Non-Muscle-invasive Bladder Cancer (NMIBC) (DBCOND0082324)

Identifiers

Synonyms
Non-Muscle- Invasive Bladder Cancer / NMIBC / Non-muscle Invasive Bladder Cancer / Non Muscle-invasive Bladder Cancer / Non-muscle-invasive Bladder Cancer / Non-muscle Invasive Bladder Cancer (NMIBC) / Non Muscle Invasive Bladder Cancer / Nonmuscle Invasive Bladder Cancer / Non-Muscle Invasive Bladder Neoplasms / Carcinoma of urinary bladder, superficial (disorder) / Urothelial carcinoma bladder / Bladder transitional cell carcinoma / Transitional cell carcinoma of bladder (disorder)

Associated Data

Indicated Drugs and Targets
Not Available
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT05943106
BCG in Combination With Durvalumab in Adult BCG-naïve, High-risk NMIBC Participantstreatment3recruiting
NCT06630871
A Clinical Trial Evaluating the Efficacy and Safety of Disitamab Vedotin Plus Tislelizumab Combined with Re-TURBT in the Treatment of HER-2-high Expression(2+-3+) Non-muscle Invasive Bladder Cancer At High-risk and Very High-risk.treatment2not_yet_recruiting
NCT06588179
SHR-1501 Combined With SHR-2005 for High-Risk Non-Muscle Invasive Bladder Cancer Which is Not Completely Resectable by TURBtNo drug interventionstreatment1 / 2not_yet_recruiting
NCT05943379
RC48-ADC in Combination With Gemcitabine in High Risk NMIBC Subjectstreatment2recruiting
NCT05014139
A Study of Intravesical Enfortumab Vedotin For Treatment of Patients With Non-muscle Invasive Bladder Cancer (NMIBC)treatment1recruiting
NCT03914794
A Study of Pemigatinib in Non-muscle Invasive Bladder Cancer Patients With Recurrent Low- or Intermediate-Risk Tumorstreatment2recruiting
NCT05375903
A Phase 1 Dose-escalation Study of UGN-301 in Patients With Recurrent Non-muscle Invasive Bladder Cancer (NMIBC)treatment1recruiting
NCT06181266
A Phase 1/1b Study of ZH9 Treatment in Patients With Non-Muscle Invasive Bladder CancerNo drug interventionstreatment1recruiting
NCT03038321
Solifenacin, Levofloxacin or Lornoxicam, Which Is Ideal for Management of Intravesical Instillation BCG Side Effects?treatment4unknown_status
NCT06351904
A Study of RAG-01 in Patients With Non-muscle-invasive Bladder Cancer (NMIBC) Who Have Failed Bacillus Calmette Guérin (BCG) TherapyNo drug interventionstreatment1recruiting
NCT06186414
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of SIM0237 Alone or in Combination With BCG in NMIBCNo drug interventionstreatment1recruiting
NCT06637423
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Patients With Bladder Cancer (MK-2870-027)No drug interventionstreatment1 / 2not_yet_recruiting
NCT06632964
A Clinical Trial Aimed At Assessing the Efficacy and Safety of VT-101 for the Treatment of Non-muscle Invasive Bladder CancerNo drug interventionstreatment1recruiting
NCT06319820
A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With Bladder Cancertreatment3recruiting
NCT06503614
A Trial of Durvalumab (MEDI4736) Plus Monalizumab in Non-Muscle-Invasive Bladder Cancertreatment2not_yet_recruiting
NCT01310803
Multi-center Study to Evaluate the Efficacy and Safety of Maintenance Therapy With Valrubicin Versus no Maintenance, in Subjects Treated With Valrubicin Induction for Carcinoma in Situ (CIS) of the Bladdertreatment3terminated
NCT05085990
Safety and Toxicity Study of Intravesical Instillation of TARA-002 in Adults With High-grade Non-muscle Invasive Bladder Cancer (Phase 1b)No drug interventionstreatment1active_not_recruiting
NCT04498702
