UGT1A4 substrates

Name

UGT1A4 substrates

Accession Number

DBCAT004564

Description

Not Available

Drugs

Drug	Drug Description
Lamotrigine	A phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder.
Paricalcitol	A vitamin D analog used to treat hyperparathyroidism associated with stage 3 or greater chronic kidney disease.
Trifluoperazine	A phenothiazine used to treat depression, anxiety, and agitation.
Clozapine	An atypical or second-generation antipsychotic drug used in treatment-resistant schizophrenia and to decrease suicide risk in schizophrenic patients.
Troglitazone	For the treatment of Type II diabetes mellitus. It is used alone or in combination with a sulfonylurea, metformin, or insulin as an adjunct to diet and exercise.
Ezogabine	An antiepileptic agent used as an adjuvant treatment of partial-onset seizures.
Asenapine	An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia.
Midazolam	A short-acting benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders.
Valproic acid	An anticonvulsant used to control complex partial seizures and both simple and complex absence seizures.
Imidafenacin	An antispasmodic with anticholinergic effects used to reduce urinary frequency.
Enasidenib	An isocitrate dehydrogenase-2 inhibitor used to treat relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-2 mutation.
Olanzapine	An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders.
Pexidartinib	An antitumor agent that is used for the treatment of rare disease tenosynovial giant cell tumors (TGCT) by inhibiting colony-stimulating factor 1 and its receptor.
Idelalisib	An antineoplastic kinase inhibitor used to treat chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL).
Cyclobenzaprine	A skeletal muscle relaxant that works on the brainstem to treat muscle spasms of local origin.
Tecovirimat	An antiviral medication used to treat smallpox, monkeypox, and cowpox.
Anastrozole	A competitive, selective, non-steroidal aromatase inhibitor used as adjuvant therapy for the treatment of hormone receptor-positive breast cancer in postmenopausal women.
Amitriptyline	A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety.
Lumateperone	A novel 2nd generation antipsychotic used to manage both positive and negative symptoms in patients with schizophrenia.
Phenytoin	An anticonvulsant drug used in the prophylaxis and control of various types of seizures.
Ethinylestradiol	An estradiol used as a contraceptive.
Osilodrostat	An oral inhibitor of cortisol synthesis used to treat Cushing's disease by normalizing hypercortisolism.
Bazedoxifene	A selective estrogen receptor modulator (SERM) used to treat moderate to severe vasomotor symptoms in menopause and osteoporosis alone or in combination with conjugated estrogens.
Ketotifen	A histamine H1 receptor blocker and mast cell stabilizer used to treat mild atopic asthma and allergic conjunctivitis.
Cyproheptadine	A combined serotonin and histamine antagonist used in the treatment of allergic symptoms, for appetite stimulation, and off-label in the treatment of serotonin syndrome.
Nandrolone decanoate	An anabolic steroid indicated for the management of the anemia of renal insufficiency by increasing hemoglobin and red cell mass.

Drugs & Drug Targets

Drug	Target	Type
Lamotrigine	Voltage-gated sodium channel alpha subunit	target
Lamotrigine	UDP-glucuronosyltransferases (UGTs)	enzyme
Lamotrigine	P-glycoprotein 1	transporter
Lamotrigine	Dihydrofolate reductase	enzyme
Lamotrigine	5-hydroxytryptamine receptor 3A	target
