Accession Number

Agents counteracting or neutralizing the action of POISONS.

ATC Classification
DrugDrug Description
PralidoximeA cholinesterase reactivator used to treat organophosphate poisoning.
FlumazenilA benzodiazepine antagonist that is used for the complete or partial reversal of the sedative effects caused by benzodiazepines in various clinical settings, such as induced general anesthesia for diagnostic and therapeutic procedures.
FomepizoleAn inhibitor of alcohol dehydrogenase used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning.
Prussian blueA chelating agent used to reduce the extent of systemic contamination with radioactive cesium and/or radioactive or non-radioactive thallium.
Cupric sulfateA compound used as an intravenous copper supplement for Total Parenteral Nutrition (TPN).
4-dimethylaminophenolNot Annotated
LeucovorinA folate analog used to treat the toxic effects of methotrexate and other folate antagonists, to treat megaloblastic anemia, and to provide palliative treatment of colorectal cancer.
Digoxin Immune Fab (Ovine)An antibody binding fragment which binds digoxin molecules which is used as an antidote to digoxin overdose.
SugammadexA modified gamma cyclodextrin used to reverse neuromuscular blockade induced by vecuronium bromide and rocuronium bromide which are agents used for anesthesia.
Nitrous acidAn iron binder used to reverse life-threatening acute cyanide poisoning.
HydroxocobalaminA synthetic form of vitamin B12 used to treat vitamin B12 associated disorders and cyanide poisoning.
AcetylcysteineA medication that can be used as a mucolytic in patients with certain lung conditions and as an antidote for acetaminophen overdose.
Thiosulfuric acidA sulfur donor used sequentially with sodium nitrite for the reversal of life-threatening acute cyanide poisoning. Also used to reduce the risk of ototoxicity associated with cisplatin.
PicrotoxinUsed internally for relieving respiratory distress. Also for use as an antidote in poisoning by CNS depressants, especially barbiturates.
SuccimerA mercaptodicarboxylic acid heavy metal chelator used in the treatment of heavy metal poisoning.
PenicillamineA chelator used to treat Wilson's disease, cystinuria, and rheumatoid arthritis.
EdrophoniumA cholinesterase inhibitor used to diagnose and evaluate myasthenia gravis.
AttapulgiteA veterinary antidiarrheal agent used to treat non-infectious diarrhea in animals.
OglufanideInvestigated for use/treatment in hepatitis (viral, C).
Ubiquinone Q2Not Available
Activated charcoalA gastric decontamination agent used in emergency clinical settings as a antidote to treat poisonings following excessive oral ingestion of certain medications or poisons.
BentoniteNot Annotated
LevoleucovorinA folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer.
MontmorilloniteA purified clay indicated in the treatment of intestinal pain and diarrhea.
Pentetic acidDTPA is widely used in industry and medicine. As a medical agent, it is approved for its use in medical imaging and for the decorporation of internally deposited radionuclides. It...
MethionineAn amino acid commonly found as a component in total parenteral nutrition.
GlutathioneFor nutritional supplementation, also for treating dietary shortage or imbalance
PhysostigmineA cholinesterase inhibitor used to treat glaucoma and anticholinergic toxicity.
NaloxoneAn opioid receptor antagonist used to rapidly reverse an opioid overdose. Also included in some drug formulations as an abuse deterrent to prevent injection.
Amyl NitriteA fast acting vasodilator used for rapid relief of angina pectoris.
DimercaprolA chelating agent used as an antidote to arsenic, gold, and mercury poisoning, as well as acute lead poisoning in combination with edetate calcium disodium.
IdarucizumabAn antibody that binds dabigatran for the reversal of anticoagulant effects of dabigatran.
NalorphineUsed to reverse opioid overdose.
ProtamineA heparin antagonist indicated in the treatment of heparin overdoses, to counteract heparins preoperatively, or during cardiac surgery and dialysis.
