Bronchospasm (DBCOND0013567)

Identifiers

Synonyms

Bronchial Spasm / Bronchospasm (rare) / Bronchospasms / Spasm bronchial / Bronchospasm (finding) / Bronchospasm NOS

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Albuterol	A beta-2 adrenergic receptor agonist used to treat asthma, bronchitis, COPD, as well as prevent exercise induced bronchospasms.	Beta-2 adrenergic receptortarget Beta-1 adrenergic receptortarget Cytochrome P450 3A4enzyme Beta-3 adrenergic receptortarget
Ambroxol acefyllinate	A bronchodilator indicated in the symptomatic treatment of bronchopulmonary disorders associated with bronchospasm.	Cytochrome P450 3A Subfamilyenzyme
Aminophylline	A bronchodilator consisting of theophylline that is used for the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis.	cGMP-inhibited 3',5'-cyclic phosphodiesterase 3Atarget Adenosine receptor A3target Adenosine receptor A1target Cytochrome P450 1A2enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A4enzyme Histone deacetylase 2target
Atropine	A muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs.	Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M5target Muscarinic acetylcholine receptor M3target Glycine receptor subunit alpha-1target Neuronal acetylcholine receptor subunit alpha-4target Neuronal acetylcholine receptor subunit beta-2target Bile salt export pumptransporter Alpha-1-acid glycoprotein 1carrier
Bambuterol	A long acting beta2-adrenoceptor agonist for the management of lung diseases associated with bronchospasm.	Beta-2 adrenergic receptortarget Cholinesteraseenzyme Cholinesterasetarget
Bamifylline	A methylxanthine derivative indicated in the treatment of bronchial asthma and other conditions with bronchospasm.	Cytochrome P450 1A2enzyme
Caroverine	A calcium channel blocker indicated in the treatment of smooth muscle spasms, alcohol and drug withdrawal, and tinnitus.	Cytochrome P450 3A4enzyme
Dyphylline	A theophylline derivative used to treat asthma, bronchospasm, and COPD.	3',5'-cyclic-AMP phosphodiesterase 4Btarget 3',5'-cyclic-AMP phosphodiesterase 4Atarget 3',5'-cyclic-AMP phosphodiesterase 4Ctarget 3',5'-cyclic-AMP phosphodiesterase 4Dtarget Adenosine receptor A1target Adenosine receptor A2atarget 5'-nucleotidasetarget
Epinephrine	A hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma.	Alpha-1A adrenergic receptortarget Beta-1 adrenergic receptortarget Beta-2 adrenergic receptortarget Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme Alpha-1B adrenergic receptortarget Alpha-1D adrenergic receptortarget Alpha-2A adrenergic receptortarget Alpha-2B adrenergic receptortarget Tumor necrosis factortarget Catechol O-methyltransferaseenzyme Monoamine oxidaseenzyme
Etafedrine	A beta-2 adrenoceptor agonist used to treat a cough associated with inflamed mucosa.	Beta-2 adrenergic receptortarget
Guaifenesin	An expectorant commonly found in OTC products for the symptomatic relief from congested chests and coughs associated with cold, bronchitis, and/or other breathing illnesses.	NMDA receptortarget
Ipratropium	An anticholinergic drug used in the control of symptoms related to bronchospasm in chronic obstructive pulmonary disease (COPD).	Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M3target Organic cation/carnitine transporter 2transporter Solute carrier family 22 member 4transporter Albumincarrier alpha1-acid glycoproteincarrier
Isoprenaline	A catecholamine non-selective beta-adrenergic agonist typically used to treat bradycardia and heart block.	Beta-1 adrenergic receptortarget Beta-2 adrenergic receptortarget Beta-3 adrenergic receptortarget Cytochrome P450 1A1enzyme Superoxide dismutase [Cu-Zn]target Cytochrome P450 1B1enzyme Albumincarrier Catechol O-methyltransferaseenzyme Cholinesteraseenzyme Interleukin-12 subunit betatarget
Levosalbutamol	A beta-2 adrenergic receptor agonist used to treat COPD and asthma.	Beta-2 adrenergic receptortarget Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter
Orciprenaline	A beta-2 adrenergic agonist used to treat bronchospasm, asthma, and COPD.	Beta-2 adrenergic receptortarget
Procaterol	A beta-2 adrenergic receptor agonist and bronchodilator used for the treatment of asthma and chronic obstructive pulmonary disease (COPD).	Beta-2 adrenergic receptortarget
Terbutaline	A beta-2 adrenergic agonist used as a bronchodilator and to prevent premature labor.	Beta-2 adrenergic receptortarget Cholinesteraseenzyme Beta-3 adrenergic receptortarget Beta-1 adrenergic receptortarget Sulfotransferaseenzyme UDP-glucuronosyltransferases (UGTs)enzyme Organic cation/carnitine transporter 2transporter Solute carrier family 22 member 2transporter