Lamotrigine	Voltage-dependent R-type calcium channel subunit alpha-1E (CACNA1E)	target
Lamotrigine	Adenosine receptor A1	target
Lamotrigine	Adenosine receptor A2a	target
Lamotrigine	Alpha-1A adrenergic receptor	target
Lamotrigine	Alpha-2A adrenergic receptor	target
Lamotrigine	Beta-1 adrenergic receptor	target
Lamotrigine	D(1) dopamine receptor	target
Lamotrigine	Dopamine D2 receptor	target
Lamotrigine	GABA(A) Receptor	target
Lamotrigine	GABA(A) Receptor Benzodiazepine Binding Site	target
Lamotrigine	Histamine H1 receptor	target
Lamotrigine	Kappa-type opioid receptor	target
Lamotrigine	Acetylcholine receptor subunit alpha	target
Lamotrigine	5-hydroxytryptamine receptor 2A	target
Lamotrigine	Solute carrier family 22 member 2	transporter
Lamotrigine	Serum albumin	carrier
Lamotrigine	Solute carrier family 22 member 1	transporter
Lamotrigine	Glutamate receptor 1	target
Paricalcitol	Vitamin D3 receptor	target
Paricalcitol	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	enzyme
Paricalcitol	Cytochrome P450 3A4	enzyme
Paricalcitol	UDP-glucuronosyltransferase 1-4	enzyme
Trifluoperazine	Dopamine D2 receptor	target
Trifluoperazine	Alpha-1A adrenergic receptor	target
Trifluoperazine	Neuron-specific vesicular protein calcyon	target
Trifluoperazine	Xanthine dehydrogenase/oxidase	enzyme
Trifluoperazine	UDP-glucuronosyltransferase 1-4	enzyme
Trifluoperazine	Cytochrome P450 1A2	enzyme
Trifluoperazine	P-glycoprotein 1	transporter
Trifluoperazine	Calmodulin	target
Trifluoperazine	Troponin C, slow skeletal and cardiac muscles	target
Trifluoperazine	Protein S100-A4	target
Clozapine	Dopamine D4 receptor	target
Clozapine	Histamine H1 receptor	target
Clozapine	Dopamine D2 receptor	target
Clozapine	Neuron-specific vesicular protein calcyon	target
Clozapine	Histamine H4 receptor	target
Clozapine	5-hydroxytryptamine receptor 2A	target
Clozapine	5-hydroxytryptamine receptor 1A	target
Clozapine	5-hydroxytryptamine receptor 2C	target
Clozapine	Dopamine D1 receptor	target
Clozapine	Cytochrome P450 1A2	enzyme
Clozapine	Cytochrome P450 2D6	enzyme
Clozapine	Dopamine D3 receptor	target
Clozapine	Muscarinic acetylcholine receptor M1	target
Clozapine	Muscarinic acetylcholine receptor M2	target
Clozapine	Muscarinic acetylcholine receptor M3	target
Clozapine	Muscarinic acetylcholine receptor M4	target
Clozapine	Muscarinic acetylcholine receptor M5	target
Clozapine	5-hydroxytryptamine receptor 1B	target
Clozapine	5-hydroxytryptamine receptor 1D	target
Clozapine	5-hydroxytryptamine receptor 1E	target
Clozapine	5-hydroxytryptamine receptor 3A	target
Clozapine	5-hydroxytryptamine receptor 6	target
Clozapine	5-hydroxytryptamine receptor 7	target
Clozapine	Alpha-1A adrenergic receptor	target
Clozapine	Alpha-1B adrenergic receptor	target
Clozapine	Alpha-2A adrenergic receptor	target
Clozapine	Alpha-2B adrenergic receptor	target
Clozapine	Alpha-2C adrenergic receptor	target
Clozapine	Cytochrome P450 2C9	enzyme
Clozapine	P-glycoprotein 1	transporter
Clozapine	Cytochrome P450 3A4	enzyme
Clozapine	Cytochrome P450 2C19	enzyme
Clozapine	Dimethylaniline monooxygenase [N-oxide-forming] 3	enzyme
Clozapine	UDP-glucuronosyltransferase 1-4	enzyme
Clozapine	Cytochrome P450 1A1	enzyme
Clozapine	Cytochrome P450 2A6	enzyme
Clozapine	Cytochrome P450 2C8	enzyme
Clozapine	Glutathione S-transferase P	target
Clozapine	Alpha-1-acid glycoprotein 1	carrier
Clozapine	Serum albumin	carrier
Clozapine	Dopamine D5 receptor	target
Clozapine	Gamma-aminobutyric acid type B receptor subunit 1	target
Clozapine	Gamma-aminobutyric acid type B receptor subunit 2	target