ObidoximeNot Annotated
Methylene blueAn oxidation-reduction agent used for the treatment of pediatric and adult patients with acquired methemoglobinemia.
PhentolamineAn alpha-adrenergic blocker used to treat hypertensive episodes, diagnose pheochromocytoma, treat norepinephrine administration site reactions, and reverse soft tissue anesthesia and mydriasis.
PrednisoloneA glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.
EthanolFor therapeutic neurolysis of nerves or ganglia for the relief of intractable chronic pain in such conditions as inoperable cancer and trigeminal neuralgia (tic douloureux), in patients for whom neurosurgical...
PromethazineA first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness.
Potassium IodideAn oral antithyroid agent used for the prevention of radioactive iodine uptake into the thyroid gland during a nuclear radiation emergency.
IpecacAn emetic agent used to induce vomiting in poisoning.
Potassium permanganateNot Annotated
Andexanet alfaA recombinant Factor Xa used to reverse anticoagulation caused by rivaroxaban and apixaban.
2,3-Dimercapto-1-propanesulfonic acidNot Annotated
Dimercaptosuccinic acidNot Annotated
GlucarpidaseA carboxypeptidase enzyme used to reduce plasma concentrations of methotrexate in patients with impaired renal function.
NalmefeneAn opioid antagonist used to reduce alcohol consumption in adults with alcohol dependence and treat and prevent opioid overdose.
Drugs & Drug Targets
FlumazenilGamma-aminobutyric acid receptor subunit alpha-1target
FlumazenilGamma-aminobutyric acid receptor subunit gamma-2target
FlumazenilGamma-aminobutyric acid receptor subunit alpha-5target
FlumazenilGABA(A) Receptortarget
FomepizoleAlcohol dehydrogenase 1Atarget
FomepizoleAlcohol dehydrogenase 1Btarget
FomepizoleAlcohol dehydrogenase 1Ctarget
FomepizoleCytochrome P450 2E1enzyme
FomepizoleCytochrome P450 2A6enzyme
Cupric sulfateSerum albumintransporter
Cupric sulfateCeruloplasmintransporter
Cupric sulfatePhenylalanine-4-hydroxylaseenzyme
Cupric sulfateProtein-lysine 6-oxidaseenzyme
Cupric sulfateCytochrome c oxidase subunit 1enzyme
LeucovorinSolute carrier family 22 member 8transporter
Digoxin Immune Fab (Ovine)Digoxintarget
Nitrous acidHemoglobin subunit alphatarget
Nitrous acidHemoglobin subunit betatarget
Nitrous acidMyoglobintarget
HydroxocobalaminMethylmalonic aciduria type A protein, mitochondrialtarget
HydroxocobalaminProtein amnionlesstarget
HydroxocobalaminMethylmalonyl-CoA mutase, mitochondrialtarget
HydroxocobalaminMethionine synthasetarget
HydroxocobalaminMethylmalonic aciduria and homocystinuria type C proteintarget
AcetylcysteineSolute carrier organic anion transporter family member 1B1transporter
AcetylcysteineNAPQI (N-acetyl-p-benzoquinone imine)target
AcetylcysteineSolute carrier family 22 member 6transporter
AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit alphatarget
AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit betatarget
AcetylcysteineGlutathione synthetasetarget
AcetylcysteineCystine/glutamate transportertarget
AcetylcysteineGlutamate receptor ionotropic, NMDA 2Btarget
AcetylcysteineGlutamate receptor ionotropic, NMDA 1target
AcetylcysteineGlutamate receptor ionotropic, NMDA 2Atarget
