Dry Macular Degeneration (DBCOND0067350)

Identifiers

Synonyms
Geographic Atrophy (GA) / Macular Degeneration, Dry / Atrophy, Geographic / Geographic Atrophy / Dry macular degeneration / Nonexudative age-related macular degeneration / Dry age-related macular degeneration

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Avacincaptad pegol
An RNA aptamer inhibiting the complement C5 indicated for the treatment of geographic atrophy secondary to age-related macular degeneration.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT06541704
A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophytreatment3not_yet_recruiting
NCT04640649
Prediction of Progression of Age-Related Macular DegenerationNo drug interventionsdiagnosticNot Availableunknown_status
NCT04847635
Subthreshold Laser Treatment for Reticular Pseudodrusen Secondary to Age-related Macular DegenerationNo drug interventionstreatmentNot Availablerecruiting
NCT04084587
Visual Rehabilitation Through Acoustic Biofeedback With Retimax Vision Trainer in Patients With Advanced Age-related Macular DegenerationNo drug interventionstreatmentNot Availablecompleted
NCT05418231
Observation of the Natural Course of Age-related Macular DegenerationNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT03921931
Retinal Photoreceptor Outer Segment Length Before and After Light Stimulation - a Pilot StudyNo drug interventionsbasic_scienceNot Availablerecruiting
NCT02684578
Metformin for the Minimization of Geographic Atrophy Progression in Patients With AMDtreatment2completed
NCT04469140
Non Exudative AMD Imaged With SS-OCT- ExtensionNo drug interventionsNot AvailableNot Availablerecruiting
NCT03688243
Non Exudative AMD Imaged With SS-OCTNo drug interventionsNot AvailableNot Availableunknown_status
NCT02699216
BioCurrent Electrical Stimulation for the Treatment of Dry ARMDNo drug interventionstreatmentNot Availablewithdrawn
NCT02590692
Study of Subretinal Implantation of Human Embryonic Stem Cell-Derived RPE Cells in Advanced Dry AMDNo drug interventionsother1 / 2unknown_status
NCT02024269
Study to Assess the Safety and Effects of Cells Injected Intravitreal in Dry Macular DegenerationNo drug interventionstreatmentNot Availablewithdrawn
NCT01342926
Clinical Study to Investigate Safety and Efficacy of GSK933776 in Adult Patients With Geographic Atrophy Secondary to Age-related Macular DegenerationNo drug interventionstreatment2completed
NCT02033668
Pharmacokinetic (PK) Study of GSK933776 in Healthy VolunteersNo drug interventionstreatment1completed
NCT03845582
Phase 3 Study of ALK-001 in Geographic Atrophytreatment3active_not_recruiting
NCT05811351
A Study to Evaluate Intravitreal JNJ-81201887 (AAVCAGsCD59) Compared to Sham Procedure for the Treatment of Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)treatment2recruiting
NCT06635148
A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)No drug interventionstreatment2recruiting
NCT05019521
A Study of Danicopan in Participants With Geographic Atrophy Secondary to Age-Related Macular Degenerationtreatment2active_not_recruiting
NCT05626114
A Study to Optimize Subretinal Surgical Delivery and to Evaluate Safety and Activity of Opregen in Participants With Geographic Atrophy Secondary to Age-Related Macular DegenerationNo drug interventionstreatment2recruiting
NCT06018558
Study to Assess the Safety and Efficacy of OCU410 for Geographic AtrophyNo drug interventionstreatment1 / 2recruiting
NCT05961332
COmparison of Clarus and Optos Ultrawide Field Imaging Systems for Geographic AtrophyNo drug interventionsotherNot Availablerecruiting
NCT06394232
Safety & Efficacy of Eyecyte-RPE™ in Patients With Geographic Atrophy Secondary to Dry Age-related Macular Degeneration.treatment1 / 2recruiting
NCT02332343
Sparing of the Fovea in Geographic Atrophy ProgressionNo drug interventionsNot AvailableNot Availablecompleted
NCT04339764