Clozapine	Solute carrier family 22 member 1	transporter
Clozapine	Solute carrier family 22 member 2	transporter
Clozapine	Solute carrier family 22 member 3	transporter
Clozapine	Gamma-aminobutyric acid receptor subunit alpha-1	target
Clozapine	Gamma-aminobutyric acid receptor subunit beta-1	target
Clozapine	Gamma-aminobutyric acid receptor subunit gamma-1	target
Troglitazone	Peroxisome proliferator-activated receptor gamma	target
Troglitazone	Long-chain-fatty-acid--CoA ligase 4	target
Troglitazone	Plasminogen activator inhibitor 1	target
Troglitazone	Equilibrative nucleoside transporter 1	target
Troglitazone	Cytochrome P450 3A4	enzyme
Troglitazone	Cytochrome P450 2C19	enzyme
Troglitazone	UDP-glucuronosyltransferase 1-1	enzyme
Troglitazone	Cytochrome P450 2C8	enzyme
Troglitazone	Bile salt export pump	transporter
Troglitazone	Solute carrier organic anion transporter family member 1B1	transporter
Troglitazone	Estrogen-related receptor gamma	target
Troglitazone	Steroid hormone receptor ERR1	target
Troglitazone	Cytochrome P450 19A1	enzyme
Troglitazone	Cytochrome P450 1A1	enzyme
Troglitazone	Cytochrome P450 2B6	enzyme
Troglitazone	Cytochrome P450 2C9	enzyme
Troglitazone	Cytochrome P450 3A5	enzyme
Troglitazone	Cytochrome P450 3A7	enzyme
Troglitazone	UDP-glucuronosyltransferase 1-3	enzyme
Troglitazone	UDP-glucuronosyltransferase 1-4	enzyme
Troglitazone	UDP-glucuronosyltransferase 1-6	enzyme
Troglitazone	UDP-glucuronosyltransferase 1-7	enzyme
Troglitazone	UDP-glucuronosyltransferase 1-8	enzyme
Troglitazone	UDP-glucuronosyltransferase 1-9	enzyme
Troglitazone	UDP-glucuronosyltransferase 1-10	enzyme
Troglitazone	UDP-glucuronosyltransferase 2B7	enzyme
Troglitazone	UDP-glucuronosyltransferase 2B15	enzyme
Troglitazone	Peroxisome proliferator-activated receptor delta	target
Troglitazone	Peroxisome proliferator-activated receptor alpha	target
Troglitazone	Glutathione S-transferase P	target
Ezogabine	Potassium voltage-gated channel subfamily KQT member 2	target
Ezogabine	Potassium voltage-gated channel subfamily KQT member 3	target
Ezogabine	Potassium voltage-gated channel subfamily KQT member 4	target
Ezogabine	Potassium voltage-gated channel subfamily KQT member 5	target
Ezogabine	UDP-glucuronosyltransferase 1-1	enzyme
Ezogabine	UDP-glucuronosyltransferase 1-3	enzyme
Ezogabine	UDP-glucuronosyltransferase 1-4	enzyme
Ezogabine	UDP-glucuronosyltransferase 1-9	enzyme
Ezogabine	Arylamine N-acetyltransferase 2	enzyme
Asenapine	5-hydroxytryptamine receptor 1A	target
Asenapine	5-hydroxytryptamine receptor 1B	target
Asenapine	5-hydroxytryptamine receptor 2A	target
Asenapine	5-hydroxytryptamine receptor 2B	target
Asenapine	5-hydroxytryptamine receptor 2C	target
Asenapine	5-hydroxytryptamine receptor 6	target
Asenapine	5-hydroxytryptamine receptor 7	target
Asenapine	Alpha-2A adrenergic receptor	target
Asenapine	Alpha-2B adrenergic receptor	target
Asenapine	Alpha-2C adrenergic receptor	target
Asenapine	Alpha-1A adrenergic receptor	target
Asenapine	Dopamine D1 receptor	target
Asenapine	Dopamine D2 receptor	target
Asenapine	Dopamine D3 receptor	target
Asenapine	Dopamine D4 receptor	target
Asenapine	Histamine H1 receptor	target
Asenapine	Histamine H2 receptor	target
Asenapine	Cytochrome P450 1A2	enzyme
Asenapine	Cytochrome P450 2D6	enzyme
Asenapine	5-hydroxytryptamine receptor 5A	target
Asenapine	UDP-glucuronosyltransferase 1-4	enzyme
Asenapine	Cytochrome P450 3A4	enzyme
Asenapine	Beta-1 adrenergic receptor	target
Asenapine	Beta-2 adrenergic receptor	target
Asenapine	Serum albumin	carrier