AcetylcysteineGlutamate receptor ionotropic, NMDA 2Dtarget
AcetylcysteineGlutamate receptor ionotropic, NMDA 3Atarget
AcetylcysteineSerum albumincarrier
Thiosulfuric acidSolute carrier family 13 member 4transporter
Thiosulfuric acidThiosulfate sulfurtransferaseenzyme
Thiosulfuric acidThiosulfate:glutathione sulfurtransferaseenzyme
Thiosulfuric acidCytochrome P450 2B6enzyme
PicrotoxinGamma-aminobutyric acid receptor subunit rho-1target
PicrotoxinGamma-aminobutyric acid receptor subunit alpha-1target
PicrotoxinGlycine receptor subunit alpha-2target
PicrotoxinGlycine receptor subunit alpha-3target
PicrotoxinCytochrome P450 1A1enzyme
PicrotoxinGlutamine synthetaseenzyme
PicrotoxinGlycine receptor subunit alpha-1target
PenicillamineSolute carrier organic anion transporter family member 1B1transporter
Ubiquinone Q2Succinate dehydrogenase flavoprotein subunittarget
Ubiquinone Q2Succinate dehydrogenase iron-sulfur subunittarget
Ubiquinone Q2Succinate dehydrogenase cytochrome b556 subunittarget
Ubiquinone Q2Succinate dehydrogenase hydrophobic membrane anchor subunittarget
Ubiquinone Q2Cytochrome c1, heme protein, mitochondrialtarget
Ubiquinone Q2Cytochrome btarget
Ubiquinone Q2Cytochrome b-c1 complex subunit 1, mitochondrialtarget
Ubiquinone Q2Cytochrome b-c1 complex subunit 2, mitochondrialtarget
Ubiquinone Q2Cytochrome b-c1 complex subunit 6, mitochondrialtarget
Ubiquinone Q2Cytochrome b-c1 complex subunit 8target
Ubiquinone Q2Cytochrome b-c1 complex subunit Rieske, mitochondrialtarget
Ubiquinone Q2Cytochrome b-c1 complex subunit 10target
Ubiquinone Q2Cytochrome b-c1 complex subunit 7target
Ubiquinone Q2Cytochrome b-c1 complex subunit 9target
Ubiquinone Q2Photosynthetic reaction center cytochrome c subunittarget
Ubiquinone Q2Reaction center protein H chaintarget
Ubiquinone Q2Reaction center protein L chaintarget
Ubiquinone Q2Reaction center protein M chaintarget
Ubiquinone Q2Disulfide bond formation protein Btarget
Ubiquinone Q2Cytochrome btarget
Ubiquinone Q2Ubiquinol-cytochrome c reductase iron-sulfur subunittarget
Ubiquinone Q2Cytochrome c1target
Ubiquinone Q2Reaction center protein L chaintarget
Ubiquinone Q2Reaction center protein M chaintarget
Ubiquinone Q2Reaction center protein H chaintarget
LevoleucovorinSerine hydroxymethyltransferasetarget
Pentetic acidTransuranium elementstarget
Pentetic acidAlpha-1-antitrypsincarrier
MethionineMethionine synthase reductasetarget
MethionineMethionine synthasetarget
MethionineMethionine aminopeptidase 2target
MethionineBetaine--homocysteine S-methyltransferase 1target
MethionineS-methylmethionine--homocysteine S-methyltransferase BHMT2target
MethionineGlutamine synthetaseenzyme
MethionineMethylenetetrahydrofolate reductaseenzyme
MethionineMonocarboxylate transporter 10transporter
MethionineS-adenosylmethionine synthase isoform type-2enzyme
MethionineMethionine-R-sulfoxide reductase B2, mitochondrialenzyme
MethionineS-adenosylmethionine synthase isoform type-1enzyme
MethionineMethionine-R-sulfoxide reductase B1enzyme
MethionineMitochondrial peptide methionine sulfoxide reductaseenzyme
MethionineMethionine--tRNA ligase, cytoplasmicenzyme
MethionineMethionine--tRNA ligase, mitochondrialenzyme
MethionineMethionine adenosyltransferase 2 subunit betaenzyme
