Pancreatic Insufficiency (DBCOND0031191)

Identifiers

Synonyms

Pancreatic insufficiency / Pancreatic failure / Pancreatic insufficiency (disorder) / Insufficiency pancreatic / Exocrine pancreatic insufficiency / Pancreatic exocrine insufficiency / Exocrine pancreatic insufficiency (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Dimethicone	An ingredient used to treat dry and irritated eyes.	No drug targets
Ox bile extract	Not Annotated	No drug targets
Pancrelipase	A purified form of porcine pancreatic lipase, amylase, and protease enzymes used to treat malabsorption associated with pancreatic insufficiency resulting from cystic fibrosis and pancreatitis.	Dietary fattarget Dietary proteintarget Dietary starchtarget
Pancrelipase lipase	A lipase used to treat pancreatic exocrine insufficiency.	Dietary fattarget
Simethicone	An anti-flatulence agent used to relieve pressure, bloating, and symptoms referred to as gas.	No drug targets

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00432861	Evaluation of the Safety and Efficacy of Pancrecarb® MS-16 in Cystic Fibrosis	Pancrelipase	treatment	3	completed
NCT01879228	Effect of Chronic Incretin-based Therapy in Cystic Fibrosis	Sitagliptin	other	Not Available	completed
NCT00705978	Creon 40,000 for Treatment of PEI (Pancreatic Exocrine Insufficiency) Due to Chronic Pancreatitis	Pancrelipase	treatment	3	completed
NCT00095732	Oral TheraCLEC™ - Total in Cystic Fibrosis Subjects With Exocrine Pancreatic Insufficiency	ALTU-135	treatment	2	completed
NCT00880100	Use of Ultrase® MT12 in Young Cystic Fibrosis Children (CF)	Pancrelipase	treatment	3	completed
NCT00572975	Malabsorption Blood Test:Toward a Novel Approach to Quantify Steatorrhea	No drug interventions	diagnostic	4	completed
NCT00406536	Study of LYM-X-SORB™ to Improve Fatty Acid and Choline Status in Children With CF and PI	No drug interventions	supportive_care	2	completed
NCT00513682	Efficacy and Safety of Ultrase® MT20 in Improving the Coefficient of Fat Absorption (CFA) in Children With Cystic Fibrosis (CF) and Pancreatic Insufficiency (PI)	Pancrelipase	treatment	3	completed
NCT01851694	Beta-cell Response to Incretin Hormones in Cystic Fibrosis	No drug interventions	other	Not Available	recruiting
NCT00763412	Pilot and Feasibility Study for the Treatment of Pre-diabetes in Patients With Cystic Fibrosis	Repaglinide	other	Not Available	completed
NCT01012908	Clinical Non-Inferiority of Pancreatic Enzymes (Norzyme ® - Bergamo) Compared To Creon ® (Solvay Pharmaceutical) in Patients With Exocrine Pancreatic Insufficiency	No drug interventions	treatment	2 / 3	unknown_status
NCT03279653	Pancreatic Exocrine Insufficiency After Bariatric Surgery	No drug interventions	Not Available	Not Available	unknown_status
NCT01144507	Prediction by Ultrasound of the Risk of Hepatic Cirrhosis in Cystic Fibrosis	No drug interventions	Not Available	Not Available	completed
NCT00535756	Creon After Pancreatic Surgery	Pancrelipase amylase Pancrelipase lipase Pancrelipase protease	treatment	4	completed
NCT03551691	Proton Pump Inhibitors (PPI) and Fat Absorption in Cystic Fibrosis (CF) and Exocrine Pancreatic Insufficiency (EPI)	Omeprazole	treatment	2	completed
NCT01710644	Efficacy and Tolerability of NM-BL in Patients With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis	Burlulipase	treatment	1 / 2	completed
NCT02979340	MRI to Characterize and Predict CF Liver Disease in PUSH Cohort	No drug interventions	Not Available	Not Available	completed
NCT02985801	PERT for Treatment of Exocrine Pancreatic Insufficiency in Patients With Unresectable Pancreatic Cancer	Pancrelipase Pancrelipase amylase Pancrelipase lipase Pancrelipase protease	treatment	1 / 2	terminated
NCT05700604	Hypoglycemia and Glucagon Response in CF	No drug interventions	Not Available	Not Available	completed
NCT04731272	GLP-1 Agonist Therapy in Cystic Fibrosis-Related Glucose Intolerance	Dulaglutide	other	2	recruiting
NCT03450772	Equivalence Study to Compare Two Strengths of Creon in China	Pancrelipase amylase Pancrelipase lipase Pancrelipase protease	treatment	3	unknown_status
NCT01988350	Pancreatic Insufficiency Secondary to Tobacco Exposure	No drug interventions	Not Available	Not Available	completed
NCT05466838	PERT to Improve Quality of Life in Patients Undergoing Pancreaticoduodenectomy: A Pilot Randomized Controlled Trial	No drug interventions	treatment	Not Available	recruiting