NCT03904628
Phase I Clinical Study of Oral TG02 Capsule in the Treatment of Recurrent / Progressive High-grade Glioma Patients No drug interventions treatment 1 unknown_status NCT02263105
Efficacy and Tolerability of Cisplatin Plus Alternating Weekly Temozolomide in Recurrent High-grade Gliomas No drug interventions treatment 2 completed NCT04253873
Clinical Study of Apatinib Combined With Temozolomide in the Treatment of Uncontrolled or Repeated High-grade Gliomas No drug interventions treatment 2 unknown_status NCT00393094
Bevacizumab and Irinotecan to Treat Brain Tumors No drug interventions treatment 2 terminated NCT02473380
Fluorescence Spectroscopy Guided Surgery No drug interventions diagnostic 1 completed NCT03434262
SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors treatment 1 completed NCT00302159
Valproic Acid With Temozolomide and Radiation Therapy to Treat Brain Tumors treatment 2 completed NCT00918281
Reproducibility of 18F Uptake by Solid Tumors Using PET Imaging Following Intravenous Administration of (18F) Injection No drug interventions diagnostic 2 completed NCT00743353
Exploratory, Phase 0 Study of Positron Emission Tomography (PET) Imaging Agent, F-18 RGD-K5 No drug interventions diagnostic 0 completed NCT00386919
Short Course of Radiation for Gliomas in Elderly Patients No drug interventions treatment 2 completed NCT06482905
Safety and Efficacy Study of TX103 CAR-T Cell Therapy for Recurrent or Progressive Grade 4 Glioma. No drug interventions treatment 1 not_yet_recruiting NCT00624728
Assessment of 18FLT PET-CT for Volume Definition of High-grade Gliomas (GLIO-TEP) No drug interventions diagnostic 1 / 2 completed NCT06002711
Multi-Dimensional MRI Spatial Heterogeneity Analysis for Predicting Key Genes and Prognosis of High-Grade Gliomas: A Multi-Center Study No drug interventions Not Available Not Available not_yet_recruiting NCT04552756
Seizures During Radiotherapy for High-grade Gliomas No drug interventions diagnostic Not Available unknown_status NCT02305056
Study of Tumor Metabolism by Isotopic Tagging in Patients With High-grade Glioma (CARBONOMIC) diagnostic 1 terminated NCT04730349
A Study of Bempegaldesleukin (BEMPEG: NKTR-214) in Combination With Nivolumab in Children, Adolescents and Young Adults With Recurrent or Treatment-resistant Cancer treatment 1 / 2 terminated NCT04851834
NTX-301 Monotherapy in Advanced Solid Tumours and in Combination With Platinum-based Chemotherapy in Advanced Ovarian & Bladder Cancer and in Combination With Temozolomide in High-grade Glioma treatment 1 / 2 terminated NCT01644773
Study of the Combination of Crizotinib and Dasatinib in Pediatric Research Participants With Diffuse Pontine Glioma (DIPG) and High-Grade Glioma (HGG) treatment 1 completed NCT06209567
A Study of 68Ga-PSMA-11 PET Scans in People With Brain Tumors No drug interventions diagnostic 0 recruiting NCT05873946
Assessing the Effectiveness of 2D Non-Navigated Intraoperative Ultrasound in Glioma Surgery No drug interventions Not Available Not Available completed NCT00548938
Gliadel Wafer, Temozolomide and Radiation Therapy for Newly Diagnosed GBM No drug interventions treatment 2 terminated NCT00565721
A Proof-of-concept Study to Assess the Ability of [18F]AH-111585 PET Imaging to Detect Tumours and Angiogenesis No drug interventions diagnostic 2 completed NCT04482933
HSV G207 With a Single Radiation Dose in Children With Recurrent High-Grade Glioma No drug interventions treatment 2 not_yet_recruiting NCT06201351
Study of Adaptive Radiotherapy for High-grade Glioma Based on Interfraction MRI No drug interventions Not Available Not Available not_yet_recruiting NCT05929456
Multispectral Bimodal Fluorescence Guided Surgery of High-grade Glioma With Cetuximab-800CW and 5-ALA (5-aminolevulinic Acid) No drug interventions diagnostic 1 recruiting NCT02239952
HGG-TCP (High Grade Glioma - Tumor Concentrations of Protein Kinase Inhibitors) No drug interventions diagnostic Not Available unknown_status NCT05561374
Study of Safety and Pharmacokinetic Properties of Oral OKN-007 in Patients With Recurrent High-Grade Glioma No drug interventions treatment 1 recruiting NCT02848794
Apatinib and Irinotecan in Treating Patients With Recurrent High-grade Glioma No drug interventions treatment 1 / 2 unknown_status NCT04299191