Study of Continuous APL-1202 Treatment in Subjects With High-Risk Non-Muscle-Invasive Bladder Cancer (NMIBC) Relapsed From Intravesical Chemo/BCG TherapyNo drug interventionstreatment2completed
NCT03560479
A First-in-Human Study of alpha1H in Patients With Non-muscle Invasive Bladder CancerNo drug interventionstreatment1 / 2unknown_status
NCT04100733
Surveillance of High-grade Non-muscle Invasive Bladder Tumours Using the Xpert Bladder Cancer MonitorNo drug interventionsdiagnosticNot Availableactive_not_recruiting
NCT05332353
Machine Learning-Based Prediction of BCG Response in High-Risk Non-Muscle Invasive Bladder Cancer PatientsNo drug interventionsNot AvailableNot Availableunknown_status
NCT01458847
Cis-urocanic Acid (Cis-UCA) in Patients With Primary or Recurrent Non-muscle Invasive Bladder CancerNo drug interventionstreatment1completed
NCT05327647
A Phase II Trial of Bicalutamide in Patients Receiving Intravesical BCG for Non-muscle Invasive Bladder Cancertreatment2recruiting
NCT06253845
Study of CG0070 After Transurethral Resection in Patients With IR NMIBCtreatment1recruiting
NCT05337397
Outpatient Laser Ablation of Recurrent Non-muscle Invasive Bladder CancerNo drug interventionsNot AvailableNot Availablerecruiting
NCT02316171
CAVATAK (CVA21) in Non-muscle Invasive Bladder Cancer (VLA-012 CANON)treatment1completed
NCT05672615
Mood Alterations in the Patients With Non-Muscle Invasive Bladder Cancer Treated With BCGNo drug interventionsNot AvailableNot Availablerecruiting
NCT05996952
RC48-ADC in Adjuvant/Salvage Treatment of HER2 Positive Non-muscle-invasive Bladder CancerNo drug interventionstreatment2not_yet_recruiting
NCT06187506
Disitamab Vedotin Combined With BCG Therapy in HER2-expressing High-risk Non-muscle Invasive Bladder Cancertreatment2recruiting
NCT04664816
Omega-3 Polyunsaturated Fatty Acids and Non-Muscle Invasive Bladder CancerNo drug interventionspreventionNot Availableunknown_status
NCT04644835
Low Energy Shock Wave Therapy and Non-Muscle Invasive Bladder CancerNo drug interventionstreatmentNot Availableunknown_status
NCT05957757
RC48 Combined With Tislelizumab for Bladder Sparing Treatment in NMIBC With BCG Treatment Failure and HER2 Expressiontreatment2recruiting
NCT04943094
Clinical and Functional Consequences of Photodynamic Diagnosis (PDD) and Intravesical Instillation TherapyNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT05223491
En Bloc Transurethral Resection of Non-muscle Invasive Bladder CancerNo drug interventionsdiagnosticNot Availablerecruiting
NCT06245603
A Study to Evaluate Efficacy and Safety of Hydeal Cyst® Intravesical Instillations in Patients Treated With Intravesical Chemotherapy or Immunotherapy in Non-muscle Invasive Bladder CancerNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT05951179
Safety and Efficacy Study of Intravesical Instillation of TARA-002 in Adults With High-grade Non-muscle Invasive Bladder CancerNo drug interventionstreatment2recruiting
NCT04859751
Study of VB4-845 Injection for Treating Patients With Non-muscle Invasive Bladder Cancertreatment3unknown_status
NCT06235853
Biomarkers of Recurrence and Progression in Non-muscle Invasive Bladder CancerNo drug interventionsNot AvailableNot Availablecompleted
NCT05085977
Safety and Toxicity Study of Intravesical Instillation of TARA-002 in Adults With High-grade Non-muscle Invasive Bladder Cancer (Phase 1a)No drug interventionstreatment1active_not_recruiting
NCT04490993
Safety and Efficacy of APL-1202 in Combination With Epirubicin Hydrochloride Versus Epirubicin Hydrochloride Alone in Intermediate and High-risk Chemo-refractory Non-muscle Invasive Bladder Cancer (NMIBC) Patientstreatment3unknown_status
