Pruritis of the skin (DBCOND0024301)

Identifiers

Synonyms

Itching of skin / Itching of the skin / Itching skin / Skin Itching / Itchy skin / Itch of skin / Pruritus of the Skin / Pruritus, unspecified / Pruritus / Itching of skin (finding) / Itching (finding) / Itch / Pruritus NOS / Itching / Itch of skin (observable entity) / Pruritus cutaneous / Itchy

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Cinchocaine	An anesthetic used for local or regional anesthesia.	Sodium channel protein type 5 subunit alphatarget Sodium channel protein type 10 subunit alphatarget Cholinesteraseenzyme Calmodulintarget
Crotamiton	A topical scabicidal and antipruritic agent used for scabies eradication and for the relief of pruritus.	No drug targets
Eucalyptus oil	An ingredient used in a variety of natural health products.	No drug targets
Eugenol	A phenol used for the temporary relief of toothaches.	Estrogen receptortarget Estrogen receptor betatarget Androgen receptortarget Transient receptor potential cation channel subfamily V member 3target Amine oxidase [flavin-containing] Btarget
Hydrocortisone	A glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders.	Annexin A1target Glucocorticoid receptortarget Sex hormone-binding globulincarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 11B2, mitochondrialenzyme Cytochrome P450 2C8enzyme Corticosteroid-binding globulincarrier Organic anion transporter 3transporter Aldo-keto reductase family 1 member D1enzyme 3-oxo-5-alpha-steroid 4-dehydrogenase 2enzyme 11-beta-hydroxysteroid dehydrogenase type 2enzyme 11-beta-hydroxysteroid dehydrogenase 1enzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme
Mepyramine	An antihistamine agent used for the symptomatic treatment of allergy, hypersensitivity reactions, and pruritic skin disorders.	Cytochrome P450 2D6enzyme Histamine H1 receptortarget Solute carrier family 22 member 4transporter Organic cation/carnitine transporter 2transporter
Phenol	An antiseptic and disinfectant used in a variety of settings.	Thermolysintarget Albumintarget Carbonic anhydrase 1target Carbonic anhydrase 4target Carbonic anhydrase 12target Carbonic anhydrase 2target Carbonic anhydrase 14target Carbonic anhydrase 9target
Sodium bicarbonate	A compound used for the symptomatic treatment of heartburn, acid indigestion, and upset stomach as well as the treatment of metabolic acidosis associated with conditions such as severe renal disease and circulatory insufficiency due to shock.	Electrogenic sodium bicarbonate cotransporter 1transporter Sodium bicarbonate cotransporter 3transporter Electroneutral sodium bicarbonate exchanger 1transporter Electrogenic sodium bicarbonate cotransporter 4transporter Hydrogen ionstarget Sodium-driven chloride bicarbonate exchangertransporter Voltage-dependent T-type calcium channel subunit alpha-1Htarget A-type voltage-gated potassium channel KCND3target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00737451	Association of Thyroid Autoimmunity and Chronic Urticaria	No drug interventions	Not Available	Not Available	completed