	transporter
Trastuzumab deruxtecan	Multidrug and toxin extrusion protein 2	transporter
Trastuzumab deruxtecan	Multidrug resistance-associated protein 1	transporter
Trastuzumab deruxtecan	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Ubrogepant	ATP-dependent translocase ABCB1	transporter
Ubrogepant	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Ubrogepant	Cytochrome P450 3A4	enzyme
Ubrogepant	Cytochrome P450 2C8	enzyme
Ubrogepant	Cytochrome P450 2C9	enzyme
Ubrogepant	Cytochrome P450 2D6	enzyme
Ubrogepant	Cytochrome P450 2C19	enzyme
Ubrogepant	Amine oxidase [flavin-containing] A	enzyme
Ubrogepant	UDP-glucuronosyltransferase 1A1	enzyme
Ubrogepant	Solute carrier organic anion transporter family member 1B1	transporter
Ubrogepant	Solute carrier organic anion transporter family member 1B3	transporter
Ubrogepant	Solute carrier family 22 member 6	transporter
Ubrogepant	Solute carrier family 22 member 2	transporter
Ubrogepant	Calcitonin gene-related peptide type 1 receptor	target
Bempedoic acid	ATP-citrate synthase	target
Bempedoic acid	Long-chain fatty acid transport protein 2	enzyme
Bempedoic acid	Solute carrier organic anion transporter family member 1B1	transporter
Bempedoic acid	ATP-binding cassette sub-family C member 3	transporter
Bempedoic acid	Solute carrier organic anion transporter family member 1B3	transporter
Bempedoic acid	UDP-glucuronosyltransferase 2B7	enzyme
Bempedoic acid	NUAK family SNF1-like kinase 2	enzyme
Prasterone	Cytochrome P450 3A7	enzyme
Prasterone	Peroxisome proliferator-activated receptor alpha	target
Prasterone	Estrogen receptor	target
Prasterone	Sigma non-opioid intracellular receptor 1	target
Prasterone	Estrogen receptor beta	target
Prasterone	Nuclear receptor subfamily 1 group I member 2	target
Prasterone	Nuclear receptor subfamily 1 group I member 3	target
Prasterone	GABA(A) Receptor	target
Prasterone	NMDA receptor	target
Prasterone	Androgen receptor	target
Prasterone	17-beta-hydroxysteroid dehydrogenase type 1	enzyme
Prasterone	Sulfotransferase 2A1	enzyme
Prasterone	Sulfotransferase 2B1	enzyme
Prasterone	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1	enzyme
Prasterone	Cholesterol oxidase	enzyme
Prasterone	Steroid 17-alpha-hydroxylase/17,20 lyase	enzyme
Prasterone	Solute carrier organic anion transporter family member 1B3	transporter
Prasterone	Solute carrier organic anion transporter family member 2B1	transporter
Prasterone	Solute carrier organic anion transporter family member 1B1	transporter
Prasterone	Solute carrier organic anion transporter family member 1A2	transporter
Prasterone	Multidrug resistance-associated protein 1	transporter
Prasterone	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Prasterone	ATP-binding cassette sub-family C member 4	transporter
Prasterone	Glucose-6-phosphate 1-dehydrogenase	target
Empagliflozin	Sodium/glucose cotransporter 2	target
Empagliflozin	UDP-glucuronosyltransferase 2B7	enzyme
Empagliflozin	UDP-glucuronosyltransferase 1A3	enzyme
Empagliflozin	UDP-glucuronosyltransferase 1A8	enzyme
Empagliflozin	UDP-glucuronosyltransferase 1A9	enzyme
Empagliflozin	ATP-dependent translocase ABCB1	transporter
Empagliflozin	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Empagliflozin	Organic anion transporter 3	transporter
Empagliflozin	Solute carrier organic anion transporter family member 1B1	transporter
Empagliflozin	Solute carrier organic anion transporter family member 1B3	transporter
Belantamab mafodotin	Solute carrier organic anion transporter family member 1B1	transporter
Belantamab mafodotin	Solute carrier organic anion transporter family member 1B3	transporter
Belantamab mafodotin	Multidrug resistance-associated protein 1	transporter
Belantamab mafodotin	ATP-binding cassette sub-family C member 2	transporter
Belantamab mafodotin	ATP-binding cassette sub-family C member 3	transporter
Belantamab mafodotin	Bile salt export pump	transporter