Asenapine	alpha1-acid glycoprotein	carrier
Midazolam	Cytochrome P450 3A4	enzyme
Midazolam	Cytochrome P450 3A5	enzyme
Midazolam	UDP-glucuronosyltransferase 1-4	enzyme
Midazolam	Cytochrome P450 3A7	enzyme
Midazolam	GABA(A) Receptor	target
Midazolam	GABA(A) Receptor Benzodiazepine Binding Site	target
Midazolam	P-glycoprotein 1	transporter
Midazolam	Serum albumin	carrier
Midazolam	Alpha-1-acid glycoprotein 1	carrier
Midazolam	Adenosine receptor A2a	target
Midazolam	Excitatory amino acid transporter 2	transporter
Midazolam	UDP-glucuronosyltransferase 2B7	enzyme
Midazolam	UDP-glucuronosyltransferase 2B4	enzyme
Valproic acid	Histone deacetylase 9	target
Valproic acid	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	target
Valproic acid	Cytochrome P450 2A6	enzyme
Valproic acid	Cytochrome P450 2B6	enzyme
Valproic acid	Cytochrome P450 2C9	enzyme
Valproic acid	Solute carrier family 22 member 5	transporter
Valproic acid	Solute carrier family 22 member 6	transporter
Valproic acid	Solute carrier family 22 member 8	transporter
Valproic acid	Monocarboxylate transporter 1	transporter
Valproic acid	Solute carrier family 22 member 7	transporter
Valproic acid	Cytochrome P450 3A5	enzyme
Valproic acid	UDP-glucuronosyltransferase 1-9	enzyme
Valproic acid	Prostaglandin G/H synthase 1	enzyme
Valproic acid	Cytochrome P450 1A2	enzyme
Valproic acid	Cytochrome P450 2C19	enzyme
Valproic acid	Cytochrome P450 3A4	enzyme
Valproic acid	UDP-glucuronosyltransferase 1-4	enzyme
Valproic acid	UDP-glucuronosyltransferase 1-8	enzyme
Valproic acid	UDP-glucuronosyltransferase 1-10	enzyme
Valproic acid	UDP-glucuronosyltransferase 1-6	enzyme
Valproic acid	UDP-glucuronosyltransferase 1-3	enzyme
Valproic acid	UDP-glucuronosyltransferase 2B7	enzyme
Valproic acid	UDP-glucuronosyltransferase 2B15	enzyme
Valproic acid	2-oxoglutarate dehydrogenase, mitochondrial	target
Valproic acid	Succinate-semialdehyde dehydrogenase, mitochondrial	target
Valproic acid	Sodium channel protein	target
Valproic acid	Histone deacetylase 2	target
Valproic acid	Peroxisome proliferator-activated receptor alpha	target
Valproic acid	Peroxisome proliferator-activated receptor delta	target
Valproic acid	Peroxisome proliferator-activated receptor gamma	target
Valproic acid	Serum albumin	carrier
Valproic acid	UDP-glucuronosyltransferase 1-1	enzyme
Valproic acid	Solute carrier organic anion transporter family member 2B1	transporter
Valproic acid	Histone deacetylase	target
Valproic acid	Cyclin-dependent kinase inhibitor 1	target
Valproic acid	Hepatocyte growth factor	target
Valproic acid	Ornithine decarboxylase	target
Valproic acid	Programmed cell death 1 ligand 1	target
Imidafenacin	Muscarinic acetylcholine receptor M1	target
Imidafenacin	Muscarinic acetylcholine receptor M2	target
Imidafenacin	Muscarinic acetylcholine receptor M3	target
Imidafenacin	Cytochrome P450 3A4	enzyme
Imidafenacin	UDP-glucuronosyltransferase 1-4	enzyme
Imidafenacin	Serum albumin	carrier
Imidafenacin	alpha1-acid glycoprotein	carrier
Enasidenib	Cytochrome P450 1A2	enzyme
Enasidenib	Cytochrome P450 2B6	enzyme
Enasidenib	Isocitrate dehydrogenase [NADP], mitochondrial	target
Enasidenib	Cytochrome P450 2C8	enzyme
Enasidenib	Cytochrome P450 2C9	enzyme
Enasidenib	Cytochrome P450 2C19	enzyme
Enasidenib	Cytochrome P450 2D6	enzyme
Enasidenib	Cytochrome P450 3A4	enzyme
Enasidenib	UDP-glucuronosyltransferase 1-1	enzyme
Enasidenib	UDP-glucuronosyltransferase 1-3	enzyme
Enasidenib	UDP-glucuronosyltransferase 1-4	enzyme
Enasidenib	UDP-glucuronosyltransferase 1-9	enzyme
Enasidenib	UDP-glucuronosyltransferase 2B7	enzyme
