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Drug Repurposing Data Package

This package has 13 modules. The Structured Pharmacology Module has 11 tables. Preview the first five rows of each table or Explore the schema

Structured Pharmacology Module

11 Tables

The Structured Pharmacology Module provides essential pharmacokinetic parameters: LD50, Clearance, Half-Life, Volume of Distribution, Bioavailability, AUC, Cmax, Tmax, and Protein Binding.

LD50

Covers median lethal dosages (LD50), a measure of substance toxicity indicating the dose that causes death in 50% of animal test subjects. Structured pharmacokinetic data from the toxicity field of the pharmacologies table.

id
drug_id
value
min
max
unit
fda_label_reference
msds_reference
organism_id
dosage_route_id
3
8920
300.0
mg/kg
1
1
1582
84
6
40
39.0
mg/kg
0
0
1579
70
9
73
27.0
mg/kg
1
1
1582
84
12
73
32.0
mg/m³
1
1
1582
93
15
73
37.0
mg/m³
1
1
1579
93
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Clearance

Comprises clearance (CL) data, a measurement of the rate at which a drug leaves the body. Structured pharmacokinetic data derived from the clearance field of the pharmacologies table.

id
drug_id
value
min
max
unit
normalized_value
normalized_min
normalized_max
normalized_unit
dosage_route_id
dosage_form_id
dose_value
dose_min
dose_max
dose_unit
normalized_dose_value
normalized_dose_min
normalized_dose_max
normalized_dose_unit
fda_label_reference
sex
age_group
63491
1
139.0
mL/min
8.34
L/h
0
unspecified
seniors
63496
1
61.0
mL/min
3.66
L/h
0
unspecified
unspecified
63501
1
114.0
mL/min
6.84
L/h
0
unspecified
unspecified
63506
1
164.0
mL/min
9.84
L/h
0
unspecified
adult
63511
6
3.4
mL/min/kg
0.204
L/h/kg
0
unspecified
unspecified
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Half-Life

Covers half-lives (t1/2), a measurement of the time required for the concentration of an administered drug within the body to decrease by half. Structured pharmacokinetic data derived from the half-life field of the pharmacologies table.

id
drug_id
value
min
max
unit
normalized_value
normalized_min
normalized_max
normalized_unit
dosage_route_id
dosage_form_id
dose_value
dose_min
dose_max
dose_unit
normalized_dose_value
normalized_dose_min
normalized_dose_max
normalized_dose_unit
fda_label_reference
sex
age_group
47156
4
70.0
80.0
minutes
1.166667
1.333333
h
0
unspecified
unspecified
47161
8
164.0
84.0
353.0
hours
164.0
84.0
353.0
h
0
unspecified
unspecified
47166
1281
16.7
12.0
23.0
days
400.8
288.0
552.0
h
0
unspecified
unspecified
47171
1281
13.1
8.0
25.0
day
314.4
192.0
600.0
h
0
unspecified
unspecified
47176
1281
14.3
days
343.2
h
98
0
unspecified
adult
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Volume of Distribution

Covers volumes of distribution (Vd), a measurement describing the distribution of a drug throughout the body after administration. Structured pharmacokinetic data derived from the volume of distribution field of the pharmacologies table.

id
drug_id
value
min
max
unit
normalized_value
normalized_min
normalized_max
normalized_unit
dosage_route_id
dosage_form_id
dose_value
dose_min
dose_max
dose_unit
normalized_dose_value
normalized_dose_min
normalized_dose_max
normalized_dose_unit
fda_label_reference
sex
age_group
83651
5084
50.0
L
50.0
L
0
unspecified
unspecified
83656
1281
0.07
L/kg
0.07
L/kg
70
0
unspecified
unspecified
83661
1281
0.09
L/kg
0.09
L/kg
70
0
unspecified
unspecified
83666
1281
0.11
L/kg
0.11
L/kg
98
0
unspecified
unspecified
83671
15619
100.0
L
100.0
L
70
0
unspecified
unspecified
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Bioavailability

Comprises bioavailabilities (F), a measure of the extent to which a drug is absorbed into the systemic circulation. Structured pharmacokinetic data derived from the absorption field of the pharmacologies table.

id
drug_id
value
min
max
unit
normalized_value
normalized_min
normalized_max
normalized_unit
dosage_route_id
dosage_form_id
dose_value
dose_min
dose_max
dose_unit
normalized_dose_value
normalized_dose_min
normalized_dose_max
normalized_dose_unit
fda_label_reference
sex
age_group
72316
17
71.0
%
71.0
%
98
0
unspecified
unspecified
72321
17
66.0
%
66.0
%
50
0
unspecified
unspecified
72326
17
3.0
5.0
%
3.0
5.0
%
58
0
unspecified
unspecified
72331
26
95.0
%
95.0
%
98
65
70.0
mg
70.0
mg
0
unspecified
unspecified
72336
38
80.0
%
80.0
%
0
unspecified
unspecified
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AUC

Comprises area under the curve (AUC) values, a measurement of the total systemic exposure to a drug following administration. Structured pharmacokinetic data derived from the absorption field of the pharmacologies table.