NCT02969109
Validation of a Urine-based Assay With Genomic Markers for Predicting Recurrence for Non-muscle Invasive Bladder CancerNo drug interventionsNot AvailableNot Availablecompleted
NCT04375813
Trial of Encapsulated Rapamycin (eRapa) for Bladder Cancer Preventionprevention2recruiting
NCT04165317
A Study of Sasanlimab in People With Non-muscle Invasive Bladder Cancertreatment3active_not_recruiting
NCT02138734
A Study of Intravesical BCG in Combination With ALT-803 in Patients With Non-Muscle Invasive Bladder Cancertreatment1 / 2recruiting
NCT06126796
Urine-based Molecular Testing vs Cystoscopy for Surveillance of Nonmuscle Invasive Bladder Cancer (NMIBC)No drug interventionsNot AvailableNot Availablerecruiting
NCT03081858
Proliposomal Intravesical Paclitaxel for Treatment of Low-Grade, Stage Ta, Non Muscle Invasive Bladder Cancertreatment1 / 2completed
NCT03933826
CISTO: Comparison of Intravesical Therapy and Surgery as Treatment Options for Bladder CancerNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT06227065
Precise Neoadjuvant Chemoresection of Low Grade NMIBCtreatment2not_yet_recruiting
NCT05704231
The Effect of Telephone-Assisted Smoking Cessation Program in Patients Diagnosed With Non-Muscle Invasive Bladder CancerNo drug interventionssupportive_careNot Availablenot_yet_recruiting
NCT01625260
A Study of ALT-801 in Patients With Bacillus Calmette-Guerin (BCG) Failure Non-Muscle Invasive Bladder Cancertreatment1 / 2terminated
NCT04736394
A Phase 3 Study to Evaluate the Safety and Efficacy of APL-1202 as a Single-agent Oral Treatment Versus Intravesical Instillation of Epirubicin Hydrochloride in naïve Intermediate-risk NMIBC Patientstreatment3recruiting
NCT03221062
"En Bloc" Resection of NMIBC: a Prospective, Single Centre,Randomized StudyNo drug interventionstreatment4unknown_status
NCT06443944
An Expanded Access Program of Cretostimogene Grenadenorepvec for Treatment of NMIBC for Patients Unresponsive to BCGNot AvailableNot Availableavailable
NCT05126472
Study of 2141-V11 in People With Non-muscle Invasive Bladder Cancer That Did Not Respond to Standard TreatmentNo drug interventionstreatment1recruiting
NCT06241755
Clinical Trial for Evaluating the Efficacy and Safety of BCG for Therapeutic Use in the Prevention of Postoperative Recurrence of Medium/High-risk Non-muscle Invasive Bladder Cancer (NMIBC)No drug interventionstreatment3recruiting
NCT02075060
Evaluation of Immediate Preoperative Instillation (IPOI) of Mitomycin C Compared to Early Postoperative Instillation (IPOP) in Non-muscle Invasive Bladder CancerNo drug interventionstreatment2unknown_status
NCT05544552
Safety and Preliminary Anti-Tumor Activity of TYRA-300 in Advanced Urothelial Carcinoma and Other Solid Tumors With FGFR3 Gene AlterationsNo drug interventionstreatment1 / 2recruiting
NCT05519241
A Phase I Intravesical PPM Therapy for NMIBCtreatment1recruiting
NCT05962541
Vesical Imaging-Reporting and Data System (VI-RADS) Followed by Photodynamic Trans-urethral Resection of Bladder Tumours (PDD-TURBT) to Avoid Secondary Resections (Re-TURBT) in Non-Muscle Invasive Bladder Cancers (NMIBCs)treatment4not_yet_recruiting
NCT05580354
Safety and Efficacy of BCG Combined With Tislelizumab for BCG-untreated Patients With High-risk Non-muscle Invasive Bladder Cancertreatment4not_yet_recruiting
NCT06245759
The Prognostic Impact of Tumor Location in Non-Muscle-Invasive Bladder Cancer PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT05796375