Enasidenib	UDP-glucuronosyltransferase 2B15	enzyme
Enasidenib	P-glycoprotein 1	transporter
Enasidenib	ATP-binding cassette sub-family G member 2	transporter
Enasidenib	Solute carrier family 22 member 6	transporter
Enasidenib	Solute carrier organic anion transporter family member 1B1	transporter
Enasidenib	Solute carrier family 22 member 2	transporter
Enasidenib	Solute carrier organic anion transporter family member 1B3	transporter
Enasidenib	Solute carrier family 22 member 8	transporter
Olanzapine	Dopamine D1 receptor	target
Olanzapine	Muscarinic acetylcholine receptor M1	target
Olanzapine	Muscarinic acetylcholine receptor M3	target
Olanzapine	5-hydroxytryptamine receptor 2A	target
Olanzapine	Dopamine D4 receptor	target
Olanzapine	Histamine H1 receptor	target
Olanzapine	Muscarinic acetylcholine receptor M4	target
Olanzapine	Muscarinic acetylcholine receptor M2	target
Olanzapine	Dopamine D2 receptor	target
Olanzapine	5-hydroxytryptamine receptor 2C	target
Olanzapine	Dopamine D3 receptor	target
Olanzapine	Alpha-1B adrenergic receptor	target
Olanzapine	Cytochrome P450 1A2	enzyme
Olanzapine	5-hydroxytryptamine receptor 3A	target
Olanzapine	5-hydroxytryptamine receptor 6	target
Olanzapine	Alpha-1A adrenergic receptor	target
Olanzapine	Dopamine D5 receptor	target
Olanzapine	Serum albumin	carrier
Olanzapine	Alpha-1-acid glycoprotein 1	carrier
Olanzapine	Dimethylaniline monooxygenase [N-oxide-forming] 3	enzyme
Olanzapine	Cytochrome P450 2D6	enzyme
Olanzapine	P-glycoprotein 1	transporter
Olanzapine	Cytochrome P450 2C19	enzyme
Olanzapine	D(1) dopamine receptor	target
Olanzapine	Beta adrenergic receptor	target
Olanzapine	5-hydroxytryptamine receptor 1	target
Olanzapine	GABA(A) Receptor Benzodiazepine Binding Site	target
Olanzapine	Cytochrome P450 2C9	enzyme
Olanzapine	UDP-glucuronosyltransferase 1-4	enzyme
Olanzapine	Cytochrome P450 3A4	enzyme
Olanzapine	Cytochrome P450 3A Subfamily	enzyme
Pexidartinib	Cytochrome P450 3A4	enzyme
Pexidartinib	UDP-glucuronosyltransferase 1-4	enzyme
Pexidartinib	Macrophage colony-stimulating factor 1 receptor	target
Pexidartinib	Cytochrome P450 2B6	enzyme
Pexidartinib	Cytochrome P450 2C9	enzyme
Pexidartinib	UDP-glucuronosyltransferase 1-1	enzyme
Pexidartinib	Multidrug and toxin extrusion protein 1	transporter
Pexidartinib	Multidrug and toxin extrusion protein 2	transporter
Pexidartinib	Solute carrier organic anion transporter family member 1B1	transporter
Pexidartinib	Solute carrier organic anion transporter family member 1B3	transporter
Pexidartinib	Solute carrier organic anion transporter family member 2B1	transporter
Pexidartinib	Serum albumin	carrier
Pexidartinib	Alpha-1-acid glycoprotein 1	carrier
Pexidartinib	Mast/stem cell growth factor receptor Kit	target
Pexidartinib	Receptor-type tyrosine-protein kinase FLT3	target
Pexidartinib	Platelet-derived growth factor receptor beta	target
Idelalisib	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	target
Idelalisib	ATP-binding cassette sub-family G member 2	transporter
Idelalisib	P-glycoprotein 1	transporter
Idelalisib	Aldehyde oxidase	enzyme
Idelalisib	Cytochrome P450 2C8	enzyme
Idelalisib	Cytochrome P450 2C19	enzyme
Idelalisib	Cytochrome P450 2B6	enzyme
Idelalisib	Cytochrome P450 3A4	enzyme
Idelalisib	Solute carrier organic anion transporter family member 1B1	transporter
Idelalisib	Solute carrier organic anion transporter family member 1B3	transporter
Idelalisib	Cytochrome P450 3A5	enzyme
Idelalisib	Cytochrome P450 3A43	enzyme
Idelalisib	Cytochrome P450 3A7	enzyme