Study of LAM561 Acid in Pediatric Patients With Malignant Glioma and Other Advanced Solid Tumors No drug interventions treatment 1 / 2 recruiting NCT05610891
Novel Targeted Radiotherapy in Pediatric Patients With Inoperable Relapsed or Refractory HGG No drug interventions treatment 1 recruiting NCT04908267
How the Precise Habitats Can Predict the IDH Mutation Status and Prognosis of the Patients With High-grade Gliomas No drug interventions Not Available Not Available recruiting NCT03458312
Nurse-led Family and Network Consultations No drug interventions supportive_care Not Available completed NCT06118723
The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 2201) No drug interventions Not Available Not Available recruiting NCT04209790
Neoadjuvant Chemoradiation for Resectable Glioblastoma No drug interventions treatment 2 recruiting NCT05979064
Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM) No drug interventions treatment Not Available recruiting NCT05839379
Targeted Pediatric High-Grade Glioma Therapy No drug interventions Not Available Not Available not_yet_recruiting NCT04737577
Glioma Supra Marginal Incision Trial No drug interventions other Not Available recruiting NCT06357377
A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors treatment 1 not_yet_recruiting NCT03392545
Combination of Immunization and Radiotherapy for Malignant Gliomas (InSituVac1) No drug interventions treatment 1 unknown_status NCT06428045
STARLITE for Unresectable High-Grade Gliomas treatment 1 not_yet_recruiting NCT03952598
Studying the Biology of IDH-mutant Gliomas Via Longitudinal Observation of 2-hydroxyglutarate (2-HG) Using MR Spectroscopy No drug interventions diagnostic Not Available recruiting NCT01240161
Personalized Translational Platform for Biomarker Discovery in Brain Tumors No drug interventions Not Available Not Available completed NCT02041611
Prospective Evaluation of T-cell Immune Status in Patients With Newly Diagnosed High Grade Gliomas No drug interventions other Not Available completed NCT04559685
Study of Sonodynamic Therapy in Participants With Recurrent High-Grade Glioma No drug interventions treatment 0 recruiting NCT04865315
A Living Tissue Bank of Patient-Derived Organoids From Glioma Tumors No drug interventions Not Available Not Available active_not_recruiting NCT04766632
Contribution of Cerebral 18F-DOPA PET-CT Scan in High-grade Recurrent Gliomas No drug interventions device_feasibility Not Available recruiting NCT06016452
A Study of Chlorophyllin for the Management of Brain Radio-necrosis in Patients With Diffuse Glioma No drug interventions treatment 2 recruiting NCT02500459
Topotecan in Glioma Undergoing A Clinically-Indicated Surgical Resection treatment 0 terminated NCT00589875
Phase 2a Study of CAN-2409 With Standard Radiation Therapy for Malignant Glioma treatment 2 completed NCT05925218
Circulating Tumor DNA Collection From Patients With High Grade Gliomas No drug interventions Not Available Not Available recruiting NCT05375318
BIOhabitats: Biological Validation of Vascular Habitats Within Astrocytoma Grade 4 at Molecular, Cellular, and Histopathological Levels No drug interventions Not Available Not Available unknown_status NCT05565118
Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma as a Predictor of Progression No drug interventions treatment 1 recruiting NCT00780819
Borderzone Sampling No drug interventions diagnostic Not Available completed NCT04254419
Intra-tumoral Injection of Natural Killer Cells in High-Grade Gliomas treatment 1 not_yet_recruiting NCT00469534
Minimized Time to Beam in Patients With High Grade Gliomas No drug interventions treatment Not Available withdrawn NCT02607124
A Phase I/II Study of Ribociclib,a CDK4/6 Inhibitor, Following Radiation Therapy treatment 1 / 2 terminated NCT02885324
Pilot Study of Cabozantinib for Recurrent or Progressive Central Nervous System Tumors in Children treatment 2 terminated NCT00003535
Antineoplaston Therapy in Treating Children With Recurrent or Refractory High-Grade Glioma treatment 2 terminated NCT06161974
Study of Olutasidenib and Temozolomide in HGG treatment 2 not_yet_recruiting NCT06519682
A Pilot Study Investigating Upfront Adaptive Immunotherapy Approach in Children, Adolescent and Young Adult (CAYA) Patients With Replication-Repair Deficient (RRD) High-Grade Gliomas (HGG) treatment Not Available not_yet_recruiting NCT03352427
