Pancrelipase protease is a lipase used to treat pancreatic exocrine insufficiency. Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and proteases.
- Mechanism
- Curator reviewed · 1 reference
Pancrelipase protease acts on the peptide bonds within the proteins. The two constituents of the pancrelipase protease, trypsin, and chymotrypsin, are grouped under the family of serine proteases. Trypsin acts on lysine and arginine residues while chymotrypsin acts in hydrophobic residues such as tryptophan, tyrosine and phenylalanine. Both constituents present a catalytic site in the S1 binding pocket formed by a triad of serine, histidine and aspartate.
- Primary indication
- Please refer to DB00085.Curator reviewed · 2 structured indications
- First approval
- Canada, 2011 · United States, 2009
- Also known as
- Protease, pancreatic
- Brand names
Resolves to
What you can answer from here — as of April 02, 2025
Which other approved drugs treat the same conditions as Pancrelipase protease, and which companies have late-stage candidates in those indications?
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