Idelalisib	UDP-glucuronosyltransferase 1-4	enzyme
Cyclobenzaprine	5-hydroxytryptamine receptor 2A	target
Cyclobenzaprine	Cytochrome P450 1A2	enzyme
Cyclobenzaprine	Cytochrome P450 3A4	enzyme
Cyclobenzaprine	Cytochrome P450 2D6	enzyme
Cyclobenzaprine	Serum albumin	carrier
Cyclobenzaprine	UDP-glucuronosyltransferase 1-4	enzyme
Cyclobenzaprine	UDP-glucuronosyltransferase 2B10	enzyme
Cyclobenzaprine	5-hydroxytryptamine receptor 2B	target
Cyclobenzaprine	5-hydroxytryptamine receptor 2C	target
Cyclobenzaprine	5-hydroxytryptamine receptor 7	target
Cyclobenzaprine	5-hydroxytryptamine receptor 6	target
Cyclobenzaprine	Sodium-dependent serotonin transporter	target
Cyclobenzaprine	Sodium-dependent noradrenaline transporter	target
Cyclobenzaprine	Toll-like receptor 4	target
Cyclobenzaprine	Aldehyde oxidase	target
Tecovirimat	Envelope protein F13	target
Tecovirimat	UDP-glucuronosyltransferase 1-1	enzyme
Tecovirimat	UDP-glucuronosyltransferase 1-4	enzyme
Tecovirimat	Cytochrome P450 3A4	enzyme
Tecovirimat	Cytochrome P450 2C8	enzyme
Tecovirimat	Cytochrome P450 2C19	enzyme
Tecovirimat	UDP-glucuronosyltransferase 1-3	enzyme
Tecovirimat	ATP-binding cassette sub-family G member 2	transporter
Tecovirimat	Cytochrome P450 2B6	enzyme
Anastrozole	Cytochrome P450 19A1	target
Anastrozole	P-glycoprotein 1	transporter
Anastrozole	Cytochrome P450 3A4	enzyme
Anastrozole	Cytochrome P450 3A5	enzyme
Anastrozole	Cytochrome P450 2C8	enzyme
Anastrozole	UDP-glucuronosyltransferase 1-4	enzyme
Anastrozole	UDP-glucuronosyltransferase 1-3	enzyme
Anastrozole	UDP-glucuronosyltransferase 2B7	enzyme
Anastrozole	Cytochrome P450 1A2	enzyme
Anastrozole	Cytochrome P450 2C9	enzyme
Amitriptyline	Sodium-dependent serotonin transporter	target
Amitriptyline	Sodium-dependent noradrenaline transporter	target
Amitriptyline	Potassium voltage-gated channel subfamily KQT member 2	target
Amitriptyline	Alpha-2A adrenergic receptor	target
Amitriptyline	Cytochrome P450 1A2	enzyme
Amitriptyline	Cytochrome P450 2C19	enzyme
Amitriptyline	Cytochrome P450 2D6	enzyme
Amitriptyline	Serum albumin	carrier
Amitriptyline	Alpha-1-acid glycoprotein 1	carrier
Amitriptyline	Histamine H1 receptor	target
Amitriptyline	5-hydroxytryptamine receptor 2A	target
Amitriptyline	5-hydroxytryptamine receptor 1A	target
Amitriptyline	Alpha-1A adrenergic receptor	target
Amitriptyline	Cytochrome P450 3A4	enzyme
Amitriptyline	Cytochrome P450 3A5	enzyme
Amitriptyline	Potassium voltage-gated channel subfamily A member 1	target
Amitriptyline	Alpha-1D adrenergic receptor	target
Amitriptyline	Delta-type opioid receptor	target
Amitriptyline	Kappa-type opioid receptor	target
Amitriptyline	High affinity nerve growth factor receptor	target
Amitriptyline	BDNF/NT-3 growth factors receptor	target
Amitriptyline	Cytochrome P450 2C9	enzyme
Amitriptyline	Cytochrome P450 2B6	enzyme
Amitriptyline	Cytochrome P450 2C8	enzyme
Amitriptyline	Histamine H2 receptor	target
Amitriptyline	Histamine H4 receptor	target
Amitriptyline	Sigma non-opioid intracellular receptor 1	target
Amitriptyline	5-hydroxytryptamine receptor 2C	target
Amitriptyline	Alpha-1B adrenergic receptor	target
Amitriptyline	5-hydroxytryptamine receptor 7	target
Amitriptyline	5-hydroxytryptamine receptor 1D	target
Amitriptyline	Mu-type opioid receptor	target
Amitriptyline	5-hydroxytryptamine receptor 1B	target
Amitriptyline	5-hydroxytryptamine receptor 6	target
Amitriptyline	Potassium voltage-gated channel subfamily KQT member 3	target
Amitriptyline	UDP-glucuronosyltransferase 2B10	enzyme
Amitriptyline	5-hydroxytryptamine receptor 1C	target
