Antidepressive Agents
- Name
- Antidepressive Agents
- Accession Number
- DBCAT000345
- Description
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
- ATC Classification
- Drugs
Drug Drug Description 2,5-Dimethoxy-4-ethylthioamphetamine 2,5-Dimethoxy-4-ethylthioamphetamine (ALEPH-2) is a phenylisopropylamine derivative with alleged anxiolytic and hallucinogenic properties. 4-Bromo-2,5-dimethoxyphenethylamine Not Available 5-methoxy-N,N-dimethyltryptamine 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a tryptamine with psychedelic properties. It is found in a wide variety of plant species, and a single psychoactive toad species, the Colorado River toad. This drug,... 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline Potent reversible inhibitor of phenylethanolamine N-methyltransferase. Acepromazine Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and... Adinazolam For the treatment of anxiety and status epilepticus. Agomelatine Agomelatine is indicated to treat major depressive episodes in adults. Alaproclate Alaproclate was developed as one of the first selective serotonin reuptake inhibitor (SSRI) antidepressants by Astra AB (now AstraZeneca) in the 1970s. Development was discontinued due to concerns over hepatotoxicity... Almotriptan A 5-HT1B/1D receptor agonist used to treat migraines. Alnespirone Alnespirone is a small molecule drug. The usage of the INN stem '-pirone' in the name indicates that Alnespirone is a anxiolytic, buspirone derivative. Alnespirone has a monoisotopic molecular weight... Alosetron A 5-HT3 antagonist used to treat diarrhea-predominant IBS. Alprenolol For the treatment of hypertension, angina, and arrhythmia Altanserin Altanserin is a small molecule drug. The usage of the INN stem '-anserin' in the name indicates that Altanserin is a serotonin receptor antagonist. Altanserin is under investigation in clinical... Alverine A smooth muscle relaxant used to relieve abdominal pain associated with gastrointestinal conditions like heartburn, flatulence, and Irritable Bowel Syndrome. Amesergide Amesergide is a small molecule drug. Amesergide has a monoisotopic molecular weight of 393.28 Da. Amibegron Investigated for use/treatment in depression, irritable bowel syndrome (IBS), and obesity. Amiflamine Amiflamine is a small molecule drug. Amiflamine has a monoisotopic molecular weight of 192.16 Da. Amineptine For the treatment of depression. Amisulpride A dopamine D2 receptor antagonist used in the treatment of acute and chronic schizophrenia, and in the prevention and treatment of postoperative nausea and vomiting in adults. Amitriptyline A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety. Amitriptylinoxide A tricyclic antidepressant indicated in the treatment of depressive disorders. Amoxapine A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression. Amperozide Amperozide is a diphenylbutylpiperazine atypical antipsychotic which antagonizes 5-HT2A receptors. It inhibits dopamine release and alters the firing of dopaminergic neurons. Investigations regarding the use of the agent revolved primarily... Aniracetam A nootropic drug used to ameliorate memory and attention disturbances accompanying cerebrovascular diseases and degenerative brain disorders. Apomorphine A morphine derivative D2 dopamine agonist used to treat hypomobile "off" episodes of advanced Parkinson's disease. Aripiprazole An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome. Aripiprazole lauroxil An antipsychotic used to treat schizophrenia in adults. Asenapine An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia. Azasetron Not Annotated Befiradol Befiradol is under investigation in clinical trial NCT05148884 (Study to Assess the Safety, Tolerability and Preliminary Efficacy of NLX-112 Versus Placebo in L-dopa-induced Dyskinesia). Benactyzine Benactyzine is an anticholinergic drug used as an antidepressant in the treatment of depression and associated anxiety. Benactyzine is no longer widely used in medicine, although it is still a... Benmoxin For the treatment of depression. Benzphetamine A sympathomimetic used to manage exogenous obesity short term. Bifemelane Not Annotated Blonanserin Used for the treatment of schizophrenia . Brexanolone Brexanolone is a synthetic neuroactive steroid gamma-aminobutyric acid A (GABA(a)) receptor positive modulator indicated for the treatment of postpartum depression (PPD) in adult women [FDA Label] . Brexpiprazole A serotonin–dopamine activity modulator used in the treatment of major depressive disorder as an adjunct, schizophrenia, and agitation associated with dementia due to Alzheimer’s disease. Brilaroxazine Investigated for the treatment of schizophrenia and schizoaffective disorder. Brofaromine Not Annotated Brolamfetamine Not Available Bromerguride Bromerguride is a small molecule drug. Bromerguride has a monoisotopic