Autologous Transplantation of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Geographic Atrophy Associated With Age-Related Macular DegenerationNo drug interventionstreatment1 / 2recruiting
NCT01666821
A Population-based Study of Macular Choroidal Neovascularization in a Chinese PopulationNo drug interventionsNot AvailableNot Availablecompleted
NCT06161584
A Prospective, Multicenter, Open-Label, Observational Phase 4 Study to Evaluate Real-World Safety, Tolerability, and Treatment Patterns of Pegcetacoplan (Syfovre) in Patients With Geographic Atrophy Secondary to Age-Related Macular DegenerationNot AvailableNot Availablerecruiting
NCT02247479
A Study Investigating the Efficacy and Safety of Lampalizumab Intravitreal Injections in Participants With Geographic Atrophy Secondary to Age-Related Macular Degenerationtreatment3terminated
NCT06164587
Evaluation of Kamuvudine-8 in Subjects With Geographic AtrophyNo drug interventionstreatment1recruiting
NCT04676854
Restoration of Central Vision With the PRIMA System in Patients With Atrophic AMDNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT04014777
Study of NGM621 in Participants With Geographic AtrophyNo drug interventionstreatment1completed
NCT01675947
Intravitreal Injections of Sirolimus in the Treatment of Geographic Atrophytreatment2terminated
NCT02659098
A Study to Evaluate the Safety and Clinical Response of Subretinal Administration of CNTO 2476 in Participants With Geographic Atrophytreatment2completed
NCT05536297
Avacincaptad Pegol Open-Label Extension for Patients With Geographic Atrophytreatment3active_not_recruiting
NCT00973011
A Study of the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Intravitreal Injections of FCFD4514S in Patients With Geographic Atrophytreatment1completed
NCT03846193
FOCUS: A Phase I/II First in Human Study to Evaluate the Safety and Efficacy of GT005 Administered in Subjects With Dry AMDNo drug interventionstreatment1 / 2terminated
NCT01866371
High Resolution Retinal ImagingNo drug interventionsNot AvailableNot Availablerecruiting
NCT04358471
Intravitreal AAVCAGsCD59 for Advanced Dry Age-related Macular Degeneration (AMD) With Geographic Atrophy (GA)No drug interventionstreatment2withdrawn
NCT06499571
Geographic Atrophy Long-Terms Outcomes StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT02800356
Subthreshold Laser Treatment for Reticular Pseudodrusen and Geographic Atrophy Secondary to AMDNo drug interventionstreatmentNot Availablecompleted
NCT02137915
Long-Term Follow-up Safety Study of Human Central Nervous System Stem Cells in Subjects With Geographic Atrophy of Age-Related Macular DegenerationNo drug interventionsNot AvailableNot Availableterminated
NCT02895815
Efficacy and Safety Study of CNTO 2476 in Participants With Visual Acuity Impairment Associated With Geographic Atrophy (GA) Secondary to Age Related Macular Degeneration (AMD)treatment2withdrawn
NCT02503332
Study of Pegcetacoplan (APL-2) Therapy in Patients With Geographic Atrophytreatment2completed
NCT03525600
Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy With Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degenerationtreatment3completed
NCT02288559
A Study of Lampalizumab Intravitreal Injections Administered Every Two Weeks or Every Four Weeks to Participants With Geographic Atrophytreatment2completed
NCT00429936
Study of Fenretinide in the Treatment of Geographic Atrophy Associated With Dry Age-Related Macular Degenerationtreatment2completed
NCT02372916
Geographic Atrophy and Intravitreal Ranibizumab InjectionsNot AvailableNot Availableunknown_status
NCT06510816
A Study Investigating the Efficacy and Safety of Intravitreal (IVT) Injections of ANX007 in Participants With Geographic Atrophy (GA)No drug interventionstreatment3recruiting
NCT02686658
Zimura in Participants With Geographic Atrophy Secondary to Dry Age-Related Macular Degenerationtreatment2 / 3completed
NCT03815825
GOLDEN STUDY: A Study to Assess Safety and Efficacy of Multiple Doses of IONIS-FB-LRx in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (AMD)No drug interventionstreatment2completed
