Insulin Secretagogues

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Name: Insulin Secretagogues
Accession Number: DBCAT005661
Description: Agents that stimulate the secretion of insulin.
Drugs: Drug Drug Description
Acetohexamide Used in the management of diabetes mellitus type 2 (adult-onset).
Carbutamide Not Annotated
Chlorpropamide A sulfonylurea used in the treatment of non insulin dependent diabetes mellitus.
Glibornuride Glibornuride is a sulfonylurea-type anti-diabetic drug.
Gliclazide A sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus.
Glimepiride A sulfonylurea drug used to treat type 2 diabetes mellitus.
Glipizide A sulfonylurea medication used in Type 2 Diabetes to sensitize pancreatic beta cells and stimulate insulin release.
Gliquidone A sulfonylurea drug used in the management of diabetes mellitus type 2.
Glisoxepide For the treatment of diabetes mellitus type 2.
Glyburide A sulfonylurea used in the treatment of non insulin dependent diabetes mellitus.
Metahexamide Not Annotated
Nateglinide A meglitinide used to treat non insulin dependent diabetes mellitus.
Repaglinide A antihyperglycemic used to improve glycemic control in diabetes.
Tolazamide A sulfonylurea used in the treatment of non insulin dependent diabetes mellitus.
Tolbutamide A sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus.
Drugs & Drug Targets: Drug Target Type
Acetohexamide ATP-binding cassette sub-family C member 8 target
Acetohexamide Cytochrome P450 2C9 enzyme
Acetohexamide Albumin carrier
Acetohexamide Carbonyl reductase [NADPH] 1 enzyme
Acetohexamide ATP-sensitive inward rectifier potassium channel 1 target
Carbutamide Albumin carrier
Carbutamide Cytochrome P450 2C9 enzyme
Chlorpropamide ATP-binding cassette sub-family C member 8 target
Chlorpropamide Solute carrier family 15 member 1 transporter
Chlorpropamide Solute carrier family 15 member 2 transporter
Chlorpropamide Solute carrier family 22 member 6 transporter
Chlorpropamide Cytochrome P450 2C9 enzyme
Chlorpropamide Cytochrome P450 2C19 enzyme
Chlorpropamide Prostaglandin G/H synthase 1 enzyme
Chlorpropamide ATP-sensitive inward rectifier potassium channel 10 target
Glibornuride Cytochrome P450 2C9 enzyme
Gliclazide Cytochrome P450 2C19 enzyme
Gliclazide Cytochrome P450 2C9 enzyme
Gliclazide Vascular endothelial growth factor A, long form target
Gliclazide Albumin carrier
Gliclazide ATP-binding cassette sub-family C member 8 target
Glimepiride ATP-binding cassette sub-family C member 9 target
Glimepiride Bile salt export pump transporter
Glimepiride ATP-binding cassette sub-family C member 8 target
Glimepiride Cytochrome P450 2C9 enzyme
Glimepiride ATP-sensitive inward rectifier potassium channel 11 target
Glimepiride ATP-sensitive inward rectifier potassium channel 1 target
Glipizide ATP-sensitive inward rectifier potassium channel 10 target
Glipizide Albumin carrier
Glipizide Bile salt export pump transporter
Glipizide Cytochrome P450 2C9 enzyme
Glipizide Peroxisome proliferator-activated receptor gamma target
Glipizide ATP-binding cassette sub-family C member 8 target
Glipizide UDP-glucuronosyltransferase 1A1 enzyme
Gliquidone ATP-sensitive inward rectifier potassium channel 10 target
Gliquidone Cytochrome P450 2C9 enzyme
Gliquidone ATP-sensitive inward rectifier potassium channel 8 target
Gliquidone ATP-binding cassette sub-family C member 8 target
Glisoxepide ATP-sensitive inward rectifier potassium channel 10 target
Glisoxepide Insulin target
Glisoxepide Cytochrome P450 2C9 enzyme
Glisoxepide ATP-sensitive inward rectifier potassium channel 8 target
Glyburide ATP-binding cassette sub-family C member 8 target
Glyburide Transient receptor potential cation channel subfamily M member 4 target
Glyburide Cytochrome P450 3A5 enzyme
Glyburide Multidrug resistance-associated protein 1 transporter
Glyburide ATP-dependent translocase ABCB1 transporter
Glyburide Bile salt export pump transporter
Glyburide ATP-binding cassette sub-family C member 3 transporter
Glyburide Cytochrome P450 2C9 enzyme
Glyburide Cytochrome P450 3A7 enzyme
Glyburide Carnitine O-palmitoyltransferase 1, liver isoform target
Glyburide Mitochondrial ATP-sensitive potassium channel target
Glyburide Albumin carrier