molecular weight of 416.12 Da. Bromocriptine A dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome. Bufotenine A hallucinogenic serotonin analog found in frog or toad skins, mushrooms, higher plants, and mammals, especially in the brains, plasma, and urine of schizophrenics. Bufotenin has been used as a... Bupropion A norepinephrine and dopamine reuptake inhibitor used in the treatment of major depressive disorder (MDD), seasonal affective disorder (SAD), and as an aid to smoking cessation. Buspirone An anxiolytic agent used for short-term treatment of generalized anxiety and second-line treatment of depression. Butanserin Butanserin is a small molecule drug. The usage of the INN stem '-anserin' in the name indicates that Butanserin is a serotonin receptor antagonist. Butanserin has a monoisotopic molecular weight... Butriptyline Butriptyline is a tricyclic antidepressant which has been used in Europe since 1974. It is the isobutyl side chain homologue of amitriptyline. Cabergoline A dopamine receptor agonist used for the treatment of hyperprolactinemic conditions due to various causes. Cannabidiol An active cannabinoid used as an adjunctive treatment for the management of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome and symptomatic relief of moderate to severe neuropathic pain or other painful conditions, like cancer. Captodiame Captodiame is indicated for the treatment of anxiety. Cariprazine An atypical antipsychotic used to treat schizophrenia and acute manic or mixed episodes due to bipolar I disorder. Caroxazone For the treatment of depression. Carphenazine Used in the treatment of acute or chronic schizophrenic reactions in hospitalized patients. Centanafadine A once-daily norepinephrine-dopamine-serotonin reuptake inhibitor and CNS stimulant indicated for ADHD in adults and pediatric patients. Cerlapirdine Cerlapirdine has been investigated for the treatment of Alzheimer Disease. Chlorpheniramine A histamine-H1 receptor antagonist indicated for the management of symptoms associated with upper respiratory allergies. Chlorpromazine A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. Chlorprothixene A thioxanthene antipsychotic. Cianopramine Cianopramine is a small molecule drug. The usage of the INN stem '-pramine' in the name indicates that Cianopramine is a substance of the imipramine group. Cianopramine has a monoisotopic... Cilansetron For the treatment of symptoms associated with irritable bowel syndrome. Cinitapride A benzamide with gastroprokinetic and antiemetic properties typically used for the treatment of gastrointestinal motility disorders such as gastroesophageal reflux disease (GERD), non-ulcer dyspepsia, and delayed gastric emptying. Cisapride A medication used to treat heartburn associated with GERD. Citalopram A selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression. Clomipramine A tricyclic antidepressant used in the treatment of obsessive-compulsive disorder and disorders with an obsessive-compulsive component, such as depression, schizophrenia, and Tourette’s disorder. Clorgiline An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE. Clovoxamine Clovoxamine is a small molecule drug. Clovoxamine has a monoisotopic molecular weight of 284.13 Da. Clozapine An atypical or second-generation antipsychotic drug used in treatment-resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Cotriptyline Cotriptyline is a small molecule drug. Cotriptyline has a monoisotopic molecular weight of 291.16 Da. Cyamemazine Cyamemazine (Tercian), also known as cyamepromazine, is a typical antipsychotic drug of the phenothiazine class used primarily in the treatment of schizophrenia and psychosis-associated anxiety. Cyamemazine actually behaves like an... Cyclobenzaprine A skeletal muscle relaxant that works on the brainstem to treat muscle spasms of local origin. Cyproheptadine A combined serotonin and histamine antagonist used in the treatment of allergic symptoms, for appetite stimulation, and off-label in the treatment of serotonin syndrome. DA-8031 DA-8031 is under investigation in clinical trial NCT01798667 (Clinical Trial to Evaluate the Efficacy and Safety of DA-8031 in Male Patients With Premature Ejaculation). Dapoxetine A selective serotonin reuptake inhibitor used in the treatment of premature ejaculation. Deanol Deanol is commonly referred to as 2-(dimethylamino)ethanol, dimethylaminoethanol (DMAE) or dimethylethanolamine (DMEA). It holds tertiary amine and primary alcohol groups as functional groups. Deanol has been used in the treatment... Deramciclane Investigated for use/treatment in anxiety disorders. Desipramine A tricyclic antidepressant used in the treatment of depression. Desvenlafaxine An antidepressant agent and SNRI used for the treatment of major depressive disorders in adults. Dexfenfluramine For the management of obesity