NCT04607148
A Study Assessing the Long-Term Safety and Tolerability of Galegenimab (FHTR2163) in Participants With Geographic Atrophy Secondary to Age-Related Macular Degenerationtreatment2terminated
NCT01445548
Sirolimus for Advanced Age-Related Macular Degenerationtreatment1 / 2completed
NCT06351657
Personalized Monitoring of Non-foveal, Non-vision Compromising Atrophic Age-related Macular Degeneration With Artificial Intelligence and Identification of Disease ProgressionNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT01802866
Safety and Efficacy Assessment Treatment Trials of Emixustat Hydrochloridetreatment2 / 3completed
NCT05391074
Oral Postbiotics in Patients With Macular AtrophyNo drug interventionstreatmentNot Availableunknown_status
NCT02247531
A Study Investigating the Safety and Efficacy of Lampalizumab Intravitreal Injections in Participants With Geographic Atrophy Secondary to Age-Related Macular Degenerationtreatment3terminated
NCT02130531
Pharmacokinetic and Pharmacodynamic Study of Emixustat in Subjects With Geographic Atrophy Associated With Dry Age-Related Macular Degenerationtreatment1completed
NCT06557460
A PHASE IIB, RANDOMIZED, ASSESSOR-MASKED, MULTICENTER CLINICAL TRIAL TO ASSESS THE SAFETY AND EFFICACY OF SUBRETINAL IMPLANTATION OF THE CPCB-RPE1 IMPLANT IN SUBJECTS WITH ADVANCED, DRY AMD (GEOGRAPHIC ATROPHY)No drug interventionstreatment2not_yet_recruiting
NCT04744662
ONL1204 Ophthalmic Solution in Patients With Geographic Atrophy Associated With Age-related Macular Degenerationtreatment1completed
NCT01782989
Clinical Study to Evaluate Treatment With ORACEA® for Geographic Atrophy (TOGA)treatment2 / 3completed
NCT05963646
Optical Coherence Tomography and Microperimetry Biomarker Evaluation in Patients With Geographic Atrophy StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT00599846
The Natural History of Geographic Atrophy Progression (GAP) StudyNo drug interventionsNot AvailableNot Availableterminated
NCT01694095
Evolution and Risk Factors Associated With Geographic Atrophy ProgressionNo drug interventionsNot AvailableNot Availablecompleted
NCT04465955
A Study of NGM621 in Participants With Geographic AtrophyNo drug interventionstreatment2completed
NCT01002950
Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ACU-4429 in Subjects With Geographic Atrophytreatment2completed
NCT01692938
Evaluation of the Precision of the Microperimetry Function of the Spectral OCT/SLONo drug interventionsNot AvailableNot Availablecompleted
NCT01799564
Micropulse Laser for Geographic AtrophyNo drug interventionstreatmentNot Availablecompleted
NCT03295877
Safety and Tolerability Study of RO7171009 in Participants With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD)treatment1completed
NCT00890097
Geographic Atrophy Treatment EvaluationNo drug interventionstreatment3terminated
NCT04656561
A Study Investigating the Efficacy and Safety of Intravitreal Injections of ANX007 in Patients With Geographic AtrophyNo drug interventionstreatment2completed
NCT05949593
Phase 3, Randomized, Placebo-Controlled Study of Tinlarebant to Explore Safety and Efficacy in Geographic Atrophytreatment3recruiting
NCT00306488
OT-551 Antioxidant Eye Drops to Treat Geographic Atrophy in Age-Related Macular Degenerationtreatment2completed
NCT03972709
A Study Assessing the Safety, Tolerability, and Efficacy of Galegenimab (FHTR2163) in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (AMD)treatment2terminated
NCT06006585
A Study to Test How Well Different Doses of BI 771716 Are Tolerated by People With an Advanced Form of Age-related Macular Degeneration (AMD) Called Geographic AtrophyNo drug interventionstreatment1completed
NCT02087085
A Safety and Efficacy Study of Brimonidine Intravitreal Implant in Geographic Atrophy Secondary to Age-related Macular Degenerationtreatment2terminated
NCT01229215