Belantamab mafodotin	ATP-dependent translocase ABCB1	transporter
Belantamab mafodotin	Tumor necrosis factor receptor superfamily member 17	target
Opicapone	Cytochrome P450 2C19	enzyme
Opicapone	Cytochrome P450 2C8	enzyme
Opicapone	Catechol O-methyltransferase	target
Opicapone	Solute carrier organic anion transporter family member 1B1	transporter
Opicapone	ATP-dependent translocase ABCB1	transporter
Opicapone	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Opicapone	Solute carrier organic anion transporter family member 1B3	transporter
Opicapone	Solute carrier organic anion transporter family member 2B1	transporter
Opicapone	Cytochrome P450 2C9	enzyme
Opicapone	Cytochrome P450 1A2	enzyme
Opicapone	Cytochrome P450 2B6	enzyme
Brincidofovir	Cytochrome P450 4F2	enzyme
Brincidofovir	Sphingomyelin phosphodiesterase	enzyme
Brincidofovir	DNA polymerase	target
Brincidofovir	Cytochrome P450 1A2	enzyme
Brincidofovir	Cytochrome P450 2B6	enzyme
Brincidofovir	Cytochrome P450 2C8	enzyme
Brincidofovir	Cytochrome P450 2C9	enzyme
Brincidofovir	Cytochrome P450 2C19	enzyme
Brincidofovir	Cytochrome P450 2D6	enzyme
Brincidofovir	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Brincidofovir	ATP-binding cassette sub-family C member 2	transporter
Brincidofovir	Bile salt export pump	transporter
Brincidofovir	Solute carrier organic anion transporter family member 1B1	transporter
Brincidofovir	Solute carrier family 22 member 6	transporter
Brincidofovir	Organic anion transporter 3	transporter
Brincidofovir	Solute carrier organic anion transporter family member 1B3	transporter
Brincidofovir	Variola virus DNA	target
Brincidofovir	DNA polymerase theta	target
Brincidofovir	DNA polymerase beta	target
Brincidofovir	DNA polymerase subunit gamma-2	target
Brincidofovir	DNA polymerase subunit gamma-1	target
Brincidofovir	DNA polymerase epsilon subunit 2	target
Belzutifan	Endothelial PAS domain-containing protein 1	target
Belzutifan	UDP-glucuronosyltransferase 2B17	enzyme
Belzutifan	Cytochrome P450 2C19	enzyme
Belzutifan	Cytochrome P450 3A4	enzyme
Belzutifan	ATP-dependent translocase ABCB1	transporter
Belzutifan	Solute carrier organic anion transporter family member 1B1	transporter
Belzutifan	Solute carrier organic anion transporter family member 1B3	transporter
Belzutifan	Multidrug and toxin extrusion protein 2	transporter
Atogepant	Calcitonin gene-related peptide type 1 receptor	target
Atogepant	Cytochrome P450 3A4	enzyme
Atogepant	Solute carrier organic anion transporter family member 1B1	transporter
Atogepant	Solute carrier organic anion transporter family member 1B3	transporter
Atogepant	Solute carrier family 22 member 6	transporter
Atogepant	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Atogepant	ATP-dependent translocase ABCB1	transporter
Atogepant	Solute carrier family 22 member 1	transporter
Atogepant	Multidrug and toxin extrusion protein 1	transporter
Pafolacianine	Folate receptor alpha	target
Pafolacianine	Solute carrier organic anion transporter family member 1B1	transporter
Pafolacianine	Solute carrier organic anion transporter family member 1B3	transporter
Pafolacianine	Solute carrier family 22 member 6	transporter
Testosterone undecanoate	Androgen receptor	target
Testosterone undecanoate	Cytochrome P450 3A4	enzyme
Testosterone undecanoate	Amine oxidase [flavin-containing] A	enzyme
Testosterone undecanoate	Cholesterol side-chain cleavage enzyme, mitochondrial	enzyme
Testosterone undecanoate	Albumin	carrier
Testosterone undecanoate	Sex hormone-binding globulin	carrier
Testosterone undecanoate	Cytochrome P450 3A5	enzyme
Testosterone undecanoate	Cytochrome P450 3A7	enzyme
Testosterone undecanoate	Solute carrier organic anion transporter family member 1A2	transporter
Testosterone undecanoate	Organic anion transporter 3	transporter
Testosterone undecanoate	Solute carrier family 22 member 7	transporter