including weight loss and maintenance of weight loss in patients on a reduced calorie diet Dexmethylphenidate A norepinephrine-dopamine reuptake inhibitor used in the treatment of ADHD in conjunction with other therapies. Dextofisopam Investigated for use/treatment in irritable bowel syndrome (IBS). Dextromethorphan An NMDA receptor antagonist used to treat cases of dry cough. Dibenzepin Dibenzepin is approved for use in Europe. Dihydroergotamine An ergot alkaloid used in the acute treatment of migraine headache and cluster headache. Dimetacrine Dimetacrine is also known as dimethacrine or acripamine. It is marketed under the names Istonil, Istonyl, Linostil, and Miroistonil. Dimetacrine is a tricyclic antidepressant (TCA) with imipramine-like effects used in... Dimethyltryptamine Some people use this compound as a psychedelic inducing agent. Dolasetron An antinauseant and antiemetic used in chemotherapy and postoperatively. Dosulepin A tricyclic antidepressant commonly used only in patients for whom alternative therapies are ineffective due to its toxicity potential. Dotarizine A calcium antagonist used to treat and prevent migraines. Doxepin A psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia. Droperidol A butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting. DU125530 DU125530 is under investigation in clinical trial NCT01119430 (Fluoxetine Versus Fluoxetine Plus DU125530 in Major Depressive Disorder). Duloxetine A serotonin norepinephrine reuptake inhibitor used to treat generalized anxiety disorder, neuropathic pain, osteoarthritis, and stress incontinence. Ebalzotan Ebalzotan is a small molecule drug. Ebalzotan has a monoisotopic molecular weight of 318.23 Da. Edivoxetine Edivoxetine is a drug which acts as a selective norepinephrine reuptake inhibitor and is currently under development by Eli Lilly for attention-deficit hyperactivity disorder (ADHD) and as an antidepressant treatment.... Eletriptan A triptan used for the treatment of migraines. Eltoprazine Eltoprazine has been used in trials studying the treatment of Schizophrenia and Cognitive Impairment. Epinastine An H1 receptor antagonist used to prevent itching in allergic conjunctivitis. Eplivanserin Eplivanserin has been used in trials studying the treatment of Sleep, Insomnia, Chronic Pain, Fibromyalgia, and Primary Insomnia, among others. Ergoloid mesylate A nootropic with an unknown mechanism of action indicated in individuals over sixty who manifest signs and symptoms of an idiopathic decline in mental capacity. Ergometrine An ergot alkaloid used for the treatment of postpartum haemorrhage and post abortion hemorrhage in patients with uterine atony. Ergotamine An alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches. Escitalopram A selective serotonin re-uptake inhibitor used in the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), and other select psychiatric disorders such as obsessive-compulsive disorder (OCD). Esketamine A NMDA receptor antagonist used for treatment-resistant depression. Esmirtazapine Investigated for use/treatment in insomnia and sleep disorders. Esreboxetine Esreboxetine has been used in trials studying the treatment and basic science of Fibromyalgia. Etoperidone Etoperidone has been studied for the treatment of depression , tremors in Parkinson, extrapyramidal symptoms and male impotence . It is not certain if it was ever approved and marketed... F-15599 Not Annotated Fananserin Fananserin is a small molecule drug. The usage of the INN stem '-anserin' in the name indicates that Fananserin is a serotonin receptor antagonist. Fananserin has a monoisotopic molecular weight... Felcisetrag Felcisetrag (TD-8954) has been used in trials studying the treatment of Enteral Feeding Intolerance and Gastrointestinal Motility Disorder. Femoxetine Femoxetine is a small molecule drug. Femoxetine has a monoisotopic molecular weight of 311.19 Da. Fenclonine Not Annotated Fenfluramine Fenfluramine is a phenethylamine that is structurally similar to serotonin. Due to its ability to increase extracellular serotonin levels, modulate serotonergic and other neurologic receptors, and control neurotransmission, it is effective in treating pharmacoresistant seizures. Fentanyl An opioid analgesic used in anesthesia, for breakthrough cancer pain, or round the clock pain management. Flesinoxan Flesinoxan is a small molecule drug. The usage of the INN stem '-oxan(e)' in the name indicates that Flesinoxan is a benzodioxane derivative. Flesinoxan has a monoisotopic molecular weight of... Flibanserin A 5-HT receptor modulator used for the treatment of selected premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD). Fluoxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I. Flupentixol A thioxanthene neuroleptic used to treat schizophrenia and depression. Fluphenazine A phenothiazine used to treat