MethionineS-methylmethionine--homocysteine S-methyltransferase BHMT2enzyme
GlutathioneGlutathione reductase, mitochondrialtarget
GlutathioneGlutathione synthetasetarget
GlutathioneGlutathione S-transferase Mu 1target
GlutathioneGlutathione S-transferase kappa 1target
GlutathioneGlutathione S-transferase A3target
GlutathioneGlutathione S-transferase Mu 3target
GlutathioneGlutathione S-transferase A4target
GlutathioneGlutathione S-transferase Mu 4target
GlutathioneGlutathione S-transferase A5target
GlutathioneGlutathione S-transferase Ptarget
GlutathioneGlutathione S-transferase omega-1target
GlutathioneGlutathione peroxidase 1target
GlutathioneGlutathione peroxidase 2target
GlutathioneGlutathione S-transferase theta-1target
GlutathioneMaleylacetoacetate isomerasetarget
GlutathioneEpididymal secretory glutathione peroxidasetarget
GlutathioneGlutathione peroxidase 3target
GlutathioneLactoylglutathione lyasetarget
GlutathioneLeukotriene C4 synthasetarget
GlutathioneMicrosomal glutathione S-transferase 3target
GlutathioneHematopoietic prostaglandin D synthasetarget
GlutathioneGlutathione S-transferase A1target
GlutathioneGlutathione S-transferase A2target
GlutathioneMicrosomal glutathione S-transferase 1target
GlutathioneS-formylglutathione hydrolasetarget
GlutathioneGamma-glutamyltranspeptidase 1target
GlutathioneGlutathione S-transferase Mu 2target
GlutathionePhospholipid hydroperoxide glutathione peroxidase, mitochondrialtarget
GlutathioneGlutathione S-transferase Mu 5target
GlutathioneGlutathione peroxidase 6target
GlutathioneHydroxyacylglutathione hydrolase, mitochondrialtarget
GlutathioneGlutathione peroxidasetarget
GlutathioneGlutathione peroxidase 7target
GlutathioneMicrosomal glutathione S-transferase 2target
GlutathioneGlutathione S-transferase omega-2target
GlutathioneGlutaredoxin-2, mitochondrialtarget
GlutathioneGlutathione S-transferase A2enzyme
GlutathioneGlutathione S-transferase A1enzyme
GlutathioneMultidrug resistance-associated protein 1transporter
GlutathioneCanalicular multispecific organic anion transporter 1transporter
GlutathioneCanalicular multispecific organic anion transporter 2transporter
GlutathioneMultidrug resistance-associated protein 4transporter
GlutathioneMultidrug resistance-associated protein 5transporter
GlutathioneAldose reductasetarget
GlutathioneMatrix metalloproteinase-9target
GlutathioneCytochrome P450 3A4target
GlutathioneGlutathione peroxidasetarget
PhysostigmineNeuronal acetylcholine receptor subunit alpha-4target
PhysostigmineNeuronal acetylcholine receptor subunit beta-2target
NaloxoneMu-type opioid receptortarget
NaloxoneEstrogen receptor alphatarget
NaloxoneCyclic AMP-responsive element-binding protein 1target
NaloxoneDelta-type opioid receptortarget
NaloxoneSolute carrier organic anion transporter family member 1A2transporter
NaloxoneP-glycoprotein 1transporter
NaloxoneKappa-type opioid receptortarget
NaloxoneCytochrome P450 3A4enzyme
NaloxoneSerum albumincarrier
NaloxoneToll-like receptor 4target
NaloxoneLiver carboxylesterase 1target
NaloxoneUDP-glucuronosyltransferase 1-1enzyme
NaloxoneCytochrome P450 2C18enzyme
NaloxoneCytochrome P450 2C19enzyme
Amyl NitriteAtrial natriuretic peptide receptor 1target