Amitriptyline	Muscarinic acetylcholine receptor	target
Amitriptyline	HERG human cardiac K+ channel	target
Amitriptyline	P-glycoprotein 1	transporter
Amitriptyline	UDP-glucuronosyltransferase 1-4	enzyme
Amitriptyline	Glutathione S-transferases (Cytosolic)	enzyme
Lumateperone	5-hydroxytryptamine receptor 2A	target
Lumateperone	Dopamine D2 receptor	target
Lumateperone	Dopamine D1 receptor	target
Lumateperone	Sodium-dependent serotonin transporter	target
Lumateperone	Glutamate receptor ionotropic, NMDA 2B	target
Lumateperone	Aldo-keto reductase family	enzyme
Lumateperone	Cytochrome P450 3A4	enzyme
Lumateperone	Cytochrome P450 2C8	enzyme
Lumateperone	Cytochrome P450 1A2	enzyme
Lumateperone	UDP-glucuronosyltransferase 1-1	enzyme
Lumateperone	UDP-glucuronosyltransferase 1-4	enzyme
Lumateperone	UDP-glucuronosyltransferase 2B15	enzyme
Lumateperone	Aldo-keto reductase family 1 member C1	enzyme
Lumateperone	Aldo-keto reductase family 1 member B10	enzyme
Lumateperone	Aldo-keto reductase family 1 member C4	enzyme
Phenytoin	Sodium channel protein type 5 subunit alpha	target
Phenytoin	Sodium channel protein type 1 subunit alpha	target
Phenytoin	Cytochrome P450 2C8	enzyme
Phenytoin	Cytochrome P450 2C19	enzyme
Phenytoin	Cytochrome P450 2C9	enzyme
Phenytoin	Cytochrome P450 2B6	enzyme
Phenytoin	Cytochrome P450 3A5	enzyme
Phenytoin	Serum albumin	carrier
Phenytoin	Cytochrome P450 3A4	enzyme
Phenytoin	Solute carrier organic anion transporter family member 1C1	transporter
Phenytoin	P-glycoprotein 1	transporter
Phenytoin	Canalicular multispecific organic anion transporter 1	transporter
Phenytoin	Cytochrome P450 11B1, mitochondrial	enzyme
Phenytoin	Cytochrome P450 3A7	enzyme
Phenytoin	Nuclear receptor subfamily 1 group I member 2	target
Phenytoin	Sodium channel subunit beta-1	target
Phenytoin	Sodium channel protein type 3 subunit alpha	target
Phenytoin	UDP-glucuronosyltransferase 1-1	enzyme
Phenytoin	UDP-glucuronosyltransferase 1-6	enzyme
Phenytoin	UDP-glucuronosyltransferase 1-9	enzyme
Phenytoin	Thyroxine-binding globulin	carrier
Phenytoin	Potassium voltage-gated channel subfamily H member 2	target
Phenytoin	Voltage-dependent L-type calcium channel	target
Phenytoin	Sodium channel protein type 2 subunit alpha	target
Phenytoin	Sodium channel protein type 8 subunit alpha	target
Phenytoin	GABA(A) Receptor	target
Phenytoin	Cytochrome P450 1A2	enzyme
Phenytoin	Cytochrome P450 2A6	enzyme
Phenytoin	Cytochrome P450 2D6	enzyme
Phenytoin	Cytochrome P450 2E1	enzyme
Phenytoin	Epoxide hydrolase 1	enzyme
Phenytoin	UDP-glucuronosyltransferase 1-4	enzyme
Phenytoin	Catechol O-methyltransferase	enzyme
Phenytoin	NAD(P)H dehydrogenase [quinone] 1	enzyme
Phenytoin	Cytochrome P450 2C18	enzyme
Ethinylestradiol	Estrogen receptor alpha	target
Ethinylestradiol	Nuclear receptor subfamily 1 group I member 2	target
Ethinylestradiol	Cytochrome P450 3A4	enzyme
Ethinylestradiol	Cytochrome P450 2C8	enzyme
Ethinylestradiol	Bile salt export pump	transporter
Ethinylestradiol	Sodium/bile acid cotransporter	transporter
Ethinylestradiol	Canalicular multispecific organic anion transporter 1	transporter
Ethinylestradiol	P-glycoprotein 1	transporter
Ethinylestradiol	UDP-glucuronosyltransferase 1-1	enzyme
Ethinylestradiol	Cytochrome P450 2C19	enzyme
Ethinylestradiol	UDP-glucuronosyltransferase 1-4	enzyme
Ethinylestradiol	UDP-glucuronosyltransferase 1-9	enzyme
Ethinylestradiol	Cytochrome P450 2C9	enzyme
Ethinylestradiol	Cytochrome P450 1A2	enzyme
Ethinylestradiol	Estrogen sulfotransferase	enzyme
Ethinylestradiol	Sulfotransferase 1A3/1A4	enzyme