Testosterone undecanoate	ATP-dependent translocase ABCB1	transporter
Testosterone undecanoate	Hepatic sodium/bile acid cotransporter	transporter
Testosterone undecanoate	Solute carrier family 22 member 4	transporter
Testosterone undecanoate	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Testosterone undecanoate	Cytochrome P450 1A1	enzyme
Testosterone undecanoate	Cytochrome P450 1B1	enzyme
Testosterone undecanoate	Cytochrome P450 2A13	enzyme
Testosterone undecanoate	Cytochrome P450 2B6	enzyme
Testosterone undecanoate	Cytochrome P450 2C19	enzyme
Testosterone undecanoate	Cytochrome P450 2C8	enzyme
Testosterone undecanoate	Cytochrome P450 2C9	enzyme
Testosterone undecanoate	Cytochrome P450 3A43	enzyme
Testosterone undecanoate	3-oxo-5-alpha-steroid 4-dehydrogenase	enzyme
Testosterone undecanoate	Solute carrier family 22 member 2	transporter
Testosterone undecanoate	Multidrug and toxin extrusion protein 1	transporter
Testosterone undecanoate	Solute carrier organic anion transporter family member 1B3	transporter
Testosterone undecanoate	Aromatase	enzyme
Pralatrexate	Dihydrofolate reductase	target
Pralatrexate	Thymidylate synthase	target
Pralatrexate	Reduced folate transporter	transporter
Pralatrexate	ATP-binding cassette sub-family C member 2	transporter
Pralatrexate	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Pralatrexate	Albumin	carrier
Pralatrexate	Folylpolyglutamate synthase, mitochondrial	target
Pralatrexate	Proton-coupled folate transporter	transporter
Pralatrexate	ATP-binding cassette sub-family C member 3	transporter
Pralatrexate	Solute carrier organic anion transporter family member 1B3	transporter
Pralatrexate	Peptide deformylase, mitochondrial	target
Dabrafenib	Cytochrome P450 3A4	enzyme
Dabrafenib	Cytochrome P450 2C8	enzyme
Dabrafenib	ATP-dependent translocase ABCB1	transporter
Dabrafenib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Dabrafenib	Solute carrier organic anion transporter family member 1B1	transporter
Dabrafenib	Solute carrier organic anion transporter family member 1B3	transporter
Dabrafenib	Solute carrier family 22 member 6	transporter
Dabrafenib	Organic anion transporter 3	transporter
Dabrafenib	Serine/threonine-protein kinase B-raf	target
Dabrafenib	RAF proto-oncogene serine/threonine-protein kinase	target
Dabrafenib	Serine/threonine-protein kinase SIK1	target
Dabrafenib	Serine/threonine-protein kinase Nek11	target
Dabrafenib	LIM domain kinase 1	target
Dabrafenib	Cytochrome P450 2B6	enzyme
Dabrafenib	Cytochrome P450 2C9	enzyme
Dabrafenib	Cytochrome P450 2C19	enzyme
Dabrafenib	Cytochrome P450 1A2	enzyme
Dabrafenib	Albumin	carrier
Dabrafenib	Solute carrier organic anion transporter family member 1A2	transporter
Dabrafenib	Solute carrier family 22 member 2	transporter
Dabrafenib	UDP-glucuronosyltransferase 1A1	enzyme
Imatinib	Platelet-derived growth factor receptor beta	target
Imatinib	Tyrosine-protein kinase ABL1	target
Imatinib	Mast/stem cell growth factor receptor Kit	target
Imatinib	Proto-oncogene tyrosine-protein kinase receptor Ret	target
Imatinib	High affinity nerve growth factor receptor	target
Imatinib	Macrophage colony-stimulating factor 1 receptor	target
Imatinib	Platelet-derived growth factor receptor alpha	target
Imatinib	Epithelial discoidin domain-containing receptor 1	target
Imatinib	Cytochrome P450 3A4	enzyme
Imatinib	Breakpoint cluster region protein	target
Imatinib	Cytochrome P450 1A2	enzyme
Imatinib	Cytochrome P450 2D6	enzyme
Imatinib	Cytochrome P450 2C9	enzyme
Imatinib	Cytochrome P450 2C19	enzyme
Imatinib	Cytochrome P450 3A5	enzyme
Imatinib	Cytochrome P450 3A7	enzyme
Imatinib	Solute carrier family 22 member 1	transporter
Imatinib	ATP-dependent translocase ABCB1	transporter
Imatinib	Solute carrier family 22 member 2	transporter
Imatinib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Imatinib	Phospholipid-transporting ATPase ABCA3	transporter