Amyl NitriteAldehyde dehydrogenase, mitochondrialenzyme
DimercaprolAmyloid beta A4 proteintarget
Methylene blueGuanylate cyclase soluble subunit alpha-2target
Methylene blueNitric oxide synthase, braintarget
Methylene blueUDP-glucuronosyltransferase 1-4enzyme
Methylene blueUDP-glucuronosyltransferase 1-9enzyme
Methylene blueCytochrome P450 1A2enzyme
Methylene blueCytochrome P450 2B6enzyme
Methylene blueCytochrome P450 2C8enzyme
Methylene blueCytochrome P450 2C9enzyme
Methylene blueCytochrome P450 2C19enzyme
Methylene blueCytochrome P450 3A4enzyme
Methylene blueCytochrome P450 3A5enzyme
Methylene blueSerum albumincarrier
Methylene blueP-glycoprotein 1transporter
Methylene blueSolute carrier family 22 member 2transporter
Methylene blueMultidrug and toxin extrusion protein 2transporter
Methylene blueMultidrug and toxin extrusion protein 1transporter
Methylene blueFlavin reductase (NADPH)enzyme
Methylene blueCytochrome P450 2D6enzyme
PhentolamineAlpha-1 adrenergic receptorstarget
PhentolamineAlpha-2 adrenergic receptorstarget
PhentolamineATP-sensitive inward rectifier potassium channel 11target
PrednisoloneCorticosteroid-binding globulincarrier
PrednisoloneCytochrome P450 3A4enzyme
PrednisoloneGlucocorticoid receptortarget
PrednisoloneSolute carrier organic anion transporter family member 1A2transporter
PrednisoloneP-glycoprotein 1transporter
PrednisoloneSerum albumincarrier
EthanolGamma-aminobutyric acid receptor subunit alpha-1target
EthanolGlutamate receptor ionotropic, NMDA 3Atarget
EthanolGlycine receptor subunit alpha-1target
EthanolGlycine receptor subunit alpha-2target
EthanolCytochrome P450 2E1enzyme
EthanolCytochrome P450 1A1enzyme
EthanolCytochrome P450 1A2enzyme
EthanolCytochrome P450 2B6enzyme
EthanolCytochrome P450 2C19enzyme
EthanolCytochrome P450 2C9enzyme
EthanolCytochrome P450 3A4enzyme
EthanolCytochrome P450 4A11enzyme
EthanolAlcohol dehydrogenase 1Aenzyme
EthanolAlcohol dehydrogenase 1Benzyme
EthanolAlcohol dehydrogenase 1Cenzyme
EthanolAlcohol dehydrogenase class-3enzyme
EthanolVoltage-dependent L-type calcium channel subunit beta-1target
Ethanol5-hydroxytryptamine receptor 3Atarget
EthanolAlcohol dehydrogenase 4enzyme
EthanolGamma-aminobutyric acid receptor subunit alpha-2target
EthanolNeuronal acetylcholine receptor subunit alpha-10target
EthanolVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
EthanolGamma-aminobutyric acid receptor subunit alpha-5target
EthanolGamma-aminobutyric acid receptor subunit alpha-4target
EthanolAlcohol dehydrogenase class 4 mu/sigma chainenzyme
EthanolGamma-aminobutyric acid receptor subunit alpha-3target
EthanolGlutamate receptor 1target
EthanolVoltage-dependent calcium channel gamma-1 subunittarget
EthanolNeuronal acetylcholine receptor subunit alpha-2target
EthanolGamma-aminobutyric acid receptor subunit alpha-6target
EthanolGlutamate receptor 2target
EthanolGlutamate receptor 4target
EthanolGlutamate receptor 3target
EthanolNeuronal acetylcholine receptor subunit alpha-4target
EthanolNeuronal acetylcholine receptor subunit beta-2target
EthanolG protein-activated inward rectifier potassium channel 1target
EthanolG protein-activated inward rectifier potassium channel 2target
EthanolVascular cell adhesion protein 1target
