Ebola Virus Disease (DBCOND0035575)

Identifiers

Synonyms
Ebola Hemorrhagic Fever / Hemorrhagic Fever, Ebola / Ebola Virus Infection / Ebola Disease / Ebola Virus Disease, Ebola Virus Infection, Ebola / Ebola Viral Disease / Ebolavirus Disease / Ebola virus disease / Ebola virus disease (disorder) / Ebola haemorrhagic fever

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Ansuvimab
A fully human monoclonal IgG1 antibody directed against the GP1,2 surface protein of Zaire ebolavirus that is an effective treatment for Ebola virus disease.
Atoltivimab
Part of a product containing three monoclonal IgG1κ antibodies directed against the GP1,2 glycoprotein of Zaire ebolavirus. Together, these three antibodies act to neutralize viral particles and to recruit immune effectors for the destruction of both viral particles and infected cells.
Ebola Zaire vaccine (live, attenuated)
A vaccine used in the prophylaxis of Ebola virus disease caused by the species of Zaire ebolaviruses.
No drug targets
Maftivimab
Part of a product containing three monoclonal IgG1κ antibodies directed against the GP1,2 glycoprotein of Zaire ebolavirus. Together, these three antibodies act to neutralize viral particles and to recruit immune effectors for the destruction of both viral particles and infected cells.
Modified vaccinia ankara
A live, non-replicating orthopoxvirus vaccine used to prevent smallpox, monkeypox, and other diseases caused by vaccinia virus.
No drug targets
Odesivimab
Part of a product containing three monoclonal IgG1κ antibodies directed against the GP1,2 glycoprotein of Zaire ebolavirus. Together, these three antibodies act to neutralize viral particles and to recruit immune effectors for the destruction of both viral particles and infected cells.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT02911415
Open Study of the Duration of Immunity After Vaccination With GamEvac-CombiNo drug interventionsNot AvailableNot Availablecompleted
NCT01353027
Safety Study of Single Administration Post-Exposure Prophylaxis Treatment for Ebola VirusNo drug interventionstreatment1completed
NCT01593072
A Study to Assess the Safety, Tolerability and Pharmacokinetics of AVI-7537 in Healthy Adult Volunteerstreatment1withdrawn
NCT00374309
Experimental Vaccine for Prevention of Ebola Virus InfectionNo drug interventionsprevention1completed
NCT02661464
Long-term Safety Follow-up of Participants Exposed to the Candidate Ebola Vaccines Ad26.ZEBOV and/or MVA-BN-Filoprevention3terminated
NCT00072605
Experimental Ebola Vaccine TrialNo drug interventionstreatment1completed
NCT05284097
Ad26.ZEBOV, MVA-BN-Filo Vaccination in Children and Adults Previously Vaccinated With Control in the EBOVAC-Salone Studyprevention2active_not_recruiting
NCT02911428
Open Study of the Duration of Immunity After Vaccination With GamEvacNo drug interventionsNot AvailableNot Availablecompleted
NCT02342171
Emergency Evaluation of Convalescent Plasma for Ebola Viral Disease (EVD) in GuineaNo drug interventionstreatment2 / 3completed
NCT02564575
Evaluating the Safety of and Immune Response to a Human Parainfluenza Virus Type 3 Ebola Virus Vaccine (HPIV3-EbovZ GP) in Healthy AdultsNo drug interventionsprevention1completed
NCT02354404
Clinical Trial of Ebola Vaccines cAd3-EBO, cAd3-EBOZ and MVA-EbolaZ in Healthy Adults in UgandaNo drug interventionsprevention1completed
NCT02564523
Safety, Tolerability and Immunogenicity Study of 3 Prime-boost Regimens for Ebola Vaccines Ad26.ZEBOV/MVA-BN-Filo in Healthy Adults, Children and Human Immunodeficiency Virus Positive (HIV+) Adultsprevention2completed
NCT02378753
STRIVE (Sierra Leone Trial to Introduce a Vaccine Against Ebola)No drug interventionsprevention2 / 3completed
NCT02598388
Safety, Tolerability and Immunogenicity Study of 2-dose Heterologous Regimens for Ebola Vaccines Ad26.ZEBOV/MVA-BN-Filoprevention2completed
NCT02283099
Phase I Trial to Assess the Safety, Tolerability and Immunogenicity of a Ebola Virus Vaccine (rVSVΔG-ZEBOV-GP)No drug interventionstreatment1completed
NCT05067166
Open-Label Expanded Access for Ebola-Infected Patients to Receive Human mAb Ansuvimab as Therapeutic or for HR PEPNot AvailableNot Availableavailable
