Hydroxocobalamin is a synthetic form of vitamin B12 used to treat vitamin B12 associated disorders and cyanide poisoning. It is also used in cyanide poisoning, Leber's optic atrophy, and toxic amblyopia.
- Mechanism
- Curator reviewed
Vitamin B12 exists in four major forms referred to collectively as cobalamins; deoxyadenosylcobalamin, methylcobalamin, hydroxocobalamin, and cyanocobalamin. Two of these, methylcobalamin and 5-deoxyadenosyl cobalamin, are primarily used by the body. Methionine synthase needs methylcobalamin as a cofactor. This enzyme is involved in the conversion of the amino acid homocysteine into methionine. Methionine in turn is required for DNA methylation. 5-Deoxyadenosyl cobalamin is a cofactor needed by the enzyme that converts L-methylmalonyl-CoA to succinyl-CoA. This conversion is an important step in the extraction of energy from proteins and fats. Furthermore, succinyl CoA is necessary for the production of hemoglobin, the substances that carries oxygen in red blood cells.
- Primary indication
- For treatment of pernicious anemia and the prevention and treatment of vitamin B12 deficiency arising from alcoholism, malabsorption, tapeworm infestation, celiac, hyperthyroidism, hepatic-biliary tract disease, persistent diarrhea, ileal resection, pancreatic cancer, renal disease, prolonged stress,...Curator reviewed · 14 structured indications
- Formula / weight
- C62H89CoN13O15P · 1346.3551 g/mol (avg)
- First approval
- Canada, 2010 · United States, 2007 · European Union, 2016
- Also known as
- Hydroxocobalamine · Hydroxycobalamin · OH-Cbl · Vitamin B-12b
- Brand names
Resolves to
YOZNUFWCRFCGIH-WZHZPDAFSA-KSMILES[N+]1=2[Co-3]345([N+]6=C7[C@H]([C@@](CC(=O)N)(C)[C@@]6([C@@]6(N3C(=C(C)C3=[N+]4C(C(C)(C)[C@@H]3CCC(=O)N)=CC3=[N+]5C(=C7C)[C@@](CC(=O)N)([C@@H]3CCC(=O)N)C)[C@@](C)([C@H]6CC(=O)N)CCC(NC[C@@H](C)OP(=O)(O[C@@H]3[C@H](O[C@H](N(C4=CC(=C(C=C14)C)C)C=2)[C@@H]3O)CO)[O-])=O)[H])C)CCC(=O)N)O[H]What you can answer from here — as of September 23, 2026
Which drugs share a target with Hydroxocobalamin, and which of those have an active Phase 3 trial?
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