Ethinylestradiol	Cytochrome P450 3A5	enzyme
Ethinylestradiol	UDP-glucuronosyltransferase 2B7	enzyme
Ethinylestradiol	UDP-glucuronosyltransferase 1-3	enzyme
Ethinylestradiol	Catechol O-methyltransferase	enzyme
Ethinylestradiol	Solute carrier organic anion transporter family member 1A2	transporter
Ethinylestradiol	Serum albumin	carrier
Ethinylestradiol	Sex hormone-binding globulin	carrier
Osilodrostat	Cytochrome P450 11B1, mitochondrial	target
Osilodrostat	Cytochrome P450 11B2, mitochondrial	target
Osilodrostat	Cytochrome P450 3A4	enzyme
Osilodrostat	Cytochrome P450 2B6	enzyme
Osilodrostat	Cytochrome P450 2D6	enzyme
Osilodrostat	UDP-glucuronosyltransferase 1-4	enzyme
Osilodrostat	UDP-glucuronosyltransferase 2B7	enzyme
Osilodrostat	UDP-glucuronosyltransferase 2B10	enzyme
Osilodrostat	Cytochrome P450 3A5	enzyme
Osilodrostat	Cytochrome P450 1A2	enzyme
Osilodrostat	Cytochrome P450 2C19	enzyme
Osilodrostat	Cytochrome P450 2E1	enzyme
Osilodrostat	UDP-glucuronosyltransferase 1A1	enzyme
Osilodrostat	Solute carrier organic anion transporter family member 1B1	transporter
Osilodrostat	Solute carrier family 22 member 1	transporter
Osilodrostat	Solute carrier family 22 member 2	transporter
Osilodrostat	Solute carrier family 22 member 6	transporter
Osilodrostat	Solute carrier family 22 member 8	transporter
Osilodrostat	Multidrug and toxin extrusion protein 1	transporter
Bazedoxifene	Estrogen receptor alpha	target
Bazedoxifene	UDP-glucuronosyltransferase 1-4	enzyme
Bazedoxifene	Estrogen receptor beta	target
Bazedoxifene	UDP-glucuronosyltransferase 1-8	enzyme
Bazedoxifene	UDP-glucuronosyltransferase 1-10	enzyme
Ketotifen	Histamine H1 receptor	target
Ketotifen	6-phosphogluconate dehydrogenase, decarboxylating	target
Ketotifen	UDP-glucuronosyltransferase 1-3	enzyme
Ketotifen	UDP-glucuronosyltransferase 1-4	enzyme
Ketotifen	UDP-glucuronosyltransferase 2B10	enzyme
Cyproheptadine	5-hydroxytryptamine receptor 2A	target
Cyproheptadine	Histamine H1 receptor	target
Cyproheptadine	Muscarinic acetylcholine receptor M1	target
Cyproheptadine	Muscarinic acetylcholine receptor M2	target
Cyproheptadine	Muscarinic acetylcholine receptor M3	target
Cyproheptadine	5-hydroxytryptamine receptor 2C	target
Cyproheptadine	UDP-glucuronosyltransferase 1-3	enzyme
Cyproheptadine	5-hydroxytryptamine receptor 7	target
Cyproheptadine	UDP-glucuronosyltransferase 2B10	enzyme
Cyproheptadine	UDP-glucuronosyltransferase 1-4	enzyme
Cyproheptadine	5-hydroxytryptamine receptor 2B	target
Cyproheptadine	Histamine H2 receptor	target
Cyproheptadine	Solute carrier family 22 member 1	transporter
Cyproheptadine	Serum albumin	carrier
Nandrolone decanoate	Androgen receptor	target
Nandrolone decanoate	Cytochrome P450 19A1	enzyme
Nandrolone decanoate	Amine oxidase [flavin-containing] B	enzyme
Nandrolone decanoate	Amine oxidase [flavin-containing] A	enzyme
Nandrolone decanoate	Proto-oncogene c-Fos	target
Nandrolone decanoate	5-hydroxytryptamine 2 receptor	target
Nandrolone decanoate	5-hydroxytryptamine receptor 1B	target
Nandrolone decanoate	Insulin-like growth factor 1 receptor	target
Nandrolone decanoate	Dopamine receptor	target
Nandrolone decanoate	UDP-glucuronosyltransferase 2B7	enzyme
Nandrolone decanoate	UDP-glucuronosyltransferase 1-4	enzyme
Nandrolone decanoate	UDP-glucuronosyltransferase 2B4	enzyme
Nandrolone decanoate	UDP-glucuronosyltransferase 1-3	enzyme
Nandrolone decanoate	UDP-glucuronosyltransferase 1-1	enzyme
Nandrolone decanoate	UDP-glucuronosyltransferase 1-10	enzyme
Nandrolone decanoate	Sex hormone-binding globulin	carrier