Study of Dasatinib in Combination With Everolimus for Children and Young Adults With Gliomas Harboring Platelet-Derived Growth Factor Receptor (PDGFR) Alterations treatment 2 terminated NCT06528691
Entrectinib as a Single Agent in Upfront Therapy for Children <3 Years of Age With NTRK1/2/3 or ROS1-FUSED CNS Tumors treatment 2 recruiting NCT04220892
Pilot Study of Pembrolizumab Combined With Pemetrexed or Abemaciclib for High Grade Glioma No drug interventions treatment 0 withdrawn NCT04734444
SonoClear Acoustic Coupling Fluid (ACF) Mimicking Brain Tissue No drug interventions other Not Available recruiting NCT03690869
REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination With Radiotherapy in Pediatric Patients With Newly Diagnosed or Recurrent Glioma No drug interventions treatment 1 / 2 terminated NCT01191346
Radiation Planning Study for High Grade Brain Tumors No drug interventions Not Available Not Available completed NCT04267146
Nivolumab in Combination With Temozolomide and Radiotherapy in Children and Adolescents With Newly Diagnosed High-grade Glioma No drug interventions treatment 1 / 2 unknown_status NCT03925246
Efficacy of Nivolumab for Recurrent IDH Mutated High-Grade Gliomas No drug interventions treatment 2 completed NCT04608812
Convection-enhanced Delivery of OS2966 for Patients With High-grade Glioma Undergoing a Surgical Resection No drug interventions treatment 1 terminated NCT01403610
Safety and Efficacy Study of TH-302 CNS Penetration in Recurrent High Grade Astrocytoma Following Bevacizumab No drug interventions treatment 2 completed NCT01499823
Permeability Map to Distinguish Progression From Pseudoprogression in High-Grade Glioma No drug interventions Not Available Not Available unknown_status NCT05630664
Liquid Biopsy in High-grade Gliomas and Meningiomas No drug interventions Not Available Not Available recruiting NCT04911621
Adjuvant Dendritic Cell Immunotherapy for Pediatric Patients With High-grade Glioma or Diffuse Intrinsic Pontine Glioma No drug interventions treatment 1 / 2 active_not_recruiting NCT05835687
Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors No drug interventions treatment 1 recruiting NCT01222754
Lenalidomide and Radiation Therapy in High Grade Gliomas or Diffuse Intrinsic Pontine Gliomas No drug interventions treatment 1 completed NCT05023551
Study of DSP-0390 in Patients With Recurrent High-Grade Glioma No drug interventions treatment 0 active_not_recruiting NCT05843253
Study of Ribociclib and Everolimus in HGG and DIPG No drug interventions treatment 2 not_yet_recruiting NCT05850377
5-Aminolevulinic Acid (5-ALA) Gliolan®: Usage Increase Proposal for Neurosurgical Procedures in High-Grade Gliomas No drug interventions Not Available Not Available not_yet_recruiting NCT03128047
HUMC 1612: Optune NovoTTF-200A System No drug interventions treatment 1 active_not_recruiting NCT03334305
Adoptive Cellular Therapy in Pediatric Patients With High-grade Gliomas No drug interventions treatment 1 active_not_recruiting NCT04099797
C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B) No drug interventions treatment 1 recruiting NCT00897611
Tumor DNA and MRI/CT Scan Findings in Patients With Grade III or Grade IV Malignant Glioma No drug interventions Not Available Not Available completed NCT05082493
A Multicenter, Study of the Safety and Pharmacokinetics of Intravenously Infused Berubicin in Pediatric Patients With Progressive, Refractory, or Recurrent High Grade Gliomas No drug interventions treatment 1 withdrawn NCT01902771
Dendritic Cell Vaccine Therapy With In Situ Maturation in Pediatric Brain Tumors No drug interventions treatment 1 terminated NCT06264388
DB107-Retroviral Replicating Vector (RRV) Combined With DB107-Flucytosine (FC) in Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma No drug interventions treatment 2 recruiting NCT05362409
Study to Evaluate 5-ALA Combined With CV01 Delivery of Ultrasound in Recurrent High Grade Glioma No drug interventions treatment 1 active_not_recruiting NCT04485559
Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021) No drug interventions treatment 1 recruiting NCT06333899
Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion No drug interventions treatment 0 not_yet_recruiting NCT03340506
Dabrafenib and/or Trametinib Rollover Study No drug interventions treatment 4 recruiting NCT03973918