patients requiring long-term neuroleptic therapy. Fluspirilene An antipsychotic agent used in the treatment of schizophrenia. Fluvoxamine A selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder. Frovatriptan A 5-HT1B/1D receptor agonist used to treat migraines. Furazolidone A drug for the treatment of infectious diarrhea. Gepirone A serotonin receptor agonist used to treat major depressive disorder in adults Granisetron A 5HT3 antagonist used to treat nausea and vomiting in cancer therapy and postoperatively. GSK-163090 Not Annotated Haloperidol An antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium. Harmaline Not Annotated Harmine Not Available Hydracarbazine Was used for the treatment of hypertension . Hypericin Hypericin is under investigation for the treatment of Cutaneous T-cell Lymphoma. Idalopirdine Idalopirdine has been used in trials studying the treatment of Cognition, Schizophrenia, and Alzheimer's Disease. Iferanserin Iferanserin has been investigated for the treatment of Hemorrhoids. Iloperidone An atypical antipsychotic agent used to treat schizophrenia and manic or mixed episodes associated with bipolar I disorder in adults. Imipramine A tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis. Imipramine oxide Not Annotated Indalpine Indalpine was one of the first selective serotonin reuptake inhibitors to reach the American market. It was initially marketed by Pharmuka. However, after the emergence of widespread concern regarding adverse... Iprazochrome Not Annotated Iprindole Not Annotated Iproclozide For the treatment of depression. Iproniazid For the treatment of depression (originally intended to treat tuberculosis). Ipsapirone Ipsapirone is a small molecule drug. The usage of the INN stem '-pirone' in the name indicates that Ipsapirone is a anxiolytic, buspirone derivative. Ipsapirone has a monoisotopic molecular weight... Isocarboxazid A monoamine oxidase inhibitor used to treat enduring and debilitating symptoms of depression following inadequate clinical response to other antidepressant drugs. Ketanserin Ketanserin has been investigated for the treatment of Septic Shock, Severe Sepsis, and Diabetic Foot Ulcer. Landipirdine Landipirdine is under investigation in clinical trial NCT02258152 (SYN120 Study to Evaluate Its Safety, Tolerability and Efficacy in Parkinson's Disease Dementia (SYNAPSE)). Lanicemine Lanicemine has been used in trials studying the treatment and basic science of Depression, Major Depressive Disorder, and Treatment Resistant Major Depressive Disorder. Lasmiditan An oral 5HT1F agonist used for the acute treatment of migraine headache with or without aura. Lazabemide Lazabemide is a small molecule drug. Lazabemide has a monoisotopic molecular weight of 199.05 Da. Lecozotan Lecozotan has been used in trials studying the treatment of Alzheimer Disease. Levomilnacipran A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder (MDD) in adults. Levotofisopam Levotofisopam is under investigation in clinical trial NCT01519687 (Study of Levotofisopam 50 Mg Three Times a Day (TID) Administered for 7 Days on Hyperuricemia and Gout). Linezolid An oxazolidinone antibiotic used to treat infections by susceptible strains of aerobic Gram-positive bacteria. Lisuride For the management of Parkinson's Disease Lithium carbonate A medication used to treat manic episodes of bipolar disorder. Lithium cation A drug used for the management of bipolar disorder and other psychiatric conditions. Lithium citrate Lithium is used as a mood stabilizer, and is used for treatment of depression and mania. It is often used in bipolar disorder treatment. Lofepramine Not Annotated Lofexidine A centrally acting alpha2-adrenergic agonist used for the symptomatic treatment of acute opioid withdrawal syndrome to facilitate abrupt opioid discontinuation in adults. Lorcaserin A serotonin 2C receptor agonist used in conjunction with physical activity and calorie restriction for weight loss in obese patients with a body mass index (BMI) of 30 and above, and in overweight patients with weight-related comorbidities. Lorpiprazole In 2016, lorpiprazole was classified in the "Chemical structure-related drug-like criteria of global approved drugs" as an antipsychotic and anxiolytic. An antipsychotic is a medication used to treat a state... Lortalamine Lortalamine (LM-1404) is a selective norepinephrine reuptake inhibitor developed in the 1980s. This drug never made it past clinical trials, likely due to ocular toxicity in animals, but has been... Loxapine A antipsychotic used for the treatment of schizophrenia. Lumateperone A novel 2nd generation atypical antipsychotic used to manage schizophrenia, bipolar depression, and major depressive disorder. Lurasidone An atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder. Lysergic acid diethylamide Debate continues over the nature and