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Disease Prioritization Data Package

This package has 16 modules. The BlackBox Warnings Module has 5 tables. Preview the first five rows of each table or Explore the schema

BlackBox Warnings Module

5 Tables

Structured data representing warnings from the black box section of drug labels. Black box warnings may include specific criteria as to when they apply, as well as potential risks, contraindications, or adverse effects.

BlackBox Warning Attributes

Boxed warnings can have additional relevant attributes represented in the blackbox_warning_attributes table. Each row captures a value and a relationship (such as lab_value, route, age_group, etc.).

blackbox_warning_id
relationship
value
0012269c-c0e7-462b-8d9b-d6cc39e0323e
age_group
adolescent
0012269c-c0e7-462b-8d9b-d6cc39e0323e
age_group
adult
0012269c-c0e7-462b-8d9b-d6cc39e0323e
age_group
pediatric
0012269c-c0e7-462b-8d9b-d6cc39e0323e
route
Oral
003fa5d3-4a38-4b2b-b7b4-9e63df4f4fd7
dose_form
Cream
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BlackBox Warning Categories

Certain boxed warnings are specific to combinations of categories of drugs, and these relationships are represented in this table (coadmin indicates if the boxed warnings is specific to coadministration of the drug and the related category).

blackbox_warning_id
category_id
coadmin
0004a413-b69d-4795-a487-2b46136f8dcd
399
0
01a52d72-f5e0-4392-96f5-b5d37914c3cb
708
0
01dff626-3ff7-44f2-8e3b-81e256430273
450
0
026b5556-1f07-4d9b-8673-6f35af390250
1004
0
0767c6fa-e1ea-4cf9-8467-206e06e829bb
708
0
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BlackBox Warning Conditions

Boxed warnings are linked to multiple DrugBank conditions, such as prerequisite therapies and patient diseases and conditions.

blackbox_warning_id
condition_id
relationship
ea6e9dbf-d0af-4c16-8874-3428f6f9b6ec
213
risk
1c7a0518-aca0-4dad-97b5-7c4b6e11e616
283
required_use
6f67151c-127f-4a7d-ab3d-89a4edb885c1
480
risk
980f5ada-eccc-404e-acb0-ed1ec2ce3b78
480
risk
a1a78315-aa1a-40eb-b288-e52c5d6d56a9
480
risk
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BlackBox Warning Drugs

Certain boxed warnings are specific to combinations of drugs, and the relationships with these additional drugs are represented in this table.

blackbox_warning_id
drug_id
coadmin
041f5ce1-adaa-4dd3-b087-231dc4d796a0
929
0
0e56cc80-f062-433a-9bf5-c7e488c9bcf2
6833
0
13f1bca6-216b-4483-a3fc-b1b646bbf49c
1156
0
156b29e0-d1fa-4fd0-ae2a-154400de9f7a
586
0
158754af-d1e3-4937-84da-0dc6446177ce
945
0
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Structured BlackBox Warnings

Each row in this table describes a structured boxed warning for a drug, referenced by the drug_id column.

id
drug_id
kind
recommendation
management
administration
timeline
sex_group
min_age_amount
min_age_unit
max_age_amount
max_age_unit
0004a413-b69d-4795-a487-2b46136f8dcd
6205
interaction
Reserve concomitant prescribing of tapentadol tablets and benzodiazepines or other CNS depressants for use in patients for whom alternative treatment options are inadequate.
0012269c-c0e7-462b-8d9b-d6cc39e0323e
472
warning
Advise families and caregivers of the need for close observation and communication with the prescriber. Do not use in patients less than seven years of age.
Monitor closely for worsening and for emergence of suicidal thoughts and behaviors.
24
year
00178ae5-22b3-4d77-8db5-a271275bbff2
6713
warning
Severe bronchoconstriction can occur, even at the lowest recommended dose. Methacholine is contraindicated in adult and pediatric patients with baseline FEV1 < 60% of the predicted value and in adult patients with baseline FEV1 < 1.5 L. Use in patients with clinically apparent wheezing or asthma is not recommended.
Ensure access to emergency medical equipment and medication to treat respiratory distress. Severe bronchoconstriction should be reversed immediately with a rapidly acting β-agonist bronchodilator.
Ensure baseline spirometry is performed accurately such that baseline FEV1 is accurate and inappropriately high doses of methacholine are not administered.
003fa5d3-4a38-4b2b-b7b4-9e63df4f4fd7
286
warning
6.8-7.1 years of treatment
female
50
year
79
year
00594171-2317-42e0-bdc1-e44aa9012dea
8
warning
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Showing 5 of 5 tables