Replacing Invasive Cystoscopy With Urine Testing for Non-muscle Invasive Bladder Cancer SurveillanceNo drug interventionshealth_services_researchNot Availablerecruiting
NCT05864599
External Validation of Uromonitor as a Biomarker for Optimization of NMIBC Management by the CUETO GroupNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04690699
LUMINOS-103: A Basket Trial Evaluating the Safety and Efficacy of Lerapolturev (PVSRIPO) and Lerapolturev in Combination With Anti-PD-1/L1 Checkpoint Inhibitors in Patients With Advanced Solid Tumorstreatment1 / 2active_not_recruiting
NCT05232136
OH2 Oncolytic Viral Therapy in Non-Muscle-Invasive Bladder Cancertreatment1 / 2recruiting
NCT05547516
Blue Laser -5ala Photodynamic Therapy (PDT) in High-Risk Non-muscle Invasive Bladder Cancer (NMIBC) PatientstreatmentNot Availableunknown_status
NCT03664258
A Multi-National Study In Bladder Cancer Patients to Detect Recurrences After TURB (Trans-urethral Resection of the Bladder) Earlier With the Xpert Bladder Cancer Monitor Assay (ANTICIPATE X)No drug interventionsNot AvailableNot Availablecompleted
NCT05538663
Intravesical BCG vs GEMDOCE in NMIBCtreatment3recruiting
NCT05710848
A Study of STM-416 Administered to Patients Undergoing TURBT for Recurrent Bladder CancerNo drug interventionstreatment1 / 2recruiting
NCT03528694
Assessment of Efficacy and Safety of Durvalumab Plus BCG Compared to the Standard Therapy With BCG in Non-muscle Invasive Bladder Cancertreatment3active_not_recruiting
NCT03950362
Bladder PREserVation by RadioTherapy and Immunotherapy in BCG Unresponsive Non-muscle Invasive Bladder Cancertreatment2unknown_status
NCT05626101
Safety and Efficacy of Scheduled Intravesical Gemcitabine Versus Intravesical BCG for Intermediate and High Risk Non Muscle Invasive Bladder Cancer: A Prospective, Randomized StudytreatmentNot Availablerecruiting
NCT05483868
A Phase 1, Open-label Trial of Belzupacap Sarotalocan (AU-011) in Bladder Cancertreatment1recruiting
NCT05825950
Artificial Intelligence Prediction Tool in Non-muscle Invasive Bladder Cancer (NMIBC)No drug interventionsNot AvailableNot Availablerecruiting
NCT05002556
AFU Registry of the Therapeutic Management and Follow-up of Non-Muscle-Invasive Bladder CancerNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT06327932
HIVEC in Patients With Non-Muscle-Invasive Bladder Cancerprevention3not_yet_recruiting
NCT05671900
Gemcitabine and Docetaxel Therapy in High-risk BCG-naive Patients With Non-muscle Invasive Bladder CancertreatmentNot Availableactive_not_recruiting
NCT05675176
Antegrade Observational Comparative Study for the Intravesical Instillation Therapy of Bacillus Calmette Guerin With the Use of Different Types of Urinary Catheters in Patients With Urinary Bladder CancerNo drug interventionsNot AvailableNot Availablecompleted
NCT05790850
Pre-Habilitation With Mindfulness and Exercise for Patients Undergoing Radical Cystectomy (PRIMER Trial)No drug interventionssupportive_careNot Availablerecruiting
NCT05176145
Demonstration of the Medical Interest of the VisioCyt® Artificial Intelligence TestNo drug interventionsdiagnosticNot Availablerecruiting
NCT02009332
Phase 1/2 Study of ABI-009 in Nonmuscle Invasive Bladder Cancertreatment1 / 2completed
NCT03719300
Codex: Study of Inodiftagene Vixteplasmid (BC-819) in Unresponsive NMIBCtreatment2terminated
NCT04179162
Bacillus Calmette-Guérin (BCG) and Gemcitabine in People With High-Grade Non-Muscle Invasive Bladder Cancer That Came Back After BCG Treatmenttreatment1 / 2recruiting
NCT03839472
Continuous Bladder Irrigation Following Transurethral Resection of Bladder TumorsNo drug interventionstreatmentNot Availablewithdrawn