causes of chronic flashbacks. Explanations in terms of LSD physically remaining in the body for months or years after consumption have been discounted by... m-Chlorophenylpiperazine m-Chlorophenylpiperazine has been used in trials studying the treatment of Alcoholism. Maprotiline A tetracyclic antidepressant used to treat depressive illness, major depressive disorder, bipolar disorder, and anxiety associated with depression. Mazindol A sympathomimetic used to treat obesity in combination with lifestyle modifications. Mebanazine For the treatment of depression. Medifoxamine Medifoxamine was marketed as an atypical antidepressant, with anxiolyitc properties in France, Spain, and Morrocco in the 1990s but was later withdrawn from the market due to it causing cases... Melitracen A thioxanthene neuroleptic indicated in the treatment of anxiety, depression, and asthenia. Meperidine An opioid agonist with analgesic and sedative properties used to manage severe pain. Mescaline Mescaline is under investigation in clinical trial NCT05933213 (Comparing Mescaline Sodium Enteric-coated Tablets vs Morte-mescaline in the Treatment of Adult Lupus Nephritis). Mesoridazine A phenothiazine antipsychotic used to treat schizophrenia, organic brain disorders, alcoholism, and psychoneuroses. Mesulergine Mesulergine is a small molecule drug. Mesulergine has a monoisotopic molecular weight of 362.18 Da. Metamfetamine A sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and exogenous obesity. Metergoline An ergot-derivative that acts as an antagonist at certain 5-HT receptor subtypes and as an agonist at dopamine receptors. It is often used in situations where inhibition of prolactin is desirable. Methadone An opioid analgesic indicated for management of severe pain that is not responsive to alternative treatments. Also used to aid in detoxification and maintenance treatment of opioid addiction. Methotrimeprazine A phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder. Methylene blue An oxidation-reduction agent used for the treatment of pediatric and adult patients with acquired methemoglobinemia. Methysergide An ergot alkaloid used for the prophylaxis of migraine and cluster headaches. Metixene Used for the symptomatic treatment of parkinsonism. Mianserin A tetracyclic antidepressant with therapeutic activity similar to amitriptyline used to treat depression and anxiety. Midomafetamine Clinical trials are now testing the therapeutic potential of MDMA for post-traumatic stress disorder (PTSD) and anxiety associated with terminal cancer. MDMA is one of the four most widely used... Milacemide Milacemide is a small molecule drug. Milacemide has a monoisotopic molecular weight of 144.13 Da. Milnacipran A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of fibromyalgia and a short-term treatment of major depressive disorder. Milsaperidone An atypical antipsychotic used to treat adults with schizophrenia and manic or mixed episodes associated with bipolar I disorder. Minaprine For the treatment of depression Minesapride Minesapride is a small molecule drug. The usage of the INN stem '-pride' in the name indicates that Minesapride is a sulpiride derivative and analogue. Minesapride has a monoisotopic molecular... Mirtazapine A tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite. MK-212 MK-212 has been used in trials studying the treatment of Alcoholism. MMDA MMDA is a recreational drug. It has no current medical uses and is a Schedule I controlled substance in the USA at present. Moclobemide A monoamine oxidase inhibitor used in the treatment of major depressive disorder and bipolar disorder. Mofegiline Mofegiline is a small molecule drug. The usage of the INN stem '-giline' in the name indicates that Mofegiline is a monoamine oxydase (MAO)-inhibitor type B. Mofegiline has a monoisotopic... Molindone An antipsychotic used to treat schizophrenia. Mosapride A prokinetic 5-HT4 receptor agonist used to stimulate gastric motility. N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine 25CN-NBOH (N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine) is a newly developed selective 5-HT2A agonist. It has been tested with regard to the head-twitch-response (HTR) model of 5-HT2A activity and effects on locomotion . It was... Naftidrofuryl A peripheral vasodilator indicated in the treatment of chronic venous ulcers. Naluzotan Investigated for use/treatment in anxiety disorders and depression. Naratriptan A 5-HT1B/1D receptor agonist used to treat migraines. Naronapride Investigated for use/treatment in gastroesophageal reflux disease (GERD) and gastroparesis. Nefazodone An antidepressant used in the treatment of depression. Nialamide Withdrawn from the Canadian, US, and UK markets in 1963 due to interactions with food products containing tyrosine. Nisoxetine Nisoxetine is a selective norepinephrine reuptake