NCT02041715
Safety, Tolerability and Pharmacokinetic First in Human (FIH) Study for Intravenous (IV) TKM-100802No drug interventionstreatment1terminated
NCT02363322
Putative Investigational Therapeutics in the Treatment of Patients With Known Ebola Infectiontreatment1 / 2completed
NCT02319772
A Phase 1 Study to Evaluate the Safety, Tolerability and Pharmacokinetics of BCX4430treatment1completed
NCT01518881
Safety, Tolerability and Pharmacokinetic First in Human (FIH) Study of Intravenous (IV) TKM-100201 InfusionNo drug interventionstreatment1terminated
NCT02575456
A Clinical Trial to Evaluate the Recombinant Human Type5 Adenovirus Vector Based Ebola Virus Disease VaccineNo drug interventionsprevention2completed
NCT03583606
A Trial to Evaluate the Safety and Systems Biology Response of Ebolavirus Zaire Vaccine (ChAd3-EBO-Z)prevention1completed
NCT02891980
A Safety Trial to Test MVA-BN(R)-Filo and Ad26.ZEBOV Vaccines in Healthy Volunteersprevention1completed
NCT02416453
A Study to Assess Safety, Tolerability, and Immunogenicity of Three Heterologus 2-dose Regimens of the Candidate Prophylactic Vaccines for Ebola in Healthy Adultstreatment2completed
NCT02287480
VSV-ZEBOV Geneva Vaccine TrialNo drug interventionsprevention1 / 2completed
NCT05494801
Natural History, Disease Progression, and Long-Term Neurologic Sequelae of Ebola Virus Disease (EVD) Survivors in PREVAIL IIINo drug interventionsNot AvailableNot Availablerecruiting
NCT06587503
Safety and Immunogenicity of rVSVΔG-ZEBOV-GP Vaccination When Dosed Concurrently With mRNA COVID-19 Vaccine Booster Dosesprevention4not_yet_recruiting
NCT03576690
R3470-3471-3479 (REGN-EB3) Expanded Access Protocol (EAP) for Treatment of Ebola Virus DiseaseNot AvailableNot Availableavailable
NCT02329054
Efficacy of Favipiravir Against Ebola (JIKI)treatment2completed
NCT02296983
A Study to Find Out if the New Ebola Vaccine is Safe and Stimulates Immunity That Might Protect Adults in Kilifi, Kenya.No drug interventionsprevention1unknown_status
NCT04235361
Mobile Point of Care Diagnostic Testing for Ebola Virus Disease in DRCNo drug interventionsNot AvailableNot Availableunknown_status
NCT02333578
Clinical Trial to Evaluate the Efficacy and Safety of Convalescent Plasma for Ebola TreatmentNo drug interventionstreatmentNot Availableunknown_status
NCT05202288
Pilot Study Evaluating the Impact of Delay Between Administration of Inmazeb Administration and Vaccination by Ervebo on Vaccine Immune Response on Healthy Volunteersprevention2unknown_status
NCT00997607
Evaluating an Ebola and a Marburg Vaccine in UgandaNo drug interventionsprevention1completed
NCT02267109
Phase 1 Trial of Ebola Vaccine in MaliNo drug interventionsprevention1completed
NCT03820739
EBOVAC-Salone ExtensionNo drug interventionsNot AvailableNot Availablecompleted
NCT04717830
An Open Study of the Safety and Pharmacokinetics of a Drug for the Emergency Prevention of Ebola Virus DiseaseNo drug interventionstreatment1unknown_status
NCT04815174
Observational Study of the Clinico-biological Evolution and Standard of Care Offered to Patients With Ebola Virus DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT04822376
Prophylaxis Vaccine Antibodies Ebolaprevention2unknown_status
NCT02451891
A Phase I Study to Assess Ebola Vaccines cAd3-EBO Z and MVA-EBO ZNo drug interventionsprevention1unknown_status
NCT02307591
Clinical Study to Assess Efficacy and Safety of Amiodarone in Treating Patients With Ebola. Virus Disease (EVD) in Sierra Leone. EASE (EMERGENCY Amiodarone Study Against Ebola)treatment2 / 3withdrawn
NCT05992480
REVIVE (Response to the Ebola Virus Vaccine)prevention4not_yet_recruiting
NCT04250168
Piloting Clinical Bacteriology in the Ebola Virus Disease Care ResponseNo drug interventionsNot AvailableNot Availableterminated
NCT06093646
Addressing Medium- to Long-term EBOLA Associated Psychological Distress and Psychosocial Problems in Central UgandaNo drug interventionssupportive_careNot Availablerecruiting
NCT00605514
Ebola and Marburg Virus VaccinesNo drug interventionsprevention1completed
NCT04723602
Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy AdultsNo drug interventionsprevention1completed