EthanolEquilibrative nucleoside transporter 1target
EthanolG protein-activated inward rectifier potassium channel 4target
EthanolNeuronal acetylcholine receptor subunit alpha-7target
EthanolNeuronal acetylcholine receptor subunit alpha-9target
EthanolGamma-aminobutyric acid receptor subunit beta-1target
EthanolGamma-aminobutyric acid receptor subunit beta-3target
EthanolGamma-aminobutyric acid receptor subunit beta-2target
EthanolVoltage-dependent L-type calcium channel subunit alpha-1Starget
EthanolVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
EthanolAlcohol dehydrogenase 6enzyme
EthanolNeuronal acetylcholine receptor subunit beta-4target
EthanolNeuronal acetylcholine receptor subunit alpha-3target
EthanolNeuronal acetylcholine receptor subunit alpha-5target
EthanolNeuronal acetylcholine receptor subunit alpha-6target
EthanolNeuronal acetylcholine receptor subunit beta-3target
EthanolGamma-aminobutyric acid receptor subunit gamma-1target
EthanolGamma-aminobutyric acid receptor subunit gamma-3target
EthanolGamma-aminobutyric acid receptor subunit epsilontarget
EthanolGamma-aminobutyric acid receptor subunit pitarget
EthanolGamma-aminobutyric acid receptor subunit thetatarget
EthanolGamma-aminobutyric acid receptor subunit deltatarget
EthanolAlcohol dehydrogenase [NADP(+)]enzyme
EthanolEquilibrative nucleoside transporter 2target
Ethanol5-hydroxytryptamine receptor 3Etarget
Ethanol5-hydroxytryptamine receptor 3Btarget
Ethanol5-hydroxytryptamine receptor 3Dtarget
Ethanol5-hydroxytryptamine receptor 3Ctarget
EthanolVoltage-dependent calcium channel gamma-2 subunittarget
EthanolG protein-activated inward rectifier potassium channel 3target
EthanolNeural cell adhesion molecule L1target
EthanolAlcohol dehydrogenase class 4 mu/sigma chaintarget
PromethazineDopamine D2 receptortarget
PromethazineHistamine H1 receptortarget
PromethazineMuscarinic acetylcholine receptor M4target
PromethazineMuscarinic acetylcholine receptor M1target
PromethazineMuscarinic acetylcholine receptor M5target
PromethazineMuscarinic acetylcholine receptor M2target
PromethazineMuscarinic acetylcholine receptor M3target
PromethazineCytochrome P450 2D6enzyme
PromethazineCytochrome P450 2B6enzyme
PromethazineP-glycoprotein 1transporter
PromethazineCytochrome P450 2C9enzyme
PromethazineHistamine H2 receptortarget
PromethazineAlpha adrenergic receptortarget
PromethazineP2 Purinoceptorstarget
PromethazineVoltage-gated sodium channel alpha subunittarget
PromethazineVoltage-gated Potassium Channelstarget
PromethazineCanalicular multispecific organic anion transporter 2transporter
PromethazineMultidrug resistance-associated protein 4transporter
PromethazineSerum albumincarrier
Potassium IodideTyrosinetarget
IpecacCytochrome P450 2D6enzyme
IpecacCytochrome P450 3A4enzyme
Andexanet alfaTissue factor pathway inhibitortarget
Dimercaptosuccinic acidMercurytarget
Dimercaptosuccinic acidArsenictarget
NalmefeneMu-type opioid receptortarget
NalmefeneKappa-type opioid receptortarget
NalmefeneDelta-type opioid receptortarget
NalmefeneUDP-glucuronosyltransferase 2B7enzyme
NalmefeneUDP-glucuronosyltransferase 1-3enzyme
NalmefeneUDP-glucuronosyltransferase 1-8enzyme
NalmefeneCytochrome P450 3A4enzyme
NalmefeneCytochrome P450 3A5enzyme