inhibitor (SNRI) developed in the 1970s. It was originally investigated as an antidepressant but has no current clinical applications aside from being a research... Nomifensine Nomifensine, formerly marketed as Merital capsules, was associated with an increased incidence of hemolytic anemia. The approved application holder removed Merital capsules from the market on January 23, 1986. FDA... Nortriptyline A tricyclic antidepressant used in the treatment of depression. Noxiptiline Noxiptiline is a small molecule drug. Noxiptiline has a monoisotopic molecular weight of 294.17 Da. Octamoxin For the treatment of depression. Olanzapine An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders. Ondansetron A serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively. Opipramol A medication to treat general anxiety and somatoform disorders. Opiranserin Opiranserin is under investigation in clinical trial NCT03997838 (Evaluate the Efficacy and Safety of VVZ-149 Injections for the Treatment of Post-operative Pain Following Abdominoplasty). Orvepitant Orvepitant has been used in trials studying the treatment of Depressive Disorder, Depressive Disorder, Major, Post-Traumatic Stress Disorder, and Posttraumatic Stress Disorder (PTSD). Oxaflozane Not Annotated Oxaprotiline Investigated for the treatment of depression. Oxitriptan A naturally occurring amino acid that is used to manage post-hypoxic myoclonus. Paliperidone An atypical antipsychotic used in the treatment of schizophrenia and other schizoaffective or delusional disorders. Palonosetron A serotonin antagonist used in the prophylaxis or management of vomiting that results from emetogenic chemotherapy, and for the management of postoperative nausea and vomiting. Pargyline For the treatment of moderate to severe hypertension. Paroxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. Penbutolol A beta-adrenergic antagonist used for the management of mild to moderate arterial hypertension, alone or in combination with other antihypertensive agents. Pergolide A long-acting dopamine agonist that is uncommonly used for the management of Parkinson's disease, due to the risk for cardiac valvulopathy. Phenelzine A monoamine oxidase inhibitor used to treat atypical, nonendogenous, or neurotic depression. Pheniprazine For the treatment of depression, schizophrenia, and angina pectoris. Phenoxypropazine For the treatment of depression. Piclozotan Piclozotan has been investigated for the treatment of Parkinson's Disease. Pimavanserin A second generation atypical antipsychotic used for the treatment of hallucinations and delusions caused by Parkinson's Disease. Pimozide An antipsychotic used to manage debilitating motor and phonic tics in patients with Tourette's Disorder. Pindolol A beta adrenoceptor antagonist used to treat hypertension, edema, ventricular tachycardias, and atrial fibrillation. Pipamperone Treatment of chronic psychoses and states of aggressiveness of various origins . Pipotiazine An antipsychotic indicated for the management of chronic, non-agitated schizophrenic patients. Pirlindole For the treatment of major depression. It is being studied in the treatment of fibromyalgia pain syndrome. One study determined that the effect of pirlindole on sensorimotor performance while driving... Pivagabine Pivagabine has been used in trials studying the treatment of Stress and Anxiety. Pivhydrazine For the treatment of depression. Pizotifen A serotonin and tryptamine antagonist indicated for migraine prophylaxis. Procaine A local anesthetic used for anesthesia, peripheral nerve block, and spinal nerve block. Procarbazine An antineoplastic agent indicated for the treatment of stage III and stage IV Hodgkin's disease in combination with other chemotherapeutic agents. Progabide Indicated for the treatment of epilepsy. Promazine A phenothiazine used to manage schizophrenia. Promethazine A first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness. Propiomazine Propiomazine is largely used for its antihistamininc sleep inducing effects in treating insomnia. Propranolol A non-selective beta adrenergic antagonist used to treat hypertension, angina, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, and pheochromocytoma. Protriptyline A tricyclic antidepressant that is indicated in the treatment of depression only under close clinical supervision. Prucalopride A 5-HT4 receptor agonist indicated to treat adults with chronic idiopathic constipation. PRX-08066 Investigated for use/treatment in chronic obstructive pulmonary disease (COPD) and pulmonary hypertension. Quetiapine An atypical antipsychotic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder. Quinupramine Quinupramine has been approved in France under the brand name Kinupril, as an antidepressant . Quipazine Quipazine is a small molecule drug. Quipazine has a monoisotopic molecular