A Study of Safety, Tolerability, and Evidence of Activity of FCFD4514S Administered Monthly or Every Other Month to Patients With Geographic Atrophytreatment2completed
NCT03777332
Study to Evaluate the Safety of Intravitreal APL-2 in Patients Diagnosed With Geographic Atrophytreatment1completed
NCT05438732
Multicenter Clinical Study of the SING-IMT in Patients With Late-stage AMDNo drug interventionsotherNot Availablerecruiting
NCT01527500
Intravitreal LFG316 in Patients With Age-related Macular Degeneration (AMD)treatment2completed
NCT05891275
Patients With Geographic Atrophy and Their Patient Journey in the United States (US)No drug interventionsNot AvailableNot Availablecompleted
NCT01093170
A Phase I Open Label Dose Escalation Trial of RNA-144101 in the Treatment of Geographic AtrophyNo drug interventionstreatment1withdrawn
NCT02515942
CLG561 Proof-of-Concept Study as a Monotherapy and in Combination With LFG316 in Subjects With Geographic Atrophy (GA)treatment2completed
NCT03525613
A Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy With Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degenerationtreatment3completed
NCT04739319
Project AMD: Comprehensive Characterisation of Age-Related Macular Degeneration and Its ProgressionNo drug interventionsNot AvailableNot Availablerecruiting
NCT02745119
Long-Term Safety of Lampalizumab Intravitreal (ITV) Injections in Participants With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (OMASPECT)treatment3terminated
NCT06381596
Retinal Fundus Flavoprotein Fluorescence in Age Related Macular DegenerationNo drug interventionsotherNot Availablerecruiting
NCT05797896
Investigating Geographic Atrophy Insights (i-GAIN) Natural History StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT02479386
A Study of Disease Progression in Participants With Geographic Atrophy Secondary to Age-Related Macular DegenerationNo drug interventionsNot AvailableNot Availableterminated
NCT04643886
A Multiple Dose Study of Repeat Intravitreal Injections of GEM103 in Dry Age-related Macular DegenerationNo drug interventionstreatment2terminated
NCT04615325
A Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Intravitreal Injections of RO7303359 in Participants With Geographic Atrophy Secondary to Age-related Macular DegenerationNo drug interventionstreatment1completed
NCT04246866
First in Human Study to Evaluate the Safety and Tolerability of GEM103 in Geographic Atrophy Secondary to Dry Age Related Macular DegenerationNo drug interventionstreatment1completed
NCT04435366
A Phase 3 Safety and Efficacy Study of Intravitreal Administration of Zimura (Complement C5 Inhibitor)treatment3completed
NCT01602120
An Extension Study to Evaluate the Long-Term Safety of Lampalizumab in Participants With Geographic Atrophytreatment2terminated
NCT03894020
GTSCOPE - To Evaluate the Natural Progression of Dry Age-related Macular Degeneration (AMD)No drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT05941273
A Study of the SING IMT in an Israeli CohortNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT01272076
Cirrus HD-OCT Measurement of Area of Increased Light Penetration Under the Retinal Pigment Epithelium (RPE)No drug interventionsNot AvailableNot Availablecompleted
NCT05380492
Study of VOY-101 in Patients With Advanced Non-Neovascular Age-Related Macular DegenerationNo drug interventionstreatment1 / 2active_not_recruiting
NCT03446144
Safety and Efficacy of IONIS-FB-Lrx in up to 120 Patients 55 and Older With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD)No drug interventionstreatment2withdrawn
NCT02399072
A Study of Disease Progression in Participants With Geographic Atrophy Secondary to Age-Related Macular DegenerationNo drug interventionsNot AvailableNot Availableterminated
NCT01603043
A Multicenter, Proof-Of-Concept Study Of Intravitreal AL-78898A In Patients With Geographic Atrophy (GA) Associated With Age-Related Macular Degeneration (AMD)No drug interventionstreatment2terminated