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Add-OnClinical Trials & Rare Diseases
Clinical Trials & Rare Diseases
This package has 3 modules. The Drug-Protein Relationships and Drug Targets Module has 4 tables. Preview the first five rows of each table or Explore the schema
Drug-Protein Relationships and Drug Targets Module
4 Tables
Describes the relationship between drugs and targets, enzymes, carriers, or transporters. Annotation includes the pharmacological action, and the type of interaction (antagonist, agonist, substrate, inhibitor, or inducer).
biodb_id | name | kind | organism |
|---|---|---|---|
BE0000001 | Peptidoglycan synthase FtsI | protein | Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) |
BE0000002 | Histidine decarboxylase | protein | Humans |
BE0000003 | Glutaminase liver isoform, mitochondrial | protein | Humans |
BE0000004 | Coagulation factor XIII A chain | protein | Humans |
BE0000005 | Nitric oxide synthase, inducible | protein | Humans |
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biodb_id | component_type | component_id |
|---|---|---|
BE0000001 | Polypeptide | P45059 |
BE0000002 | Polypeptide | P19113 |
BE0000003 | Polypeptide | Q9UI32 |
BE0000004 | Polypeptide | P00488 |
BE0000005 | Polypeptide | P35228 |
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id | type | drug_id | biodb_id | pdb_id | position | pharmacological_action | antagonist | agonist | substrate | inhibitor | inducer | other_action | inducer_strength | inhibitor_strength | induction_clinically_sig | inhibition_clinically_sig |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | TargetBond | 1 | BE0000048 | 1 | yes | 0 | 0 | 0 | 1 | 0 | unknown | 0 | 0 | |||
2 | TargetBond | 2 | BE0000767 | 1 | yes | 0 | 0 | 0 | 0 | 0 | binder | 0 | 0 | |||
3 | TargetBond | 4 | BE0000658 | 1 | yes | 0 | 0 | 0 | 0 | 0 | binder | 0 | 0 | |||
4 | TargetBond | 5 | BE0000704 | 1 | yes | 0 | 0 | 0 | 1 | 0 | antibody | unknown | 0 | 0 | ||
5 | TargetBond | 6 | BE0000048 | 1 | yes | 0 | 0 | 0 | 1 | 0 | unknown | 0 | 0 |
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uniprot_id | name | uniprot_name | gene_name | organism_id | molecular_weight | theoretical_pi | general_function | specific_function | signal_regions | transmembrane_regions | pdb_ids | genbank_gene_id | genbank_protein_id | genecard_id | locus | genatlas_id | hgnc_id | meta_cyc_id | ncbi_sequence_ids | tissue_specificity | cofactor | subunit | cellular_location | amino_acid_sequence | gene_sequence |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A0A023W3H0 | Class D OXA-48 carbapenemase | A0A023W3H0_KLEPN | OXA-48 | 144 | 16920.07 | Penicillin binding | >lcl|BSEQ0022471|Class D OXA-48 carbapenemase
VVKDEHQVFKWDGQTRDIATWNRDHNLITAMKYSVVPVYQEFARQIGEARMSKMLHAFDY
GNEDISGNVDSFWLDGGIRISATEQISFLRKLYHNKLHVSERSQRIVKQAMLTEANGDYI
IRAKTGYSTRIEPKIGWWVGWVELD | ||||||||||||||||||
A0A024R8I1 | Voltage-dependent N-type calcium channel subunit alpha | A0A024R8I1_HUMAN | CACNA1B | 154 | 111676.12 | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. | Voltage-gated calcium channel activity | 99-116
136-156
223-245
333-355
484-504
510-527
548-566
609-631
687-709 | Membrane | >lcl|BSEQ0052085|Voltage-dependent N-type calcium channel subunit alpha
MVRFGDELGGRYGGPGGGERARGGGAGGAGGPGPGGLQPGQRVLYKQSIAQRARTMALYN
PIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPD
GDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWKVMDFVVVLTGILA
TAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAII
GLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNI
LFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFA
KERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAA
TKKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVK
AQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRS
YFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVV
SLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAILTVFQIL
TGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTK
DEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQNSAKARSVWEQRASQLRLQNL
RASCEALYSEMDPEERLRFATTRHLRPDMKTHLDRPLVVELGRDGARGPVGGKARPEAAE
APEGVDPPRRHHRHRDKDKTPAAGDQDRAEAPKAESGEPGAREERPRPHRSHSKEAAGPP
EARSERGRGPGPEGGRRHHRRGSPEEAAEREPRRHRAHRHQDPSKESPRQGRAARAAPRR
PPSGAPGGGERGGAGAAAPGPAQGAACSRGCGEGDHGEGGHGEGG | |||||||||||||||
A0A024WHL8 | Multidrug resistance protein 2 | A0A024WHL8_PLAFA | 2228 | 119382.33 | Abc-type transporter activity | 27-49
69-88
108-126
138-161
360-381
401-418
479-499
505-522
596-614
626-647 | Membrane | >lcl|BSEQ0054224|Multidrug resistance protein 2
MDVSNYEYLRSYGIKNELKRKRTHKKIIIYHLLDIIIFFLLFFSCYNFNLELCYKYEKAI
FYNFFKSSVDLFLLNVIRIIYTVILFRLHKKLTELNTLGKVYVLSRHITGILVILNVIKM
INYSYVIKSENPLYNTNMYLITLKVLFMVYSMISSIYYYFIQFKLYNIKKKYIIARVELE
KILINDIKSKKYNIYKSDENSGLLGTDNNSTIMNNEYLNLDYKNLLDMNISYNKLNEKIN
NDIINNTSDVQEKNMDYNDIHNFQKKKKSSNFAYLNFFHKESKDNKIDVKESFLNKRYGS
NKRSSKIYDNNNNNNNNNNNNINSKIDYLENNITYTEFKKILLPYLWPSKRIDMKGNSSI
LRTYIVLIFLFILVSKVFSVISPIYLGWASNEVLKKSLSSSVYYLGLYVTFFFISKFLKE
VCGVLYSQVQQSAFIELQESIFQTFHNLSYEWYSSKNSGGIMRIVDRGTESANNLMSSVL
MYIIPATIEGLITCVIFIFKYKNSLLGSVLFIGLTLYIYSTIKITKWRKKIRTKANEMDN
VYHDIAHDSLTNYENVKYFSNEKFEIKKFCNALSNYHRYNLKILNSLGILNTVQQFILNG
TLFFTLLCVIYMIVKEGSDPGTFISVVVYTSNVFAPLSILGTLYATIIKSFTDISDLIDI
LRDKIDISNDKNLKNFDLTSQEKKFGVSIEFNNVHFNYPTQPLHTSLKDINIYIKPGTTC
ALVGHTGSGKTTISKLLYRFYDSKGEIKIGGRNINEYTRNSIRNIIGIVPQDTILFNESI
KYNILYGKLDATEEELIQAVKSAQLYDFIQSLPKKWDTLVGDKGVKLSGGERQRISIARC
LLKDPKIVIFDEATSSLDSRTEYLFQKAVEDLRKNRTIIIIAHKLCTITTAELIILLNKG
KIIERGTHLDLLKCNGEYTEMWNMQSKSNEPHTETNSSIDKDDVNKNNNKNNDVILNTCK
NDITTSFRSNSEKSSQEFSDASNHIKQSKTSNDHNNNINVHKKNEQEQLFLTNDKTDMDD
NMNNKKK | |||||||||||||||||
A0A045ISQ8 | Cytochrome D Ubiquinol oxidase subunit II | A0A045ISQ8_MYCTX | cydB | 13 | 37626.835 | Oxidoreductase activity | 6-24
87-107
119-142
162-188
200-221
227-247
254-275
303-326 | >lcl|BSEQ0052081|Cytochrome D Ubiquinol oxidase subunit II
MVLQELWFGVIAALFLGFFILEGFDFGVGMLMAPFAHVGMGDPETHRRTALNTIGPVWDG
NEVWLITAGAAIFAAFPGWYATVFSALYLPLLAILFGMILRAVAIEWRGKIDDPKWRTGA
DFGIAAGSWLPALLWGVAFAILVRGLPVDANGHVALSIPDVLNAYTLLGGLATAGLFSLY
GAVFIALKTSGPIRDDAYRFAVWLSLPVAGLVAGFGLWTQLAYGKDWTWLVLAVAGCAQA
AATVLVWRRVSDGWAFMCTLIVVAAVVVLLFGALYPNLVPSTLNPQWSLTIHNASSTPYT
LKIMTWVTAFFAPLTVAYQTWTYWVFRQRISAERIPPPTGLARRAP | |||||||||||||||||
A0A045KKX4 | Cytochrome D ubiquinol oxidase subunit I | A0A045KKX4_MYCTX | cydA | 13 | 53826.08 | Electron transfer activity | 20-41
53-71
91-115
127-150
187-208
220-242
339-361
373-394
429-451 | Cell inner membrane | >lcl|BSEQ0052080|Cytochrome D ubiquinol oxidase subunit I
MNVVDISRWQFGITTVYHFIFVPLTIGLAPLIAVMQTLWVVTDNPAWYRLTKFFGKLFLI
NFAIGVATGIVQEFQFGMNWSEYSRFVGDVFGAPLAMEGLAAFFFESTFIGLWIFGWNRL
PRLVHLACIWIVAIAVNVSAFFIIAANSFMQHPVGAHYNPTTGRAELSSIVVLLTNNTAQ
AAFTHTVSGALLTAGTFVAAVSAWWLVRSSTTHADSDTQAMYRPATILGCWVALAATAGL
LFTGDHQGKLMFQQQPMKMASAESLCDTQTDPNFSVLTVGRQNNCDSLTRVIEVPYVLPF
LAEGRISGVTLQGIRDLQQEYQQRFGPNDYRPNLFVTYWSFRMMIGLMAIPVLFALIALW
LTRGGQIPNQRWFSWLALLTMPAPFLANSAGWVFTEMGRQPWVVVPNPTGDQLVRLTVKA
GVSDHSATVVATSLLMFTLVYAVLAVIWCWLLKRYIVEGPLEHDAEPAAHGAPRDDEVAP
LSFAY |
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Showing 4 of 4 tables
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