Imatinib	Albumin	carrier
Imatinib	Alpha-1-acid glycoprotein 1	carrier
Imatinib	Bile salt export pump	transporter
Imatinib	Cytochrome P450 2C8	enzyme
Imatinib	ATP-binding cassette sub-family C member 2	transporter
Imatinib	Multidrug resistance-associated protein 1	transporter
Imatinib	Organic cation/carnitine transporter 2	transporter
Imatinib	Solute carrier organic anion transporter family member 1B3	transporter
Imatinib	ATP-binding cassette sub-family C member 4	transporter
Imatinib	Solute carrier organic anion transporter family member 1A2	transporter
Imatinib	Discoidin domain-containing receptor 2	target
Imatinib	Induced myeloid leukemia cell differentiation protein Mcl-1	target
Linzagolix	Cytochrome P450 2C8	enzyme
Linzagolix	Gonadotropin-releasing hormone receptor	target
Linzagolix	Albumin	carrier
Linzagolix	Cytochrome P450 2C9	enzyme
Linzagolix	Cytochrome P450 3A4	enzyme
Linzagolix	Solute carrier organic anion transporter family member 1B1	transporter
Linzagolix	Solute carrier organic anion transporter family member 1B3	transporter
Linzagolix	Organic anion transporter 3	transporter
Linzagolix	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Linzagolix	Solute carrier family 22 member 6	transporter
Mesalazine	Prostaglandin G/H synthase 1	target
Mesalazine	Prostaglandin G/H synthase 2	target
Mesalazine	Peroxisome proliferator-activated receptor gamma	target
Mesalazine	Inhibitor of nuclear factor kappa-B kinase subunit alpha	target
Mesalazine	Inhibitor of nuclear factor kappa-B kinase subunit beta	target
Mesalazine	Polyunsaturated fatty acid 5-lipoxygenase	target
Mesalazine	Arylamine N-acetyltransferase 1	enzyme
Mesalazine	Solute carrier organic anion transporter family member 1B1	transporter
Mesalazine	Solute carrier organic anion transporter family member 1B3	transporter
Mesalazine	Solute carrier organic anion transporter family member 2B1	transporter
Mesalazine	Nitric oxide synthase, inducible	target
Zavegepant	Calcitonin gene-related peptide type 1 receptor	target
Zavegepant	Cytochrome P450 3A4	enzyme
Zavegepant	Cytochrome P450 2D6	enzyme
Zavegepant	Solute carrier organic anion transporter family member 1B3	transporter
Zavegepant	Hepatic sodium/bile acid cotransporter	transporter
Zavegepant	ATP-dependent translocase ABCB1	transporter
Zavegepant	Multidrug and toxin extrusion protein 1	transporter
Zavegepant	Multidrug and toxin extrusion protein 2	transporter
Momelotinib	Cytochrome P450 3A4	enzyme
Momelotinib	Cytochrome P450 2C8	enzyme
Momelotinib	Cytochrome P450 2C9	enzyme
Momelotinib	Cytochrome P450 2C19	enzyme
Momelotinib	Cytochrome P450 1A2	enzyme
Momelotinib	Cytochrome P450 2B6	enzyme
Momelotinib	UDP-glucuronosyltransferase 1A1	enzyme
Momelotinib	UDP-glucuronosyltransferase 1A9	enzyme
Momelotinib	ATP-dependent translocase ABCB1	transporter
Momelotinib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Momelotinib	Solute carrier organic anion transporter family member 1B1	transporter
Momelotinib	Solute carrier organic anion transporter family member 1B3	transporter
Momelotinib	Tyrosine-protein kinase JAK1	target
Momelotinib	Tyrosine-protein kinase JAK2	target
Momelotinib	Tyrosine-protein kinase JAK3	target
Momelotinib	Non-receptor tyrosine-protein kinase TYK2	target
Momelotinib	Activin receptor type-1	target
Momelotinib	Receptor-type tyrosine-protein kinase FLT3	target
Resmetirom	Cytochrome P450 2C8	enzyme
Resmetirom	UDP-glucuronosyltransferase 1A4	enzyme
Resmetirom	UDP-glucuronosyltransferase 1A9	enzyme
Resmetirom	Solute carrier organic anion transporter family member 1B1	transporter
Resmetirom	Solute carrier organic anion transporter family member 1B3	transporter
Resmetirom	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Resmetirom	Organic anion transporter 3	transporter
Resmetirom	Bile salt export pump	transporter
Resmetirom	Thyroid hormone receptor beta	target