NCT05130398
Safety and Immunogenicity of the rVSVΔG-ZEBOV-GP Ebola Virus Vaccine Candidate in Children Living in Lambaréné, Gabonprevention1 / 2completed
NCT04409405
Evaluation and Support to EVD Cured Patients and Their Contacts (Les Vainqueurs d'Ebola)No drug interventionsNot AvailableNot Availablecompleted
NCT02876328
Partnership for Research on Ebola VACcinationsprevention2completed
NCT05064956
Ad26.ZEBOV Booster in HIV+ Adults Previously Vaccinated With Ad26.ZEBOV/MVA-BN-Filo (EBOVAC HIV+ Booster Study)prevention2completed
NCT04711356
Ad26.ZEBOV Booster in Children Previously Vaccinated With Ad26.ZEBOV and MVA-BN-Filo (EBOVAC Booster Study)prevention2completed
NCT04186000
Study to Evaluate the Immunogenicity and Safety of a Heterologous Vaccine Regimen Against Ebolaprevention2completed
NCT05888649
Community Preparedness for Outbreak Response and Readiness for Ebola Vaccination in LiberiaNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT04028349
ZEBOVAC (Ebola Vaccine Trial, Ad26.ZEBOV/MVA-BN-Filo)prevention2completed
NCT06100913
Immunology of Ebola Vaccinebasic_science2recruiting
NCT02368119
Ebola CVD-Mali #2000 (Bivalent) VRC-EBOAdc069-00-vp (cAd3-EBO)No drug interventionsprevention1completed
NCT04152486
Effectiveness and Safety of a Heterologous, Two-dose Ebola Vaccine in the DRCprevention3unknown_status
NCT06126822
Safety and Immunogenicity of Ervebo® and Zabdeno® Booster Vaccines Against Ebola Virus Following Previous Vaccination With the Zabdeno/Mvabea® or Ervebo® Vaccine Schedules in DRCprevention3not_yet_recruiting
NCT02380625
Multiple Treatments for Ebola Virus Disease (EVD)treatment1 / 2unknown_status
NCT03072030
International Multicenter Study of the Immunogenicity of Medicinal Product GamEvac-CombiNo drug interventionsprevention4completed
NCT03929757
A Study of 2-dose Vaccination Regimen of Ad26.ZEBOV and MVA-BN-Filo in Infantsprevention2completed
NCT04268966
An Open-Label Study , Safety and Tolerability of Brincidofovir for Post Exposure Prophylaxis of Ebolatreatment2withdrawn
NCT03161366
Providing Additional Information on the Safety and Effectiveness of an Ebola VaccineNo drug interventionsprevention3completed
NCT03140774
Persistence of the Immune Response After Immunisation With Ebola Virus VaccinesNo drug interventionsNot AvailableNot Availablecompleted
NCT02658331
Evaluation of the FilmArray BioThreat-E TestNo drug interventionsNot AvailableNot Availablecompleted
NCT02401373
A Phase I Trial to Evaluate Ad5-EBOV in Healthy Adult Africans in China.No drug interventionsprevention1completed
NCT02326194
A Phase I Clinical Trial to Evaluate the Ebola Adenovirus Vector Vaccine (Ad5-EBOV) in Healthy Adults.No drug interventionsprevention1completed
NCT02509494
Staged Phase 3 Study to Assess the Safety and Immunogenicity of Ebola Candidate Vaccines Ad26.ZEBOV and MVA-BN-Filoprevention3completed
NCT02533791
A Booster Dose of Ad5-EBOV in Healthy Adults After Primary ImmunizationNo drug interventionsprevention1completed
NCT03098862
PREVAIL VI: Identification of Host Genetic Factors Underlying Ebola Virus Disease Risk, Mortality, Long-term Sequelae, Viral RNA Persistence, Humoral Immunity, and Ebola Vaccine ResponseNo drug interventionsNot AvailableNot Availablecompleted
NCT04906629
INO-4201 as Booster in Healthy VSV-ZEBOV VaccineesNo drug interventionsprevention1completed
NCT03462004
Evaluating the Live-Attenuated Human Parainfluenza Virus Type 3 Vectored Vaccine Candidate Expressing Ebolavirus Zaire Glycoprotein as the Sole Envelope GlycoproteinNo drug interventionsprevention1suspended
NCT02718469
Trial to Evaluate Safety and Immunogenicity of an Ebola Zaire Vaccine in Healthy AdultsNo drug interventionsprevention1completed
NCT02495246
A Study to Assess Ebola Vaccines ChAd3-EBO-Z and Ad26.ZEBOVprevention1completed
NCT02485912
Evaluation of a New Ebola Vaccine Using a Short-interval Prime-boost VaccinationNo drug interventionsprevention1completed
NCT02662855
Efficacy of Favipiravir Against Severe Ebola Virus Diseasetreatment2completed
NCT02431923
Ebola Virus Disease Survivors: Clinical and Immunologic Follow-upNo drug interventionsNot AvailableNot Availablecompleted