id
drug_id
value
min
max
unit
normalized_value
normalized_min
normalized_max
normalized_unit
dosage_route_id
dosage_form_id
dose_value
dose_min
dose_max
dose_unit
normalized_dose_value
normalized_dose_min
normalized_dose_max
normalized_dose_unit
fda_label_reference
sex
age_group
61536
1
2500.0
ng•h/mL
2.5
mg.h/L
70
65
0.4
mg/kg
0.4
mg/kg
0
all
unspecified
61541
1
612.0
ng•h/mL
0.612
mg.h/L
70
65
0.1
mg/kg
0.1
mg/kg
0
male
unspecified
61546
1
1184.0
ng•h/mL
1.184
mg.h/L
70
65
0.15
mg/kg
0.15
mg/kg
0
male
unspecified
61551
1
1446.0
ng•h/mL
1.446
mg.h/L
70
65
0.2
mg/kg
0.2
mg/kg
0
male
unspecified
61556
46
2360.0
2390.0
pmol hr/L
0.0000000024
0.0000000024
mol.h/L
98
0
unspecified
unspecified
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Cmax

Comprises maximum concentration (Cmax) values, a measurement of the peak serum concentration reached by a drug following its administration. Structured pharmacokinetic data derived from the absorption field of the pharmacologies table.

id
drug_id
value
min
max
unit
normalized_value
normalized_min
normalized_max
normalized_unit
dosage_route_id
dosage_form_id
dose_value
dose_min
dose_max
dose_unit
normalized_dose_value
normalized_dose_min
normalized_dose_max
normalized_dose_unit
fda_label_reference
sex
age_group
44711
1
2924.0
ng/mL
2.924
mg/L
70
65
0.4
mg/kg
0.4
mg/kg
0
all
unspecified
44716
1
111.0
ng/mL
0.111
mg/L
70
65
0.1
mg/kg
0.1
mg/kg
0
male
unspecified
44721
1
203.0
ng/mL
0.203
mg/L
70
65
0.15
mg/kg
0.15
mg/kg
0
male
unspecified
44726
1
2446.0
ng/mL
2.446
mg/L
70
65
0.2
mg/kg
0.2
mg/kg
0
male
unspecified
44731
5
1.1
mcg/L
0.0011
mg/L
98
25.0
mg
25.0
mg
0
unspecified
unspecified
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Tmax

Comprises time to maximum concentration (Tmax) values, a measurement of the time it takes for a drug to reach its maximum concentration (Cmax). Structured pharmacokinetic data derived from the absorption field of the pharmacologies table.

id
drug_id
value
min
max
unit
normalized_value
normalized_min
normalized_max
normalized_unit
dosage_route_id
dosage_form_id
dose_value
dose_min
dose_max
dose_unit
normalized_dose_value
normalized_dose_min
normalized_dose_max
normalized_dose_unit
fda_label_reference
sex
age_group
80051
1
0.17
hours
0.17
h
70
65
0.4
mg/kg
0.4
mg/kg
0
all
unspecified
80056
5
69.0
h
69.0
h
98
25.0
mg
25.0
mg
0
unspecified
unspecified
80061
16
20.0
25.0
hours
20.0
25.0
h
98
1
unspecified
unspecified
80066
16
5.0
24.0
hours
5.0
24.0
h
98
1
unspecified
pediatric
80071
19
1.0
2.0
days
24.0
48.0
h
98
0
unspecified
unspecified
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Protein Binding

Covers protein binding data expressed as a percentage, indicating the proportion of drug which is protein-bound following administration. Structured pharmacokinetic data derived from the protein_binding field of the pharmacologies table.

id
drug_id
value
min
max
unit
normalized_value
normalized_min
normalized_max
normalized_unit
dosage_route_id
dosage_form_id
dose_value
dose_min
dose_max
dose_unit
normalized_dose_value
normalized_dose_min
normalized_dose_max
normalized_dose_unit
fda_label_reference
sex
age_group
8331
1
3.0
%
3.0
%
0
unspecified
unspecified
8336
7
43.0
49.0
%
43.0
49.0
%
0
unspecified
unspecified
8341
14
27.3
%
27.3
%
0
unspecified
unspecified
8346
17
30.0
40.0
%
30.0
40.0
%
0
unspecified
unspecified
8351
35
17.3
%
17.3
%
0
unspecified
unspecified
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Protein Binding Bio-entities

Serves to map structured protein binding values to their corresponding proteins when used in conjunction with the Protein Binding submodule. Data derived from the protein_binding field of the pharmacologies table.

structured_pharmacology_protein_binding_id
bio_entity_id
8371
BE0000530
8376
BE0000925
8411
BE0001141
8451
BE0000530
8536
BE0000530
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Route of Elimination

Comprises route of elimination data as a percentage, indicating the proportion of drug eliminated by different routes. Structured pharmacokinetic data derived from the route_of_elimination field of the pharmacologies table.

id
drug_id
value
min
max
unit
normalized_value
normalized_min
normalized_max
normalized_unit
dosage_route_id
dosage_form_id
dose_value
dose_min
dose_max
dose_unit
normalized_dose_value
normalized_dose_min
normalized_dose_max
normalized_dose_unit
fda_label_reference
importance
elimination_type
sex
age_group
9296
1
48.3
%
48.3
%
0
unspecified
urine
unspecified
unspecified
9301
7
0.0
5.0
%
0.0
5.0
%
3.75
mg
3.75
mg
0
minor
urine
unspecified
unspecified
9306
9
80.0
%
80.0
%
0
major
urine
unspecified
unspecified
9311
13
%
0
unspecified
urine
unspecified
unspecified
9316
13
%
0
unspecified
feces
unspecified
unspecified
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Showing 11 of 11 tables