Theophylline	A xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction.	cGMP-inhibited 3',5'-cyclic phosphodiesterase 3Atarget 3',5'-cyclic-AMP phosphodiesterase 4Btarget Adenosine receptor A2btarget 3',5'-cyclic-AMP phosphodiesterase 4Atarget cGMP-specific 3',5'-cyclic phosphodiesterasetarget Adenosine receptor A1target Adenosine receptor A2atarget Cytochrome P450 1A2enzyme Adenosine deaminaseenzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A4enzyme Solute carrier family 22 member 7transporter Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2D6enzyme Histone deacetylase 2target Copine-1target Minor histocompatibility antigen H13target BOS complex subunit NOMO1target Poly [ADP-ribose] polymerase 1target Protein RIC-3target Tubulin monoglycylase TTLL3target 5'-nucleotidasetarget
Tulobuterol	An inhaled long-acting beta2-adrenergic receptor agonist used as a bronchodilator in the management of asthma and COPD.	Beta-2 adrenergic receptortarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01265342	Efficacy of Nebulised Beclometasone in Viral Wheezing Prophylaxis	Beclomethasone dipropionate	prevention	4	completed
NCT02939625	NIV Application in the Treatment of Asthmatic Children	No drug interventions	treatment	Not Available	completed
NCT03064659	Driving Pressure And EFL in Adult Cardiac Surgery	No drug interventions	Not Available	Not Available	completed
NCT03000413	Ketamine Efficacy for Acute Severe Bronchospasm in ICU: MACANUDO Trial	Fentanyl Ketamine	treatment	2 / 3	completed
NCT02419196	Perioperative Change of Regional Ventilation During Spontaneous Breathing	No drug interventions	Not Available	Not Available	completed
NCT01189396	Escalating and Cumulative-Dose Study of Pharmacokinetics (PK), Pharmacodynamics (PD) and Safety of A006	Albuterol	treatment	2	completed
NCT00400660	A First Time In Human Study To Assess The Compound GSK615915	No drug interventions	treatment	1	completed
NCT05360810	Wei Nasal Jet Tube vs Gastro Laryngeal Tube in Endoscopic Retrograde Cholangiopancreatography	No drug interventions	screening	Not Available	completed
NCT00806455	Exercise-Induced Bronchospasm in Cystic Fibrosis	No drug interventions	Not Available	Not Available	completed
NCT00118690	A Study Measuring Asthma Control In Pediatric And Adolescent Subjects Whose Asthma Is Worsened By Activity Or Exercise	Fluticasone propionate Salmeterol	treatment	4	completed
NCT01188577	Epinephrine Inhalation Aerosol USP, a HFA-MDI Study for Assessment of Pharmacokinetics	Epinephrine	treatment	1 / 2	completed
NCT02090205	Mechanical Ventilation During Cardiac Surgery	No drug interventions	prevention	Not Available	unknown_status
NCT04427605	Efficacy and Safety of Continuous Infusion of Ketamine in Pediatric Intensive Care Unit (KISS Study)	No drug interventions	Not Available	Not Available	completed
NCT05025709	Bronchospasm During Anesthetic Induction: Study of Clinical Characteristics and Treatments Administered According to Etiology	No drug interventions	Not Available	Not Available	completed
NCT01174732	Dose-Ranging Study of A006 DPI, in Adult Asthma Patients	Albuterol	treatment	2	completed
NCT04373499	Virtual Teach-to-Goal Education vs. Brief Education for Children	No drug interventions	health_services_research	Not Available	completed
NCT05555134	INHALATION CHAMBER MANAGEMENT IN PEDIATRICS: EFFICACY OF AN EDUCATIONAL INTERVENTION IN PATIENTS DIAGNOSED WITH BRONCHOSPASM AND THEIR FAMILY CAREGIVERS.	No drug interventions	prevention	1	recruiting
NCT00118716	A Study Measuring Asthma Control In Pediatric And Adolescent Subjects Whose Asthma Is Worsened By Activity Or Exercise	Fluticasone propionate Salmeterol	treatment	4	completed
NCT03962725	Avoiding Neuromuscular Blockers to Reduce Complications	Dexmedetomidine Ketamine Propofol Rocuronium	treatment	4	terminated
NCT00890162	A Randomized, Double-Blind, Placebo-Controlled Study of Omalizumab for Idiopathic Anaphylaxis	Epinephrine Omalizumab	treatment	2	completed
NCT00634829	Single-Dose Cross-Over Study of the Effects of Albuterol-HFA in Exercise Induced Bronchoconstriction	Albuterol	prevention	3	terminated
NCT01156701	Prophylactic Efficacy of Relenza Against Influenza A and B	Zanamivir	Not Available	Not Available	completed
NCT02779595	Change of Regional Ventilation During Spontaneous Breathing After Lung Surgery	No drug interventions	Not Available	Not Available	completed
NCT05783050	Wei Nasal Jet Tube vs Nasal Cannula Oxygen Support in Gastrointestinal Endoscopy Patients	No drug interventions	prevention	Not Available	completed
NCT01488643	Observational Study on Obese Patients During General Anesthesia	No drug interventions	Not Available	Not Available	unknown_status