Study of Binimetinib With Encorafenib in Adults With Recurrent BRAF V600-Mutated HGG No drug interventions treatment 2 terminated NCT05553041
18F-Fluciclovine PET-MRI in High-grade Glioma No drug interventions diagnostic 0 recruiting NCT03294434
Predicting Sites of Tumour Progression in the Invasive Margin of Glioblastomas (PRaM-GBM Study) No drug interventions Not Available Not Available unknown_status NCT03971734
Determining Dose of Regadenoson Most Likely to Transiently Alter the Integrity of the Blood-Brain Barrier in Patients With High Grade Gliomas No drug interventions treatment 1 terminated NCT05954858
Surgical Tissue Flap to Bypass the Blood Brain Barrier in Glioblastoma No drug interventions treatment Not Available recruiting NCT01466686
Low Dose Radiation Therapy for Glioblastoma Multiforme No drug interventions treatment 2 completed NCT06072586
Study of BDTX-1535 in Recurrent High-Grade Glioma (HGG) Participants With EGFR Alterations or Fusions No drug interventions treatment 0 recruiting NCT00826930
Trans Sodium Crocetinate (TSC) Study of Intra-tumoral Oxygen Concentration, Safety, and Pharmacokinetics in Patients With High Grade Glioma No drug interventions basic_science 1 terminated NCT01390948
A Study of Bevacizumab (Avastin) in Combination With Temozolomide (TMZ) and Radiotherapy in Paediatric and Adolescent Participants With High-Grade Glioma No drug interventions treatment 2 completed NCT02970448
Expedited Laser Interstitial Thermal Therapy + Chemoradiation For Newly Diagnosed High Grade Gliomas No drug interventions treatment 0 recruiting NCT05773326
Superselective Intra-arterial Cerebral Infusion of Temsirolimus in HGG No drug interventions treatment 0 recruiting NCT01808820
Dendritic Cell (DC) Vaccine for Malignant Glioma and Glioblastoma No drug interventions treatment 1 completed NCT00561873
Nimotuzumab in Children With HGG No drug interventions Not Available Not Available completed NCT03355794
A Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG) No drug interventions treatment 1 completed NCT05632562
Multiparametic Metabolic and Hypoxic PET/MRI for Disease Assessment in High Grade Glioma No drug interventions diagnostic 0 recruiting NCT05644080
68Ga/177Lu-PSMA Theranostics in Recurrent Grade 3 and Grade 4 Glioma No drug interventions treatment Not Available recruiting NCT02022644
Study of Convection-Enhanced, Image-Assisted Delivery of Liposomal-Irinotecan In Recurrent High Grade Glioma No drug interventions treatment 1 completed NCT04573140
A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM) No drug interventions treatment 1 recruiting NCT02655601
Trial of Newly Diagnosed High Grade Glioma Treated With Concurrent Radiation Therapy, Temozolomide and BMX-001 No drug interventions treatment 2 active_not_recruiting NCT04655404
A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion No drug interventions treatment 0 recruiting NCT05212272
MRI in High-Grade Glioma Patients Undergoing Chemoradiation No drug interventions Not Available Not Available recruiting NCT03775369
Glioma and Exercising No drug interventions supportive_care Not Available completed NCT05096481
PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma No drug interventions treatment 2 recruiting NCT06504381
DB107-RRV, DB107-FC, and Radiation Therapy With or Without Temozolomide (TMZ) for High Grade Glioma No drug interventions treatment 1 / 2 not_yet_recruiting NCT05298995
GD2-CAR T Cells for Pediatric Brain Tumours No drug interventions treatment 1 recruiting NCT06215495
A Novel Target Delineation Scheme in High-grade Glioma Patients: a Randomized Single-blind Clinical Trial No drug interventions treatment Not Available recruiting NCT04289155
Individual Patient Compassionate Use of GX-I7 No drug interventions Not Available Not Available no_longer_available NCT03605550
A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma No drug interventions treatment 1 active_not_recruiting NCT03411408
Accelerated Hypofractionated Intensity - Modulated Radiotherapy After Hyperbaric Oxygenation for Recurrent High Grade Glioma. No drug interventions treatment Not Available recruiting NCT05278208
Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors No drug interventions treatment 1 / 2 recruiting NCT03718767
Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotype No drug interventions treatment 2 recruiting