NCT03167151
Pembrolizumab in Intermediate Risk Recurrent Non-muscle Invasive Bladder Cancer (NMIBC)treatment1 / 2terminated
NCT06069453
Hyaluronic Acid Sodium Salt and Hydeal-D in the Management of LUTS After TURBT for NMIBC.No drug interventionstreatmentNot Availableterminated
NCT03148158
Assessment Of Bladder Tumors Stage And Grade By Outpatient Flexible Cystoscopy Performed By Urology ResidentNo drug interventionsNot AvailableNot Availableunknown_status
NCT03672240
Study of APL-1202 in Non-Muscle Invasive Bladder Cancer Patients Who Are Resistant to One Induction Course of BCG TreatmentNo drug interventionstreatment1 / 2completed
NCT06205277
Predictors of Residual Tumor at Second Transurethral Resection for pT1 Non-muscle Invasive Bladder CancerNo drug interventionsNot AvailableNot Availablecompleted
NCT04387461
Study of CG0070 Given in Combination With Pembrolizumab, in Non-Muscle Invasive Bladder Cancer, Unresponsive to Bacillus Calmette-Guerintreatment2unknown_status
NCT01004211
Prospective Randomized Comparison of Transurethral Resection by Mean of White Light and Narrow Band ImagingNo drug interventionstreatmentNot Availablecompleted
NCT01731652
Study With TMX-101 in Patients With Carcinoma In Situ (CIS) Bladder Cancertreatment2completed
NCT01799499
A Prospective Open Label Comparative Dose Ranging Study Evaluating the Effect of Pre-TURBT Intravesical Instillation of Mitomycin C (MMC) Mixed With TC-3 Gel in Patients With Non Muscle Invasive Bladder Cancer (NMIBC)No drug interventionstreatmentNot Availablewithdrawn
NCT03421236
Intravesical Ty21a for the Treatment of Patients With Non-muscle-invasive Bladder Cancer (NMIBC)No drug interventionstreatment1unknown_status
NCT06287541
The Necessity of a Second Transurethral Resection in High-risk Non-muscle-invasive Bladder Cancer Patients With Negative Urine Biomarker After Initial Transurethral ResectionNo drug interventionstreatmentNot Availablerecruiting
NCT06111235
A Study of Adjuvant Cretostimogene Grenadenorepvec for Treatment of Intermediate Risk NMIBC Following TURBTtreatment3recruiting
NCT04452591
Study of Cretostimogene Given in Patients With Non-Muscle Invasive Bladder Cancer ,Unresponsive to Bacillus-Calmette-GuerinNo drug interventionstreatment3recruiting
NCT02982395
Study to Evaluate the Efficacy and Safety Of Intravesical Nanoxel®M In BCG Refractory NMIBCtreatment3terminated
NCT02343614
Celecoxib for the Treatment of Non-muscle Invasive Bladder Cancertreatment2completed
NCT06020807
Analytical Specificity of Bladder EpiCheck Test in Healthy Population and Urology Patients Without Prior History or Evidence of Bladder CancerNo drug interventionsNot AvailableNot Availablecompleted
NCT06167356
Study on the Occurrence of Possible Relapses and on the Quality of Life in Patients Who Underwent TURBK.No drug interventionsNot AvailableNot Availablerecruiting
NCT02895620
Effect on Xpert® Bladder Test of Urines Inflammatory Milieu Induced by BCG Treatment of Patients With NMIBCNo drug interventionsNot AvailableNot Availableunknown_status
NCT05981131
Follow up of Intravesical N-803 Plus BCG in BCG-Naive Non-Muscle Invasive Bladder Cancer (NMIBC)Not AvailableNot Availableactive_not_recruiting
NCT05945108
Brazilian Reality of Urinary Bladder Cancers - BRA-BLADDERNo drug interventionsNot AvailableNot Availablecompleted
NCT00582387
Genetic Susceptibility to Tumor Recurrence and Progression in Patients With Non-Muscle Invasive Bladder CancerNo drug interventionsNot AvailableNot Availablecompleted