weight of 213.13 Da. Ramosetron A selective 5-HT3 antagonist used as an antiemetic for chemotherapy- and postoperative-associated nausea and vomiting. It may also possess efficacy in irritable bowel syndrome. Rasagiline An irreversible inhibitor of monoamine oxidase used for the symptomatic management of idiopathic Parkinson's disease as initial monotherapy and as adjunct therapy to levodopa. Reboxetine A drug used for the acute treatment of major depression and for maintenance therapy of depression. Renzapride For the treatment of constipation-predominant irritable bowel syndrome (IBS-C). Repinotan Investigated for use/treatment in strokes, cerebral ischemia, and depression. Reserpine For the treatment of hypertension Rilapine Rilapine is a small molecule drug. Rilapine has a monoisotopic molecular weight of 361.13 Da. Risperidone A second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. Ritanserin Ritanserin has been used in trials studying the treatment of Cocaine-Related Disorders. Rizatriptan A triptan used to treat migraines with or without aura. Robalzotan Investigated for use/treatment in anxiety disorders and depression. Rolipram A phosphodiesterase inhibitor with antidepressant properties. Roluperidone Roluperidone has been used in trials studying the treatment of Schizophrenia. Rotigotine A non-selective dopamine agonist used for the treatment of Parkinson's Disease and Restless Leg Syndrome. Roxindole Roxindole is a small molecule drug. Roxindole has a monoisotopic molecular weight of 346.2 Da. Safinamide A MAO-B inhibitor used as an add-on treatment to levodopa/carbidopa for Parkinson's disease during "off" episodes. Safrazine For the treatment of depression. Saredutant Investigated for use/treatment in depression and anxiety disorders. Sarpogrelate Sarpogrelate has been investigated for the treatment of Diabetes Mellitus, Diabetic Nephropathy, Coronary Artery Disease, and Renal Insufficiency, Chronic. SB-773812 SB-773812 is under investigation in clinical trial NCT00259870 (SB-773812 Administered in Adults With Schizophrenia). Seganserin Seganserin is a small molecule drug. The usage of the INN stem '-anserin' in the name indicates that Seganserin is a serotonin receptor antagonist. Seganserin has a monoisotopic molecular weight... Selegiline A monoamine oxidase inhibitor used to treat major depressive disorder and Parkinson's. Seproxetine Seproxetine is also known as (S)-norfluoxetine. It is a selective serotonin reuptake inhibitor (SSRI). It is an active metabolite of fluoxetine. Seproxetine was being investigated by Eli Lilly as an... Serotonin For temporary relief of nervousness, anxiety, mood swings, joint pains, weakness, drowsiness, itching and lethargy. Not evaluated by the FDA, homeopathic product. Sertindole An atypical antipsychotic indicated in the treatment of schizophrenia. Sertraline A selective serotonin reuptake inhibitor (SSRI) indicated to treat major depressive disorder, social anxiety disorder and many other psychiatric conditions. Setoperone Setoperone is a small molecule drug. The usage of the INN stem '-perone' in the name indicates that Setoperone is a tranquillizer, neuroleptic, 4'-fluoro-4-piperidinobutyrophenone derivative. Setoperone has a monoisotopic molecular... Sibutramine A norepinephrine, serotonin and dopamine reuptake inhibitor indicated to assist with weight loss in obesity. Solriamfetol Solriamfetol is indicated for treatment of daytime sleepiness associated with obstructive sleep apnea and narcolepsy, but is not a treatment for the underlying airway obstruction in apnea patients[FDA Label] . Spiramide Spiramide is a small molecule drug. Spiramide has a monoisotopic molecular weight of 383.2 Da. St. John's Wort An herbal ingredient used in non-prescription therapeutic products for the short-term treatment of minor skin irritations, insomnia, depression, and anxiety. Sulpiride A selective D2 dopamine receptor antagonist indicated to treat chronic and acute schizophrenia. Sultopride Sultopride is used in Japan, Hong Kong, and Europe to treat schizophrenia. It is of the drug class atypical antipsychotics . Sumatriptan A serotonin receptor agonist used to treat migraines and cluster headaches. SUVN-502 Investigated for use/treatment in neurologic disorders. Talipexole Talipexole is a small molecule drug. Talipexole has a monoisotopic molecular weight of 209.1 Da. Talopram Talopram is a selective norepinephrine reuptake inhibitor (SNRI) that is structurally similar to citalopram and melitracen. It was researched in the 1960s and 1970s but never marketed. Tandospirone Tandospirone has been used in trials studying the treatment of Schizophrenia. Tapentadol An opioid used to manage severe pain that has not responded to non-opioid medications, and for which opioid analgesic therapy is appropriate. Tedatioxetine Tedatioxetine has been used