Glyburide Solute carrier organic anion transporter family member 1A2 transporter
Glyburide Solute carrier family 15 member 1 transporter
Glyburide Solute carrier family 15 member 2 transporter
Glyburide Solute carrier family 22 member 6 transporter
Glyburide ATP-binding cassette sub-family C member 2 transporter
Glyburide Broad substrate specificity ATP-binding cassette transporter ABCG2 transporter
Glyburide Solute carrier family 22 member 7 transporter
Glyburide Solute carrier organic anion transporter family member 2B1 transporter
Glyburide Cytochrome P450 2C19 enzyme
Glyburide Cytochrome P450 3A4 enzyme
Glyburide ATP-binding cassette sub-family C member 9 target
Glyburide Bile salt export pump target
Glyburide Phospholipid-transporting ATPase ABCA1 target
Glyburide Cystic fibrosis transmembrane conductance regulator target
Glyburide Sulfonylurea receptor 1, Kir6.2 target
Metahexamide Cytochrome P450 2C9 enzyme
Nateglinide Cytochrome P450 3A5 enzyme
Nateglinide Cytochrome P450 3A7 enzyme
Nateglinide Solute carrier family 15 member 1 transporter
Nateglinide Peroxisome proliferator-activated receptor gamma target
Nateglinide Solute carrier family 22 member 6 transporter
Nateglinide Monocarboxylate transporter 1 transporter
Nateglinide Prostaglandin G/H synthase 1 enzyme
Nateglinide UDP-glucuronosyltransferase 1A9 enzyme
Nateglinide Cytochrome P450 2D6 enzyme
Nateglinide ATP-binding cassette sub-family C member 4 transporter
Nateglinide Albumin carrier
Nateglinide Alpha-1-acid glycoprotein 1 carrier
Nateglinide Cytochrome P450 2C9 enzyme
Nateglinide Cytochrome P450 3A4 enzyme
Nateglinide ATP-binding cassette sub-family C member 8 target
Nateglinide Solute carrier family 15 member 2 transporter
Repaglinide ATP-binding cassette sub-family C member 9 target
Repaglinide ATP-binding cassette sub-family C member 8 target
Repaglinide Cytochrome P450 2C8 enzyme
Repaglinide Peroxisome proliferator-activated receptor gamma target
Repaglinide Cytochrome P450 3A4 enzyme
Repaglinide Albumin carrier
Repaglinide Solute carrier organic anion transporter family member 1B1 transporter
Repaglinide Bile salt export pump transporter
Repaglinide Histamine H1 receptor target
Tolazamide Cytochrome P450 2C9 enzyme
Tolazamide ATP-sensitive inward rectifier potassium channel 10 target
Tolazamide Sulfonylurea receptor 1, Kir6.2 target
Tolbutamide ATP-binding cassette sub-family C member 9 target
Tolbutamide Albumin carrier
Tolbutamide Solute carrier organic anion transporter family member 2B1 transporter
Tolbutamide Solute carrier family 22 member 6 transporter
Tolbutamide Solute carrier family 15 member 2 transporter
Tolbutamide Solute carrier organic anion transporter family member 1A2 transporter
Tolbutamide Solute carrier family 15 member 1 transporter
Tolbutamide ATP-binding cassette sub-family C member 8 target
Tolbutamide Cytochrome P450 2C8 enzyme
Tolbutamide Cytochrome P450 2C9 enzyme
Tolbutamide Cytochrome P450 2C19 enzyme
Tolbutamide ATP-sensitive inward rectifier potassium channel 1 target
Tolbutamide Cytochrome P450 2C18 enzyme

Drug	Drug Description
Acetohexamide	Used in the management of diabetes mellitus type 2 (adult-onset).
Carbutamide	Not Annotated
Chlorpropamide	A sulfonylurea used in the treatment of non insulin dependent diabetes mellitus.
Glibornuride	Glibornuride is a sulfonylurea-type anti-diabetic drug.
Gliclazide	A sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus.
Glimepiride	A sulfonylurea drug used to treat type 2 diabetes mellitus.
Glipizide	A sulfonylurea medication used in Type 2 Diabetes to sensitize pancreatic beta cells and stimulate insulin release.
Gliquidone	A sulfonylurea drug used in the management of diabetes mellitus type 2.
Glisoxepide	For the treatment of diabetes mellitus type 2.
Glyburide	A sulfonylurea used in the treatment of non insulin dependent diabetes mellitus.
Metahexamide	Not Annotated
Nateglinide	A meglitinide used to treat non insulin dependent diabetes mellitus.
Repaglinide	A antihyperglycemic used to improve glycemic control in diabetes.
Tolazamide	A sulfonylurea used in the treatment of non insulin dependent diabetes mellitus.
Tolbutamide	A sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus.

Insulin Secretagogues

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