in trials studying the treatment of Major Depressive Disorder. Tedizolid phosphate An oxazolidinone class antibiotic that inhibits bacterial protein synthesis and is proven to be effective in the treatment of certain Gram-positive bacterial infections. Tegaserod A serotonin-4 (5-HT4) receptor agonist indicated for the treatment of constipation predominant irritable bowel syndrome (IBS-C) specifically in women under the age of 65. There is currently no safety or efficacy data for use of tegaserol in men. Temanogrel For the treatment and prophylaxis of arterial thrombosis. Tenamfetamine An amphetamine derivative that inhibits uptake of catecholamine neurotransmitters. It is a hallucinogen. It is less toxic than its methylated derivative but in sufficient doses may still destroy serotonergic neurons... Terguride Not Annotated Tetrahydrocannabivarin THCV does not currently have any FDA, Health Canada, or EMA approved indications. Thioproperazine An antipsychotic indicated for the management of acute and chronic schizophrenia, including cases that are refractory to more common neuroleptics. May also be used to treat manic syndromes. Thioridazine A phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder. Thiothixene An antipsychotic indicated for the management of schizophrenia. Tianeptine An atypical tricyclic antidepressant with antidepressant and anxiolytic effects primarily used to treat major depressive disorder. Tidembersat Tidembersat is a small molecule drug. Tidembersat has a monoisotopic molecular weight of 375.13 Da. Tofisopam For the treatment of anxiety and alcohol withdrawal. Toloxatone For the treatment of major depressive disorder. Tramadol A centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults. Tranylcypromine A monoamine oxidase inhibitor used to treat major depressive disorder. Trazodone A serotonin uptake inhibitor used to treat major depressive disorder. Trifluoperazine A phenothiazine used to treat depression, anxiety, and agitation. Triflupromazine Used mainly in the management of psychoses. Also used to control nausea and vomiting. Trimipramine A tricyclic antidepressant used to treat depression. Tropisetron A 5HT-3 receptor antagonist used as an antiemetic in the treatment of chemotherapy-induced nausea and vomiting. Tryptophan An amino acid commonly found as a component of total parenteral nutrition. Umespirone Umespirone is a small molecule drug. The usage of the INN stem '-pirone' in the name indicates that Umespirone is a anxiolytic, buspirone derivative. Umespirone has a monoisotopic molecular weight... Urapidil A combination adrenergic antagonist and serotonin agonist given orally for the treatment of essential hypertension and intravenously in hypertensive emergencies. Vabicaserin Vabicaserin has been used in trials studying the health services research and treatment of Schizophrenia. Venlafaxine A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depression, generalized or social anxiety disorder, and panic disorder. Vilazodone An antidepressant agent used for the treatment of major depressive disorder that targets the 5-HT transporter and 5-HT1A receptors. Viloxazine A selective norepinephrine reuptake inhibitor indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in adults in children. Volinanserin Volinanserin is under investigation in clinical trial NCT00464243 (Efficacy and Safety of Volinanserin on Sleep Maintenance Insomnia - Polysomnographic Study). Vortioxetine A serotonin modulating antidepressant indicated for the treatment of major depressive disorder (MDD). Wortmannin Wortmannin is a steroid metabolite of Penicillium funiculosum and Talaromyces wortmannii fungi. This drug acts as a nonspecific, covalent inhibitor of phosphoinositide 3-kinase enzymes (PI3Ks). Xaliproden Investigated for use/treatment in amyotrophic lateral sclerosis (ALS) and alzheimer's disease. YKP-1358 Investigated for use/treatment in schizophrenia and schizoaffective disorders. Yohimbine An alpha-2-adrenergic blocker and sympatholytic found in supplements used to. Zimelidine For the treatment of depression. Ziprasidone An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia. Zolmitriptan A member of the triptan class of 5-HT(1B/1D/1F) receptor agonist drugs used for the acute treatment of migraine with or without aura in adults. Zotepine Zotepine, like other atypical antipsychotics, is considered as the first-line treatment in newly diagnosed schizophrenia. It is usually thought to be an option of choice for managing acute schizophrenic episodes... Zuclopenthixol An antipsychotic indicated for the management of schizophrenia. The acuphase formulation is indicated for initial treatment of acute psychosis or exacerbation of psychosis, while the depot formulation is best for maintenance. Zuranolone A neuroactive steroid drug used to treat postpartum depression